JP2018520170A5 - - Google Patents
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- Publication number
- JP2018520170A5 JP2018520170A5 JP2018500737A JP2018500737A JP2018520170A5 JP 2018520170 A5 JP2018520170 A5 JP 2018520170A5 JP 2018500737 A JP2018500737 A JP 2018500737A JP 2018500737 A JP2018500737 A JP 2018500737A JP 2018520170 A5 JP2018520170 A5 JP 2018520170A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolo
- pyridin
- ethanone
- methyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCC(N(*)*=C)=O Chemical compound CCC(N(*)*=C)=O 0.000 description 8
- HEGBCELAQOHAPT-UHFFFAOYSA-N CC(C)Cc1n[o]c(CC(C(C)C)c2ccc(C(F)(F)F)[o]2)c1 Chemical compound CC(C)Cc1n[o]c(CC(C(C)C)c2ccc(C(F)(F)F)[o]2)c1 HEGBCELAQOHAPT-UHFFFAOYSA-N 0.000 description 1
- LJPCNSSTRWGCMZ-UHFFFAOYSA-N CC1COCC1 Chemical compound CC1COCC1 LJPCNSSTRWGCMZ-UHFFFAOYSA-N 0.000 description 1
- JOKJDIADTFUNEZ-UHFFFAOYSA-N CCC(N(C1)CC1F)=O Chemical compound CCC(N(C1)CC1F)=O JOKJDIADTFUNEZ-UHFFFAOYSA-N 0.000 description 1
- QACZUJYJMJUZTB-UHFFFAOYSA-N CCC1=NC(C)NO1 Chemical compound CCC1=NC(C)NO1 QACZUJYJMJUZTB-UHFFFAOYSA-N 0.000 description 1
- IHTNRDIBNXBSIF-UHFFFAOYSA-N CCC1OCCCC1 Chemical compound CCC1OCCCC1 IHTNRDIBNXBSIF-UHFFFAOYSA-N 0.000 description 1
- YYYGSQOZWZQGSM-UHFFFAOYSA-N CNCC1OC1 Chemical compound CNCC1OC1 YYYGSQOZWZQGSM-UHFFFAOYSA-N 0.000 description 1
- YETKREVFIJUZAV-UHFFFAOYSA-N CNCc1ncc[o]1 Chemical compound CNCc1ncc[o]1 YETKREVFIJUZAV-UHFFFAOYSA-N 0.000 description 1
- KFTRXTSNTQSGNE-UHFFFAOYSA-N C[n]1ncc(CN)c1 Chemical compound C[n]1ncc(CN)c1 KFTRXTSNTQSGNE-UHFFFAOYSA-N 0.000 description 1
- SBIORXWGAIAEKG-UHFFFAOYSA-N C[n]1nnc(CI)c1 Chemical compound C[n]1nnc(CI)c1 SBIORXWGAIAEKG-UHFFFAOYSA-N 0.000 description 1
- SZQCPPRPWDXLMM-UHFFFAOYSA-N Cc1c[n](C)nc1 Chemical compound Cc1c[n](C)nc1 SZQCPPRPWDXLMM-UHFFFAOYSA-N 0.000 description 1
- OJAWOLWHEQUTDE-UHFFFAOYSA-N Cc1c[n](C)nn1 Chemical compound Cc1c[n](C)nn1 OJAWOLWHEQUTDE-UHFFFAOYSA-N 0.000 description 1
- MXDRPNGTQDRKQM-UHFFFAOYSA-N Cc1cccnn1 Chemical compound Cc1cccnn1 MXDRPNGTQDRKQM-UHFFFAOYSA-N 0.000 description 1
- TWGNOYAGHYUFFR-UHFFFAOYSA-N Cc1cncnc1 Chemical compound Cc1cncnc1 TWGNOYAGHYUFFR-UHFFFAOYSA-N 0.000 description 1
- FICAQKBMCKEFDI-UHFFFAOYSA-N Cc1n[o]c(C)c1 Chemical compound Cc1n[o]c(C)c1 FICAQKBMCKEFDI-UHFFFAOYSA-N 0.000 description 1
- HNJOAIYFUCQZAA-UHFFFAOYSA-N Cc1n[o]c(C)n1 Chemical compound Cc1n[o]c(C)n1 HNJOAIYFUCQZAA-UHFFFAOYSA-N 0.000 description 1
- ZCHCHJQEWYIJDQ-UHFFFAOYSA-N Cc1ncc[o]1 Chemical compound Cc1ncc[o]1 ZCHCHJQEWYIJDQ-UHFFFAOYSA-N 0.000 description 1
- ZMWQBNFYSOMTTH-UHFFFAOYSA-N Fc1cnc(CI)nc1 Chemical compound Fc1cnc(CI)nc1 ZMWQBNFYSOMTTH-UHFFFAOYSA-N 0.000 description 1
- TXQWFIVRZNOPCK-UHFFFAOYSA-N NCc1ccncc1 Chemical compound NCc1ccncc1 TXQWFIVRZNOPCK-UHFFFAOYSA-N 0.000 description 1
