JP2018526344A - Ｔｇｆベータ受容体アンタゴニスト - Google Patents

Ｔｇｆベータ受容体アンタゴニスト Download PDF

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Publication number
JP2018526344A
JP2018526344A JP2018504171A JP2018504171A JP2018526344A JP 2018526344 A JP2018526344 A JP 2018526344A JP 2018504171 A JP2018504171 A JP 2018504171A JP 2018504171 A JP2018504171 A JP 2018504171A JP 2018526344 A JP2018526344 A JP 2018526344A
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JP
Japan
Prior art keywords
alkyl
hydrogen
heteroatoms selected
alkoxy
ring containing
Prior art date
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Application number
JP2018504171A
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English (en)
Japanese (ja)
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JP2018526344A5 (https=
Inventor
ラルグディ・エス・ハリクリシュナン
ブライアン・イー・フィンク
ロバート・エム・ボルジレリ
ゴピキシャン・トヌクヌル
ジャヤクマール・サンカラ・ウォリアー
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2018526344A publication Critical patent/JP2018526344A/ja
Publication of JP2018526344A5 publication Critical patent/JP2018526344A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018504171A 2015-07-28 2016-07-27 Ｔｇｆベータ受容体アンタゴニスト Withdrawn JP2018526344A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562197667P 2015-07-28 2015-07-28
US62/197,667 2015-07-28
PCT/US2016/044233 WO2017019757A1 (en) 2015-07-28 2016-07-27 Tgf beta receptor antagonists

Publications (2)

Publication Number Publication Date
JP2018526344A true JP2018526344A (ja) 2018-09-13
JP2018526344A5 JP2018526344A5 (https=) 2019-08-15

Family

ID=56609982

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018504171A Withdrawn JP2018526344A (ja) 2015-07-28 2016-07-27 Ｔｇｆベータ受容体アンタゴニスト

Country Status (6)

Country Link
US (1) US10399987B2 (https=)
EP (1) EP3328861A1 (https=)
JP (1) JP2018526344A (https=)
KR (1) KR20180034548A (https=)
CN (1) CN108137597A (https=)
WO (1) WO2017019757A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022530371A (ja) * 2019-04-22 2022-06-29 エピタス バイオサイエンシズ（シャンハイ）カンパニー，リミティド ピリミド５員複素環化合物及び変異型ｉｄｈ２阻害薬としてのその使用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116621843B (zh) * 2022-06-13 2024-05-24 四川大学华西医院 一种dna甲基转移酶1抑制剂及其制备方法和用途

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ES2305744T3 (es) 2003-03-12 2008-11-01 Millennium Pharmaceuticals, Inc. Derivados de quinazolina como inhibidores e tgf-beta.
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TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
AU2006230099B2 (en) 2005-03-25 2012-04-19 Gitr, Inc. GITR binding molecules and uses therefor
PL1879573T3 (pl) 2005-05-10 2013-05-31 Incyte Holdings Corp Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
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CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
ES2444574T3 (es) 2006-09-19 2014-02-25 Incyte Corporation N-hidroxiamidinoheterociclos como moduladores de la indolamina 2,3-dioxigenasa
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
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EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
JP5583592B2 (ja) 2007-11-30 2014-09-03 ニューリンク ジェネティクス コーポレイション Ｉｄｏ阻害剤
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CA2789076C (en) 2010-03-05 2017-11-21 F. Hoffmann-La Roche Ag Antibodies against human colony stimulating factor-1 receptor and uses thereof
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HRP20201595T1 (hr) 2011-11-28 2020-12-11 Merck Patent Gmbh Anti-pd-l1 protutijela i njihova uporaba
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022530371A (ja) * 2019-04-22 2022-06-29 エピタス バイオサイエンシズ（シャンハイ）カンパニー，リミティド ピリミド５員複素環化合物及び変異型ｉｄｈ２阻害薬としてのその使用

Also Published As

Publication number Publication date
CN108137597A (zh) 2018-06-08
US10399987B2 (en) 2019-09-03
EP3328861A1 (en) 2018-06-06
WO2017019757A1 (en) 2017-02-02
KR20180034548A (ko) 2018-04-04
US20180215762A1 (en) 2018-08-02

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