CA2976347A1 - Detection of brain injury - Google Patents
Detection of brain injury Download PDFInfo
- Publication number
- CA2976347A1 CA2976347A1 CA2976347A CA2976347A CA2976347A1 CA 2976347 A1 CA2976347 A1 CA 2976347A1 CA 2976347 A CA2976347 A CA 2976347A CA 2976347 A CA2976347 A CA 2976347A CA 2976347 A1 CA2976347 A1 CA 2976347A1
- Authority
- CA
- Canada
- Prior art keywords
- patient
- mir
- brain injury
- tbi
- mirna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461970613P | 2014-03-26 | 2014-03-26 | |
| US14/669,454 | 2015-03-26 | ||
| US14/669,454 US9605315B2 (en) | 2014-03-26 | 2015-03-26 | Detection of traumatic brain injury |
| PCT/US2015/051518 WO2016153549A1 (en) | 2015-03-26 | 2015-09-22 | Detection of brain injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2976347A1 true CA2976347A1 (en) | 2016-09-29 |
Family
ID=56979279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2976347A Pending CA2976347A1 (en) | 2014-03-26 | 2015-09-22 | Detection of brain injury |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9605315B2 (OSRAM) |
| EP (1) | EP3274008B1 (OSRAM) |
| JP (1) | JP2018518147A (OSRAM) |
| CN (1) | CN107427614B (OSRAM) |
| AU (2) | AU2015387481B2 (OSRAM) |
| CA (1) | CA2976347A1 (OSRAM) |
| CL (1) | CL2017002420A1 (OSRAM) |
| ES (1) | ES3014311T3 (OSRAM) |
| IL (1) | IL253889A0 (OSRAM) |
| SG (1) | SG11201707332XA (OSRAM) |
| WO (1) | WO2016153549A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105861712B (zh) | 2011-04-18 | 2021-05-14 | 迪阿米尔有限责任公司 | 使用来自体液的miRNA来早期检测和监控轻度认知障碍(MCI)和阿尔茨海默病(AD)的方法 |
| ES2813699T3 (es) | 2013-11-18 | 2021-03-24 | Diamir Llc | Métodos de uso de miARN de fluidos corporales para la detección y monitoreo de la enfermedad de Parkinson (PD) |
| WO2017087726A1 (en) * | 2015-11-18 | 2017-05-26 | Dignity Health | Methods of diagnosing epilepsy |
| US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
| GB201603967D0 (en) * | 2016-03-08 | 2016-04-20 | Univ Birmingham | Biomarkers of traumatic brain injury |
| EP3433381B1 (en) | 2016-03-21 | 2024-07-24 | Diamir, LLC | Methods of using mirnas from bodily fluids for detection and differentiation of neurodegenerative diseases |
| CN108300788B (zh) * | 2017-01-13 | 2021-07-09 | 中国人民解放军南京军区南京总医院 | 一种用于检测轻型脑外伤的微小核糖核酸组合及其应用 |
| WO2018175941A1 (en) * | 2017-03-23 | 2018-09-27 | Quadrant Biosciences Inc. | Analysis and prediction of traumatic brain injury and concusion symptoms |
| US10781487B2 (en) | 2017-07-24 | 2020-09-22 | Diamir, Llc | miRNA-based methods for detecting and monitoring aging |
| CN112424606B9 (zh) * | 2018-05-31 | 2025-03-07 | 阿米达斯公司 | 用于检测创伤性脑损伤的组合物和方法 |
| WO2025039033A1 (en) * | 2023-08-21 | 2025-02-27 | Glia Diagnostics Pty Ltd | Methods and reagents for diagnosis and/or prognosis of traumatic brain injury |
| CN118314963B (zh) * | 2023-11-13 | 2024-10-29 | 中国人民解放军空军特色医学中心 | 一种基于lasso回归的血小板储存损伤风险预测模型及其构建方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL145209A0 (en) * | 2000-09-06 | 2002-06-30 | Pfizer Prod Inc | Pharmaceutical combinations for the treatment of stroke and traumatic brain injury |
| AU2003237379A1 (en) * | 2002-06-10 | 2003-12-22 | Oklahoma Medical Research Foundation | A method for using tethered bis(polyhydroxyphenyls) and o-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system |
