JP2018512440A5 - - Google Patents
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- JP2018512440A5 JP2018512440A5 JP2017554388A JP2017554388A JP2018512440A5 JP 2018512440 A5 JP2018512440 A5 JP 2018512440A5 JP 2017554388 A JP2017554388 A JP 2017554388A JP 2017554388 A JP2017554388 A JP 2017554388A JP 2018512440 A5 JP2018512440 A5 JP 2018512440A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- plant
- fraction
- peptide
- free supernatant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 241000196324 Embryophyta Species 0.000 claims 24
- 239000006228 supernatant Substances 0.000 claims 20
- 210000004027 cell Anatomy 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 10
- 239000002609 medium Substances 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 7
- 239000003102 growth factor Substances 0.000 claims 7
- 239000003636 conditioned culture medium Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 238000000926 separation method Methods 0.000 claims 6
- 102000040945 Transcription factor Human genes 0.000 claims 5
- 108091023040 Transcription factor Proteins 0.000 claims 5
- 230000012010 growth Effects 0.000 claims 5
- 230000008635 plant growth Effects 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 239000000725 suspension Substances 0.000 claims 5
- 244000025254 Cannabis sativa Species 0.000 claims 4
- 244000163122 Curcuma domestica Species 0.000 claims 4
- 244000000626 Daucus carota Species 0.000 claims 4
- 235000002767 Daucus carota Nutrition 0.000 claims 4
- 240000006240 Linum usitatissimum Species 0.000 claims 4
- 235000004431 Linum usitatissimum Nutrition 0.000 claims 4
- 240000007817 Olea europaea Species 0.000 claims 4
- 244000294611 Punica granatum Species 0.000 claims 4
- 235000014360 Punica granatum Nutrition 0.000 claims 4
- 230000006037 cell lysis Effects 0.000 claims 4
- 239000006285 cell suspension Substances 0.000 claims 4
- 210000002421 cell wall Anatomy 0.000 claims 4
- 238000004587 chromatography analysis Methods 0.000 claims 4
- 235000003373 curcuma longa Nutrition 0.000 claims 4
- 230000001086 cytosolic effect Effects 0.000 claims 4
- 230000003834 intracellular effect Effects 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 4
- 230000000699 topical effect Effects 0.000 claims 4
- 244000052707 Camellia sinensis Species 0.000 claims 3
- 206010020649 Hyperkeratosis Diseases 0.000 claims 3
- 235000006468 Thea sinensis Nutrition 0.000 claims 3
- 240000006365 Vitis vinifera Species 0.000 claims 3
- 235000014787 Vitis vinifera Nutrition 0.000 claims 3
- 230000001973 epigenetic effect Effects 0.000 claims 3
- 238000001914 filtration Methods 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 230000002934 lysing effect Effects 0.000 claims 3
- 238000002414 normal-phase solid-phase extraction Methods 0.000 claims 3
- 235000015097 nutrients Nutrition 0.000 claims 3
- 230000006920 protein precipitation Effects 0.000 claims 3
- 238000000108 ultra-filtration Methods 0.000 claims 3
- 235000008697 Cannabis sativa Nutrition 0.000 claims 2
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 claims 2
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 claims 2
- 244000146462 Centella asiatica Species 0.000 claims 2
- 235000004032 Centella asiatica Nutrition 0.000 claims 2
- 229920000742 Cotton Polymers 0.000 claims 2
- 235000003392 Curcuma domestica Nutrition 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 241000219146 Gossypium Species 0.000 claims 2
- 240000002024 Gossypium herbaceum Species 0.000 claims 2
- 235000004341 Gossypium herbaceum Nutrition 0.000 claims 2
- 235000002725 Olea europaea Nutrition 0.000 claims 2
- 101800000602 Phytosulfokine-beta Proteins 0.000 claims 2
- 108050009654 Rapid ALkalinization Factor Proteins 0.000 claims 2
