JP2018534311A5 - - Google Patents
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- Publication number
- JP2018534311A5 JP2018534311A5 JP2018525700A JP2018525700A JP2018534311A5 JP 2018534311 A5 JP2018534311 A5 JP 2018534311A5 JP 2018525700 A JP2018525700 A JP 2018525700A JP 2018525700 A JP2018525700 A JP 2018525700A JP 2018534311 A5 JP2018534311 A5 JP 2018534311A5
- Authority
- JP
- Japan
- Prior art keywords
- dose
- raf
- inhibitor
- administered
- medicament according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 38
- 102000018471 Proto-Oncogene Proteins B-raf Human genes 0.000 claims 28
- 108010091528 Proto-Oncogene Proteins B-raf Proteins 0.000 claims 28
- 239000003112 inhibitor Substances 0.000 claims 23
- 201000001441 melanoma Diseases 0.000 claims 15
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 10
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 10
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 10
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 10
- 229940124647 MEK inhibitor Drugs 0.000 claims 7
- 229960002271 cobimetinib Drugs 0.000 claims 7
- RESIMIUSNACMNW-BXRWSSRYSA-N cobimetinib fumarate Chemical group OC(=O)\C=C\C(O)=O.C1C(O)([C@H]2NCCCC2)CN1C(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F.C1C(O)([C@H]2NCCCC2)CN1C(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F RESIMIUSNACMNW-BXRWSSRYSA-N 0.000 claims 7
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 7
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical group CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 claims 5
- 229960003862 vemurafenib Drugs 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 229960003852 atezolizumab Drugs 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- -1 (S)-[3,4-difluoro-2- (2-fluoro-4-iodophenylamino) phenyl] [3-hydroxy-3- (piperidin-2-yl) azetidin-1-yl ] Chemical group 0.000 claims 2
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 208000021039 metastatic melanoma Diseases 0.000 claims 2
- WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000005723 MEK inhibition Effects 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000011275 oncology therapy Methods 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical group CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562257645P | 2015-11-19 | 2015-11-19 | |
| US62/257,645 | 2015-11-19 | ||
| PCT/US2016/062859 WO2017087851A1 (en) | 2015-11-19 | 2016-11-18 | Methods of treating cancer using b-raf inhibitors and immune checkpoint inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018534311A JP2018534311A (ja) | 2018-11-22 |
| JP2018534311A5 true JP2018534311A5 (enExample) | 2019-12-26 |
| JP6952691B2 JP6952691B2 (ja) | 2021-10-20 |
Family
ID=57485956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525700A Active JP6952691B2 (ja) | 2015-11-19 | 2016-11-18 | Ｂ−ｒａｆ阻害剤及び免疫チェックポイント阻害剤を使用してがんを治療する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20180256552A1 (enExample) |
| EP (1) | EP3377107B1 (enExample) |
| JP (1) | JP6952691B2 (enExample) |
| KR (1) | KR102702851B1 (enExample) |
| CN (2) | CN121154828A (enExample) |
| AU (1) | AU2016355320B2 (enExample) |
| ES (1) | ES2824120T3 (enExample) |
| HK (1) | HK1256367A1 (enExample) |
| IL (1) | IL259055B (enExample) |
| MX (1) | MX377351B (enExample) |
| PL (1) | PL3377107T3 (enExample) |
| WO (1) | WO2017087851A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016233495B2 (en) | 2015-03-13 | 2022-02-24 | Cytomx Therapeutics, Inc | Anti-PDL1 antibodies, activatable anti-PDL1 antibodies, and methods of use thereof |
| ES2889906T3 (es) | 2015-05-21 | 2022-01-14 | Harpoon Therapeutics Inc | Proteínas de unión triespecíficas y usos médicos |
| AR107303A1 (es) | 2016-01-08 | 2018-04-18 | Hoffmann La Roche | Métodos de tratamiento de cánceres positivos para ace utilizando antagonistas de unión a eje pd-1 y anticuerpos biespecíficos anti-ace / anti-cd3, uso, composición, kit |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| CA3024723A1 (en) | 2016-05-20 | 2017-11-23 | Robert B. Dubridge | Single domain serum albumin binding protein |
| MX393780B (es) | 2017-01-17 | 2025-03-24 | Heparegenix Gmbh | Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos |
| BR112019025188A2 (pt) * | 2017-06-01 | 2020-06-23 | Cytomx Therapeutics, Inc. | Anticorpos anti-pdl1 ativáveis e métodos de uso dos mesmos |
| JP7084990B2 (ja) | 2017-10-13 | 2022-06-15 | ハープーン セラピューティクス，インク． | 三重特異性タンパク質と使用方法 |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| CN113286817B (zh) | 2018-09-25 | 2025-01-28 | 哈普恩治疗公司 | Dll3结合蛋白及使用方法 |