| US20110111976A1 (en) * | 2008-04-25 | 2011-05-12 | Merck Sharp & Dohme Corp. | Microrna biomarkers of tissue injury |
| JP5909447B2 (ja) * | 2009-09-14 | 2016-04-26 | バンヤン・バイオマーカーズ・インコーポレーテッド | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| WO2011149354A1 (en) * | 2010-05-28 | 2011-12-01 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg | Mirnas involved in the blood brain barrier function |
| TW201231671A (en) * | 2011-01-28 | 2012-08-01 | Univ Kaohsiung Medical | Method and kit for in vitro diagnosis of atherosclerosis |
| WO2013032962A2 (en) | 2011-08-28 | 2013-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Micro rnas to treat stroke, ischemic brain injury, traumatic brain injury, and neurodegenerative disease |
| WO2013036993A1 (en) * | 2011-09-13 | 2013-03-21 | Commonwealth Scientific And Industrial Research Organisation | Detection of viral infection |
| WO2013122778A1 (en) * | 2012-02-15 | 2013-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of treating and preventing diseases and disorders of the central nervous system |
| US9101580B2 (en) * | 2012-12-18 | 2015-08-11 | Matthew Bennett | Compositions and methods for treating traumatic brain injury |
-
2015
- 2015-03-26 US US14/669,454 patent/US9605315B2/en active Active
- 2015-09-22 ES ES15886700T patent/ES3014311T3/es active Active
- 2015-09-22 AU AU2015387481A patent/AU2015387481B2/en active Active
- 2015-09-22 CA CA2976347A patent/CA2976347A1/en active Pending
- 2015-09-22 WO PCT/US2015/051518 patent/WO2016153549A1/en not_active Ceased
- 2015-09-22 CN CN201580077882.4A patent/CN107427614B/zh active Active
- 2015-09-22 JP JP2017541658A patent/JP2018518147A/ja active Pending
- 2015-09-22 SG SG11201707332XA patent/SG11201707332XA/en unknown
- 2015-09-22 EP EP15886700.2A patent/EP3274008B1/en active Active
-
2017
- 2017-02-14 US US15/432,172 patent/US10202649B2/en active Active
- 2017-08-07 IL IL253889A patent/IL253889A0/en unknown
- 2017-09-26 CL CL2017002420A patent/CL2017002420A1/es unknown
-
2018
- 2018-12-17 US US16/222,864 patent/US10815529B2/en active Active
-
2021
- 2021-10-29 AU AU2021258088A patent/AU2021258088B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016153549A1 (en) | 2016-09-29 |
| SG11201707332XA (en) | 2017-10-30 |
| EP3274008A4 (en) | 2018-10-24 |
| ES3014311T3 (en) | 2025-04-21 |
| US10815529B2 (en) | 2020-10-27 |
| US10202649B2 (en) | 2019-02-12 |
| EP3274008B1 (en) | 2024-12-04 |
| EP3274008A1 (en) | 2018-01-31 |
| US20170268058A1 (en) | 2017-09-21 |
| CL2017002420A1 (es) | 2018-07-13 |
| AU2015387481B2 (en) | 2021-08-05 |
| US20190352716A1 (en) | 2019-11-21 |
| US20150344954A1 (en) | 2015-12-03 |
| AU2015387481A1 (en) | 2017-08-03 |
| AU2021258088B2 (en) | 2024-11-28 |
| CN107427614A (zh) | 2017-12-01 |
| IL253889A0 (en) | 2017-10-31 |
| US9605315B2 (en) | 2017-03-28 |
| JP2018518147A (ja) | 2018-07-12 |
| AU2021258088A1 (en) | 2021-11-25 |
| CN107427614B (zh) | 2021-10-15 |
| EP3274008C0 (en) | 2024-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20200916 |
|
| EEER | Examination request |
Effective date: 20200916 |
|
| EEER | Examination request |
Effective date: 20200916 |
|
| EEER | Examination request |
Effective date: 20200916 |
|
| EEER | Examination request |
Effective date: 20200916 |
|
| EEER | Examination request |
Effective date: 20200916 |
|
| EEER | Examination request |
Effective date: 20200916 |