JP2018518147A5 - - Google Patents
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- JP2018518147A5 JP2018518147A5 JP2017541658A JP2017541658A JP2018518147A5 JP 2018518147 A5 JP2018518147 A5 JP 2018518147A5 JP 2017541658 A JP2017541658 A JP 2017541658A JP 2017541658 A JP2017541658 A JP 2017541658A JP 2018518147 A5 JP2018518147 A5 JP 2018518147A5
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- JP
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- Prior art keywords
- patient
- mir
- expression level
- brain injury
- seq
- Prior art date
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- 238000000034 method Methods 0.000 claims 20
- 208000029028 brain injury Diseases 0.000 claims 16
- 239000000523 sample Substances 0.000 claims 15
- 108700011259 MicroRNAs Proteins 0.000 claims 12
- 239000002679 microRNA Substances 0.000 claims 12
- 239000012472 biological sample Substances 0.000 claims 11
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 11
- 239000003963 antioxidant agent Substances 0.000 claims 5
- 230000003078 antioxidant effect Effects 0.000 claims 5
- 235000006708 antioxidants Nutrition 0.000 claims 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- 230000006931 brain damage Effects 0.000 claims 4
- 231100000874 brain damage Toxicity 0.000 claims 4
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 4
- 102000016938 Catalase Human genes 0.000 claims 2
- 108010053835 Catalase Proteins 0.000 claims 2
- 108010024636 Glutathione Proteins 0.000 claims 2
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims 2
- 102000007456 Peroxiredoxin Human genes 0.000 claims 2
- 102000019197 Superoxide Dismutase Human genes 0.000 claims 2
- 108010012715 Superoxide dismutase Proteins 0.000 claims 2
- 102000002933 Thioredoxin Human genes 0.000 claims 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 2
- 229940087168 alpha tocopherol Drugs 0.000 claims 2
- 229940072107 ascorbate Drugs 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 150000001746 carotenes Chemical class 0.000 claims 2
- 235000005473 carotenes Nutrition 0.000 claims 2
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 2
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 2
- 229940109262 curcumin Drugs 0.000 claims 2
- 235000012754 curcumin Nutrition 0.000 claims 2
- 239000004148 curcumin Substances 0.000 claims 2
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims 2
- XLZOVRYBVCMCGL-BPNVQINPSA-L disodium;4-[(z)-[tert-butyl(oxido)azaniumylidene]methyl]benzene-1,3-disulfonate Chemical compound [Na+].[Na+].CC(C)(C)[N+](\[O-])=C\C1=CC=C(S([O-])(=O)=O)C=C1S([O-])(=O)=O XLZOVRYBVCMCGL-BPNVQINPSA-L 0.000 claims 2
- 229960003180 glutathione Drugs 0.000 claims 2
- 235000003969 glutathione Nutrition 0.000 claims 2
- 235000019136 lipoic acid Nutrition 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108030002458 peroxiredoxin Proteins 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 229960002663 thioctic acid Drugs 0.000 claims 2
- 108060008226 thioredoxin Proteins 0.000 claims 2
- 229940094937 thioredoxin Drugs 0.000 claims 2
- 229960005155 tirilazad Drugs 0.000 claims 2
- RBKASMJPSJDQKY-RBFSKHHSSA-N tirilazad Chemical compound O=C([C@@H]1[C@@]2(C)CC=C3[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)CN(CC1)CCN1C(N=1)=CC(N2CCCC2)=NC=1N1CCCC1 RBKASMJPSJDQKY-RBFSKHHSSA-N 0.000 claims 2
- 229960000984 tocofersolan Drugs 0.000 claims 2
- 230000009529 traumatic brain injury Effects 0.000 claims 2
- 229940116269 uric acid Drugs 0.000 claims 2
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 claims 2
- 239000002076 α-tocopherol Substances 0.000 claims 2
- 235000004835 α-tocopherol Nutrition 0.000 claims 2
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 claims 1
- 238000000636 Northern blotting Methods 0.000 claims 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 210000005013 brain tissue Anatomy 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 208000017004 dementia pugilistica Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000007901 in situ hybridization Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000002751 oligonucleotide probe Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/669,454 | 2015-03-26 | ||
| US14/669,454 US9605315B2 (en) | 2014-03-26 | 2015-03-26 | Detection of traumatic brain injury |
| PCT/US2015/051518 WO2016153549A1 (en) | 2015-03-26 | 2015-09-22 | Detection of brain injury |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018518147A JP2018518147A (ja) | 2018-07-12 |
| JP2018518147A5 true JP2018518147A5 (OSRAM) | 2018-10-25 |
Family
