JP2018526423A - 眼科疾患を処置するための化合物および製剤 - Google Patents

眼科疾患を処置するための化合物および製剤 Download PDF

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Publication number
JP2018526423A
JP2018526423A JP2018513359A JP2018513359A JP2018526423A JP 2018526423 A JP2018526423 A JP 2018526423A JP 2018513359 A JP2018513359 A JP 2018513359A JP 2018513359 A JP2018513359 A JP 2018513359A JP 2018526423 A JP2018526423 A JP 2018526423A
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optionally substituted
formulation
compound
salt
pharmaceutical formulation
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JP2018513359A
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Japanese (ja)
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JP2018526423A5 (https=
Inventor
レア マクリー，
レア マクリー，
ジェリー ケーグル，
ジェリー ケーグル，
エンジェル パディリャ，
エンジェル パディリャ，
デイビッド ベイカー，
デイビッド ベイカー，
ゲイリー クック，
ゲイリー クック，
ハルン タクルリ，
ハルン タクルリ，
エメット カニンガム，
エメット カニンガム，
Original Assignee
ビューポイント セラピューティクス， インコーポレイテッド
ビューポイント セラピューティクス， インコーポレイテッド
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Application filed by ビューポイント セラピューティクス， インコーポレイテッド, ビューポイント セラピューティクス， インコーポレイテッド filed Critical ビューポイント セラピューティクス， インコーポレイテッド
Publication of JP2018526423A publication Critical patent/JP2018526423A/ja
Publication of JP2018526423A5 publication Critical patent/JP2018526423A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2018513359A 2015-09-08 2016-09-08 眼科疾患を処置するための化合物および製剤 Pending JP2018526423A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562215629P 2015-09-08 2015-09-08
US62/215,629 2015-09-08
US201562269013P 2015-12-17 2015-12-17
US201562269019P 2015-12-17 2015-12-17
US62/269,019 2015-12-17
US62/269,013 2015-12-17
PCT/US2016/050823 WO2017044659A1 (en) 2015-09-08 2016-09-08 Compounds and formulations for treating ophthalmic diseases

Publications (2)

Publication Number Publication Date
JP2018526423A true JP2018526423A (ja) 2018-09-13
JP2018526423A5 JP2018526423A5 (https=) 2019-10-24

Family

ID=58240060

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018513359A Pending JP2018526423A (ja) 2015-09-08 2016-09-08 眼科疾患を処置するための化合物および製剤

Country Status (8)

Country Link
US (1) US20180250313A1 (https=)
EP (1) EP3347368A4 (https=)
JP (1) JP2018526423A (https=)
CN (1) CN108350021A (https=)
AU (1) AU2016321254A1 (https=)
CA (1) CA2998134A1 (https=)
HK (1) HK1258588A1 (https=)
WO (1) WO2017044659A1 (https=)