| WO2020079581A1 (en) * | 2018-10-16 | 2020-04-23 | Novartis Ag | Tumor mutation burden alone or in combination with immune markers as biomarkers for predicting response to targeted therapy |
| WO2021016228A1 (en) * | 2019-07-22 | 2021-01-28 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Combination therapy for treating ras-mutant cancers |
| WO2022131667A1 (ko) * | 2020-12-18 | 2022-06-23 | 경희대학교 산학협력단 | Oligodendrocyte transcription factor 2 억제제를 유효성분으로 포함하는 흑색종 치료 효과 증진용 약학적 조성물 |
| US20240239895A1 (en) * | 2021-04-09 | 2024-07-18 | Genentech, Inc. | Combination therapy with a raf inhibitor and a pd-1 axis inhibitor |
| WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
| WO2025235862A1 (en) | 2024-05-10 | 2025-11-13 | Inndura Therapeutics Inc. | A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| TW200639163A (en) | 2005-02-04 | 2006-11-16 | Genentech Inc | RAF inhibitor compounds and methods |
| ES2720160T3 (es) | 2005-05-09 | 2019-07-18 | Ono Pharmaceutical Co | Anticuerpos monoclonales humanos contra muerte programada 1(PD-1) y métodos para tratar el cáncer usando anticuerpos dirigidos contra PD-1 solos o junto con otras sustancias inmunoterapéuticas |
| PL2395004T3 (pl) | 2005-06-22 | 2016-08-31 | Plexxikon Inc | Pochodne pirolo[2,3-b]pirydyny jako inhibitory kinazy białkowej |
| EA019344B1 (ru) | 2005-07-01 | 2014-03-31 | МЕДАРЕКС, Эл.Эл.Си. | Человеческие моноклональные антитела против лиганда-1 запрограммированной гибели клеток (pd-l1) и их применения |
| DE602006021205D1 (de) | 2005-10-07 | 2011-05-19 | Exelixis Inc | Azetidine als mek-inhibitoren bei der behandlung proliferativer erkrankungen |
| EP2242773B1 (en) | 2008-02-11 | 2017-06-14 | Cure Tech Ltd. | Monoclonal antibodies for tumor treatment |
| MX2010009410A (es) | 2008-02-29 | 2010-11-30 | Array Biopharma Inc | Compuestos del inhibidor de raf y métodos de uso de los mismos. |
| CL2009000448A1 (es) | 2008-02-29 | 2009-11-27 | Genentech Inc | Compuestos derivados de 3-sulfonilamino-n-(1h-pirazolo-[3,4-b]piridin-5il)benzamida; procesos de preparacion; compuestos intermediarios; composicion farmaceutica; y uso para el tratamiento del cancer, tal como sarcoma, carcinoma, adenoma, entre otros. |
| JP2011513329A (ja) | 2008-02-29 | 2011-04-28 | アレイ バイオファーマ、インコーポレイテッド | ＲＡＦ阻害化合物として使用されるイミダゾ［４，５−ｂ］ピリジン誘導体 |
| US20110003859A1 (en) | 2008-02-29 | 2011-01-06 | Array Biopharma Inc. | N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer |
| EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
| EP2328920A2 (en) | 2008-08-25 | 2011-06-08 | Amplimmune, Inc. | Targeted costimulatory polypeptides and methods of use to treat cancer |
| HUE065752T2 (hu) | 2008-12-09 | 2024-06-28 | Hoffmann La Roche | Anti-PD-L1 antitestek és felhasználásuk T-sejt funkció elõsegítésére |
| EP2504028A4 (en) | 2009-11-24 | 2014-04-09 | Amplimmune Inc | SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2 |
| PT2504364T (pt) | 2009-11-24 | 2017-11-14 | Medimmune Ltd | Agentes de ligação direcionados contra b7-h1 |
| SI2884979T1 (sl) * | 2012-08-17 | 2019-10-30 | Hoffmann La Roche | Kombinirana zdravljenja melanoma, ki vključujejo dajanje kobimetiniba in vemurafeniba |
| JP6720075B2 (ja) * | 2013-05-31 | 2020-07-08 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 癌のための併用療法 |
| HK1216231A1 (zh) * | 2013-06-03 | 2016-10-28 | Novartis Ag | Anti-pd-l1抗体及mek抑制剂及/或braf抑制剂的混合物 |
-
2016
- 2016-11-18 CN CN202510876831.3A patent/CN121154828A/zh active Pending
- 2016-11-18 CN CN201680051333.4A patent/CN108136022A/zh active Pending
- 2016-11-18 MX MX2018006152A patent/MX377351B/es active IP Right Grant
- 2016-11-18 KR KR1020187016785A patent/KR102702851B1/ko active Active
- 2016-11-18 WO PCT/US2016/062859 patent/WO2017087851A1/en not_active Ceased
- 2016-11-18 HK HK18115456.5A patent/HK1256367A1/zh unknown
- 2016-11-18 ES ES16806416T patent/ES2824120T3/es active Active
- 2016-11-18 JP JP2018525700A patent/JP6952691B2/ja active Active
- 2016-11-18 EP EP16806416.0A patent/EP3377107B1/en active Active
- 2016-11-18 PL PL16806416T patent/PL3377107T3/pl unknown
- 2016-11-18 AU AU2016355320A patent/AU2016355320B2/en active Active
-
2018
- 2018-04-30 IL IL259055A patent/IL259055B/en unknown
- 2018-05-18 US US15/984,067 patent/US20180256552A1/en not_active Abandoned
-
2019
- 2019-11-13 US US16/683,082 patent/US20200155520A1/en not_active Abandoned
-
2023
- 2023-12-18 US US18/544,236 patent/US20240115555A1/en active Pending
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