ID=56979279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017541658A Pending JP2018518147A (ja) | 2015-03-26 | 2015-09-22 | 脳損傷の検出 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9605315B2 (OSRAM) |
| EP (1) | EP3274008B1 (OSRAM) |
| JP (1) | JP2018518147A (OSRAM) |
| CN (1) | CN107427614B (OSRAM) |
| AU (2) | AU2015387481B2 (OSRAM) |
| CA (1) | CA2976347A1 (OSRAM) |
| CL (1) | CL2017002420A1 (OSRAM) |
| ES (1) | ES3014311T3 (OSRAM) |
| IL (1) | IL253889A0 (OSRAM) |
| SG (1) | SG11201707332XA (OSRAM) |
| WO (1) | WO2016153549A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105861712B (zh) | 2011-04-18 | 2021-05-14 | 迪阿米尔有限责任公司 | 使用来自体液的miRNA来早期检测和监控轻度认知障碍(MCI)和阿尔茨海默病(AD)的方法 |
| ES2813699T3 (es) | 2013-11-18 | 2021-03-24 | Diamir Llc | Métodos de uso de miARN de fluidos corporales para la detección y monitoreo de la enfermedad de Parkinson (PD) |
| WO2017087726A1 (en) * | 2015-11-18 | 2017-05-26 | Dignity Health | Methods of diagnosing epilepsy |
| US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
| GB201603967D0 (en) * | 2016-03-08 | 2016-04-20 | Univ Birmingham | Biomarkers of traumatic brain injury |
| EP3433381B1 (en) | 2016-03-21 | 2024-07-24 | Diamir, LLC | Methods of using mirnas from bodily fluids for detection and differentiation of neurodegenerative diseases |
| CN108300788B (zh) * | 2017-01-13 | 2021-07-09 | 中国人民解放军南京军区南京总医院 | 一种用于检测轻型脑外伤的微小核糖核酸组合及其应用 |
| WO2018175941A1 (en) * | 2017-03-23 | 2018-09-27 | Quadrant Biosciences Inc. | Analysis and prediction of traumatic brain injury and concusion symptoms |
| US10781487B2 (en) | 2017-07-24 | 2020-09-22 | Diamir, Llc | miRNA-based methods for detecting and monitoring aging |
| CN112424606B9 (zh) * | 2018-05-31 | 2025-03-07 | 阿米达斯公司 | 用于检测创伤性脑损伤的组合物和方法 |
| WO2025039033A1 (en) * | 2023-08-21 | 2025-02-27 | Glia Diagnostics Pty Ltd | Methods and reagents for diagnosis and/or prognosis of traumatic brain injury |
| CN118314963B (zh) * | 2023-11-13 | 2024-10-29 | 中国人民解放军空军特色医学中心 | 一种基于lasso回归的血小板储存损伤风险预测模型及其构建方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL145209A0 (en) * | 2000-09-06 | 2002-06-30 | Pfizer Prod Inc | Pharmaceutical combinations for the treatment of stroke and traumatic brain injury |
| AU2003237379A1 (en) * | 2002-06-10 | 2003-12-22 | Oklahoma Medical Research Foundation | A method for using tethered bis(polyhydroxyphenyls) and o-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system |
| US20110111976A1 (en) * | 2008-04-25 | 2011-05-12 | Merck Sharp & Dohme Corp. | Microrna biomarkers of tissue injury |
| JP5909447B2 (ja) * | 2009-09-14 | 2016-04-26 | バンヤン・バイオマーカーズ・インコーポレーテッド | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| WO2011149354A1 (en) * | 2010-05-28 | 2011-12-01 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg | Mirnas involved in the blood brain barrier function |
| TW201231671A (en) * | 2011-01-28 | 2012-08-01 | Univ Kaohsiung Medical | Method and kit for in vitro diagnosis of atherosclerosis |
| WO2013032962A2 (en) | 2011-08-28 | 2013-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Micro rnas to treat stroke, ischemic brain injury, traumatic brain injury, and neurodegenerative disease |
| WO2013036993A1 (en) * | 2011-09-13 | 2013-03-21 | Commonwealth Scientific And Industrial Research Organisation | Detection of viral infection |
| WO2013122778A1 (en) * | 2012-02-15 | 2013-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of treating and preventing diseases and disorders of the central nervous system |
| US9101580B2 (en) * | 2012-12-18 | 2015-08-11 | Matthew Bennett | Compositions and methods for treating traumatic brain injury |
-
2015
- 2015-03-26 US US14/669,454 patent/US9605315B2/en active Active
- 2015-09-22 ES ES15886700T patent/ES3014311T3/es active Active
- 2015-09-22 AU AU2015387481A patent/AU2015387481B2/en active Active
- 2015-09-22 CA CA2976347A patent/CA2976347A1/en active Pending
- 2015-09-22 WO PCT/US2015/051518 patent/WO2016153549A1/en not_active Ceased
- 2015-09-22 CN CN201580077882.4A patent/CN107427614B/zh active Active
- 2015-09-22 JP JP2017541658A patent/JP2018518147A/ja active Pending
- 2015-09-22 SG SG11201707332XA patent/SG11201707332XA/en unknown
- 2015-09-22 EP EP15886700.2A patent/EP3274008B1/en active Active
-
2017
- 2017-02-14 US US15/432,172 patent/US10202649B2/en active Active
- 2017-08-07 IL IL253889A patent/IL253889A0/en unknown
- 2017-09-26 CL CL2017002420A patent/CL2017002420A1/es unknown
-
2018
- 2018-12-17 US US16/222,864 patent/US10815529B2/en active Active
-
2021
- 2021-10-29 AU AU2021258088A patent/AU2021258088B2/en active Active
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