JP2018533622A5 - - Google Patents

Download PDF

Info

Publication number
JP2018533622A5
JP2018533622A5 JP2018535266A JP2018535266A JP2018533622A5 JP 2018533622 A5 JP2018533622 A5 JP 2018533622A5 JP 2018535266 A JP2018535266 A JP 2018535266A JP 2018535266 A JP2018535266 A JP 2018535266A JP 2018533622 A5 JP2018533622 A5 JP 2018533622A5
Authority
JP
Japan
Prior art keywords
acid
group
agent
meibomian gland
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018535266A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018533622A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2016/001510 external-priority patent/WO2017055924A2/en
Publication of JP2018533622A publication Critical patent/JP2018533622A/ja
Publication of JP2018533622A5 publication Critical patent/JP2018533622A5/ja
Pending legal-status Critical Current

Links

JP2018535266A 2015-09-28 2016-09-28 マイボーム腺の脂質分泌を増加させるためのチオールおよびジスルフィド含有薬剤 Pending JP2018533622A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562233941P 2015-09-28 2015-09-28
US201562233906P 2015-09-28 2015-09-28
US62/233,941 2015-09-28
US62/233,906 2015-09-28
PCT/IB2016/001510 WO2017055924A2 (en) 2015-09-28 2016-09-28 Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020206141A Division JP7138694B2 (ja) 2015-09-28 2020-12-11 マイボーム腺の脂質分泌を増加させるためのチオールおよびジスルフィド含有薬剤

Publications (2)

Publication Number Publication Date
JP2018533622A JP2018533622A (ja) 2018-11-15
JP2018533622A5 true JP2018533622A5 (https=) 2019-09-05

Family

ID=58408743

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018535266A Pending JP2018533622A (ja) 2015-09-28 2016-09-28 マイボーム腺の脂質分泌を増加させるためのチオールおよびジスルフィド含有薬剤
JP2020206141A Active JP7138694B2 (ja) 2015-09-28 2020-12-11 マイボーム腺の脂質分泌を増加させるためのチオールおよびジスルフィド含有薬剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020206141A Active JP7138694B2 (ja) 2015-09-28 2020-12-11 マイボーム腺の脂質分泌を増加させるためのチオールおよびジスルフィド含有薬剤

Country Status (9)

Country Link
US (3) US10688122B2 (https=)
EP (1) EP3313413B1 (https=)
JP (2) JP2018533622A (https=)
KR (1) KR20180090251A (https=)
CN (2) CN108472312A (https=)
AU (1) AU2016332966A1 (https=)
CA (1) CA3000088A1 (https=)
ES (1) ES3007759T3 (https=)
WO (1) WO2017055924A2 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016022066A1 (en) 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
US9463201B2 (en) 2014-10-19 2016-10-11 M.G. Therapeutics Ltd Compositions and methods for the treatment of meibomian gland dysfunction
US10688122B2 (en) * 2015-09-28 2020-06-23 Azura Ophthalmics Ltd. Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion
US11040062B2 (en) 2016-04-14 2021-06-22 Azura Ophthalmics Ltd. Selenium disulfide compositions for use in treating meibomian gland dysfunction
EP3600272A4 (en) * 2017-03-29 2021-01-13 Azura Ophthalmics Ltd. MEANS OF INCREASING LIPID SECRETION OF THE MEIBOMAN GLAND
AU2018385766B2 (en) 2017-12-15 2022-12-01 Tarsus Pharmaceuticals, Inc. Isoxazoline parasiticide formulations and methods for treating blepharitis
WO2019175290A1 (en) 2018-03-13 2019-09-19 Beckley Canopy Therapeutics Limited Cannabis or cannabis derived compositions for promoting cessation of chemical dependence
WO2020092402A1 (en) * 2018-10-30 2020-05-07 Harrow Health, Inc. Pharmaceutical compositions of tiopronin and methods for preparing thereof
US12239644B2 (en) * 2018-11-02 2025-03-04 Kyungpook National University Industry-Academic Cooperation Foundation Composition for prevention or treatment of macular degeneration
US12502377B2 (en) 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations
JP7723603B2 (ja) * 2019-04-12 2025-08-14 アズーラ オフサルミックス エルティーディー. コンタクトレンズ不快感を処置するための組成物および方法
WO2021090070A2 (en) * 2019-11-04 2021-05-14 Azura Ophthalmics Ltd. Metered dose for disorders in or around the eye
JP2023513415A (ja) 2020-01-02 2023-03-31 アズーラ オフサルミックス エルティーディー. 二硫化セレン組成物の製造
EP4087655A4 (en) 2020-01-10 2024-02-21 Azura Ophthalmics Ltd INSTRUCTIONS FOR COMPOSITION AND SENSITIVITY
EP4232034A4 (en) * 2020-10-21 2024-12-04 Azura Ophthalmics Ltd COMPOUNDS AND METHODS FOR TREATING EYE DISORDERS
US12286451B2 (en) 2020-11-23 2025-04-29 Medtech Products Inc. Borate ester complexes of α-hydroxy carboxylic acids and their conjugate base buffers
US20220160668A1 (en) 2020-11-23 2022-05-26 Sight Sciences, Inc. Formulations and methods for treating conditions of the eye
CN112569179B (zh) * 2020-12-25 2022-12-27 上海交通大学医学院附属第九人民医院 一种可注射水凝胶体系及其制备方法
WO2023215244A1 (en) * 2022-05-02 2023-11-09 Georgetown University Use of n-acetylcysteine to treat lipid disorders and related organ dysfunctions

