JP2018523671A5 - - Google Patents
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- Publication number
- JP2018523671A5 JP2018523671A5 JP2018506981A JP2018506981A JP2018523671A5 JP 2018523671 A5 JP2018523671 A5 JP 2018523671A5 JP 2018506981 A JP2018506981 A JP 2018506981A JP 2018506981 A JP2018506981 A JP 2018506981A JP 2018523671 A5 JP2018523671 A5 JP 2018523671A5
- Authority
- JP
- Japan
- Prior art keywords
- iii
- alkyl
- tbm
- group
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 12
- -1 amino, thionyl Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000000732 arylene group Chemical group 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 125000006587 (C5-C10) heteroarylene group Chemical group 0.000 claims 6
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 6
- 125000002993 cycloalkylene group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 125000005647 linker group Chemical group 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 3
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 3
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 3
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 125000005549 heteroarylene group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical class [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 claims 3
- 150000004713 phosphodiesters Chemical class 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000002577 pseudohalo group Chemical group 0.000 claims 3
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 3
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 3
- 206010060965 Arterial stenosis Diseases 0.000 claims 1
- 206010051290 Central nervous system lesion Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 230000008499 blood brain barrier function Effects 0.000 claims 1
- 210000001218 blood-brain barrier Anatomy 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 0 CC(*(C1)(CC*(C[C@]2O3)(CC3=O)C(C(C3C=CC=C4)*34I)c3cc(OC)ccc3OC)C2OC1=O)(c(cc(cc1)OC)c1OC)c1c(C)ccc*1C Chemical compound CC(*(C1)(CC*(C[C@]2O3)(CC3=O)C(C(C3C=CC=C4)*34I)c3cc(OC)ccc3OC)C2OC1=O)(c(cc(cc1)OC)c1OC)c1c(C)ccc*1C 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021165864A JP7482099B2 (ja) | 2015-08-13 | 2021-10-08 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| JP2023192615A JP2024026077A (ja) | 2015-08-13 | 2023-11-10 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| JP2025194871A JP2026048654A (ja) | 2015-08-13 | 2025-11-14 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562204519P | 2015-08-13 | 2015-08-13 | |
| US62/204,519 | 2015-08-13 | ||
| US201662356732P | 2016-06-30 | 2016-06-30 | |
| US62/356,732 | 2016-06-30 | ||
| PCT/US2016/046874 WO2017027834A1 (en) | 2015-08-13 | 2016-08-12 | Manganese-based chelate conjugates for molecular mr imaging |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021165864A Division JP7482099B2 (ja) | 2015-08-13 | 2021-10-08 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| JP2023192615A Division JP2024026077A (ja) | 2015-08-13 | 2023-11-10 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018523671A JP2018523671A (ja) | 2018-08-23 |
| JP2018523671A5 true JP2018523671A5 (https=) | 2019-09-19 |
| JP7523883B2 JP7523883B2 (ja) | 2024-07-29 |
Family
ID=57984258
