JP2018523710A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018523710A5 JP2018523710A5 JP2018527853A JP2018527853A JP2018523710A5 JP 2018523710 A5 JP2018523710 A5 JP 2018523710A5 JP 2018527853 A JP2018527853 A JP 2018527853A JP 2018527853 A JP2018527853 A JP 2018527853A JP 2018523710 A5 JP2018523710 A5 JP 2018523710A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- cells
- composition
- nanostructure
- carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cells Anatomy 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 239000000969 carrier Substances 0.000 claims 7
- 239000002086 nanomaterial Substances 0.000 claims 7
- 210000001744 T-Lymphocytes Anatomy 0.000 claims 6
- 210000000170 Cell Membrane Anatomy 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 102100005499 PTPRC Human genes 0.000 claims 4
- 101700059076 PTPRC Proteins 0.000 claims 4
- 239000002502 liposome Substances 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 230000027455 binding Effects 0.000 claims 3
- 230000000975 bioactive Effects 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 210000003719 B-Lymphocytes Anatomy 0.000 claims 1
- 210000003958 Hematopoietic Stem Cells Anatomy 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002147 killing Effects 0.000 claims 1
- 102000005614 monoclonal antibodies Human genes 0.000 claims 1
- 108010045030 monoclonal antibodies Proteins 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
Claims (20)
- 腫瘍に向かい、生物活性タンパク質を含むナノ構造体と共役している、有核担体細胞を含む組成物、ここで担体細胞はＣＤ４５受容体を有し、ＣＤ４５受容体に結合するリガンドを有するナノ構造体と共役している、または担体細胞は負に帯電した細胞膜を有し、ナノ構造体が細胞膜と静電的に相互作用するポリカチオン性表面を有する、ここでナノ構造体はタンパク質ナノゲルまたはリポソームであり、リガンドは抗ＣＤ４５モノクローナル抗体である。
- 担体細胞が、ＣＤ４５受容体を有し、ＣＤ４５受容体に結合するリガンドを含むナノ構造体と共役している、請求項１に記載の組成物。
- 担体細胞が負に帯電した細胞膜を有し、ナノ構造体が細胞膜と静電的に相互作用するポリカチオン性表面を有する、請求項１または２に記載の組成物。
- ポリカチオンがポリリジンである、請求項３に記載の組成物
- ポリカチオンが、ポリエチレングリコール−ｂ−ポリリジン（ＰＥＧ−ＰＬＬ）である、請求項３に記載の組成物。
- ナノ構造体がタンパク質ナノゲルであり、タンパク質ナノゲルが、分解性リンカーを介して互いに可逆的かつ共有結合的に架橋する、複数の生物活性タンパク質を含む、請求項１〜５のいずれかに記載の組成物。
- 分解性リンカーが、ジスルフィド結合を含む酸化還元応答性リンカーである、請求項６に記載の組成物。
- ナノ構造体がリポソームであり、リポソームが複数の生物活性タンパク質を含む、請求項１〜５のいずれかに記載の組成物。
- リポソームが、膜間架橋多重層ベシクル（ＩＣＭＶ）または単層ベシクルである、請求項８に記載の組成物。
- 担体細胞が、Ｔ細胞、Ｂ細胞、ナチュラルキラー（ＮＫ）細胞または造血前駆細胞である、請求項１〜９のいずれかに記載の組成物。
- 担体細胞が、ＣＤ８ ＋ Ｔ細胞、ＣＤ４ ＋ Ｔ細胞、養子導入Ｔ細胞およびキメラ抗原受容体（ＣＡＲ）Ｔ細胞から選択されるＴ細胞である、請求項１０に記載の組成物。
- 生物活性タンパク質が抗体またはサイトカインである、請求項１〜１１のいずれかに記載の組成物。
- サイトカインが、ＩＬ−２、ＩＬ−１５またはＩＬ−１５−Ｓａである、請求項１２に記載の組成物。
- サイトカインがＩＬ−１５−Ｓａである、請求項１２に記載の組成物。
- ＩＬ−１５−Ｓａが、二量体ＩＬ−１５ＲαＳｕ／Ｆｃおよび２分子のＩＬ−１５Ｎ７２Ｄを含む複合体を含む、請求項１４に記載の組成物。
- 二量体ＩＬ−１５ＲαＳｕ／Ｆｃが、配列番号２に記載のアミノ酸配列を含み、ＩＬ−１５Ｎ７２Ｄ分子が、配列番号１に記載のアミノ酸配列を含む、請求項１５に記載の組成物。
- 薬学的に許容し得る担体をさらに含む、請求項１〜１６のいずれかに記載の組成物。
- 生物活性タンパク質を、腫瘍を有する対象に送達する薬物としての使用のための、請求項１〜１７のいずれかに記載の組成物。
- 腫瘍が固形腫瘍である、請求項１８に記載の組成物。
- がんを処置する薬物としての使用のための、請求項１〜１７のいずれかに記載の組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562204337P | 2015-08-12 | 2015-08-12 | |
| US62/204,337 | 2015-08-12 | ||
