AU2016313794B2 - Substituted 1,2-dihydro-3H-pyrrolo[1,2-c]imidazol-3-one antibacterial compounds - Google Patents
Substituted 1,2-dihydro-3H-pyrrolo[1,2-c]imidazol-3-one antibacterial compounds Download PDFInfo
- Publication number
- AU2016313794B2 AU2016313794B2 AU2016313794A AU2016313794A AU2016313794B2 AU 2016313794 B2 AU2016313794 B2 AU 2016313794B2 AU 2016313794 A AU2016313794 A AU 2016313794A AU 2016313794 A AU2016313794 A AU 2016313794A AU 2016313794 B2 AU2016313794 B2 AU 2016313794B2
- Authority
- AU
- Australia
- Prior art keywords
- methyl
- hydroxy
- imidazol
- pyrrolo
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C*(C)OC(C(C)(C)c(cccc1)c1OP(O)(O)=O)=O Chemical compound C*(C)OC(C(C)(C)c(cccc1)c1OP(O)(O)=O)=O 0.000 description 2
- WYSBSEUTRUEZRA-UHFFFAOYSA-N C/[O]=C/c1cc(N)c[nH]1 Chemical compound C/[O]=C/c1cc(N)c[nH]1 WYSBSEUTRUEZRA-UHFFFAOYSA-N 0.000 description 1
- GOEDKBMMCKUUIE-OAHLLOKOSA-N CC(C)COC([C@@](C)(CCNCc1cc(N)c[nH]1)S(C)(=O)=O)=O Chemical compound CC(C)COC([C@@](C)(CCNCc1cc(N)c[nH]1)S(C)(=O)=O)=O GOEDKBMMCKUUIE-OAHLLOKOSA-N 0.000 description 1
- AQNBZJFOXWSGMK-CQSZACIVSA-N CCOC([C@@](C)(CCN(Cc1cc(N)c[n]11)C1=O)S(C)(=O)=O)=O Chemical compound CCOC([C@@](C)(CCN(Cc1cc(N)c[n]11)C1=O)S(C)(=O)=O)=O AQNBZJFOXWSGMK-CQSZACIVSA-N 0.000 description 1
- SSUKQQGJASVLTA-BYPYZUCNSA-N C[C@@H](c1cc(N)c[nH]1)N Chemical compound C[C@@H](c1cc(N)c[nH]1)N SSUKQQGJASVLTA-BYPYZUCNSA-N 0.000 description 1
- CVQIQSQTMNLEMA-CYBMUJFWSA-N C[C@@](CCN(Cc1cc(I)c[n]11)C1=O)(C([IH]C)=O)S(C)(=O)=O Chemical compound C[C@@](CCN(Cc1cc(I)c[n]11)C1=O)(C([IH]C)=O)S(C)(=O)=O CVQIQSQTMNLEMA-CYBMUJFWSA-N 0.000 description 1
- XULGJHHGIKRLMZ-GFCCVEGCSA-N C[C@@](CCN(Cc1cc(N)c[n]11)C1=O)(C(O)=O)S(C)(=O)=O Chemical compound C[C@@](CCN(Cc1cc(N)c[n]11)C1=O)(C(O)=O)S(C)(=O)=O XULGJHHGIKRLMZ-GFCCVEGCSA-N 0.000 description 1
- WLUHOQDOUUSGIU-UHFFFAOYSA-N Nc(cc1CN2)c[n]1C2=O Chemical compound Nc(cc1CN2)c[n]1C2=O WLUHOQDOUUSGIU-UHFFFAOYSA-N 0.000 description 1
- NBHIICKHJQCOGT-UHFFFAOYSA-N Nc1c[nH]c(C=N)c1 Chemical compound Nc1c[nH]c(C=N)c1 NBHIICKHJQCOGT-UHFFFAOYSA-N 0.000 description 1
- FFVXBGCVRJTDKP-UHFFFAOYSA-N Nc1c[nH]c(C=O)c1 Chemical compound Nc1c[nH]c(C=O)c1 FFVXBGCVRJTDKP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2015070144 | 2015-09-03 | ||
| EPPCT/EP2015/070144 | 2015-09-03 | ||
| PCT/EP2016/070695 WO2017037221A1 (en) | 2015-09-03 | 2016-09-02 | Substituted 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one antibacterial compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2016313794A1 AU2016313794A1 (en) | 2018-04-19 |
| AU2016313794B2 true AU2016313794B2 (en) | 2020-06-04 |
Family
ID=56852279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016313794A Expired - Fee Related AU2016313794B2 (en) | 2015-09-03 | 2016-09-02 | Substituted 1,2-dihydro-3H-pyrrolo[1,2-c]imidazol-3-one antibacterial compounds |
Country Status (17)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| TW201840569A (zh) * | 2017-03-01 | 2018-11-16 | 瑞士商愛杜西亞製藥有限公司 | (2r)-n-羥基-4-(6-((1-(2-羥基乙基)氮雜環丁烷-3-基)丁-1,3-二炔-1-基)-3-氧基-1h-吡咯并[1,2-c]咪唑-2(3h)-基)-2-甲基-2-(甲磺醯基)丁醯胺之結晶形式 |
| WO2018224455A1 (en) | 2017-06-07 | 2018-12-13 | Basf Se | Substituted cyclopropyl derivatives |
| WO2019038362A1 (en) | 2017-08-24 | 2019-02-28 | Idorsia Pharmaceuticals Ltd | ANTIBACTERIAL PYRROLOIMIDAZOLONES |
