JP2018531979A5 - - Google Patents
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- Publication number
- JP2018531979A5 JP2018531979A5 JP2018522514A JP2018522514A JP2018531979A5 JP 2018531979 A5 JP2018531979 A5 JP 2018531979A5 JP 2018522514 A JP2018522514 A JP 2018522514A JP 2018522514 A JP2018522514 A JP 2018522514A JP 2018531979 A5 JP2018531979 A5 JP 2018531979A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- exosomes
- use according
- tgf
- msc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001808 exosome Anatomy 0.000 claims 7
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 4
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 4
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 239000003636 conditioned culture medium Substances 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000007917 intracranial administration Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000007919 intrasynovial administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000001331 nose Anatomy 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/929,578 | 2015-11-02 | ||
| US14/929,578 US20170121685A1 (en) | 2015-11-02 | 2015-11-02 | Mesenchymal stem cell-derived exosomes and their uses |
| PCT/EP2016/076462 WO2017076924A1 (en) | 2015-11-02 | 2016-11-02 | Mesenchymal stem cell-derived exosomes and their uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018531979A JP2018531979A (ja) | 2018-11-01 |
| JP2018531979A5 true JP2018531979A5 (OSRAM) | 2019-12-12 |
| JP7069011B2 JP7069011B2 (ja) | 2022-05-17 |
Family
ID=57517849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522514A Active JP7069011B2 (ja) | 2015-11-02 | 2016-11-02 | 間葉幹細胞由来のエクソソームおよびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20170121685A1 (OSRAM) |
| EP (1) | EP3371298A1 (OSRAM) |
| JP (1) | JP7069011B2 (OSRAM) |
| CA (1) | CA3003603A1 (OSRAM) |
| HK (1) | HK1254948A1 (OSRAM) |
| IL (1) | IL259147B (OSRAM) |
| WO (1) | WO2017076924A1 (OSRAM) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3120857B1 (en) * | 2014-03-18 | 2021-02-17 | Samsung Life Public Welfare Foundation | Compositions for use in treating inflammatory brain disease comprising stem-cell-derived exosomes as an active ingredient |
| KR20190003316A (ko) * | 2017-06-30 | 2019-01-09 | 주식회사 엑소코바이오 | 지방줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부염 개선 용도 |
| FR3068361B1 (fr) | 2017-06-30 | 2021-10-15 | Univ Paris Diderot Paris 7 | Systeme fluidique de production de vesicules extracellulaires et procede associe |
| KR20190011213A (ko) * | 2017-07-24 | 2019-02-01 | 한양대학교 에리카산학협력단 | 줄기세포로부터 추출된 엑소좀을 유효성분으로 포함하는 골다공증 예방 또는 치료용 조성물 |
| US11766402B2 (en) | 2017-11-16 | 2023-09-26 | Board Of Regents, The University Of Texas System | Methods for production of MSC-derived exosomes |
| WO2019105082A1 (zh) * | 2017-11-30 | 2019-06-06 | 苏州科睿思制药有限公司 | Galunisertib的晶型及其制备方法和用途 |