| PCT/US2016/046891 WO2017027843A1 (en) | 2015-08-12 | 2016-08-12 | Cell surface coupling of nanoparticles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018523710A JP2018523710A (ja) | 2018-08-23 |
| JP2018523710A5 true JP2018523710A5 (ja) | 2019-09-19 |
| JP6887685B2 JP6887685B2 (ja) | 2021-06-16 |
Family
ID=57983795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018527853A Active JP6887685B2 (ja) | 2015-08-12 | 2016-08-12 | ナノ粒子の細胞表面共役 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11034752B2 (ja) |
| EP (1) | EP3334417A4 (ja) |
| JP (1) | JP6887685B2 (ja) |
| CN (2) | CN108990413A (ja) |
| AU (2) | AU2016305087B2 (ja) |
| CA (1) | CA2995212A1 (ja) |
| WO (1) | WO2017027843A1 (ja) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3049114B1 (en) | 2013-09-27 | 2021-11-10 | Massachusetts Institute of Technology | Carrier-free biologically-active protein nanostructures |
| EP3334417A4 (en) * | 2015-08-12 | 2019-07-17 | Massachusetts Institute of Technology | CELL SURFACE COUPLING OF NANOPARTICLES |
| JP7185530B2 (ja) * | 2016-06-13 | 2022-12-07 | トルク セラピューティクス， インコーポレイテッド | 免疫細胞機能を促進するための方法および組成物 |
| CA3053534A1 (en) * | 2017-02-17 | 2018-08-23 | Purdue Research Foundation | Targeted ligand-payload based drug delivery for cell therapy |
| CR20190444A (es) * | 2017-02-28 | 2019-12-17 | Sanofi Sa | Arn terapéutico |
| WO2018195339A1 (en) * | 2017-04-19 | 2018-10-25 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
| BR112019022016A2 (pt) * | 2017-04-19 | 2020-05-12 | Apa- Advanced Technologies Ltd. | Lipossomas fusogênicos, composições, kits e uso dos mesmos no tratamento do câncer |
| AU2018289572A1 (en) * | 2017-06-22 | 2020-01-23 | University Of Southern California | Combination cancer therapy using chimeric antigen receptor engineered natural killer cells as chemotherapeutic drug carriers |
| EP3675892A4 (en) * | 2017-07-03 | 2021-10-06 | Torque Therapeutics, Inc. | IMMUNOSTIMULATORY FUSION MOLECULES AND THEIR USES |
| EP3678704A4 (en) | 2017-09-05 | 2021-09-01 | Torque Therapeutics, Inc. | REVERSIBLE LINKS AND THEIR USE |
| EP3678701A4 (en) | 2017-09-05 | 2021-12-01 | Torque Therapeutics, Inc. | THERAPEUTIC PROTEIN COMPOSITIONS AND METHOD FOR MANUFACTURING AND USING THEREOF |
| WO2019084273A1 (en) | 2017-10-25 | 2019-05-02 | Actinium Pharmaceuticals, Inc. | METHODS OF ANTI-CD45-BASED LYMPHODEPPLICATION AND USES THEREOF IN COMBINATION WITH ACT-BASED ANTICANCER THERAPIES |
| LU100795B1 (en) * | 2018-05-14 | 2019-11-14 | Diatron MI PLC | Immunoassay for whole blood samples |
| WO2020041655A1 (en) * | 2018-08-24 | 2020-02-27 | Sanofi | Therapeutic rna for solid tumor cancers |
| WO2020055931A1 (en) | 2018-09-10 | 2020-03-19 | Torque Therapeutics, Inc. | Antigen-specific t lymphocytes and methods of making and using the same |
| KR102257394B1 (ko) * | 2019-01-16 | 2021-05-27 | 서울대학교산학협력단 | 약물 전달 시스템 및 방법 |
| US20220195071A1 (en) * | 2019-03-29 | 2022-06-23 | Torque Therapeutics,Inc. | Immunotherapeutic compositions and use thereof |