| WO2019086452A1 (en) | 2017-10-31 | 2019-05-09 | Idorsia Pharmaceuticals Ltd | Antibacterial heteroaromatic compounds |
| WO2019121143A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Substituted cyclopropyl derivatives |
| JP7156199B2 (ja) * | 2018-08-09 | 2022-10-19 | 信越化学工業株式会社 | レジスト材料及びパターン形成方法 |
| US11458149B1 (en) | 2019-05-31 | 2022-10-04 | Ikena Oncology, Inc. | TEAD inhibitors and uses thereof |
| BR112021024108A2 (pt) | 2019-05-31 | 2022-03-22 | Ikena Oncology Inc | Inibidores de tead e usos dos mesmos |
| US12703680B2 (en) | 2019-11-21 | 2026-08-11 | University Of Utah Research Foundation | TRPV4 receptor ligands |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011073845A1 (en) * | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| WO2015036964A1 (en) * | 2013-09-13 | 2015-03-19 | Actelion Pharmaceuticals Ltd | Antibacterial 2h-indazole derivatives |
| WO2015132228A1 (en) * | 2014-03-04 | 2015-09-11 | Actelion Pharmaceuticals Ltd | 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG2013013339A (en) | 2002-03-13 | 2014-12-30 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| UA80500C2 (en) | 2003-10-17 | 2007-09-25 | Basf Ag | Fungicidal mixture and agent for controlling rice pathogens, containing triazolopyrimidine derivative and metalaxyl-m, method for controlling rice pathogens and sowing material |
| DE102008044132A1 (de) | 2008-11-27 | 2010-06-02 | BSH Bosch und Siemens Hausgeräte GmbH | Kältegerät mit zweiseitig anschlagbarer Tür |
| CA2774250C (en) | 2009-10-13 | 2013-12-17 | Pfizer Inc. | C-linked hydroxamic acid derivatives useful as antibacterial agents |
| KR20120079015A (ko) | 2011-01-03 | 2012-07-11 | 한미약품 주식회사 | Ｇ 단백질-커플링된 수용체의 조절을 위한 신규한 비사이클릭 화합물 |
| AP3336A (en) | 2011-03-07 | 2015-07-31 | Pfizer | Fluoro-pyridinone derivatives useful as antibacterial agents |
| WO2012137099A1 (en) | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| WO2012137094A1 (en) | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Isoxazole derivatives useful as antibacterial agents |
| WO2013170165A1 (en) | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
| EA201590953A1 (ru) | 2012-11-16 | 2015-08-31 | Бристол-Майерс Сквибб Компани | Пирролидиновые модуляторы gpr40 |
| WO2014165075A1 (en) | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
| WO2015066413A1 (en) | 2013-11-01 | 2015-05-07 | Novartis Ag | Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections |
| KR20160098503A (ko) | 2013-12-19 | 2016-08-18 | 액테리온 파마슈티칼 리미티드 | 항균성 1h-인다졸 및 1h-인돌 유도체 |
| WO2015173329A1 (en) | 2014-05-16 | 2015-11-19 | Actelion Pharmaceuticals Ltd | Antibacterial quinazoline-4(3h)-one derivatives |
| BR112017010474A2 (pt) | 2014-11-19 | 2017-12-26 | Actelion Pharmaceuticals Ltd | derivados antibacterianos de benzotiazol |
| AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| AR105839A1 (es) | 2015-08-28 | 2017-11-15 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos pirrolidin-2-ona anulares |
| AR105848A1 (es) | 2015-08-31 | 2017-11-15 | Actelion Pharmaceuticals Ltd | Derivados heterocíclicos antibacterianos |
| WO2017098440A1 (en) | 2015-12-08 | 2017-06-15 | Glaxosmithkline Intellectual Property Development Limited | Substituted benzazinones as antibacterial compounds |
