JP2018527316A - ２−アミノ−１，３，４−チアジアジンおよび２−アミノ−１，３，４−オキサジアジンベースの抗真菌剤 - Google Patents
２−アミノ−１，３，４−チアジアジンおよび２−アミノ−１，３，４−オキサジアジンベースの抗真菌剤 Download PDFInfo
- Publication number
- JP2018527316A JP2018527316A JP2018500924A JP2018500924A JP2018527316A JP 2018527316 A JP2018527316 A JP 2018527316A JP 2018500924 A JP2018500924 A JP 2018500924A JP 2018500924 A JP2018500924 A JP 2018500924A JP 2018527316 A JP2018527316 A JP 2018527316A
- Authority
- JP
- Japan
- Prior art keywords
- thiadiazin
- amine
- alkyl
- butyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C[C@]1CC(N)=NN=C(CCCCOCc2ccccc2*)C1 Chemical compound C[C@]1CC(N)=NN=C(CCCCOCc2ccccc2*)C1 0.000 description 3
- UIATUXXUNJOFLF-UHFFFAOYSA-N CCC(OCC1=NN=C(N)SC1)=O Chemical compound CCC(OCC1=NN=C(N)SC1)=O UIATUXXUNJOFLF-UHFFFAOYSA-N 0.000 description 1
- MMUTVMNWNNBCGK-UHFFFAOYSA-N CCCCCCCC1=CSC(N)=NN1 Chemical compound CCCCCCCC1=CSC(N)=NN1 MMUTVMNWNNBCGK-UHFFFAOYSA-N 0.000 description 1
- RJLYSFZPFRGGGB-UHFFFAOYSA-N CN1N=C(N)SC=C1CCCCCOC Chemical compound CN1N=C(N)SC=C1CCCCCOC RJLYSFZPFRGGGB-UHFFFAOYSA-N 0.000 description 1
- ULEIGFFKUPXHHO-UHFFFAOYSA-N CN1N=C(N)SC=C1c(cc1)ccc1Cl Chemical compound CN1N=C(N)SC=C1c(cc1)ccc1Cl ULEIGFFKUPXHHO-UHFFFAOYSA-N 0.000 description 1
- SSOJWQMUJKEUML-UHFFFAOYSA-N COCCC1=NN=C(N)SC1 Chemical compound COCCC1=NN=C(N)SC1 SSOJWQMUJKEUML-UHFFFAOYSA-N 0.000 description 1
- MATMFWGXJINISC-UHFFFAOYSA-N COCCCC1=NN=C(N)SC1 Chemical compound COCCCC1=NN=C(N)SC1 MATMFWGXJINISC-UHFFFAOYSA-N 0.000 description 1
- TUZXBYNHKYKZPT-UHFFFAOYSA-N NC1=NN=C(CCCCCCCOc2ccccc2)CS1 Chemical compound NC1=NN=C(CCCCCCCOc2ccccc2)CS1 TUZXBYNHKYKZPT-UHFFFAOYSA-N 0.000 description 1
- RUNJQDQPGPOVAD-UHFFFAOYSA-N NC1=NN=C(CCCCCOc2ccccc2)CS1 Chemical compound NC1=NN=C(CCCCCOc2ccccc2)CS1 RUNJQDQPGPOVAD-UHFFFAOYSA-N 0.000 description 1
- CUCSLWKAVNTKTM-UHFFFAOYSA-N NC1=NN=C(CCOc(cc2)ccc2-c2ccccc2)CS1 Chemical compound NC1=NN=C(CCOc(cc2)ccc2-c2ccccc2)CS1 CUCSLWKAVNTKTM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1512286.4A GB201512286D0 (en) | 2015-07-14 | 2015-07-14 | Chemical compounds |
| GB1512286.4 | 2015-07-14 | ||
| PCT/GB2016/052132 WO2017009651A1 (en) | 2015-07-14 | 2016-07-14 | 2-amino-1,3,4-thiadiazine and 2-amino-1,3,4-oxadiazine based antifungal agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018527316A true JP2018527316A (ja) | 2018-09-20 |
| JP2018527316A5 JP2018527316A5 (https=) | 2019-08-22 |
Family
ID=54013916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018500924A Pending JP2018527316A (ja) | 2015-07-14 | 2016-07-14 | ２−アミノ−１，３，４−チアジアジンおよび２−アミノ−１，３，４−オキサジアジンベースの抗真菌剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20180201592A1 (https=) |
| EP (1) | EP3322705A1 (https=) |
| JP (1) | JP2018527316A (https=) |
| KR (1) | KR20180030166A (https=) |
| CN (1) | CN108368102A (https=) |
| AU (1) | AU2016293316A1 (https=) |
| CA (1) | CA2991684A1 (https=) |
| GB (1) | GB201512286D0 (https=) |
| WO (1) | WO2017009651A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018189502A1 (en) * | 2017-04-12 | 2018-10-18 | Momentum Bioscience Limited | Detection and delineation of microorganisms using the ilv3 gene |
