JP2018517734A - デフェラシロクスの改善された製剤およびその作製方法 - Google Patents

デフェラシロクスの改善された製剤およびその作製方法 Download PDF

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JP2018517734A
JP2018517734A JP2017565048A JP2017565048A JP2018517734A JP 2018517734 A JP2018517734 A JP 2018517734A JP 2017565048 A JP2017565048 A JP 2017565048A JP 2017565048 A JP2017565048 A JP 2017565048A JP 2018517734 A JP2018517734 A JP 2018517734A
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pharmaceutical composition
pharmaceutical
composition
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JP2018517734A5 (cg-RX-API-DMAC7.html
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デーブ エイ． ミラー
デーブ エイ． ミラー
ジャスティン エム． キーン
ジャスティン エム． キーン
サンドラ ユー． クセラ
サンドラ ユー． クセラ
Original Assignee
ディスパーソル テクノロジーズ リミテッド ライアビリティ カンパニー
ディスパーソル テクノロジーズ リミテッド ライアビリティ カンパニー
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Publication of JP2018517734A publication Critical patent/JP2018517734A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017565048A 2015-06-17 2016-06-17 デフェラシロクスの改善された製剤およびその作製方法 Pending JP2018517734A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562180998P 2015-06-17 2015-06-17
US62/180,998 2015-06-17
PCT/US2016/038089 WO2016205658A1 (en) 2015-06-17 2016-06-17 Improved formulations of deferasirox and methods of making the same

Publications (2)

Publication Number Publication Date
JP2018517734A true JP2018517734A (ja) 2018-07-05
JP2018517734A5 JP2018517734A5 (cg-RX-API-DMAC7.html) 2019-05-30

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JP2017565048A Pending JP2018517734A (ja) 2015-06-17 2016-06-17 デフェラシロクスの改善された製剤およびその作製方法

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US (4) US10265301B2 (cg-RX-API-DMAC7.html)
EP (1) EP3310354A4 (cg-RX-API-DMAC7.html)
JP (1) JP2018517734A (cg-RX-API-DMAC7.html)
CN (1) CN107847490A (cg-RX-API-DMAC7.html)
AU (2) AU2016280280B2 (cg-RX-API-DMAC7.html)
CA (1) CA2989145C (cg-RX-API-DMAC7.html)
HK (1) HK1254608A1 (cg-RX-API-DMAC7.html)
IL (1) IL256322B (cg-RX-API-DMAC7.html)
MA (1) MA43271A (cg-RX-API-DMAC7.html)
WO (1) WO2016205658A1 (cg-RX-API-DMAC7.html)

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CN103290106B (zh) 2007-12-05 2015-07-29 考利达基因组股份有限公司 测序反应中碱基的有效确定
US10098857B2 (en) 2008-10-10 2018-10-16 The Board Of Trustees Of The Leland Stanford Junior University Topical and transdermal delivery of HIF-1 modulators to prevent and treat chronic wounds
EP2977455B1 (en) 2009-06-15 2020-04-15 Complete Genomics, Inc. Method for long fragment read sequencing
US10837879B2 (en) 2011-11-02 2020-11-17 Complete Genomics, Inc. Treatment for stabilizing nucleic acid arrays
CZ2017255A3 (cs) * 2017-05-04 2018-11-14 Zentiva, K.S. Filmem potažené tablety Deferasiroxu
WO2019055490A1 (en) 2017-09-14 2019-03-21 The Board Of Trustees Of The Leland Stanford Junior University PACKAGING OF IRRADIED FABRIC FOR FAT GREETING RETENTION
EP3706731A4 (en) * 2017-11-10 2021-08-18 Dispersol Technologies, LLC IMPROVED DRUG FORMULATIONS
CA3113175A1 (en) * 2018-09-20 2020-03-26 Tautona Group Ip Holding Company, L.L.C. Iron chelating compounds for treating aesthetic skin conditions
AU2021212258A1 (en) 2020-01-31 2022-09-29 Flex Pharma, Llc Amorphous nilotinib microparticles and uses thereof
EP4142699A1 (en) 2020-04-30 2023-03-08 Nanocopoeia LLC Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib
CN112870361A (zh) * 2021-01-28 2021-06-01 重庆医科大学 铁死亡抑制剂在制备预防或治疗铁过载导致的骨质疏松或骨丢失的药物中的应用
CN116203161A (zh) * 2022-05-30 2023-06-02 上海奥科达医药科技股份有限公司 地拉罗司颗粒剂中相关杂质的检测方法
WO2025151876A1 (en) * 2024-01-11 2025-07-17 Minneamrita Therapeutics Llc Triptolide formulations

