JP2018526460A5 - - Google Patents
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- JP2018526460A5 JP2018526460A5 JP2018532812A JP2018532812A JP2018526460A5 JP 2018526460 A5 JP2018526460 A5 JP 2018526460A5 JP 2018532812 A JP2018532812 A JP 2018532812A JP 2018532812 A JP2018532812 A JP 2018532812A JP 2018526460 A5 JP2018526460 A5 JP 2018526460A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
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- subject
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 25
- RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 11
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 7
- 108010092160 Dactinomycin Proteins 0.000 claims description 7
- RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 claims description 7
- 229960000640 dactinomycin Drugs 0.000 claims description 7
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 239000008280 blood Substances 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 230000000877 morphologic effect Effects 0.000 claims description 3
- 101001109719 Homo sapiens Nucleophosmin Proteins 0.000 claims description 2
- 102100022678 Nucleophosmin Human genes 0.000 claims description 2
- 238000001802 infusion Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 30
- 239000003814 drug Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000011275 oncology therapy Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 31
- 239000003937 drug carrier Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562218433P | 2015-09-14 | 2015-09-14 | |
| US62/218,433 | 2015-09-14 | ||
| PCT/EP2016/071599 WO2017046108A1 (en) | 2015-09-14 | 2016-09-13 | Dactinomycin compositions and methods for the treatment of acute myeloid leukemia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018526460A JP2018526460A (ja) | 2018-09-13 |
| JP2018526460A5 true JP2018526460A5 (OSRAM) | 2019-10-17 |
| JP7001599B2 JP7001599B2 (ja) | 2022-01-19 |
Family
ID=56896582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532812A Active JP7001599B2 (ja) | 2015-09-14 | 2016-09-13 | 急性骨髄性白血病の処置のためのダクチノマイシン組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10335416B2 (OSRAM) |
| EP (1) | EP3349759B1 (OSRAM) |
| JP (1) | JP7001599B2 (OSRAM) |
| AU (1) | AU2016324920B2 (OSRAM) |
| CA (1) | CA2998042C (OSRAM) |
| ES (1) | ES2809805T3 (OSRAM) |
| WO (1) | WO2017046108A1 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2998042C (en) | 2015-09-14 | 2022-07-05 | Brunangelo Falini | Dactinomycin compositions and methods for the treatment of acute myeloid leukemia |
| CA3031691A1 (en) | 2016-09-13 | 2018-03-22 | Rasna Research Inc. | Dactinomycin compositions and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia |
| EP3601249A4 (en) | 2017-03-24 | 2020-12-16 | Kura Oncology, Inc. | METHODS OF TREATMENT OF MALIGNANT HEMOPATHIES AND EWING'S SARCOMA |
| KR101954370B1 (ko) | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| EP3856173A4 (en) * | 2018-09-26 | 2022-07-06 | Kura Oncology, Inc. | TREATMENT OF HEMOPATHY MALIGNANCE WITH MENIN INHIBITORS |
| PH12021551985A1 (en) | 2019-02-22 | 2022-08-22 | Hanmi Pharmaceutical Co Ltd | Pharmaceutical composition comprising flt3 inhibitor and hypomethylating agent for treating acute myeloid leukemia |
| EP3991733A4 (en) | 2019-06-27 | 2023-07-05 | Hanmi Pharm. Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA CONTAINING FLT3 INHIBITOR AND CHEMOTHERAPY AGENTS |
| KR102886965B1 (ko) * | 2022-02-28 | 2025-11-17 | 한국유나이티드제약 주식회사 | 향상된 용해도를 가지는 닥티노마이신 함유 약학조성물의 제조방법 |
| EP4630122A1 (en) * | 2022-12-10 | 2025-10-15 | Aptose Biosciences Inc. | Methods for treating patients with hematologic malignancies |
| CN116942834B (zh) * | 2023-06-12 | 2024-04-05 | 新乡医学院 | 包含核仁应激诱导剂的抗肿瘤药物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| GB0223341D0 (en) * | 2002-10-08 | 2002-11-13 | Groningen Acad Ziekenhuis | Organic compounds |
| US20070010478A1 (en) * | 2005-07-06 | 2007-01-11 | Branimir Sikic | Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer |
| EP2397149A1 (en) * | 2010-06-17 | 2011-12-21 | Hil-Invent Ges.M.B.H. | Pharmaceutical preparation comprising actinomycin D for the treatment of B-CLL in patients having del(17p) |
| ES2685619T3 (es) | 2013-12-30 | 2018-10-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinación de un compuesto de arsénico y al menos un retinoide para tratar la leucemia mielógena aguda |
| CA2998042C (en) | 2015-09-14 | 2022-07-05 | Brunangelo Falini | Dactinomycin compositions and methods for the treatment of acute myeloid leukemia |
-
2016
- 2016-09-13 CA CA2998042A patent/CA2998042C/en active Active
- 2016-09-13 ES ES16763556T patent/ES2809805T3/es active Active
- 2016-09-13 AU AU2016324920A patent/AU2016324920B2/en active Active
- 2016-09-13 US US15/759,442 patent/US10335416B2/en active Active
- 2016-09-13 WO PCT/EP2016/071599 patent/WO2017046108A1/en not_active Ceased
- 2016-09-13 JP JP2018532812A patent/JP7001599B2/ja active Active
- 2016-09-13 EP EP16763556.4A patent/EP3349759B1/en active Active
-
2019
- 2019-05-21 US US16/418,374 patent/US11337983B2/en active Active
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