JP2018526994A5 - - Google Patents
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- Publication number
- JP2018526994A5 JP2018526994A5 JP2018510981A JP2018510981A JP2018526994A5 JP 2018526994 A5 JP2018526994 A5 JP 2018526994A5 JP 2018510981 A JP2018510981 A JP 2018510981A JP 2018510981 A JP2018510981 A JP 2018510981A JP 2018526994 A5 JP2018526994 A5 JP 2018526994A5
- Authority
- JP
- Japan
- Prior art keywords
- raav
- epo
- sequence
- promoter
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 16
- 102000003951 Erythropoietin Human genes 0.000 claims 12
- 108090000394 Erythropoietin Proteins 0.000 claims 12
- 241000702421 Dependoparvovirus Species 0.000 claims 11
- 229940105423 erythropoietin Drugs 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 239000013598 vector Substances 0.000 claims 7
- 210000000234 capsid Anatomy 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical group 0.000 claims 5
- 108020004705 Codon Proteins 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000013603 viral vector Substances 0.000 claims 4
- 241001164825 Adeno-associated virus - 8 Species 0.000 claims 3
- 241000282326 Felis catus Species 0.000 claims 3
- 208000020832 chronic kidney disease Diseases 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 241000282324 Felis Species 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 102100024151 Cadherin-16 Human genes 0.000 claims 1
- 101710196874 Cadherin-16 Proteins 0.000 claims 1
- 241000282465 Canis Species 0.000 claims 1
- 101150035002 SLC12A1 gene Proteins 0.000 claims 1
- 102000018614 Uromodulin Human genes 0.000 claims 1
- 108010027007 Uromodulin Proteins 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 230000001124 posttranscriptional effect Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562212144P | 2015-08-31 | 2015-08-31 | |
| US62/212,144 | 2015-08-31 | ||
| US201662336211P | 2016-05-13 | 2016-05-13 | |
| US62/336,211 | 2016-05-13 | ||
| PCT/US2016/049487 WO2017040524A1 (en) | 2015-08-31 | 2016-08-30 | Aav-epo for treating companion animals |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018526994A JP2018526994A (ja) | 2018-09-20 |
| JP2018526994A5 true JP2018526994A5 (OSRAM) | 2019-09-26 |
| JP6877408B2 JP6877408B2 (ja) | 2021-05-26 |
Family
ID=58188403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510981A Active JP6877408B2 (ja) | 2015-08-31 | 2016-08-30 | ペット治療用ａａｖ−ｅｐｏ |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11117942B2 (OSRAM) |
| EP (1) | EP3344650A4 (OSRAM) |
| JP (1) | JP6877408B2 (OSRAM) |
| KR (1) | KR20180057636A (OSRAM) |
| CN (1) | CN108137664B (OSRAM) |
| AU (1) | AU2016315699B2 (OSRAM) |
| CA (1) | CA2995733A1 (OSRAM) |
| HK (1) | HK1257024A1 (OSRAM) |
| WO (1) | WO2017040524A1 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020000063A2 (pt) * | 2017-07-06 | 2020-07-14 | The Trustees Of The University Of Pennsylvania | terapia gênica mediada por aav9 para tratamento de mucopolissacaridose tipo i |
| SG11202100781VA (en) * | 2018-07-27 | 2021-02-25 | Regenxbio Inc | Treatment of mucopolysaccharidosis iva |
| CA3121586A1 (en) * | 2018-12-12 | 2020-06-18 | Kindred Biosciences, Inc. | Erythropoietin analogs for veterinary use |
| WO2022067080A1 (en) * | 2020-09-28 | 2022-03-31 | Scout Bio, Inc. | Composition and uses thereof |
| CA3209779A1 (en) | 2021-02-01 | 2022-08-04 | Regenxbio Inc. | Gene therapy for neuronal ceroid lipofuscinoses |
| WO2023034880A2 (en) | 2021-08-31 | 2023-03-09 | Scout Bio, Inc. | Antigen-binding molecules and uses thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
| US6268213B1 (en) | 1992-06-03 | 2001-07-31 | Richard Jude Samulski | Adeno-associated virus vector and cis-acting regulatory and promoter elements capable of expressing at least one gene and method of using same for gene therapy |
| US5869305A (en) | 1992-12-04 | 1999-02-09 | The University Of Pittsburgh | Recombinant viral vector system |
| US5478745A (en) | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
| US6204059B1 (en) | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
| US6093570A (en) | 1995-06-07 | 2000-07-25 | The University Of North Carolina At Chapel Hill | Helper virus-free AAV production |
| US5741683A (en) | 1995-06-07 | 1998-04-21 | The Research Foundation Of State University Of New York | In vitro packaging of adeno-associated virus DNA |
| US5846528A (en) | 1996-01-18 | 1998-12-08 | Avigen, Inc. | Treating anemia using recombinant adeno-associated virus virions comprising an EPO DNA sequence |