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236730A (en) 1962-01-04 1966-02-22 Miles Lab Blepharitis composition comprising antiseptic, quaternary ammonium compound, keratolytic agent and a chelating compound
US5602130A (en) 1987-03-20 1997-02-11 Allergan Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
JP2891883B2 (ja) * 1993-11-05 1999-05-17 学校法人近畿大学 抗白内障医薬組成物
WO1997020578A1 (en) * 1995-12-04 1997-06-12 University Of Miami Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance
US5965606A (en) 1995-12-29 1999-10-12 Allergan Sales, Inc. Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity
EP0930072A1 (en) 1998-01-13 1999-07-21 Kartar Dr. Lalvani Vitamin and mineral containing compositions for the treatment of dry eye
US6348508B1 (en) 2000-04-04 2002-02-19 Bausch & Lomb Incorporated Method for treating dry eye
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
ATE355064T1 (de) 2001-10-26 2006-03-15 Angeletti P Ist Richerche Bio Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
FR2833268B1 (fr) 2001-12-12 2005-07-08 Fabre Pierre Dermo Cosmetique Nouvelle association contenant un poloxamer et de l'acide chondroitine sulfurique et/ou une glycoproteine et son utilisation
KR100564386B1 (ko) 2002-05-13 2006-03-27 주식회사 마이코플러스 4-하이드록시-5-메톡시-4-[2-메틸-3-(3-메틸-2-부테닐)-2-옥시란닐]-1-옥사스피로[2,5]옥탄-6-온을 함유한 지루치료용 약제학적 조성물
US8420699B1 (en) 2002-06-19 2013-04-16 Irvine L. Dubow Composition and methods of treatment using deionized and ozonated solution
EP1531793A1 (en) 2002-07-23 2005-05-25 Novartis AG Ophtalmic ointment composition comprising a drug, an ointment base and a solubiling/dispersing agent
EP2272340B1 (en) 2002-08-19 2018-03-14 Ira Sanders Botulinum toxin
US20040171561A1 (en) 2002-09-03 2004-09-02 Popp Karl F. Topical formulations for treatment of rosacea
EP1551399A4 (en) 2002-09-30 2011-01-05 Mark A Babizhayev METHOD FOR THE TOPICAL TREATMENT OF EYE DISEASES AND COMPOSITION AND DEVICE FOR THIS TREATMENT
US20060188471A1 (en) 2002-10-31 2006-08-24 Podolsky Daniel K Methods of treating epithelial lesions
GB0225795D0 (en) 2002-11-05 2002-12-11 Guillon Michael Wipes
US20070269537A1 (en) 2003-02-10 2007-11-22 Bioderm Research Skin Condition Improvement Including Acne, Rosacea, and Topical Wounds by Artemisia Annua Extract via Iron Siderophore Trojan Horse Delivery System
GB0322448D0 (en) 2003-09-25 2003-10-29 Lamellar Therapeutics Ltd Using lamellar bodies to modify linear biological macro molecules
US20050197614A1 (en) 2004-03-04 2005-09-08 Wilson Pritchard Occlusive biomedical devices, punctum plugs, and methods of use thereof
US8455016B2 (en) 2004-03-12 2013-06-04 Melbj Holdings, Llc Treatment for meibomian gland dysfunction or obstruction
US20050202097A1 (en) 2004-03-12 2005-09-15 Melbj Holdings, Llc, Florida Lubricant for the ocular surface
EP1621191A1 (en) 2004-07-29 2006-02-01 Werner Bollag Treatment of inflammatory diseases by RXR Antagonists
US20090214676A1 (en) 2005-04-30 2009-08-27 Tissuetech, Inc. Method for treating ocular demodex
CN101203236A (zh) * 2005-06-22 2008-06-18 坪田一男 角结膜疾病的预防或治疗剂
US7981095B2 (en) 2005-07-18 2011-07-19 Tearscience, Inc. Methods for treating meibomian gland dysfunction employing fluid jet
US8083787B2 (en) 2005-07-18 2011-12-27 Tearscience, Inc. Method and apparatus for treating meibomian gland dysfunction
WO2013003594A2 (en) 2011-06-28 2013-01-03 Tearscience, Inc. Methods and systems for treating meibomian gland dysfunction using radio-frequency energy
WO2007070463A2 (en) * 2005-12-12 2007-06-21 Riolan Technologies, Inc. Compositions, methods and kits for removing debris from an ocular area
CA2651815A1 (en) 2006-05-10 2007-11-22 Dxterity Diagnostics Detection of nucleic acid targets using chemically reactive oligonucleotide probes
WO2007137369A1 (en) 2006-05-31 2007-12-06 Medihoney Pty Ltd Medicinal compositions containing honey
WO2008027069A1 (en) 2006-08-21 2008-03-06 Tearscience, Inc. Method and apparatus for treating meibomian gland dysfunction employing fluid
US8249695B2 (en) 2006-09-29 2012-08-21 Tearscience, Inc. Meibomian gland imaging