| JP7479399B2 (ja) | 2019-05-06 | 2024-05-08 | マルコム，トーマス | 癌腫瘍に対するテーラード低免疫ナノ小胞送達系 |
| WO2021137611A1 (ko) * | 2019-12-30 | 2021-07-08 | (주)테라베스트 | 나노 구조체가 부착된 면역세포 |
| KR102657743B1 (ko) * | 2019-12-30 | 2024-04-22 | (주) 테라베스트 | 나노 구조체가 부착된 면역세포 |
| CN112807289B (zh) * | 2021-02-09 | 2022-12-06 | 中国医学科学院生物医学工程研究所 | 基于纳米颗粒的活细胞表面改造方法及其使用的纳米颗粒 |
| CN116236461A (zh) * | 2021-12-08 | 2023-06-09 | 深圳先进技术研究院 | 一种氧化还原型纳米颗粒和活细胞载体及其应用 |
| US20240159764A1 (en) * | 2022-11-12 | 2024-05-16 | OneCell Diagnostics, Inc. | Compositions and methods for selective capture, purification, release and isolation of single cells |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0440742B1 (en) | 1988-10-27 | 1997-01-15 | The Regents Of The University Of Minnesota | Liposome immunoadjuvants containing il-2 |
| JPH03244601A (ja) | 1990-02-22 | 1991-10-31 | Masuko Suzuki | マンナンと癌細胞分化誘導体の複合体、その製法及び抗癌剤 |
| US5453491A (en) | 1990-09-11 | 1995-09-26 | Kiyoshi Takatsu | Murine interleukin-5 receptor |
| US6197298B1 (en) | 1991-04-19 | 2001-03-06 | Tanox, Inc. | Modified binding molecules specific for T lymphocytes and their use as in vivo immune modulators in animals |
| CA2065658A1 (en) | 1991-04-19 | 1992-10-20 | Tse-Wen Chang | Conjugates of liposomes or microbeads and antibodies specific for t lymphocytes and their use in vivo immune modulators |
| US5753261A (en) | 1993-02-12 | 1998-05-19 | Access Pharmaceuticals, Inc. | Lipid-coated condensed-phase microparticle composition |
| US6180134B1 (en) | 1993-03-23 | 2001-01-30 | Sequus Pharmaceuticals, Inc. | Enhanced ciruclation effector composition and method |
| US5464629A (en) | 1993-11-16 | 1995-11-07 | Georgetown University | Method of forming hydrogel particles having a controlled size using liposomes |
| EP1167377B2 (en) | 1994-07-15 | 2012-08-08 | University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| IN184589B (ja) | 1996-10-16 | 2000-09-09 | Alza Corp | |
| US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| IN190388B (ja) | 1997-10-01 | 2003-07-26 | Biomira Usa Inc | |
| US6787132B1 (en) | 1997-12-04 | 2004-09-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Combined chemo-immunotherapy with liposomal drugs and cytokines |
| US6693086B1 (en) | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| US6319715B1 (en) | 2000-04-21 | 2001-11-20 | Cornell Research Foundation, Inc. | Method of enhancing the delivery of nucleic acids using silica nanoparticles |
| US20020151004A1 (en) | 2000-07-24 | 2002-10-17 | Roger Craig | Delivery vehicles and methods for using the same |
| CN1294991C (zh) | 2001-03-26 | 2007-01-17 | 阿尔扎公司 | 用于改善治疗物质的细胞内传递的脂质体组合物 |
| US20030235619A1 (en) | 2001-12-21 | 2003-12-25 | Christine Allen | Polymer-lipid delivery vehicles |
| AU2003228966C1 (en) | 2002-05-09 | 2010-05-13 | Oncothyreon Inc. | Lipid A and other carbohydrate ligand analogs |
| AU2003300043A1 (en) | 2002-10-10 | 2004-05-04 | Elizabeth Chambers | Carriers attached to blood cells |