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506981A Active JP7523883B2 (ja) | 2015-08-13 | 2016-08-12 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| JP2021165864A Active JP7482099B2 (ja) | 2015-08-13 | 2021-10-08 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| JP2023192615A Pending JP2024026077A (ja) | 2015-08-13 | 2023-11-10 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| JP2025194871A Pending JP2026048654A (ja) | 2015-08-13 | 2025-11-14 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021165864A Active JP7482099B2 (ja) | 2015-08-13 | 2021-10-08 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| JP2023192615A Pending JP2024026077A (ja) | 2015-08-13 | 2023-11-10 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| JP2025194871A Pending JP2026048654A (ja) | 2015-08-13 | 2025-11-14 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10835623B2 (https=) |
| EP (1) | EP3334464B1 (https=) |
| JP (4) | JP7523883B2 (https=) |
| CN (3) | CN114805196A (https=) |
| ES (1) | ES2987778T3 (https=) |
| WO (1) | WO2017027834A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7523883B2 (ja) * | 2015-08-13 | 2024-07-29 | ザ ジェネラル ホスピタル コーポレイション | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| CN108888781B (zh) * | 2018-06-27 | 2021-08-06 | 华东理工大学 | 一种超分子聚电解质胶束磁共振成像造影剂的制备方法 |
| US11267832B2 (en) | 2018-10-22 | 2022-03-08 | The Board Of Regents Of The University Of Texas System | Mn(II)-based sensors to detect zinc in vivo with MRI |
| CN112540095B (zh) * | 2019-09-20 | 2022-03-22 | 华中农业大学 | 酶促低场核磁共振免疫传感器检测食源性致病菌的方法 |
| IL293875A (en) * | 2019-12-17 | 2022-08-01 | Massachusetts Gen Hospital | Highly effective myeloperoxidase-activatable imaging agents |
| CN113248422B (zh) * | 2020-02-10 | 2022-07-12 | 河南工业大学 | 一种手性α-氮杂芳烃四级碳中心类化合物、其制备方法及应用 |
| US20230406873A1 (en) * | 2020-11-17 | 2023-12-21 | The General Hospital Corporation | Probes, systems, and methods for magnetic resonance ph sensing |
| WO2022235768A1 (en) | 2021-05-04 | 2022-11-10 | Sachem, Inc. | Strong binding metal-chelating resins |
| WO2022235769A1 (en) | 2021-05-04 | 2022-11-10 | Sachem, Inc. | Strong binding metal-chelating resins using macrocycle molecules |
| WO2024086331A1 (en) * | 2022-10-21 | 2024-04-25 | The General Hospital Corporation | Iron based mri probes |
| CN119499407B (zh) * | 2024-11-25 | 2026-04-07 | 中国科学院精密测量科学与技术创新研究院 | 一种Fe基T7肽靶向脑胶质瘤小分子磁共振造影剂及其制备合成方法和应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4622420A (en) | 1980-03-18 | 1986-11-11 | The Regents Of The University Of California | Chelating agents and method |
| US4899755A (en) | 1985-05-08 | 1990-02-13 | The General Hospital Corporation | Hepatobiliary NMR contrast agents |
| US4880008A (en) | 1985-05-08 | 1989-11-14 | The General Hospital Corporation | Vivo enhancement of NMR relaxivity |
| US4889931A (en) | 1988-09-27 | 1989-12-26 | Salutar, Inc. | Manganese (II) chelate manufacture |
| JP2772875B2 (ja) * | 1991-05-14 | 1998-07-09 | 富士写真フイルム株式会社 | ハロゲン化銀カラー写真感光材料の処理方法及び写真用漂白定着組成物 |
| AU4562693A (en) | 1992-07-01 | 1994-01-31 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Contrast agents for mr diagnosis |
| DE69502796T2 (de) * | 1994-10-20 | 1998-10-01 | Fuji Photo Film Co Ltd | Neuer Eisen-Komplex, Verfahren zu seiner Herstellung, photographische Verarbeitungslösung und photographisches Verarbeitungsverfahren unter Verwendung dieses Komplexes |
| JP3437013B2 (ja) * | 1994-10-20 | 2003-08-18 | 富士写真フイルム株式会社 | 新規な鉄錯体、その製造方法、写真用処理組成物およびその処理方法 |
| TW319763B (https=) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| DE19603033A1 (de) | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
| CA2257891A1 (en) * | 1996-06-19 | 1997-12-24 | Roelant Mathijs Hermant | Bleach activation by an iron catalyst comprising a polydentate ligand containing at least six heteroatoms |
| DE60012485T2 (de) | 1999-02-18 | 2005-08-18 | The Regents Of The University Of California, Oakland | Salicylamid-lanthanid komplexe zur verwendung als lumineszenzmarker |
| CA2371816C (en) | 1999-02-18 | 2010-04-27 | The Regents Of The University Of California | Phthalamide-lanthanide complexes for use as luminescent markers |