US8090426B2 (en) 2006-10-27 2012-01-03 Felder Robin A Microelectronic biosensor plug
US20100204317A1 (en) 2006-11-03 2010-08-12 Qlt Inc. Methods of treating dermatological disorders or conditions
WO2008068866A1 (en) * 2006-11-30 2008-06-12 Menicon Co., Ltd. Ophthalmic composition
BRPI0808410A2 (pt) * 2007-02-28 2015-06-23 Aciex Therapeutics Inc Métodos e composições para normalizar secreções da glândula meibomiana
US8128968B2 (en) 2007-08-29 2012-03-06 Tissuetech, Inc. Compositions and methods for treating Demodex infestations
ES2667945T3 (es) 2007-10-08 2018-05-16 Aurinia Pharmaceuticals Inc. Composiciones oftálmicas que comprenden inhibidores de calcineurina o Inhibidores de mTOR
WO2009120881A1 (en) * 2008-03-26 2009-10-01 Eric Donnenfeld Methods for improving lid margin and tear film function and treatment of lid margin desease using tetracycline family antibiotics
CN104623741A (zh) 2008-04-30 2015-05-20 马缇医疗股份有限公司 复合泪管植入物及相关方法
JP5661035B2 (ja) 2008-07-10 2015-01-28 アラーガン、インコーポレイテッドAllergan,Incorporated 眼および皮膚の疾患および症状の治療用のシクロスポリン誘導体
WO2010033800A2 (en) 2008-09-19 2010-03-25 Alacrity Biosciences, Inc. Tetracycline stabilizing formulations
CA2760591C (en) 2009-05-01 2018-01-02 Advanced Vision Research, Inc. Cleanser compositions and methods for using the same
CN101612161A (zh) 2009-08-07 2009-12-30 魏谠全 一种眼药组合物及其制剂
US9034830B2 (en) * 2009-10-30 2015-05-19 Intratus, Inc. Methods and compositions for sustained delivery of drugs
US20110294897A1 (en) 2009-12-02 2011-12-01 Bridge Pharma, Inc. Treating Xerophthalmia With Compounds Increasing Meibomian Gland Secretion
US20120093876A1 (en) 2010-10-13 2012-04-19 Aciex, Inc. Ophthalmic Formulations, Methods Of Manufacture And Methods of Normalizing Meibomian Gland Secretions
AU2011327785A1 (en) 2010-11-08 2013-03-07 Healor Ltd. Buffered ophthalmic compositions and methods of use thereof
WO2012092378A1 (en) 2010-12-29 2012-07-05 Inspire Pharmaceuticals, Inc. Method for treating blepharitis
WO2012092320A2 (en) 2010-12-29 2012-07-05 Nichamin Louis D Eye treatment
US20130281390A1 (en) 2010-12-29 2013-10-24 Kurt E. Brubaker Method for treating dry eye
KR101914940B1 (ko) 2011-01-26 2018-11-06 알러간, 인코포레이티드 안과 질환을 치료하기 위한 안드로겐 조성물
EP2711374A4 (en) 2011-05-20 2014-05-21 Univ Keio NEW METAL PROTEIN AND METHOD FOR THE PRODUCTION THEREOF, AND PROPHYLACTIC OR THERAPEUTIC AGENT AGAINST HORN OR BINDING DAMAGE WITH THIS METAL PROTEIN
CA2840626A1 (en) * 2011-06-29 2013-01-03 Insite Vision Incorporated Methods of treating recurrent meibomian glands disorder and thereby decreasing the frequency of recurrence
ITFI20120044A1 (it) 2012-03-01 2013-09-02 Biodue Spa Formulazione ad uso oftalmico comprendente olio di jojoba.
EP2838547B1 (en) * 2012-04-16 2019-09-04 Lubrizol Advanced Materials, Inc. Compounds for the treatment and/or care of the skin and/or mucous membranes and their use in cosmetic or pharmaceutical compositions
US9238018B2 (en) * 2012-11-20 2016-01-19 Revive Therapeutics Inc. Use of bucillamine in the treatment of gout
US9211397B2 (en) * 2012-12-19 2015-12-15 Senju Usa, Inc. Patch for treatment of eyelid disease containing clobetasol
US9987235B2 (en) * 2013-08-01 2018-06-05 Nicholas L. Abbott Methods and compositions for modifying mucous membranes
HUE14755117T2 (hu) 2013-08-14 2018-12-28 Kalvista Pharmaceuticals Ltd Plazma-kallikrein inhibitorok
EP3139903B1 (en) 2014-05-07 2019-07-03 Croma-Pharma Gesellschaft m.b.H. Aqueous ophthalmic solution and method for treating dry eye syndrome
US9668996B2 (en) * 2014-06-04 2017-06-06 Tersus Life Sciences, LLC Methods of treating chronic dry eye disease using C16:1n7-palmitoleate and derivatives thereof
US9463201B2 (en) * 2014-10-19 2016-10-11 M.G. Therapeutics Ltd Compositions and methods for the treatment of meibomian gland dysfunction
US10688122B2 (en) 2015-09-28 2020-06-23 Azura Ophthalmics Ltd. Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion
US11040062B2 (en) * 2016-04-14 2021-06-22 Azura Ophthalmics Ltd. Selenium disulfide compositions for use in treating meibomian gland dysfunction
JP2019513775A (ja) * 2016-04-19 2019-05-30 アズーラ オフサルミックス エルティーディー. 角化症の処置のための組成物