| US8192485B2 (en) | 2002-11-13 | 2012-06-05 | The United States of America, as represented by the Department of Veterens Affairs | Reversible hydrogel systems and methods therefor |
| US7402431B2 (en) | 2004-03-01 | 2008-07-22 | Immunovative Therapies, Ltd. | T-cell therapy formulation |
| US7435592B2 (en) | 2003-05-13 | 2008-10-14 | Immunovative Therapies, Ltd. | Compositions for allogeneic cell therapy |
| US20040247624A1 (en) | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
| US7223544B2 (en) | 2003-06-27 | 2007-05-29 | Cornell Research Foundation, Inc. | Nucleic acid-engineered materials |
| US20050042298A1 (en) | 2003-08-20 | 2005-02-24 | Pardridge William M. | Immunonanoparticles |
| EP1550458A1 (en) | 2003-12-23 | 2005-07-06 | Vectron Therapeutics AG | Synergistic liposomal adjuvants |
| US20050266067A1 (en) | 2004-03-02 | 2005-12-01 | Shiladitya Sengupta | Nanocell drug delivery system |
| WO2006080951A2 (en) | 2004-07-01 | 2006-08-03 | Yale University | Targeted and high density drug loaded polymeric materials |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| DE102004054536A1 (de) | 2004-11-06 | 2006-05-11 | Capsulution Nanoscience Ag | Multimodal veränderte Zellen als zellulare Darreichungsformen für aktive Substanzen und als diagnostische Zellpartikel |
| US8246995B2 (en) | 2005-05-10 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells |
| NZ581779A (en) | 2005-05-17 | 2011-09-30 | Univ Connecticut | Composition and methods for immunomodulation in an organism comprising interleukin-15 polypeptide and interleukin-15 receptor subunit A polypeptide complex |
| US20070148246A1 (en) | 2005-08-11 | 2007-06-28 | Dan Luo | Nucleic Acid-Based Matrixes |
| WO2007022152A2 (en) | 2005-08-15 | 2007-02-22 | The Research Foundation Of State University Of New York | Lipid nano particulates containing antigens as cancer vaccines |
| AU2006293410B2 (en) | 2005-09-20 | 2012-10-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Nanoparticles for targeted delivery of active agents |
| EP1959991B1 (en) | 2005-12-12 | 2013-03-20 | AC Immune S.A. | Therapeutic vaccine |
| WO2007080977A1 (ja) | 2006-01-13 | 2007-07-19 | Riken | 免疫疾患の予防ないし治療剤および方法 |
| BRPI0708299A2 (pt) | 2006-02-27 | 2011-05-24 | Univ Leland Stanford Junior | composições e métodos para o transporte de moléculas com propriedades melhoradas de liberação através de barreiras biológicas |
| AU2008321174A1 (en) | 2007-11-14 | 2009-05-22 | The Regents Of The University Of California | Sterol-modified amphiphilic lipids |
| JP2009149526A (ja) | 2007-12-18 | 2009-07-09 | Tokyo Medical & Dental Univ | サイトカイン−ナノゲル複合体を含む皮下注射又は筋肉内注射徐放製剤 |
| US20110206740A1 (en) | 2008-04-29 | 2011-08-25 | Karp Jeffrey M | Cell Membrane Engineering |
| EP3936122A1 (en) | 2008-11-24 | 2022-01-12 | Massachusetts Institute Of Technology | Methods and compositions for localized agent delivery |
| EP2405758B1 (en) | 2009-03-09 | 2016-04-27 | Molecular Express, Inc. | Methods and compositions for liposomal formulation of antigens and uses thereof |