- USRYWZFLGFQQEB-UHFFFAOYSA-N NCc1cncnc1 Chemical compound NCc1cncnc1 USRYWZFLGFQQEB-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021138906A JP7369743B2 (ja) | 2015-07-09 | 2021-08-27 | 置換４－アザインドール及びｇｌｕｎ２ｂ受容体調節因子としてのそれらの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562190416P | 2015-07-09 | 2015-07-09 | |
| US62/190,416 | 2015-07-09 | ||
| PCT/US2016/041339 WO2017007938A1 (en) | 2015-07-09 | 2016-07-07 | Substituted 4-azaindoles and their use as glun2b receptor modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021138906A Division JP7369743B2 (ja) | 2015-07-09 | 2021-08-27 | 置換４－アザインドール及びｇｌｕｎ２ｂ受容体調節因子としてのそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018520170A JP2018520170A (ja) | 2018-07-26 |
| JP2018520170A5 true JP2018520170A5 (enExample) | 2019-07-25 |
| JP6964576B2 JP6964576B2 (ja) | 2021-11-10 |
Family
ID=56497884
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018500737A Expired - Fee Related JP6964576B2 (ja) | 2015-07-09 | 2016-07-07 | 置換４−アザインドール及びｇｌｕｎ２ｂ受容体調節因子としてのそれらの使用 |
| JP2021138906A Active JP7369743B2 (ja) | 2015-07-09 | 2021-08-27 | 置換４－アザインドール及びｇｌｕｎ２ｂ受容体調節因子としてのそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021138906A Active JP7369743B2 (ja) | 2015-07-09 | 2021-08-27 | 置換４－アザインドール及びｇｌｕｎ２ｂ受容体調節因子としてのそれらの使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9963447B2 (enExample) |
| EP (1) | EP3319963B1 (enExample) |
| JP (2) | JP6964576B2 (enExample) |
| KR (1) | KR20180026760A (enExample) |
| CN (1) | CN108026094B (enExample) |
| AU (1) | AU2016291158B2 (enExample) |
| BR (1) | BR112018000468A2 (enExample) |
| CA (1) | CA2991765C (enExample) |
| CY (1) | CY1123007T1 (enExample) |
| DK (1) | DK3319963T3 (enExample) |
| EA (1) | EA033197B1 (enExample) |
| ES (1) | ES2781867T3 (enExample) |
| HR (1) | HRP20200410T1 (enExample) |
| HU (1) | HUE047460T2 (enExample) |
| IL (1) | IL256758A (enExample) |
| LT (1) | LT3319963T (enExample) |
| MA (1) | MA42397B1 (enExample) |
| MD (1) | MD3319963T2 (enExample) |
| MX (1) | MX2018000352A (enExample) |
| PL (1) | PL3319963T3 (enExample) |
| PT (1) | PT3319963T (enExample) |
| SI (1) | SI3319963T1 (enExample) |
| SM (1) | SMT202000134T1 (enExample) |
| WO (1) | WO2017007938A1 (enExample) |
| ZA (1) | ZA201800827B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3180329B1 (en) | 2014-08-15 | 2020-03-18 | Janssen Pharmaceuticals, Inc. | Triazoles as nr2b receptor inhibitors |
| PT3180315T (pt) | 2014-08-15 | 2020-05-27 | Janssen Pharmaceuticals Inc | Pirazoles |
| MX2018000352A (es) | 2015-07-09 | 2018-08-15 | Janssen Pharmaceutica Nv | 4-azaindoles sustituidos y su uso como moduladores del receptor glun2b. |
| KR20180108822A (ko) | 2016-02-10 | 2018-10-04 | 얀센 파마슈티카 엔.브이. | Nr2b-선택적 nmda 조절제로서 치환된 1,2,3-트라이아졸 |
| TW201819376A (zh) | 2016-10-06 | 2018-06-01 | 比利時商健生藥品公司 | 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途 |
| EP3774732A4 (en) * | 2018-04-04 | 2022-02-09 | Janssen Pharmaceutica NV | PYRIDINE AND SUBSTITUTED PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS |
| US20220324860A1 (en) * | 2019-06-14 | 2022-10-13 | Janssen Pharmaceutica Nv | SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS |
| EP3983413A1 (en) | 2019-06-14 | 2022-04-20 | Janssen Pharmaceutica NV | Substituted pyrazolo-pyrazines and their use as glun2b receptor modulators |
| AU2020290772A1 (en) | 2019-06-14 | 2022-01-06 | Janssen Pharmaceutica Nv | Pyrazine carbamates and their use as GluN2B receptor modulators |
| JP7667097B2 (ja) | 2019-06-14 | 2025-04-22 | ヤンセン ファーマシューティカ エヌ．ベー． | 置換ピラゾロ－ピリジンアミド及びｇｌｕｎ２ｂ受容体調節因子としてのその使用 |
| SG11202112407PA (en) * | 2019-06-14 | 2021-12-30 | Janssen Pharmaceutica Nv | Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators |
| AU2020291188A1 (en) * | 2019-06-14 | 2022-01-20 | Janssen Pharmaceutica Nv | Substituted heteroaromatic Pyrazolo-pyridines and their use as GluN2B receptor modulators |
| BR112021025132A2 (pt) | 2019-06-14 | 2022-01-25 | Janssen Pharmaceutica Nv | Carbamatos de piridina e seu uso como moduladores do receptor glun2b |
| CN114621125B (zh) * | 2020-12-14 | 2024-07-09 | 中国科学技术大学 | Nlrp3炎症小体抑制剂及其应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040111445A (ko) * | 2002-03-28 | 2004-12-31 | 에자이 가부시키가이샤 | 신경퇴행성 질환 치료용 ｃ─Ｊｕｎ Ｎ─말단 키나아제억제제로서의 ７─아자인돌 |
| AU2005214375A1 (en) | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Triazole compounds and their use as metabotropic glutamate receptor antagonists |
| US20060183758A1 (en) * | 2005-02-17 | 2006-08-17 | Cb Research And Development, Inc. | Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans |
| US7807704B2 (en) * | 2006-03-30 | 2010-10-05 | Chemocentryx, Inc. | Bicyclic, nitrogen-containing compounds modulating CXCR4 and/or CCXCKR2 |
| PE20090717A1 (es) * | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| KR20100017372A (ko) | 2007-05-25 | 2010-02-16 | 애보트 게엠베하 운트 콤파니 카게 | 향대사성 글루타메이트 수용체 2（ｍｇｌｕ2 수용체）의 포지티브 조절자로서의 헤테로사이클릭 화합물 |
| US20100325949A1 (en) | 2007-07-03 | 2010-12-30 | Edward Scott Carlson | Support apparatus for climbing plants |
| WO2009028543A1 (ja) | 2007-08-30 | 2009-03-05 | Takeda Pharmaceutical Company Limited | 置換ピラゾール誘導体 |
| WO2009058261A1 (en) | 2007-10-31 | 2009-05-07 | Merck & Co., Inc. | Modulation of sleep with nr2b receptor antagonists |
| US20110053951A1 (en) | 2008-03-27 | 2011-03-03 | Evotec Neurosciences Gmbh | Methods for treating disorders using nmda nr2b-subtype selective antagonist |
| DK2308877T3 (da) | 2008-08-05 | 2014-04-22 | Daiichi Sankyo Co Ltd | Imidazopyridin-2-on-derivater |
| WO2010043396A1 (en) * | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| CN102264743B (zh) | 2008-11-25 | 2015-02-11 | 罗彻斯特大学 | Mlk抑制剂及其使用方法 |
| TWI625121B (zh) * | 2009-07-13 | 2018-06-01 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| EP2579717A4 (en) | 2010-06-09 | 2013-12-11 | Merck Sharp & Dohme | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 |
| WO2013130855A1 (en) | 2012-03-02 | 2013-09-06 | Takeda Pharmaceutical Company Limited | Indazole derivatives |
