JP2018527327A5 - - Google Patents

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Publication number
JP2018527327A5
JP2018527327A5 JP2018504124A JP2018504124A JP2018527327A5 JP 2018527327 A5 JP2018527327 A5 JP 2018527327A5 JP 2018504124 A JP2018504124 A JP 2018504124A JP 2018504124 A JP2018504124 A JP 2018504124A JP 2018527327 A5 JP2018527327 A5 JP 2018527327A5
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JP
Japan
Prior art keywords
hcab
antigen binding
binding specificity
ang
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018504124A
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English (en)
Japanese (ja)
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JP6916776B2 (ja
JP2018527327A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/044838 external-priority patent/WO2017020001A2/en
Publication of JP2018527327A publication Critical patent/JP2018527327A/ja
Publication of JP2018527327A5 publication Critical patent/JP2018527327A5/ja
Application granted granted Critical
Publication of JP6916776B2 publication Critical patent/JP6916776B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2018504124A 2015-07-29 2016-07-29 Ang−2に対する重鎖のみ抗体 Expired - Fee Related JP6916776B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562198518P 2015-07-29 2015-07-29
US62/198,518 2015-07-29
US201562205185P 2015-08-14 2015-08-14
US62/205,185 2015-08-14
PCT/US2016/044838 WO2017020001A2 (en) 2015-07-29 2016-07-29 Heavy chain only antibodies to ang-2

Publications (3)

Publication Number Publication Date
JP2018527327A JP2018527327A (ja) 2018-09-20
JP2018527327A5 true JP2018527327A5 (https=) 2019-07-18
JP6916776B2 JP6916776B2 (ja) 2021-08-11

Family

ID=56610025

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018504124A Expired - Fee Related JP6916776B2 (ja) 2015-07-29 2016-07-29 Ang−2に対する重鎖のみ抗体

Country Status (13)

Country Link
US (3) US10266589B2 (https=)
EP (2) EP3792279A3 (https=)
JP (1) JP6916776B2 (https=)
CN (1) CN107849126B (https=)
AU (2) AU2016298398A1 (https=)
BR (1) BR112018001762A2 (https=)
CA (1) CA2992660A1 (https=)
DK (1) DK3328886T3 (https=)
ES (1) ES2828694T3 (https=)
HU (1) HUE051165T2 (https=)
PL (1) PL3328886T3 (https=)
RU (1) RU2749674C2 (https=)
WO (1) WO2017020001A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
CA2992660A1 (en) * 2015-07-29 2017-02-02 Allergan, Inc. Heavy chain only antibodies to ang-2
EP3334762A1 (en) * 2015-08-14 2018-06-20 Allergan, Inc. Heavy chain only antibodies to pdgf
US20220185875A1 (en) * 2019-03-18 2022-06-16 Jiangsu Hengrui Medicine Co., Ltd. Bispecific antibody specifically bound to vegf and ang2
EP4240832A4 (en) * 2020-11-04 2025-01-01 Fate Therapeutics, Inc. Engineered ipsc and immune effector cells for heterogenous tumor control
CN116003591B (zh) * 2022-12-12 2023-09-19 三门峡市眼科医院 Ang-2抗体及其应用

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
ATE135397T1 (de) 1988-09-23 1996-03-15 Cetus Oncology Corp Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
US6797492B2 (en) 1991-05-17 2004-09-28 Merck & Co., Inc. Method for reducing the immunogenicity of antibody variable domains
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
KR100816621B1 (ko) 1997-04-07 2008-03-24 제넨테크, 인크. 항-vegf 항체
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
US7117096B2 (en) 2001-04-17 2006-10-03 Abmaxis, Inc. Structure-based selection and affinity maturation of antibody library
GB0110029D0 (en) 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
CN1301692C (zh) 2002-09-18 2007-02-28 阿勒根公司 眼植入物导入的器械
GB0230203D0 (en) * 2002-12-27 2003-02-05 Domantis Ltd Fc fusion
US7758859B2 (en) 2003-08-01 2010-07-20 Genentech, Inc. Anti-VEGF antibodies
WO2005087812A1 (en) 2004-03-05 2005-09-22 Ludwig Institute For Cancer Research Multivalent antibody materials and methods for vegf/pdgf family of growth factors
KR101151957B1 (ko) 2004-07-22 2012-06-01 로저 킹돈 크레이그 결합 분자
EP1819355A4 (en) * 2004-09-28 2009-08-12 Genexel Sein Inc METHOD OF USE OF A CHIMERIC COILED COIL MOLECULE
ZA200705695B (en) * 2004-12-21 2009-02-25 Astrazeneca Ab Antibodies directed to angiopoietin-2 and uses thereof
AU2007219159B8 (en) 2006-01-25 2012-06-28 Roger Kingdon Craig Generation of heavy-chain only antibodies in transgenic animals
TWI468417B (zh) 2007-11-30 2015-01-11 Genentech Inc 抗-vegf抗體
US8268314B2 (en) * 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
AU2009324354B2 (en) * 2008-12-10 2016-04-14 Ablynx Nv Amino acid sequences directed against the Angiopoietin/Tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis
GB0905023D0 (en) * 2009-03-24 2009-05-06 Univ Erasmus Medical Ct Binding molecules
AR080794A1 (es) 2010-03-26 2012-05-09 Hoffmann La Roche Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2
US9527925B2 (en) * 2011-04-01 2016-12-27 Boehringer Ingelheim International Gmbh Bispecific binding molecules binding to VEGF and ANG2
SI2831111T1 (sl) * 2012-03-30 2019-06-28 Boehringer Ingelheim International Gmbh Ang2-vezavne molekule
RU2639287C2 (ru) * 2012-06-27 2017-12-20 Ф. Хоффманн-Ля Рош Аг Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения
SG11201408538PA (en) 2012-07-13 2015-02-27 Roche Glycart Ag Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
CA2890483A1 (en) * 2012-11-09 2014-05-15 Robert ARCH Platelet-derived growth factor b specific antibodies and compositions and uses thereof
JO3405B1 (ar) 2013-01-09 2019-10-20 Regeneron Pharma الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها
WO2014141192A1 (en) 2013-03-15 2014-09-18 Erasmus University Medical Center Generation of heavy chain-only antibodies
US9828422B2 (en) * 2013-07-29 2017-11-28 Samsung Electronics Co., Ltd. Anti-Ang2 antibody
KR102146845B1 (ko) * 2013-07-30 2020-08-21 삼성전자주식회사 앤지오포이에틴-2에 특이적으로 결합하는 항체 및 그의 용도
RU2017120361A (ru) * 2014-11-10 2018-12-13 Ф.Хоффманн-Ля Рош Аг Антитела к pdgf-b и способы их применения
CA2992660A1 (en) * 2015-07-29 2017-02-02 Allergan, Inc. Heavy chain only antibodies to ang-2
EP3334762A1 (en) * 2015-08-14 2018-06-20 Allergan, Inc. Heavy chain only antibodies to pdgf

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