| AU2010224253A1 (en) | 2009-03-09 | 2011-10-27 | The Regents Of The University Of California | Single protein nanocapsules for protein delivery with long-term effect |
| CN107252482A (zh) | 2009-05-27 | 2017-10-17 | 西莱克塔生物科技公司 | 具有不同释放速率的纳米载体加工组分 |
| US20100323018A1 (en) | 2009-06-17 | 2010-12-23 | Massachusetts Institute Of Technology | Branched DNA/RNA monomers and uses thereof |
| US20100324124A1 (en) | 2009-06-17 | 2010-12-23 | Massachusetts Institute Of Technology | Compositions and methods relating to DNA-based particles |
| US9226969B2 (en) | 2009-11-18 | 2016-01-05 | Nektar Therapeutics | Salt form of a multi-arm polymer-drug conjugate |
| US20110229556A1 (en) | 2010-03-19 | 2011-09-22 | Massachusetts Institute Of Technology | Lipid-coated polymer particles for immune stimulation |
| US9149432B2 (en) | 2010-03-19 | 2015-10-06 | Massachusetts Institute Of Technology | Lipid vesicle compositions and methods of use |
| EP2547327B1 (en) | 2010-03-19 | 2018-09-05 | Massachusetts Institute of Technology | Lipid vesicle compositions and methods of use |
| WO2012024396A2 (en) * | 2010-08-17 | 2012-02-23 | Rutgers, The State University Of New Jersey | Compositions and methods for delivering nucleic acid molecules and treating cancer |
| CN103328007B (zh) | 2010-09-16 | 2016-09-21 | 北卡罗来纳州大学查珀尔希尔分校 | 作为药物试剂、化学试剂和生物试剂的递送载剂和前药的不对称双官能甲硅烷基单体及其颗粒 |
| CN107880136B (zh) * | 2010-09-21 | 2021-11-12 | 阿尔托生物科学有限公司 | 多聚体il-15可溶性融合分子与其制造与使用方法 |
| WO2012112689A1 (en) | 2011-02-15 | 2012-08-23 | The University Of North Carolina At Chapel Hill | Nanoparticle, liposomes, polymers, agents and proteins modified with reversible linkers |
| US20140037748A1 (en) | 2011-04-15 | 2014-02-06 | The Regents Of The University Of California | Redox responsive polymeric nanocapsules for protein delivery |
| US9090640B2 (en) | 2011-09-02 | 2015-07-28 | Ulrich Bierbach | Targeted delivery and prodrug designs for platinum-acridine anti-cancer compounds and methods thereof |
| JP2013173689A (ja) | 2012-02-24 | 2013-09-05 | Univ Of Tsukuba | 高分子化ニトロキシドラジカル化合物と非ステロイド性抗炎症薬の複合体 |
| US20130337471A1 (en) * | 2012-06-14 | 2013-12-19 | Emory University | Cell identification with nanoparticles, compositions and methods related thereto |
| US9149535B2 (en) | 2012-06-28 | 2015-10-06 | University Of South Carolina | Polymers and the preparation of nanogel drug cocktails |
| TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症 |
| FR3004106B1 (fr) | 2013-04-05 | 2016-08-05 | Oreal | Composition contenant des particules composites filtrant les radiations uv de taille moyenne superieure a 0,1μm et des particules d'aerogel de silice hydrophobes |
| EP3650038A1 (en) | 2013-06-19 | 2020-05-13 | Massachusetts Institute of Technology | In vivo targeting of cells with ligand-conjugated particles |
| EP3049114B1 (en) | 2013-09-27 | 2021-11-10 | Massachusetts Institute of Technology | Carrier-free biologically-active protein nanostructures |