| WO2014124651A1 (en) * | 2013-02-15 | 2014-08-21 | Københavns Universitet | Pyrrolidine-2-carboxylic acid derivatives as iglur antagonists |
| TW201444820A (zh) * | 2013-03-13 | 2014-12-01 | Abbvie Inc | 吡啶ｃｄｋ９激酶抑制劑 |
| CN105073747B (zh) * | 2013-03-15 | 2017-06-06 | 普莱希科公司 | 杂环化合物及其应用 |
| CN103626767A (zh) * | 2013-12-04 | 2014-03-12 | 上海药明康德新药开发有限公司 | 区域选择性的氮杂吲哚及其合成方法 |
| PT3180315T (pt) | 2014-08-15 | 2020-05-27 | Janssen Pharmaceuticals Inc | Pirazoles |
| EP3180329B1 (en) | 2014-08-15 | 2020-03-18 | Janssen Pharmaceuticals, Inc. | Triazoles as nr2b receptor inhibitors |
| MX2018000352A (es) | 2015-07-09 | 2018-08-15 | Janssen Pharmaceutica Nv | 4-azaindoles sustituidos y su uso como moduladores del receptor glun2b. |
| KR20180108822A (ko) | 2016-02-10 | 2018-10-04 | 얀센 파마슈티카 엔.브이. | Nr2b-선택적 nmda 조절제로서 치환된 1,2,3-트라이아졸 |
| TW201819376A (zh) | 2016-10-06 | 2018-06-01 | 比利時商健生藥品公司 | 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途 |
-
2016
- 2016-07-07 MX MX2018000352A patent/MX2018000352A/es unknown
- 2016-07-07 CN CN201680052507.9A patent/CN108026094B/zh not_active Expired - Fee Related
- 2016-07-07 MA MA42397A patent/MA42397B1/fr unknown
- 2016-07-07 EP EP16741469.7A patent/EP3319963B1/en active Active
- 2016-07-07 BR BR112018000468-5A patent/BR112018000468A2/pt not_active Application Discontinuation
- 2016-07-07 PT PT167414697T patent/PT3319963T/pt unknown
- 2016-07-07 HR HRP20200410TT patent/HRP20200410T1/hr unknown
- 2016-07-07 HU HUE16741469A patent/HUE047460T2/hu unknown
- 2016-07-07 SI SI201630594T patent/SI3319963T1/sl unknown
- 2016-07-07 WO PCT/US2016/041339 patent/WO2017007938A1/en not_active Ceased
- 2016-07-07 DK DK16741469.7T patent/DK3319963T3/da active
- 2016-07-07 PL PL16741469T patent/PL3319963T3/pl unknown
- 2016-07-07 KR KR1020187003560A patent/KR20180026760A/ko not_active Withdrawn
- 2016-07-07 LT LTEP16741469.7T patent/LT3319963T/lt unknown
- 2016-07-07 MD MDE20180505T patent/MD3319963T2/ro not_active IP Right Cessation
- 2016-07-07 AU AU2016291158A patent/AU2016291158B2/en not_active Ceased
- 2016-07-07 ES ES16741469T patent/ES2781867T3/es active Active
- 2016-07-07 CA CA2991765A patent/CA2991765C/en active Active
- 2016-07-07 SM SM20200134T patent/SMT202000134T1/it unknown
- 2016-07-07 EA EA201890245A patent/EA033197B1/ru not_active IP Right Cessation
- 2016-07-07 JP JP2018500737A patent/JP6964576B2/ja not_active Expired - Fee Related
- 2016-07-08 US US15/205,632 patent/US9963447B2/en not_active Expired - Fee Related
-
2018
- 2018-01-07 IL IL256758A patent/IL256758A/en unknown
- 2018-02-08 ZA ZA2018/00827A patent/ZA201800827B/en unknown
- 2018-03-20 US US15/926,440 patent/US10377753B2/en active Active
-
2020
- 2020-03-24 CY CY20201100280T patent/CY1123007T1/el unknown
-
2021
- 2021-08-27 JP JP2021138906A patent/JP7369743B2/ja active Active
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