JP2018526391A - 置換１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ｃ］イミダゾール−３−オン抗菌性化合物 - Google Patents

置換１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ｃ］イミダゾール−３−オン抗菌性化合物 Download PDF

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Publication number
JP2018526391A
JP2018526391A JP2018511713A JP2018511713A JP2018526391A JP 2018526391 A JP2018526391 A JP 2018526391A JP 2018511713 A JP2018511713 A JP 2018511713A JP 2018511713 A JP2018511713 A JP 2018511713A JP 2018526391 A JP2018526391 A JP 2018526391A
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Prior art keywords
methyl
hydroxy
methylsulfonyl
pyrrolo
oxo
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Ceased
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JP2018511713A
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Japanese (ja)
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JP2018526391A5 (cg-RX-API-DMAC10.html
Inventor
ブルムシュタイン アン−キャサリン
ブルムシュタイン アン−キャサリン
マテュー ガエル
マテュー ガエル
ジャコブ ロワ
ジャコブ ロワ
マッス フロランス
マッス フロランス
ミッレ アゼリー
ミッレ アゼリー
パンショー フィリップ
パンショー フィリップ
シュミット クリスティン
シュミット クリスティン
スペックリン ジャン−リュック
スペックリン ジャン−リュック
スリヴェット ジャン−フィリップ
スリヴェット ジャン−フィリップ
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Idorsia Pharmaceuticals Ltd
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Idorsia Pharmaceuticals Ltd
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Publication of JP2018526391A publication Critical patent/JP2018526391A/ja
Publication of JP2018526391A5 publication Critical patent/JP2018526391A5/ja
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2018511713A 2015-09-03 2016-09-02 置換１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ｃ］イミダゾール−３−オン抗菌性化合物 Ceased JP2018526391A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2015070144 2015-09-03
EPPCT/EP2015/070144 2015-09-03
PCT/EP2016/070695 WO2017037221A1 (en) 2015-09-03 2016-09-02 Substituted 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one antibacterial compounds

Publications (2)

Publication Number Publication Date
JP2018526391A true JP2018526391A (ja) 2018-09-13
JP2018526391A5 JP2018526391A5 (cg-RX-API-DMAC10.html) 2019-10-10

Family

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Family Applications (1)

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JP2018511713A Ceased JP2018526391A (ja) 2015-09-03 2016-09-02 置換１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ｃ］イミダゾール−３−オン抗菌性化合物

Country Status (17)

Country Link
US (1) US10314823B2 (cg-RX-API-DMAC10.html)
EP (1) EP3344630B1 (cg-RX-API-DMAC10.html)
JP (1) JP2018526391A (cg-RX-API-DMAC10.html)
KR (1) KR20180049017A (cg-RX-API-DMAC10.html)
CN (1) CN108137596A (cg-RX-API-DMAC10.html)
AR (1) AR105889A1 (cg-RX-API-DMAC10.html)
AU (1) AU2016313794B2 (cg-RX-API-DMAC10.html)
BR (1) BR112018004343A2 (cg-RX-API-DMAC10.html)
CA (1) CA2994996A1 (cg-RX-API-DMAC10.html)
CL (1) CL2018000533A1 (cg-RX-API-DMAC10.html)
EA (1) EA201890626A1 (cg-RX-API-DMAC10.html)
HK (1) HK1256614A1 (cg-RX-API-DMAC10.html)
IL (1) IL257757A (cg-RX-API-DMAC10.html)
MX (1) MX2018002644A (cg-RX-API-DMAC10.html)
PH (1) PH12018500323A1 (cg-RX-API-DMAC10.html)
TW (1) TW201714885A (cg-RX-API-DMAC10.html)
WO (1) WO2017037221A1 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023503091A (ja) * 2019-11-21 2023-01-26 ユニバーシティ オブ ユタ リサーチ ファウンデーション Ｔｒｐｖ４受容体リガンド

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
TW201840569A (zh) * 2017-03-01 2018-11-16 瑞士商愛杜西亞製藥有限公司 (2r)-n-羥基-4-(6-((1-(2-羥基乙基)氮雜環丁烷-3-基)丁-1,3-二炔-1-基)-3-氧基-1h-吡咯并[1,2-c]咪唑-2(3h)-基)-2-甲基-2-(甲磺醯基)丁醯胺之結晶形式
WO2018224455A1 (en) 2017-06-07 2018-12-13 Basf Se Substituted cyclopropyl derivatives
WO2019038362A1 (en) 2017-08-24 2019-02-28 Idorsia Pharmaceuticals Ltd ANTIBACTERIAL PYRROLOIMIDAZOLONES
WO2019086452A1 (en) 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Antibacterial heteroaromatic compounds
WO2019121143A1 (en) 2017-12-20 2019-06-27 Basf Se Substituted cyclopropyl derivatives
JP7156199B2 (ja) * 2018-08-09 2022-10-19 信越化学工業株式会社 レジスト材料及びパターン形成方法
US11458149B1 (en) 2019-05-31 2022-10-04 Ikena Oncology, Inc. TEAD inhibitors and uses thereof
BR112021024108A2 (pt) 2019-05-31 2022-03-22 Ikena Oncology Inc Inibidores de tead e usos dos mesmos