| EP3334417A4 (en) | 2015-08-12 | 2019-07-17 | Massachusetts Institute of Technology | CELL SURFACE COUPLING OF NANOPARTICLES |
| JP7185530B2 (ja) | 2016-06-13 | 2022-12-07 | トルク セラピューティクス， インコーポレイテッド | 免疫細胞機能を促進するための方法および組成物 |
-
2016
- 2016-08-12 EP EP16836005.5A patent/EP3334417A4/en active Pending
- 2016-08-12 AU AU2016305087A patent/AU2016305087B2/en active Active
- 2016-08-12 CN CN201680059459.6A patent/CN108990413A/zh active Pending
- 2016-08-12 US US15/236,186 patent/US11034752B2/en active Active
- 2016-08-12 WO PCT/US2016/046891 patent/WO2017027843A1/en active Application Filing
- 2016-08-12 JP JP2018527853A patent/JP6887685B2/ja active Active
- 2016-08-12 CN CN202211611163.4A patent/CN116212048A/zh active Pending
- 2016-08-12 CA CA2995212A patent/CA2995212A1/en active Pending
-
2021
- 2021-05-12 US US17/318,590 patent/US11261226B2/en active Active
-
2022
- 2022-02-28 US US17/682,633 patent/US20220185860A1/en active Pending
- 2022-03-24 AU AU2022202038A patent/AU2022202038A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018523710A5 (ja) | ||
| JP7394093B2 (ja) | スイッチ共刺激受容体 | |
| Lin et al. | Advances in universal CAR-T cell therapy | |
| Olden et al. | Cationic polymers for non-viral gene delivery to human T cells | |
| Newick et al. | CAR T cell therapy for solid tumors | |
| Loftus et al. | Activation of human natural killer cells by graphene oxide-templated antibody nanoclusters | |
| Zhou et al. | Interleukin 15 in cell-based cancer immunotherapy | |
| US10800828B2 (en) | Switchable non-scFv chimeric receptors, switches, and methods of use thereof to treat cancer | |
| CN112055695A (zh) | 用于基因表达的纳米粒子和其用途 | |
| Dunn et al. | T cell immunotherapy enhanced by designer biomaterials | |
| ES2748224T3 (es) | Receptores de antígeno y usos de los mismos | |
| Xue et al. | Recent advances in biomaterial-boosted adoptive cell therapy | |
| JP2017518037A5 (ja) | ||
| US20230293585A1 (en) | Pm21 particles to improve bone marrow homing of nk cells | |
| Balakrishnan et al. | Nanoparticles for enhanced adoptive T cell therapies and future perspectives for CNS tumors | |
| Leach et al. | Biomaterial-facilitated immunotherapy for established oral cancers | |
| JP2015530973A5 (ja) | ||
| Cardle et al. | Biomaterials in chimeric antigen receptor T-cell process development | |
| Roselli et al. | CAR-T engineering: optimizing signal transduction and effector mechanisms | |
| WO2019018727A1 (en) | METHODS AND COMPOSITIONS FOR T-CELL ACTIVATION | |
| Prakash et al. | Polymer micropatches as natural killer cell engagers for tumor therapy | |
| Schluck et al. | Biomaterial-based activation and expansion of tumor-specific T cells | |
| Ben-Akiva et al. | Surface engineering for lymphocyte programming | |
| Hickey et al. | Engineering platforms for t cell modulation | |
| Thomas et al. | CAR T cell therapy becomes CHIC:“cytokine help intensified CAR” T cells |