| US20210161967A1 (en) * | 2017-12-06 | 2021-06-03 | Fondazione Irccs "Ca' Granda - Ospedale Maggiore Policlinico" | Extracellular vesicles and uses thereof |
| EP3758756B1 (en) | 2018-03-02 | 2025-09-03 | The Regents of The University of California | Stem cell-derived exosomes for the treatment of corneal scarring |
| AU2019242912B2 (en) | 2018-03-28 | 2025-07-17 | Board Of Regents, The University Of Texas System | Identification of epigenetic alterations in DNA isolated from exosomes |
| EP3801028A4 (en) | 2018-05-30 | 2022-04-13 | Direct Biologics LLC | A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use |
| CN108865985A (zh) * | 2018-06-22 | 2018-11-23 | 山东省职业卫生与职业病防治研究院 | 一种干细胞源外泌体干预上皮-间质转化的方法 |
| CN109161526A (zh) * | 2018-10-12 | 2019-01-08 | 希瑞干细胞科技有限公司 | 一种绒毛膜间充质干细胞复苏培养基 |
| EP3920946A4 (en) | 2019-02-07 | 2022-11-09 | Direct Biologics LLC | METHOD FOR TREATING OSTEOARTHRITIS USING A COMBINATION OF EXOSOMES OF MESENCHYMATE STEM CELLS, SYNOVIAL MESENCHYMATE STEM CELLS AND SCAFFOLDS |
| EP3927317A4 (en) * | 2019-02-19 | 2022-08-10 | Direct Biologics, LLC | ACELLULAR INTRAVENOUS INFUSION WITH GROWTH FACTORS FROM MESENCHYMAL STEM CELLS AND EXOSOMES |
| JP7513284B2 (ja) * | 2019-03-08 | 2024-07-09 | 国立大学法人 新潟大学 | マクロファージの誘導方法、抗炎症性マクロファージの誘導剤及び医薬組成物 |
| KR102132457B1 (ko) * | 2019-05-10 | 2020-07-09 | 주식회사 바이오솔루션 | 세포외 소포를 고농도로 배양하기 위한 세포 배양배지 및 상기 세포 배양배지를 이용한 세포외 소포 고 함유 조건화 배양액의 제조방법 |
| CN110184235B (zh) * | 2019-05-21 | 2021-03-02 | 葛楠 | 一种adsc外泌体及其制备方法与应用 |
| EP4219686A1 (en) * | 2019-06-10 | 2023-08-02 | Brexogen Inc. | Composition for promoting production of stem cell-derived exosomes and increasing stemness |
| CA3146433A1 (en) | 2019-07-18 | 2021-01-21 | Direct Biologics Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| CN110946876A (zh) * | 2019-10-28 | 2020-04-03 | 天津市康婷生物工程集团有限公司 | 间充质干细胞外泌体制剂在治疗斑秃中的应用 |
| KR20230004709A (ko) | 2020-04-22 | 2023-01-06 | 다이렉트 바이오로직스 엘엘씨 | 감염성 질환과 연관된 염증성 병태를 치료하기 위한 방법 및 조성물 |
| KR102319735B1 (ko) * | 2020-04-28 | 2021-11-01 | 건국대학교 산학협력단 | 3차원 배양된 줄기세포로부터 세포외 소포체를 제조하는 방법 |
| WO2021251616A1 (ko) * | 2020-06-10 | 2021-12-16 | 재단법인 대구경북첨단의료산업진흥재단 | 고양이과 동물 중간엽 줄기세포 유래 엑소좀을 포함하는 조성물 및 이를 이용한 염증질환 치료방법 |
| US12624343B2 (en) | 2020-07-09 | 2026-05-12 | Exo Biologics Sa | Extracellular vesicles (EVs) derived from mesenchymal stromal cells and method for obtaining said EVs |
| CN111849882A (zh) * | 2020-07-17 | 2020-10-30 | 尧舜泽生物医药(南京)有限公司 | 间充质干细胞外泌体及其制备方法和应用 |
| CN111944747A (zh) * | 2020-08-14 | 2020-11-17 | 福建医科大学附属协和医院 | 一种用于治疗心肌梗死的人脂肪间充质干细胞外泌体及其用途 |
| EP4212163A4 (en) | 2020-09-08 | 2024-09-18 | Dexon Pharmaceuticals Inc. | CYTOKINE STORM INHIBITOR, METHOD FOR USING CYTOKINE STORM INHIBITOR, AND METHOD FOR SCREENING CYTOKINE INHIBITOR |
| JPWO2022080461A1 (OSRAM) * | 2020-10-16 | 2022-04-21 | ||
| US20250275965A1 (en) * | 2020-12-15 | 2025-09-04 | Gritscience Biopharmaceuticals Co.,Ltd. | Compounds as casein kinase inhibitors |