Citations (3)

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JP2013512893A (ja) * 2009-12-07 2013-04-18 マピ ファーマ リミテッド デフェラシロクスの調製方法、及びデフェラシロクスの多形体
WO2014181108A1 (en) * 2013-05-10 2014-11-13 Cipla Limited Low dose pharmaceutical composition
JP2014221816A (ja) * 2007-08-21 2014-11-27 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 医薬品適用のための熱−動力学的混合

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GB0009056D0 (en) * 2000-04-12 2000-05-31 Nestle Sa Composition comprising free amino acids
AU2006303514B2 (en) * 2005-10-19 2010-06-24 Novartis Ag Dispersible tablets comprising deferasirox
WO2009067557A1 (en) * 2007-11-19 2009-05-28 Teva Pharmaceutical Industries Ltd. Deferasirox pharmaceutical compositions
EP2291360A2 (en) * 2008-04-21 2011-03-09 Actavis Group PTC ehf. Solid state forms of deferasirox salts and process for the preparation thereof
EP2929877A1 (en) * 2010-07-08 2015-10-14 ratiopharm GmbH Oral dosage form of deferasirox
EP2632907B1 (en) * 2010-08-25 2015-10-14 Davuluri, Ramamohan Rao Process for preparing 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one and its use for preparing deferasirox
MX2013003522A (es) * 2010-10-01 2013-05-22 Cipla Ltd Composicion farmaceutica.
WO2012116238A1 (en) * 2011-02-23 2012-08-30 Dispersol Technologies, Llc PHARMACEUTICAL FORMULATIONS OF ACETYL-11-KETO-β-BOSWELLIC ACID, DIINDOLYLMETHANE, AND CURCUMIN FOR PHARMACEUTICAL APPLICATIONS
TWI686215B (zh) * 2013-03-08 2020-03-01 瑞士商諾華公司 祛鐵斯若(deferasirox)之口服配方

Patent Citations (4)

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JP2014221816A (ja) * 2007-08-21 2014-11-27 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 医薬品適用のための熱−動力学的混合
JP2013512893A (ja) * 2009-12-07 2013-04-18 マピ ファーマ リミテッド デフェラシロクスの調製方法、及びデフェラシロクスの多形体
WO2014181108A1 (en) * 2013-05-10 2014-11-13 Cipla Limited Low dose pharmaceutical composition
JP2016518398A (ja) * 2013-05-10 2016-06-23 シプラ・リミテッド 低用量医薬組成物

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Publication number Publication date
CA2989145C (en) 2024-10-29
MA43271A (fr) 2018-09-26
EP3310354A4 (en) 2018-12-12
CN107847490A (zh) 2018-03-27
EP3310354A1 (en) 2018-04-25
IL256322A (en) 2018-02-28
US10258608B2 (en) 2019-04-16
IL256322B (en) 2022-03-01
AU2021277731A1 (en) 2021-12-23
AU2016280280A1 (en) 2018-01-04
HK1254608A1 (zh) 2019-07-26
US20240091201A1 (en) 2024-03-21
US20170027911A1 (en) 2017-02-02
US10265301B2 (en) 2019-04-23
US11878005B2 (en) 2024-01-23
AU2024202528A1 (en) 2024-05-09
WO2016205658A1 (en) 2016-12-22
AU2016280280B2 (en) 2021-09-02
US20190167643A1 (en) 2019-06-06
CA2989145A1 (en) 2016-12-22
US20170296514A1 (en) 2017-10-19
AU2021277731B2 (en) 2024-04-11

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