| AU2017267194A1 (en) | 2016-05-17 | 2019-01-17 | Idorsia Pharmaceuticals Ltd | 6-(BUTA-1,3-DIYN-1-YL)benzo[D]thiazole derivatives |
-
2016
- 2016-09-01 AR ARP160102671A patent/AR105889A1/es unknown
- 2016-09-02 CA CA2994996A patent/CA2994996A1/en not_active Abandoned
- 2016-09-02 AU AU2016313794A patent/AU2016313794B2/en not_active Expired - Fee Related
- 2016-09-02 MX MX2018002644A patent/MX2018002644A/es unknown
- 2016-09-02 KR KR1020187009472A patent/KR20180049017A/ko not_active Withdrawn
- 2016-09-02 EP EP16759792.1A patent/EP3344630B1/en not_active Not-in-force
- 2016-09-02 WO PCT/EP2016/070695 patent/WO2017037221A1/en not_active Ceased
- 2016-09-02 US US15/756,366 patent/US10314823B2/en not_active Expired - Fee Related
- 2016-09-02 CN CN201680049395.1A patent/CN108137596A/zh active Pending
- 2016-09-02 TW TW105128540A patent/TW201714885A/zh unknown
- 2016-09-02 JP JP2018511713A patent/JP2018526391A/ja not_active Ceased
- 2016-09-02 HK HK18115746.5A patent/HK1256614A1/zh unknown
- 2016-09-02 EA EA201890626A patent/EA201890626A1/ru unknown
- 2016-09-02 BR BR112018004343-5A patent/BR112018004343A2/pt not_active Application Discontinuation
-
2018
- 2018-02-13 PH PH12018500323A patent/PH12018500323A1/en unknown
- 2018-02-27 IL IL257757A patent/IL257757A/en unknown
- 2018-02-28 CL CL2018000533A patent/CL2018000533A1/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011073845A1 (en) * | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| WO2015036964A1 (en) * | 2013-09-13 | 2015-03-19 | Actelion Pharmaceuticals Ltd | Antibacterial 2h-indazole derivatives |
| WO2015132228A1 (en) * | 2014-03-04 | 2015-09-11 | Actelion Pharmaceuticals Ltd | 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents |
Also Published As
| Publication number | Publication date |
|---|---|
| US20180250273A1 (en) | 2018-09-06 |
| US10314823B2 (en) | 2019-06-11 |
| EA201890626A1 (ru) | 2018-09-28 |
| TW201714885A (zh) | 2017-05-01 |
| EP3344630A1 (en) | 2018-07-11 |
| CL2018000533A1 (es) | 2018-06-29 |
| AU2016313794A1 (en) | 2018-04-19 |
| BR112018004343A2 (pt) | 2018-09-25 |
| WO2017037221A1 (en) | 2017-03-09 |
| JP2018526391A (ja) | 2018-09-13 |
| IL257757A (en) | 2018-04-30 |
| KR20180049017A (ko) | 2018-05-10 |
| PH12018500323A1 (en) | 2018-08-13 |
| MX2018002644A (es) | 2018-06-20 |
| AR105889A1 (es) | 2017-11-22 |
| EP3344630B1 (en) | 2020-12-09 |
| HK1256614A1 (zh) | 2019-09-27 |
| CA2994996A1 (en) | 2017-03-09 |
| CN108137596A (zh) | 2018-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3344630B1 (en) | Substituted 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one antibacterial compounds | |
| DK3114126T3 (en) | 1,2-DIHYDRO-3H-PYRROLO [1,2-C] IMIDAZOL-3-ON DERIVATIVES AND THEIR USE AS ANTIBACTERIALS | |
| DK3044211T3 (en) | ANTIBACTERIAL 2H INDEZOL DERIVATIVES | |
| EP3143007B1 (en) | Antibacterial quinazoline-4(3h)-one derivatives | |
| EP3334737B1 (en) | Substituted 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one antibacterial compounds | |
| CA2963875A1 (en) | Antibacterial benzothiazole derivatives | |
| EP3341378A1 (en) | Antibacterial annulated pyrrolidin-2-one derivatives | |
| AU2017267194A1 (en) | 6-(BUTA-1,3-DIYN-1-YL)benzo[D]thiazole derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |