JP2018514576A5 - - Google Patents
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- Publication number
- JP2018514576A5 JP2018514576A5 JP2017557405A JP2017557405A JP2018514576A5 JP 2018514576 A5 JP2018514576 A5 JP 2018514576A5 JP 2017557405 A JP2017557405 A JP 2017557405A JP 2017557405 A JP2017557405 A JP 2017557405A JP 2018514576 A5 JP2018514576 A5 JP 2018514576A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- combination according
- cd16a
- combination
- multifunctional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 6
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 6
- 101100334515 Homo sapiens FCGR3A gene Proteins 0.000 claims 5
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 5
- 230000008595 infiltration Effects 0.000 claims 3
- 238000001764 infiltration Methods 0.000 claims 3
- 230000015788 innate immune response Effects 0.000 claims 3
- 230000002601 intratumoral effect Effects 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims 1
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 229940126546 immune checkpoint molecule Drugs 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15166303.6 | 2015-05-04 | ||
| EP15166303.6A EP3091031A1 (en) | 2015-05-04 | 2015-05-04 | Combination of a bispecific antibody with an immune modulating molecule for the treatment of a tumor |
| EP16152650 | 2016-01-25 | ||
| EP16152650.4 | 2016-01-25 | ||
| PCT/EP2016/060113 WO2016177846A1 (en) | 2015-05-04 | 2016-05-04 | Combination of a cd30xcd16 antibody with a pd-1 antagonist for therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018514576A JP2018514576A (ja) | 2018-06-07 |
| JP2018514576A5 true JP2018514576A5 (enExample) | 2019-06-13 |
| JP6609784B2 JP6609784B2 (ja) | 2019-11-27 |
Family
ID=56026814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557405A Active JP6609784B2 (ja) | 2015-05-04 | 2016-05-04 | 治療のためのｃｄ３０×ｃｄ１６抗体とｐｄ−１アンタゴニストとの組み合わせ |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US11167029B2 (enExample) |
| EP (1) | EP3292153B1 (enExample) |
| JP (1) | JP6609784B2 (enExample) |
| CN (1) | CN107847587B (enExample) |
| AU (1) | AU2016257334B2 (enExample) |
| BR (1) | BR112017023579A2 (enExample) |
| CA (2) | CA3219372A1 (enExample) |
| CY (1) | CY1122283T1 (enExample) |
| DK (1) | DK3292153T3 (enExample) |
| ES (1) | ES2754557T3 (enExample) |
| HR (1) | HRP20191933T1 (enExample) |
| HU (1) | HUE045866T2 (enExample) |
| LT (1) | LT3292153T (enExample) |
| PL (1) | PL3292153T3 (enExample) |
| PT (1) | PT3292153T (enExample) |
| RS (1) | RS59489B1 (enExample) |
| RU (1) | RU2761352C2 (enExample) |
| SI (1) | SI3292153T1 (enExample) |
| SM (1) | SMT201900598T1 (enExample) |
| WO (1) | WO2016177846A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110461357A (zh) | 2017-02-28 | 2019-11-15 | 阿菲姆德股份有限公司 | 抗cd16a抗体与细胞因子的组合 |
| JP7115758B2 (ja) * | 2017-02-28 | 2022-08-09 | アッフィメッド・ゲー・エム・ベー・ハー | Ｃｄ１６ａ指向性ｎｋ細胞エンゲージメント用タンデムダイアボディ |
| CN109706163A (zh) * | 2017-10-26 | 2019-05-03 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接人与动物靶细胞与效应细胞的桥接分子及其应用 |
| CN109706164A (zh) * | 2017-10-26 | 2019-05-03 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接人和猴cd20与效应细胞抗原的桥接分子及其应用 |
| CA3090464A1 (en) * | 2018-03-14 | 2019-09-19 | Affimed Gmbh | Bispecific egfr/cd16 antigen-binding protein |
| MX2020010728A (es) | 2018-04-13 | 2020-11-06 | Affimed Gmbh | Constructos de fusion de anticuerpos que se acoplan a celulas nk. |
| KR20210052494A (ko) * | 2018-08-27 | 2021-05-10 | 아피메트 게엠베하 | 항체 구조물이 사전 로드된 동결 보존된 nk 세포 |
| CN109402168A (zh) * | 2018-10-30 | 2019-03-01 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接her2阳性细胞与效应细胞的桥接分子及其应用 |
| AU2020292339A1 (en) * | 2019-06-11 | 2022-01-20 | Myeloid Therapeutics, Inc. | Macrophage specific engager compositions and methods of use thereof |
| WO2021130383A1 (en) * | 2019-12-27 | 2021-07-01 | Affimed Gmbh | Method for the production of bispecific fcyriii x cd30 antibody construct |
| US20240343811A1 (en) | 2021-06-29 | 2024-10-17 | Shandong Simcere Biopharmacutical Co., Ltd. | Cd16 antibody and use thereof |
| JP7503215B2 (ja) | 2021-10-08 | 2024-06-19 | ジェンマブ エー／エス | Ｃｄ３０及びｃｄ３に結合する抗体 |
| US20240424099A1 (en) * | 2021-11-04 | 2024-12-26 | Artiva Biotherapeutics, Inc. | Treatment of cancer with nk cells and multispecific engagers |
| WO2023080895A1 (en) * | 2021-11-04 | 2023-05-11 | Artiva Biotherapeutics, Inc. | Treatment of cancer with nk cells and multispecific engagers |
| CN116059348A (zh) * | 2022-09-16 | 2023-05-05 | 四川大学华西医院 | 基于nkg2d的细胞接合器分子在清除衰老细胞中的应用 |
| AU2023404602A1 (en) | 2022-11-29 | 2025-05-29 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Cldn18.2/4-1bb binding protein and medical use thereof |
| TW202506178A (zh) | 2023-04-05 | 2025-02-16 | 丹麥商珍美寶股份有限公司 | 包含與ｃｄ３０和ｃｄ３結合之抗體之醫藥組成物 |
| CN117442721B (zh) * | 2023-12-20 | 2024-03-15 | 苏州艾凯利元生物科技有限公司 | 一种包括nk细胞和nk细胞接合器分子的组合物 |
| CN118791616A (zh) * | 2024-09-14 | 2024-10-18 | 苏州为度生物技术有限公司天津分公司 | 一种抗人cd16工程抗体及应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0510790D0 (en) * | 2005-05-26 | 2005-06-29 | Syngenta Crop Protection Ag | Anti-CD16 binding molecules |
| EP3130350A1 (en) * | 2005-06-08 | 2017-02-15 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (pd-1)pathway |
| US9682143B2 (en) * | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| WO2016029073A2 (en) * | 2014-08-22 | 2016-02-25 | Bristol-Myers Squibb Company | Treatment of cancer using a combination of an anti-pd-1 antibody and an anti-cd137 antibody |
-
2016
- 2016-05-04 HU HUE16723968A patent/HUE045866T2/hu unknown
- 2016-05-04 WO PCT/EP2016/060113 patent/WO2016177846A1/en not_active Ceased
- 2016-05-04 PT PT167239680T patent/PT3292153T/pt unknown
- 2016-05-04 AU AU2016257334A patent/AU2016257334B2/en active Active
- 2016-05-04 PL PL16723968T patent/PL3292153T3/pl unknown
- 2016-05-04 ES ES16723968T patent/ES2754557T3/es active Active
- 2016-05-04 DK DK16723968.0T patent/DK3292153T3/da active
- 2016-05-04 EP EP16723968.0A patent/EP3292153B1/en active Active
- 2016-05-04 SM SM20190598T patent/SMT201900598T1/it unknown
- 2016-05-04 CA CA3219372A patent/CA3219372A1/en active Pending
- 2016-05-04 HR HRP20191933TT patent/HRP20191933T1/hr unknown
- 2016-05-04 CA CA2983706A patent/CA2983706C/en active Active
- 2016-05-04 SI SI201630463T patent/SI3292153T1/sl unknown
- 2016-05-04 JP JP2017557405A patent/JP6609784B2/ja active Active
- 2016-05-04 RU RU2017137251A patent/RU2761352C2/ru active
- 2016-05-04 LT LT16723968T patent/LT3292153T/lt unknown
- 2016-05-04 CN CN201680026411.5A patent/CN107847587B/zh active Active
- 2016-05-04 RS RS20191372A patent/RS59489B1/sr unknown
- 2016-05-04 BR BR112017023579A patent/BR112017023579A2/pt active Search and Examination
-
2017
- 2017-10-19 US US15/788,177 patent/US11167029B2/en active Active
-
2019
- 2019-10-25 CY CY20191101115T patent/CY1122283T1/el unknown
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