| CN108586273B (zh) * | 2018-03-07 | 2019-12-10 | 江南大学 | 一种盐酸普萘洛尔的制备方法 |
| CN120329218A (zh) * | 2025-06-23 | 2025-07-18 | 富祥(山东)新材料有限公司 | 一种抗hiv病毒类药物中间体的制备方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3779736A (en) * | 1971-01-04 | 1973-12-18 | Gulf Research Development Co | 1,3,4-thiadiazine herbicides |
| JPS49110696A (https=) * | 1973-03-10 | 1974-10-22 | ||
| US4254259A (en) * | 1978-11-02 | 1981-03-03 | Indiana University Foundation | 2-Amino-5-ethylovalyl-6H-1,3,4-thiadiazine oxime |
| JP2013533258A (ja) * | 2010-06-28 | 2013-08-22 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 細胞増殖を阻害するための化合物 |
| WO2014182950A1 (en) * | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS428033Y1 (https=) * | 1966-11-05 | 1967-04-24 | ||
| JPS58177482A (ja) * | 1982-04-10 | 1983-10-18 | Mitsui Petrochem Ind Ltd | ２，６−ジ−ｔｅｒｔ−ブチル−４−アシロキシメチルフエノ−ルの製法 |
-
2015
- 2015-07-14 GB GBGB1512286.4A patent/GB201512286D0/en not_active Ceased
-
2016
- 2016-07-14 JP JP2018500924A patent/JP2018527316A/ja active Pending
- 2016-07-14 US US15/744,510 patent/US20180201592A1/en not_active Abandoned
- 2016-07-14 CN CN201680053383.6A patent/CN108368102A/zh active Pending
- 2016-07-14 AU AU2016293316A patent/AU2016293316A1/en not_active Abandoned
- 2016-07-14 WO PCT/GB2016/052132 patent/WO2017009651A1/en not_active Ceased
- 2016-07-14 KR KR1020187004510A patent/KR20180030166A/ko not_active Withdrawn
- 2016-07-14 EP EP16750201.2A patent/EP3322705A1/en not_active Withdrawn
- 2016-07-14 CA CA2991684A patent/CA2991684A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3779736A (en) * | 1971-01-04 | 1973-12-18 | Gulf Research Development Co | 1,3,4-thiadiazine herbicides |
| JPS49110696A (https=) * | 1973-03-10 | 1974-10-22 | ||
| US4254259A (en) * | 1978-11-02 | 1981-03-03 | Indiana University Foundation | 2-Amino-5-ethylovalyl-6H-1,3,4-thiadiazine oxime |
| JP2013533258A (ja) * | 2010-06-28 | 2013-08-22 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 細胞増殖を阻害するための化合物 |
| WO2014182950A1 (en) * | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
Non-Patent Citations (5)
| Title |
|---|
| AKITA KOGYO KOTO SENMON GAKKO KENKYU KIYO, vol. 33, JPN6020024843, 1998, pages 55 - 58, ISSN: 0004303867 * |
| BULLETIN DE L'ACADEMIE POLONAISE DES SCIENCES, SERIE DES SCIENCES CHIMIQUES, vol. 13(6), JPN6020024841, 1965, pages 393 - 6, ISSN: 0004303866 * |
| JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 15(3), JPN6020024845, 1978, pages 401 - 11, ISSN: 0004303869 * |
| JOURNAL OF MEDICINAL CHEMISTRY, vol. 57(12), JPN6020024846, 2014, pages 5094 - 5111, ISSN: 0004303870 * |
| JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2: PHYSICAL ORGANIC CHEMISTRY (1972-1999), vol. (6), JPN6020024844, 1980, pages 890 - 9, ISSN: 0004303868 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180030166A (ko) | 2018-03-21 |
| CA2991684A1 (en) | 2017-01-19 |
| WO2017009651A1 (en) | 2017-01-19 |
| EP3322705A1 (en) | 2018-05-23 |
| CN108368102A (zh) | 2018-08-03 |
| US20180201592A1 (en) | 2018-07-19 |
| AU2016293316A1 (en) | 2018-01-25 |
| GB201512286D0 (en) | 2015-08-19 |
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