| DE60021545T2 (de) * | 1999-04-01 | 2006-03-02 | Unilever N.V. | Zusammensetzung und verfahren zum bleichen eines substrats |
| EP1203026A4 (en) | 1999-07-29 | 2005-03-16 | Dyax Corp | BINDING CENTERS FOR FIBRIN |
| IL147854A0 (en) | 1999-07-29 | 2002-08-14 | Epix Medical Inc | Multimeric compounds, contrast agents containing the same and diagnostic methods utilizing the same |
| US6277841B1 (en) * | 2000-03-02 | 2001-08-21 | Mallinckrodt Inc. | Quinoline ligands and metal complexes for diagnosis and therapy |
| US6984373B2 (en) | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
| US6549798B2 (en) | 2001-02-07 | 2003-04-15 | Epix Medical, Inc. | Magnetic resonance angiography data |
| TWI240632B (en) | 2001-07-30 | 2005-10-01 | Epix Medical Inc | Purified peptides for peptide-based multimeric targeted contrast agents |
| TWI221406B (en) | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
| US6869591B2 (en) | 2002-03-26 | 2005-03-22 | Barnes-Jewish Hospital | Paramagnetic particles that provide improved relaxivity |
| FR2856689A1 (fr) | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
| FR2890657B1 (fr) * | 2005-09-15 | 2007-11-09 | Commissariat Energie Atomique | Procede d'obtention de complexes de lanthanides hautement luminescents. |
| US8034898B2 (en) | 2005-12-29 | 2011-10-11 | Collagen Medical, LLC | Methods of collagen imaging |
| CN101558081B (zh) | 2006-12-11 | 2014-08-20 | 伯拉考成像股份公司 | 用于诊断和治疗应用的纤维蛋白结合肽缀合体 |
| JP5677026B2 (ja) * | 2009-10-28 | 2015-02-25 | 住友化学株式会社 | 多座配位子金属錯体 |
| WO2011100829A1 (en) * | 2010-02-19 | 2011-08-25 | Nordion (Canada) Inc. | Bifunctional chelating agents |
| ES2634146T3 (es) * | 2012-09-24 | 2017-09-26 | Qi Wang | Quelatos, agentes quelantes, sus derivados conjugados y su uso |
| PL2941434T3 (pl) * | 2013-01-07 | 2021-09-06 | The General Hospital Corporation | Środki kontrastujące na bazie manganu do rezonansu magnetycznego |
| US20140350256A1 (en) * | 2013-05-21 | 2014-11-27 | University Of Southern Denmark | Iron and manganese complexes comprising hexadentate monocarboxylato-containing ligands and their use for the catalysis of oxidation reactions |
| WO2015085005A1 (en) * | 2013-12-03 | 2015-06-11 | The General Hospital Corporation | Molecular imaging probes |
| AR104939A1 (es) | 2015-06-10 | 2017-08-23 | Chemsenti Ltd | Método oxidativo para generar dióxido de cloro |
| US10233205B2 (en) | 2015-08-07 | 2019-03-19 | Auburn University | Magnetic resonance imaging contrast agent capable of detecting hydrogen peroxide and reducing reactive oxygen species |
| JP7523883B2 (ja) * | 2015-08-13 | 2024-07-29 | ザ ジェネラル ホスピタル コーポレイション | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
-
2016
- 2016-08-12 JP JP2018506981A patent/JP7523883B2/ja active Active
- 2016-08-12 ES ES16835998T patent/ES2987778T3/es active Active
- 2016-08-12 CN CN202210363484.0A patent/CN114805196A/zh active Pending
- 2016-08-12 CN CN202210364662.1A patent/CN114890941A/zh active Pending
- 2016-08-12 EP EP16835998.2A patent/EP3334464B1/en active Active
- 2016-08-12 US US15/751,617 patent/US10835623B2/en active Active
- 2016-08-12 WO PCT/US2016/046874 patent/WO2017027834A1/en not_active Ceased
- 2016-08-12 CN CN201680054836.7A patent/CN108136053B/zh active Active
-
2020
- 2020-08-11 US US16/990,368 patent/US11400171B2/en active Active
-
2021
- 2021-10-08 JP JP2021165864A patent/JP7482099B2/ja active Active
-
2023
- 2023-11-10 JP JP2023192615A patent/JP2024026077A/ja active Pending
-
2025
- 2025-11-14 JP JP2025194871A patent/JP2026048654A/ja active Pending
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