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US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
EP2986624B1 (en) 2013-04-17 2020-03-25 Sage Therapeutics, Inc. 19-nor neuroactive steroids for methods of treatment
US20160068563A1 (en) 2013-04-17 2016-03-10 Boyd L. Harrison 19-nor neuroactive steroids and methods of use thereof
KR102396328B1 (ko) 2013-04-17 2022-05-10 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
SI3021852T1 (sl) 2013-07-19 2021-07-30 Sage Therapeutics, Inc. Nevroaktivni steroidi, sestavki in uporabe le-teh
AU2014308621C1 (en) 2013-08-23 2022-01-06 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
CN117024501A (zh) 2014-10-16 2023-11-10 萨奇治疗股份有限公司 靶向cns障碍的组合物和方法
ME03809B (me) 2014-10-16 2021-04-20 Sage Therapeutics Inc KOMPOZICIJE I POSTUPCI ZA LEČENJE POREMEĆAJA CNS-a
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
RS61530B1 (sr) 2015-01-26 2021-04-29 Sage Therapeutics Inc Kompozicije i postupci za lečenje poremećaja cns
EP4155314A1 (en) 2015-02-20 2023-03-29 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
CN108473528B (zh) 2015-10-29 2026-01-16 弗门尼舍公司 高强度甜味剂
WO2018013615A1 (en) 2016-07-11 2018-01-18 Sage Therapeutics, Inc. C7, c12, and c16 substituted neuroactive steroids and their methods of use
MA45599A (fr) 2016-07-11 2019-05-15 Sage Therapeutics Inc Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
EP3504189A1 (en) 2016-08-23 2019-07-03 Sage Therapeutics, Inc. A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid
SG11201910136RA (en) 2017-05-03 2019-11-28 Firmenich Incorporated Methods for making high intensity sweeteners
CN108794556B (zh) * 2017-05-05 2021-01-29 清华大学 化合物及其在治疗白内障中的应用
PL3634415T3 (pl) * 2017-06-08 2026-04-07 Eye Therapies, Llc Kompozycje okulistyczne zawierające brymonidynę i ketotifen do zastosowania w leczeniu alergii
US20200281944A1 (en) * 2017-11-17 2020-09-10 Mahmood Piraee Combinations Of Lanosterol Or 25-Hydroxycholesterol Including Derivatives Thereof Useful In The Treatment Of Lens Disorders
EP3713617A1 (en) * 2017-11-22 2020-09-30 Bausch & Lomb Incorporated Ophthalmic viscoelastic compositions
US20200276211A1 (en) * 2017-11-28 2020-09-03 Viewpoint Therapeutics, Inc. Compounds for treating near vision disorders
WO2019191200A1 (en) 2018-03-27 2019-10-03 American Genomics, Llc Method and formulation for producing anesthesia of internal aspect of eye wall by topical application
EP3813794A4 (en) * 2018-06-27 2022-07-13 Cellix Bio Private Limited COMPOSITIONS AND METHODS OF TREATMENT EYE DISEASES
MX2021005219A (es) 2018-11-07 2021-06-18 Firmenich Incorporated Metodos para hacer edulcorantes de alta intensidad.
EP3860363A1 (en) 2018-11-07 2021-08-11 Firmenich Incorporated Methods for making high intensity sweeteners
AU2020245203A1 (en) * 2019-03-26 2021-11-11 Martin Uram Anesthetic composition and method of anesthetizing the eye
SG11202112391UA (en) 2019-05-31 2021-12-30 Sage Therapeutics Inc Neuroactive steroids and compositions thereof
WO2021113410A1 (en) * 2019-12-02 2021-06-10 Ampersand Biopharmaceuticals, Inc. Transdermal penetrant formulations for vitamins, minerals and supplements
WO2021113411A1 (en) * 2019-12-02 2021-06-10 Ampersand Biopharmaceuticals, Inc. Transdermal penetrant formulations for vitamins, minerals and supplements
WO2022023822A1 (en) * 2020-07-30 2022-02-03 Indoco Remedies Limited A stable ophthalmic composition of posaconazole
WO2022031830A1 (en) * 2020-08-04 2022-02-10 Harrow Ip Llc Antibacterial compositions and methods for fabricating thereof
US20220112208A1 (en) * 2020-10-08 2022-04-14 King Abdullah University Of Science And Technology Compounds with antiinflammatory activity and methods of use thereof
CN113583950A (zh) * 2021-08-06 2021-11-02 合肥滴碧云生物科技有限公司 一种制备干细胞活性因子的方法及其应用
CN115737654B (zh) * 2021-09-03 2025-11-21 成都瑞沐生物医药科技有限公司 一种滴眼给药预防和/或治疗白内障的眼用制剂
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WO2014015024A2 (en) * 2012-07-17 2014-01-23 Regents Of The University Of Michigan Non-surgical method of treatment for cataract
WO2014152818A1 (en) * 2013-03-14 2014-09-25 The University Of Massachusetts Methods of inhibiting cataracts and presbyopia
WO2017019808A1 (en) * 2015-07-27 2017-02-02 Catacore, Inc Compositions for the treatment of cataracts

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JP2013513622A (ja) * 2009-12-14 2013-04-22 ユニバーシティ オブ マサチューセッツ 白内障及び老眼を阻害する方法
WO2014015024A2 (en) * 2012-07-17 2014-01-23 Regents Of The University Of Michigan Non-surgical method of treatment for cataract
WO2014152818A1 (en) * 2013-03-14 2014-09-25 The University Of Massachusetts Methods of inhibiting cataracts and presbyopia
WO2017019808A1 (en) * 2015-07-27 2017-02-02 Catacore, Inc Compositions for the treatment of cataracts

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Also Published As

Publication number Publication date
WO2017044659A1 (en) 2017-03-16
US20180250313A1 (en) 2018-09-06
AU2016321254A1 (en) 2018-04-05
CN108350021A (zh) 2018-07-31
EP3347368A4 (en) 2019-01-23
EP3347368A1 (en) 2018-07-18
HK1258588A1 (zh) 2019-11-15
CA2998134A1 (en) 2017-03-16

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