| CN112877294B (zh) * | 2021-02-23 | 2021-08-24 | 赛浦生物科技(长春)有限公司 | 基因修饰的间充质干细胞外泌体的制备及其应用 |
| CN112915105B (zh) * | 2021-03-12 | 2024-07-19 | 上海市第六人民医院 | 间充质干细胞分泌的小细胞外囊泡在制备治疗cp/cpps的药物上的应用 |
| CN112961240B (zh) * | 2021-04-06 | 2022-07-05 | 明济生物制药（北京）有限公司 | 一种靶向TGF-β1的单克隆抗体及其与间充质干细胞外泌体的联合应用 |
| CN113174363B (zh) * | 2021-04-21 | 2023-05-30 | 天晴干细胞股份有限公司 | 用于促进iPSC分化为胰岛素分泌细胞的混合物及其制备方法 |
| CN113846047A (zh) * | 2021-06-22 | 2021-12-28 | 姜海涛 | 一种肾靶向载药外泌体及应用和治疗肾脏疾病药物 |
| CN114164172A (zh) * | 2021-08-27 | 2022-03-11 | 广州百暨基因科技有限公司 | 间充质干细胞外泌体的制备方法 |
| CN113930393A (zh) * | 2021-09-27 | 2022-01-14 | 兰州大学 | 一种脐带干细胞来源外泌体的提取及水凝胶的制备方法 |
| CN113862220B (zh) * | 2021-11-05 | 2024-02-13 | 杭州隽和生物医药有限公司 | 间充质干细胞外泌体的制备及其应用 |
| CN114540268B (zh) * | 2022-01-05 | 2024-07-23 | 陕西微泌生物科技有限公司 | 一种基于超纯固膜技术的植物外泌体复合物的制备方法 |
| US20250170183A1 (en) * | 2022-02-28 | 2025-05-29 | Jlm Exograde, Llc | Method for enriching muse cells and obtaining exosomes, microvesicles or the secretome therefrom |
| CN114591901B (zh) * | 2022-03-24 | 2023-11-24 | 和携科技有限公司 | 动物脐带间充质干细胞外泌体提取方法 |
| CN114699550A (zh) * | 2022-03-29 | 2022-07-05 | 湖南有美生物科技有限公司 | 一种含绿茶外泌体的抗hpv功能性妇科敷料及其制备方法 |
| JP7598150B2 (ja) * | 2022-03-30 | 2024-12-11 | 株式会社山田養蜂場本社 | エクソソーム分泌促進剤 |
| CN115025288B (zh) * | 2022-06-17 | 2023-06-13 | 中南大学湘雅医院 | 一种外泌体水凝胶混合体系及其制备方法 |
| JP7220938B1 (ja) | 2022-09-28 | 2023-02-13 | パナジー株式会社 | 微小粒子、ｎｋ細胞活性化剤、ｎｋ細胞の培養方法、活性化ｎｋ細胞の製造方法およびｎｋ細胞の活性化方法 |
| CN115537390B (zh) * | 2022-10-28 | 2025-02-18 | 山东医科元多能干细胞生物工程有限公司 | 一种干细胞外泌体及旁分泌活性大分子连续化生产方法 |
| WO2025226276A1 (en) | 2024-04-25 | 2025-10-30 | Direct Biologics, Llc | Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR638101A0 (en) * | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
| GB2388189B (en) | 2002-04-29 | 2006-01-11 | Robert Jeffrey Geddes Carr | Optical detection and analysis of particles |
| ES2304069B1 (es) | 2003-08-22 | 2009-08-12 | Proyecto De Biomedicina Cima, S.L. | Peptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-b1). |
| PL2254586T3 (pl) * | 2008-02-22 | 2015-09-30 | Agency For Science Tech And Research Astarstar | Cząstki mezenchymalnych komórek macierzystych |
| WO2012095743A2 (en) * | 2011-01-12 | 2012-07-19 | Cellerix Sa | Methods and compositions for use in intralymphatic cellular therapies |
| JP6450673B2 (ja) * | 2012-04-03 | 2019-01-09 | リニューロン・リミテッドＲｅＮｅｕｒｏｎ Ｌｉｍｉｔｅｄ | 幹細胞微粒子 |
-
2015
- 2015-11-02 US US14/929,578 patent/US20170121685A1/en not_active Abandoned
-
2016
- 2016-11-02 HK HK18114052.6A patent/HK1254948A1/zh unknown
- 2016-11-02 CA CA3003603A patent/CA3003603A1/en active Pending
- 2016-11-02 WO PCT/EP2016/076462 patent/WO2017076924A1/en not_active Ceased
- 2016-11-02 IL IL259147A patent/IL259147B/en unknown
- 2016-11-02 JP JP2018522514A patent/JP7069011B2/ja active Active
- 2016-11-02 EP EP16808572.8A patent/EP3371298A1/en active Pending
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