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013514345A (ja) * 2009-12-16 2013-04-25 ファイザー・インク 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体
JP2014507464A (ja) * 2011-03-07 2014-03-27 ファイザー・インク 抗菌剤として有用なフルオロ−ピリジノン誘導体
WO2015036964A1 (en) * 2013-09-13 2015-03-19 Actelion Pharmaceuticals Ltd Antibacterial 2h-indazole derivatives
JP2017508746A (ja) * 2014-03-04 2017-03-30 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ １，２−ジヒドロ−３Ｈ−ピロロ［１，２−ｃ］イミダゾール−３−オン誘導体及び抗菌剤としてのそれらの使用
JP2018526354A (ja) * 2015-08-11 2018-09-13 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 置換１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ｃ］イミダゾール−３−オン抗菌剤

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG2013013339A (en) 2002-03-13 2014-12-30 Array Biopharma Inc N3 alkylated benzimidazole derivatives as mek inhibitors
UA80500C2 (en) 2003-10-17 2007-09-25 Basf Ag Fungicidal mixture and agent for controlling rice pathogens, containing triazolopyrimidine derivative and metalaxyl-m, method for controlling rice pathogens and sowing material
DE102008044132A1 (de) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Kältegerät mit zweiseitig anschlagbarer Tür
CA2774250C (en) 2009-10-13 2013-12-17 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
KR20120079015A (ko) 2011-01-03 2012-07-11 한미약품 주식회사 Ｇ 단백질-커플링된 수용체의 조절을 위한 신규한 비사이클릭 화합물
WO2012137099A1 (en) 2011-04-08 2012-10-11 Pfizer Inc. Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
WO2012137094A1 (en) 2011-04-08 2012-10-11 Pfizer Inc. Isoxazole derivatives useful as antibacterial agents
WO2013170165A1 (en) 2012-05-10 2013-11-14 Achaogen, Inc. Antibacterial agents
EA201590953A1 (ru) 2012-11-16 2015-08-31 Бристол-Майерс Сквибб Компани Пирролидиновые модуляторы gpr40
WO2014165075A1 (en) 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
WO2015066413A1 (en) 2013-11-01 2015-05-07 Novartis Ag Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections
KR20160098503A (ko) 2013-12-19 2016-08-18 액테리온 파마슈티칼 리미티드 항균성 1h-인다졸 및 1h-인돌 유도체
WO2015173329A1 (en) 2014-05-16 2015-11-19 Actelion Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
BR112017010474A2 (pt) 2014-11-19 2017-12-26 Actelion Pharmaceuticals Ltd derivados antibacterianos de benzotiazol
AR105839A1 (es) 2015-08-28 2017-11-15 Actelion Pharmaceuticals Ltd Derivados antibacterianos pirrolidin-2-ona anulares
AR105848A1 (es) 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
WO2017098440A1 (en) 2015-12-08 2017-06-15 Glaxosmithkline Intellectual Property Development Limited Substituted benzazinones as antibacterial compounds
AU2017267194A1 (en) 2016-05-17 2019-01-17 Idorsia Pharmaceuticals Ltd 6-(BUTA-1,3-DIYN-1-YL)benzo[D]thiazole derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013514345A (ja) * 2009-12-16 2013-04-25 ファイザー・インク 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体
JP2014507464A (ja) * 2011-03-07 2014-03-27 ファイザー・インク 抗菌剤として有用なフルオロ−ピリジノン誘導体
WO2015036964A1 (en) * 2013-09-13 2015-03-19 Actelion Pharmaceuticals Ltd Antibacterial 2h-indazole derivatives
JP2017508746A (ja) * 2014-03-04 2017-03-30 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ １，２−ジヒドロ−３Ｈ−ピロロ［１，２−ｃ］イミダゾール−３−オン誘導体及び抗菌剤としてのそれらの使用
JP2018526354A (ja) * 2015-08-11 2018-09-13 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 置換１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ｃ］イミダゾール−３−オン抗菌剤

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023503091A (ja) * 2019-11-21 2023-01-26 ユニバーシティ オブ ユタ リサーチ ファウンデーション Ｔｒｐｖ４受容体リガンド
JP7624745B2 (ja) 2019-11-21 2025-01-31 ユニバーシティ オブ ユタ リサーチ ファウンデーション Ｔｒｐｖ４受容体リガンド

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US20180250273A1 (en) 2018-09-06
US10314823B2 (en) 2019-06-11
EA201890626A1 (ru) 2018-09-28
TW201714885A (zh) 2017-05-01
EP3344630A1 (en) 2018-07-11
CL2018000533A1 (es) 2018-06-29
AU2016313794A1 (en) 2018-04-19
BR112018004343A2 (pt) 2018-09-25
WO2017037221A1 (en) 2017-03-09
IL257757A (en) 2018-04-30
KR20180049017A (ko) 2018-05-10
PH12018500323A1 (en) 2018-08-13
MX2018002644A (es) 2018-06-20
AR105889A1 (es) 2017-11-22
EP3344630B1 (en) 2020-12-09
HK1256614A1 (zh) 2019-09-27
AU2016313794B2 (en) 2020-06-04
CA2994996A1 (en) 2017-03-09
CN108137596A (zh) 2018-06-08

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