JP2018531269A5 - - Google Patents
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- JP2018531269A5 JP2018531269A5 JP2018520404A JP2018520404A JP2018531269A5 JP 2018531269 A5 JP2018531269 A5 JP 2018531269A5 JP 2018520404 A JP2018520404 A JP 2018520404A JP 2018520404 A JP2018520404 A JP 2018520404A JP 2018531269 A5 JP2018531269 A5 JP 2018531269A5
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 6
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
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- 229930195725 Mannitol Natural products 0.000 claims 2
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 2
- GLEVLJDDWXEYCO-UHFFFAOYSA-N Trolox Chemical group O1C(C)(C(O)=O)CCC2=C1C(C)=C(C)C(O)=C2C GLEVLJDDWXEYCO-UHFFFAOYSA-N 0.000 claims 2
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims 2
- 229960005305 adenosine Drugs 0.000 claims 2
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 2
- 229940119744 dextran 40 Drugs 0.000 claims 2
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- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 2
- 239000006166 lysate Substances 0.000 claims 2
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- 235000010355 mannitol Nutrition 0.000 claims 2
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- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 229960004793 sucrose Drugs 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- RLNWRDKVJSXXPP-UHFFFAOYSA-N tert-butyl 2-[(2-bromoanilino)methyl]piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCCC1CNC1=CC=CC=C1Br RLNWRDKVJSXXPP-UHFFFAOYSA-N 0.000 claims 2
- 238000010257 thawing Methods 0.000 claims 2
- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 claims 1
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 206010056370 Congestive cardiomyopathy Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- -1 D163 Proteins 0.000 claims 1
- 102100029722 Ectonucleoside triphosphate diphosphohydrolase 1 Human genes 0.000 claims 1
- 108010024636 Glutathione Proteins 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 claims 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 1
- 101001012447 Homo sapiens Ectonucleoside triphosphate diphosphohydrolase 1 Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 1
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 206010062016 Immunosuppression Diseases 0.000 claims 1
- 102100025390 Integrin beta-2 Human genes 0.000 claims 1
- 208000032382 Ischaemic stroke Diseases 0.000 claims 1
- 102100033467 L-selectin Human genes 0.000 claims 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 1
- 206010051739 Pulmonary sepsis Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 206010000891 acute myocardial infarction Diseases 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 208000015100 cartilage disease Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
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- 229960003180 glutathione Drugs 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 229940099584 lactobionate Drugs 0.000 claims 1
- 229940099563 lactobionic acid Drugs 0.000 claims 1
- JYTUSYBCFIZPBE-AMTLMPIISA-N lactobionic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
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- 239000004017 serum-free culture medium Substances 0.000 claims 1
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- 231100000827 tissue damage Toxicity 0.000 claims 1
- 230000009092 tissue dysfunction Effects 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 210000005167 vascular cell Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022031113A JP2022084665A (ja) | 2015-10-23 | 2022-03-01 | 脂肪由来幹細胞に基づく幹細胞治療 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15191213 | 2015-10-23 | ||
| EP15191213.6 | 2015-10-23 | ||
| PCT/EP2016/075407 WO2017068140A1 (en) | 2015-10-23 | 2016-10-21 | Stem cell therapy based on adipose-derived stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031113A Division JP2022084665A (ja) | 2015-10-23 | 2022-03-01 | 脂肪由来幹細胞に基づく幹細胞治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018531269A JP2018531269A (ja) | 2018-10-25 |
| JP2018531269A6 JP2018531269A6 (ja) | 2018-12-13 |
| JP2018531269A5 true JP2018531269A5 (https=) | 2019-11-28 |
Family
ID=54360137
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018520404A Pending JP2018531269A (ja) | 2015-10-23 | 2016-10-21 | 脂肪由来幹細胞に基づく幹細胞治療 |
| JP2022031113A Pending JP2022084665A (ja) | 2015-10-23 | 2022-03-01 | 脂肪由来幹細胞に基づく幹細胞治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031113A Pending JP2022084665A (ja) | 2015-10-23 | 2022-03-01 | 脂肪由来幹細胞に基づく幹細胞治療 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US12433916B2 (https=) |
