JP2018518147A - 脳損傷の検出 - Google Patents

脳損傷の検出 Download PDF

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Publication number
JP2018518147A
JP2018518147A JP2017541658A JP2017541658A JP2018518147A JP 2018518147 A JP2018518147 A JP 2018518147A JP 2017541658 A JP2017541658 A JP 2017541658A JP 2017541658 A JP2017541658 A JP 2017541658A JP 2018518147 A JP2018518147 A JP 2018518147A
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patient
mir
brain injury
mirna
sample
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JP2017541658A
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Japanese (ja)
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JP2018518147A5 (OSRAM
Inventor
サージュバーイー・エー・パテル
トーマス・エフ・ラウ
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ザ ユニバーシティー オブ モンタナ
ザ ユニバーシティー オブ モンタナ
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Publication of JP2018518147A publication Critical patent/JP2018518147A/ja
Publication of JP2018518147A5 publication Critical patent/JP2018518147A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017541658A 2015-03-26 2015-09-22 脳損傷の検出 Pending JP2018518147A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/669,454 2015-03-26
US14/669,454 US9605315B2 (en) 2014-03-26 2015-03-26 Detection of traumatic brain injury
PCT/US2015/051518 WO2016153549A1 (en) 2015-03-26 2015-09-22 Detection of brain injury

Publications (2)

Publication Number Publication Date
JP2018518147A true JP2018518147A (ja) 2018-07-12
JP2018518147A5 JP2018518147A5 (OSRAM) 2018-10-25

Family

ID=56979279

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017541658A Pending JP2018518147A (ja) 2015-03-26 2015-09-22 脳損傷の検出

Country Status (11)

