JP2018517736A5 - - Google Patents
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- Publication number
- JP2018517736A5 JP2018517736A5 JP2017565134A JP2017565134A JP2018517736A5 JP 2018517736 A5 JP2018517736 A5 JP 2018517736A5 JP 2017565134 A JP2017565134 A JP 2017565134A JP 2017565134 A JP2017565134 A JP 2017565134A JP 2018517736 A5 JP2018517736 A5 JP 2018517736A5
- Authority
- JP
- Japan
- Prior art keywords
- less
- formulation
- nsaid
- formulation according
- cochleate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims 27
- 238000009472 formulation Methods 0.000 claims 26
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 13
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 13
- 150000002632 lipids Chemical class 0.000 claims 9
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 7
- 208000025865 Ulcer Diseases 0.000 claims 6
- 230000003902 lesion Effects 0.000 claims 6
- 231100000397 ulcer Toxicity 0.000 claims 6
- 150000003904 phospholipids Chemical class 0.000 claims 5
- 230000002209 hydrophobic effect Effects 0.000 claims 4
- 239000013554 lipid monolayer Substances 0.000 claims 4
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 3
- 239000010410 layer Substances 0.000 claims 3
- 229930182558 Sterol Natural products 0.000 claims 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 claims 2
- 239000003833 bile salt Substances 0.000 claims 2
- 125000002091 cationic group Chemical group 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 150000003432 sterols Chemical class 0.000 claims 2
- 235000003702 sterols Nutrition 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 229940111133 antiinflammatory and antirheumatic drug oxicams Drugs 0.000 claims 1
- 229940093761 bile salts Drugs 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 229940111134 coxibs Drugs 0.000 claims 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims 1
- 229960001860 salicylate Drugs 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562181347P | 2015-06-18 | 2015-06-18 | |
| US62/181,347 | 2015-06-18 | ||
| US201662289025P | 2016-01-29 | 2016-01-29 | |
| US62/289,025 | 2016-01-29 | ||
| US201662347014P | 2016-06-07 | 2016-06-07 | |
| US62/347,014 | 2016-06-07 | ||
| PCT/US2016/038084 WO2016205654A1 (en) | 2015-06-18 | 2016-06-17 | Compositions and methods for treating inflammatory disease or conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018517736A JP2018517736A (ja) | 2018-07-05 |
| JP2018517736A5 true JP2018517736A5 (enExample) | 2019-06-27 |
Family
ID=57546667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017565134A Withdrawn JP2018517736A (ja) | 2015-06-18 | 2016-06-17 | 炎症性疾患又は病態を治療する組成物及び方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20180185308A1 (enExample) |
| EP (1) | EP3310338A4 (enExample) |
| JP (1) | JP2018517736A (enExample) |
| KR (1) | KR20180014790A (enExample) |
| CN (1) | CN107920991A (enExample) |
| AU (1) | AU2016280276A1 (enExample) |
| CA (1) | CA2987798A1 (enExample) |
| WO (1) | WO2016205654A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180004104A (ko) | 2015-03-03 | 2018-01-10 | 마티나스 바이오파마 나노테크놀로지스, 인코포레이티드 | 코클레이트 및 약리학적 활성제의 조직 침투를 향상시키기 위해 이를 사용하는 방법 |
| JOP20190207A1 (ar) | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6759057B1 (en) * | 1986-06-12 | 2004-07-06 | The Liposome Company, Inc. | Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
| HUP9701554D0 (en) * | 1997-09-18 | 1997-11-28 | Human Oltoanyagtermeloe Gyogys | Pharmaceutical composition containing plazma proteins |
| WO2001052817A2 (en) * | 2000-01-24 | 2001-07-26 | Biodelivery Sciences, Inc. | Cochleate formulations and their use for delivering biologically relevant molecules |
| US20100173876A1 (en) * | 2000-12-19 | 2010-07-08 | The Board Of Regents Of The University Of Texas System | Oil-based nsaid compositions and methods for making and using same |
| CA2504329C (en) * | 2002-11-01 | 2013-08-20 | Biodelivery Sciences International, Inc. | Geodate delivery vehicles |
| US20050013854A1 (en) * | 2003-04-09 | 2005-01-20 | Mannino Raphael J. | Novel encochleation methods, cochleates and methods of use |
| JP6347743B2 (ja) * | 2011-05-05 | 2018-06-27 | マティナス バイオファーマ ナノテクノロジーズ，インコーポレーテッド | コクリエート組成物およびその製造および使用方法 |
| MX361155B (es) * | 2012-07-30 | 2018-11-28 | Matinas Biopharma Nanotechnologies Inc | Cocleatos hechos con fosfatidilserina de soja. |
-
2016
- 2016-06-17 CN CN201680047545.5A patent/CN107920991A/zh active Pending
- 2016-06-17 JP JP2017565134A patent/JP2018517736A/ja not_active Withdrawn
- 2016-06-17 US US15/735,708 patent/US20180185308A1/en not_active Abandoned
- 2016-06-17 CA CA2987798A patent/CA2987798A1/en not_active Abandoned
- 2016-06-17 AU AU2016280276A patent/AU2016280276A1/en not_active Abandoned
- 2016-06-17 EP EP16812525.0A patent/EP3310338A4/en not_active Withdrawn
- 2016-06-17 KR KR1020177037910A patent/KR20180014790A/ko not_active Withdrawn
- 2016-06-17 WO PCT/US2016/038084 patent/WO2016205654A1/en not_active Ceased
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