| EP (1) | EP3365432B1 (https=) |
| JP (2) | JP2018531269A (https=) |
| KR (1) | KR20180063334A (https=) |
| CN (1) | CN108135942A (https=) |
| AU (1) | AU2016342387B2 (https=) |
| CA (1) | CA3000912C (https=) |
| DK (1) | DK3365432T3 (https=) |
| ES (1) | ES2807897T3 (https=) |
| PL (1) | PL3365432T3 (https=) |
| PT (1) | PT3365432T (https=) |
| SI (1) | SI3365432T1 (https=) |
| WO (1) | WO2017068140A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3112505C (en) | 2018-09-20 | 2023-06-20 | Citospin, S.L. | Method for obtaining an enriched population of functional mesenchymal stem cells, cells obtained thereof and compositions comprising the same |
| EP3923959A1 (en) | 2019-02-15 | 2021-12-22 | Rigshospitalet | Stem cell therapy for patients with salivary gland dysfunction |
| EP3923960A1 (en) | 2019-02-15 | 2021-12-22 | Rigshospitalet, Copenhagen University Hospital | Stem cell therapy for lacrimal gland dysfunction |
| CN111269888B (zh) * | 2020-03-24 | 2022-04-08 | 山东兴瑞生物科技有限公司 | 一种adipsin基因修饰的脂肪干细胞、制备方法及其应用 |
| EP3909593A1 (en) | 2020-05-15 | 2021-11-17 | Rigshospitalet | Stem cells for treating skin lesions |
| TWI825446B (zh) * | 2020-08-14 | 2023-12-11 | 中國醫藥大學 | 醫藥組合物治療組織缺血狀況之用途 |
| US12426594B2 (en) | 2020-09-24 | 2025-09-30 | Everest Medical Innovation GmbH | Cryoprotective compositions and methods for protection of a surgical site during cryosurgery |
| US12453805B2 (en) | 2020-09-24 | 2025-10-28 | Everest Medical Innovation GmbH | Cryoprotective compositions, surgical kits, and methods for protection of a surgical site during cryosurgery |
| CO2020012570A1 (es) | 2020-10-08 | 2022-04-08 | Inst Distrital De Ciencia Biotecnologia E Innovacion En Salud Idcbis | Método de estimulación de células mesenquimales para inducir expresión de factores inmunomoduladores |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6045990A (en) | 1998-07-09 | 2000-04-04 | Baust; John M. | Inclusion of apoptotic regulators in solutions for cell storage at low temperature |
| US6492103B1 (en) * | 2000-01-31 | 2002-12-10 | Organ Recovery Systems, Inc. | System for organ and tissue preservation and hypothermic blood substitution |
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| ES2313805B1 (es) | 2004-10-04 | 2009-12-23 | Cellerix, S.L. | Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral. |
| TW200726474A (en) | 2005-07-15 | 2007-07-16 | Cognate Therapeutics Inc | The immunophenotype and immunogenicity of human adipose derived cells |
| US9598673B2 (en) | 2006-05-19 | 2017-03-21 | Creative Medical Health | Treatment of disc degenerative disease |
| US20090304654A1 (en) * | 2008-04-30 | 2009-12-10 | Regents Of The University Of California | Methods for isolating adipose-derived stem cells and therapeutic use thereof |
| CN102124098B (zh) * | 2008-06-27 | 2014-03-12 | 博傲沃德株式会社 | 细胞及组织的冷冻保存用组合物 |
| GB0822246D0 (en) | 2008-12-05 | 2009-01-14 | Reneuron Ltd | Composition |
| KR101344719B1 (ko) * | 2011-07-19 | 2013-12-26 | 한국과학기술연구원 | 응력을 가하여 줄기세포를 평활근세포로 분화시키는 방법 및 평활근세포를 함유하는 조직공학용 복합체 |
| JP6435267B2 (ja) * | 2012-11-08 | 2018-12-05 | インジェネロン インコーポレイテッド | 再生細胞の培養、保存、及び投与のための培地 |
| CN103074298B (zh) * | 2013-01-04 | 2015-10-21 | 冯文峰 | 一种人脂肪间充质干细胞库及其构建方法 |
| WO2014203267A2 (en) * | 2013-06-17 | 2014-12-24 | Kasiak Research Pvt. Ltd. | Method for isolation, purification and industrial scale expansion of human adipose tissue derived mesenchymal stem cells |
| CN104357382A (zh) | 2014-10-08 | 2015-02-18 | 黑龙江天晴干细胞有限公司 | 人脂肪干细胞的获取方法及多级同种异体脂肪干细胞库的构建方法 |
| CN108348555B (zh) * | 2015-09-08 | 2022-07-08 | 赛尔爱迪尔私人有限公司 | 细胞扩增方法和治疗组合物 |
-
2016
- 2016-10-21 PT PT167877844T patent/PT3365432T/pt unknown
- 2016-10-21 DK DK16787784.4T patent/DK3365432T3/da active
- 2016-10-21 PL PL16787784T patent/PL3365432T3/pl unknown
- 2016-10-21 SI SI201630853T patent/SI3365432T1/sl unknown
- 2016-10-21 US US15/769,873 patent/US12433916B2/en active Active
- 2016-10-21 JP JP2018520404A patent/JP2018531269A/ja active Pending
- 2016-10-21 CN CN201680061993.0A patent/CN108135942A/zh active Pending
- 2016-10-21 CA CA3000912A patent/CA3000912C/en active Active
- 2016-10-21 AU AU2016342387A patent/AU2016342387B2/en active Active
- 2016-10-21 KR KR1020187014394A patent/KR20180063334A/ko active Pending
- 2016-10-21 ES ES16787784T patent/ES2807897T3/es active Active
- 2016-10-21 EP EP16787784.4A patent/EP3365432B1/en active Active
- 2016-10-21 WO PCT/EP2016/075407 patent/WO2017068140A1/en not_active Ceased
-
2022
- 2022-03-01 JP JP2022031113A patent/JP2022084665A/ja active Pending
-
2025
- 2025-09-10 US US19/324,277 patent/US20260007702A1/en active Pending
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