Country Link
US (3) US9605315B2 (OSRAM)
EP (1) EP3274008B1 (OSRAM)
JP (1) JP2018518147A (OSRAM)
CN (1) CN107427614B (OSRAM)
AU (2) AU2015387481B2 (OSRAM)
CA (1) CA2976347A1 (OSRAM)
CL (1) CL2017002420A1 (OSRAM)
ES (1) ES3014311T3 (OSRAM)
IL (1) IL253889A0 (OSRAM)
SG (1) SG11201707332XA (OSRAM)
WO (1) WO2016153549A1 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105861712B (zh) 2011-04-18 2021-05-14 迪阿米尔有限责任公司 使用来自体液的miRNA来早期检测和监控轻度认知障碍(MCI)和阿尔茨海默病(AD)的方法
ES2813699T3 (es) 2013-11-18 2021-03-24 Diamir Llc Métodos de uso de miARN de fluidos corporales para la detección y monitoreo de la enfermedad de Parkinson (PD)
WO2017087726A1 (en) * 2015-11-18 2017-05-26 Dignity Health Methods of diagnosing epilepsy
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
GB201603967D0 (en) * 2016-03-08 2016-04-20 Univ Birmingham Biomarkers of traumatic brain injury
EP3433381B1 (en) 2016-03-21 2024-07-24 Diamir, LLC Methods of using mirnas from bodily fluids for detection and differentiation of neurodegenerative diseases
CN108300788B (zh) * 2017-01-13 2021-07-09 中国人民解放军南京军区南京总医院 一种用于检测轻型脑外伤的微小核糖核酸组合及其应用
WO2018175941A1 (en) * 2017-03-23 2018-09-27 Quadrant Biosciences Inc. Analysis and prediction of traumatic brain injury and concusion symptoms
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
CN112424606B9 (zh) * 2018-05-31 2025-03-07 阿米达斯公司 用于检测创伤性脑损伤的组合物和方法
WO2025039033A1 (en) * 2023-08-21 2025-02-27 Glia Diagnostics Pty Ltd Methods and reagents for diagnosis and/or prognosis of traumatic brain injury
CN118314963B (zh) * 2023-11-13 2024-10-29 中国人民解放军空军特色医学中心 一种基于lasso回归的血小板储存损伤风险预测模型及其构建方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005533042A (ja) * 2002-06-10 2005-11-04 オクラホマ　メディカル　リサーチ　ファウンデーション 中枢神経系の炎症状態の治療において連結ビス（ポリヒドロキシフェニル）およびそのｏ−アルキル誘導体を使用するための方法
US20140170211A1 (en) * 2012-12-18 2014-06-19 Matthew Bennett Compositions and methods for treating traumatic brain injury
US20150011626A1 (en) * 2012-02-15 2015-01-08 The United States of America, as representive by the Secretary, Department of Health and Human Serv Methods of treating and preventing diseases and disorders of the central nervous system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL145209A0 (en) * 2000-09-06 2002-06-30 Pfizer Prod Inc Pharmaceutical combinations for the treatment of stroke and traumatic brain injury
US20110111976A1 (en) * 2008-04-25 2011-05-12 Merck Sharp & Dohme Corp. Microrna biomarkers of tissue injury
JP5909447B2 (ja) * 2009-09-14 2016-04-26 バンヤン・バイオマーカーズ・インコーポレーテッド ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー
WO2011149354A1 (en) * 2010-05-28 2011-12-01 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Mirnas involved in the blood brain barrier function
TW201231671A (en) * 2011-01-28 2012-08-01 Univ Kaohsiung Medical Method and kit for in vitro diagnosis of atherosclerosis
WO2013032962A2 (en) 2011-08-28 2013-03-07 The Board Of Trustees Of The Leland Stanford Junior University Micro rnas to treat stroke, ischemic brain injury, traumatic brain injury, and neurodegenerative disease
WO2013036993A1 (en) * 2011-09-13 2013-03-21 Commonwealth Scientific And Industrial Research Organisation Detection of viral infection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005533042A (ja) * 2002-06-10 2005-11-04 オクラホマ　メディカル　リサーチ　ファウンデーション 中枢神経系の炎症状態の治療において連結ビス（ポリヒドロキシフェニル）およびそのｏ−アルキル誘導体を使用するための方法
US20150011626A1 (en) * 2012-02-15 2015-01-08 The United States of America, as representive by the Secretary, Department of Health and Human Serv Methods of treating and preventing diseases and disorders of the central nervous system
US20140170211A1 (en) * 2012-12-18 2014-06-19 Matthew Bennett Compositions and methods for treating traumatic brain injury

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY, VOL.34, NO.4, 2014, P.548-553, JPN6019027837, ISSN: 0004234516 *
J NEUROTRAUMA, 2012, VOL.29, P.1379-1387, JPN6019027835, ISSN: 0004234514 *
PLOS ONE, 2014, VOL.9, ISSUE 11, E112019, P.1-20, JPN6019027834, ISSN: 0004234515 *

Also Published As

Publication number Publication date
WO2016153549A1 (en) 2016-09-29
SG11201707332XA (en) 2017-10-30
EP3274008A4 (en) 2018-10-24
ES3014311T3 (en) 2025-04-21
US10815529B2 (en) 2020-10-27
US10202649B2 (en) 2019-02-12
EP3274008B1 (en) 2024-12-04
EP3274008A1 (en) 2018-01-31
US20170268058A1 (en) 2017-09-21
CL2017002420A1 (es) 2018-07-13
AU2015387481B2 (en) 2021-08-05
US20190352716A1 (en) 2019-11-21
US20150344954A1 (en) 2015-12-03
AU2015387481A1 (en) 2017-08-03
AU2021258088B2 (en) 2024-11-28
CN107427614A (zh) 2017-12-01
IL253889A0 (en) 2017-10-31
US9605315B2 (en) 2017-03-28
AU2021258088A1 (en) 2021-11-25
CN107427614B (zh) 2021-10-15
EP3274008C0 (en) 2024-12-04
CA2976347A1 (en) 2016-09-29

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