| DE69824859T2 (de) | 1997-04-14 | 2005-08-04 | Cell Genesys, Inc., Foster City | Methoden zur erhöhung der effizienz rekombinanter aav produkte |
| US6696411B1 (en) * | 1998-04-22 | 2004-02-24 | Cornell Research Foundation, Inc. | Canine erythropoietin gene and recombinant protein |
| EP1080218A1 (en) | 1998-05-27 | 2001-03-07 | University of Florida | Method of preparing recombinant adeno-associated virus compositions by using an iodixanol gradient |
| CA2343104A1 (en) * | 1998-09-16 | 2000-03-23 | Nexia Biotechnologies, Inc. | Recombinant protein production in urine |
| DE69941905D1 (de) | 1998-11-10 | 2010-02-25 | Univ North Carolina | Virusvektoren und verfahren für ihre herstellung und verabreichung. |
| EP1520589A1 (en) | 1998-12-17 | 2005-04-06 | Pfizer Products Inc. | Erythropoietin in the treatment of domestic and livestock animals for anaemia |
| CA2288341C (en) * | 1998-12-17 | 2005-01-04 | Pfizer Products Inc. | Erythropoietin in the treatment of domestic and livestock animals for anemia |
| ES2308989T3 (es) | 1999-08-09 | 2008-12-16 | Targeted Genetics Corporation | Aumento de la expresion de una secuencia nucleotidica heterologa a partir de vectores viricos recombinantes que contienen una secuencia que forman pares de bases intracatenarios. |
| EP1286703B1 (en) | 2000-06-01 | 2009-08-05 | University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| NZ618298A (en) | 2001-11-13 | 2015-04-24 | Univ Pennsylvania | A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby |
| PT2359869T (pt) | 2001-12-17 | 2019-04-16 | Univ Pennsylvania | Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas |
| WO2003104413A2 (en) | 2002-06-05 | 2003-12-18 | University Of Florida | Production of pseudotyped recombinant aav virions |
| EP2292780B1 (en) | 2003-09-30 | 2017-08-23 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof |
| EP2359865B1 (en) * | 2005-04-07 | 2013-10-02 | The Trustees of The University of Pennsylvania | Method of increasing the function of an AAV vector |
| US9988427B2 (en) * | 2005-05-13 | 2018-06-05 | Charite Universitaetsmedizen-Berlin | Erythropoietin variants |
| EP1736481A1 (en) * | 2005-05-13 | 2006-12-27 | Charite Universitätsmedizin-Berlin | Erythropoietin variants |
| JP4495210B2 (ja) | 2005-06-09 | 2010-06-30 | パナソニック株式会社 | 振幅誤差補償装置及び直交度誤差補償装置 |
| EP2007795B1 (en) | 2006-03-30 | 2016-11-16 | The Board Of Trustees Of The Leland Stanford Junior University | Aav capsid proteins |
| WO2010011642A2 (en) | 2008-07-21 | 2010-01-28 | The Trustees Of The University Of Pennsylvania | Methods and compositions using splicing regulatory proteins involved in tumor suppression |
| CA2737026C (en) * | 2008-09-26 | 2019-12-24 | Ambrx, Inc. | Modified animal erythropoietin polypeptides and their uses |
| DK3421603T3 (da) * | 2009-05-02 | 2022-01-10 | Genzyme Corp | Genterapi for neurodegenerative forstyrrelser |
| US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
| SG183929A1 (en) | 2010-03-29 | 2012-10-30 | Univ Pennsylvania | Pharmacologically induced transgene ablation system |
| FR2977562B1 (fr) | 2011-07-06 | 2016-12-23 | Gaztransport Et Technigaz | Cuve etanche et thermiquement isolante integree dans une structure porteuse |
| CA2886161A1 (en) | 2012-09-29 | 2014-04-03 | The Trustees Of The University Of Pennsylvania | Veterinary composition and methods for non-surgical neutering and castration |
| US9719106B2 (en) | 2013-04-29 | 2017-08-01 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof |
| WO2014182684A2 (en) | 2013-05-06 | 2014-11-13 | Cell Machines, Inc. | Methods and compositions related to large scale production of proteins |
-
2016
- 2016-08-30 HK HK18116145.0A patent/HK1257024A1/zh unknown
- 2016-08-30 KR KR1020187008958A patent/KR20180057636A/ko not_active Withdrawn
- 2016-08-30 WO PCT/US2016/049487 patent/WO2017040524A1/en not_active Ceased
- 2016-08-30 CA CA2995733A patent/CA2995733A1/en not_active Abandoned
- 2016-08-30 AU AU2016315699A patent/AU2016315699B2/en active Active
- 2016-08-30 JP JP2018510981A patent/JP6877408B2/ja active Active
- 2016-08-30 CN CN201680049590.4A patent/CN108137664B/zh active Active
- 2016-08-30 EP EP16842817.5A patent/EP3344650A4/en active Pending
- 2016-08-30 US US15/754,931 patent/US11117942B2/en active Active
-
2021
- 2021-09-10 US US17/472,037 patent/US20220056090A1/en active Pending
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