Similar Documents

Publication Publication Date Title
JP2018533622A5 (https=)
US20220226367A1 (en) Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion
EA201690069A1 (ru) Применение высоких доз придопидина для лечения болезни хантингтона
BR112022011951A2 (pt) Tratamento de esclerose lateral amiotrófica e distúrbios relacionados
EA201270221A1 (ru) Лечение болезни крона с применением лаквинимода
RU2013111954A (ru) Способ лечения от бокового амиотрофического склероза
NZ591025A (en) Formulation for oral administration of proteins
NZ714963A (en) Compositions and methods for treating anemia
NZ593467A (en) Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
AR085662A1 (es) Metodos y composiciones para tratar la hiperuricemia y trastornos metabolicos asociados con la hiperuricemia
RU2014150942A (ru) Лечение побочных эффектов в виде моторных и двигательных расстройств, связанных с лечением болезни паркинсона
MX2025010188A (es) Moduladores farmaceuticamente activos de la nedilacion de culina mediada por dcn1/2 de tipo pirazolo-piridona
AR068901A1 (es) Utilizacion de albumina humana terapeutica para la preparacion de un medicamento para el tratamiento de pacientes afectados por desordenes cognitivos
JP2013501805A5 (https=)
MX342798B (es) Compuesto de ácido (2s)-2-amino-3-(3,4-bis((2-(benzoiloxi)-2-metil propanoil)oxi)-fenil)propanóico y uso médico del mismo.
US20200383946A1 (en) Lipoic acid formulations
MX2018005298A (es) Regimen de dosificacion para un inhibidor de fosfatidilinositol 3-quinasa.
RU2015115398A (ru) N-ацетил-L-цистеин для применения в экстракорпоральном оплодотворении
WO2025012700A2 (en) Compositions and methods for the treatment of autoimmune disorders
JP2019524782A (ja) N,n−ビス−2−メルカプトエチルイソフタルアミドの新規用途
CA3223719A1 (en) Compositions and methods for vision improvement
TW202426011A (zh) 用於視力改善之組合物及方法
Nyfos A comparative clinical study of a new antirheumatic agent, tolfenamic acid (Clotam), and Phenylbutazone in rheumatoid arthritis
JP2018177773A (ja) 医薬
JP2014521648A5 (https=)