- 241001101468 Sarcocapnos crassifolia Species 0.000 claims 2
- 240000002299 Symphytum officinale Species 0.000 claims 2
- 235000005865 Symphytum officinale Nutrition 0.000 claims 2
- 235000009120 camo Nutrition 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 235000005607 chanvre indien Nutrition 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 235000004426 flaxseed Nutrition 0.000 claims 2
- 235000002532 grape seed extract Nutrition 0.000 claims 2
- 239000011487 hemp Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 238000001542 size-exclusion chromatography Methods 0.000 claims 2
- 235000013976 turmeric Nutrition 0.000 claims 2
- BSUVNQLYZGXYQY-SIDFPDLGSA-N (2S)-5-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-amino-3-(4-sulfooxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(4-sulfooxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]-5-oxopentanoic acid Chemical compound C([C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 BSUVNQLYZGXYQY-SIDFPDLGSA-N 0.000 claims 1
- 101100279849 Arabidopsis thaliana EPF1 gene Proteins 0.000 claims 1
- 241000086254 Arnica montana Species 0.000 claims 1
- 241000209507 Camellia Species 0.000 claims 1
- 208000032544 Cicatrix Diseases 0.000 claims 1
- 108700016270 ENOD40 Proteins 0.000 claims 1
- 101710142210 Early nodulin-40 Proteins 0.000 claims 1
- 241000219482 Lithops Species 0.000 claims 1
- 244000131360 Morinda citrifolia Species 0.000 claims 1
- 235000008898 Morinda citrifolia Nutrition 0.000 claims 1
- 101150044053 PSY1 gene Proteins 0.000 claims 1
- 101710129607 Phytosulfokine-alpha Proteins 0.000 claims 1
- 101800001146 Phytosulfokine-alpha Proteins 0.000 claims 1
- 241000124033 Salix Species 0.000 claims 1
- 206010072170 Skin wound Diseases 0.000 claims 1
- 241000219094 Vitaceae Species 0.000 claims 1
- 235000009754 Vitis X bourquina Nutrition 0.000 claims 1
- 235000012333 Vitis X labruscana Nutrition 0.000 claims 1
- 235000018597 common camellia Nutrition 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 235000021021 grapes Nutrition 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 235000017524 noni Nutrition 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000003716 rejuvenation Effects 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 230000037387 scars Effects 0.000 claims 1
- 108010050014 systemin Proteins 0.000 claims 1
- HOWHQWFXSLOJEF-MGZLOUMQSA-N systemin Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)OC(=O)[C@@H]1CCCN1C(=O)[C@H]1N(C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]2N(CCC2)C(=O)[C@H]2N(CCC2)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)CCC1 HOWHQWFXSLOJEF-MGZLOUMQSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15163515 | 2015-04-14 | ||
| EP15163515.8 | 2015-04-14 | ||
| PCT/EP2016/057885 WO2016166047A1 (en) | 2015-04-14 | 2016-04-11 | Cell-free plant cell culture suspension supernatant with re-youth activity and/or wound healing activity over skin cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018512440A JP2018512440A (ja) | 2018-05-17 |
| JP2018512440A5 true JP2018512440A5 (https=) | 2019-05-23 |
Family
ID=52875593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554388A Pending JP2018512440A (ja) | 2015-04-14 | 2016-04-11 | 皮膚細胞に対する若返り活性および／または創傷治癒活性を有する無細胞植物細胞培養懸濁液上清 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US12285513B2 (https=) |
| EP (1) | EP3283092B1 (https=) |
| JP (1) | JP2018512440A (https=) |
| WO (1) | WO2016166047A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12440530B2 (en) | 2013-03-01 | 2025-10-14 | Envy Medical, Inc. | Skin solution with solubilized bakuchiol |
| US12285513B2 (en) | 2015-04-14 | 2025-04-29 | Vytrus Biotech, S.L. | Cell-free plant cell culture suspension supernatant with re-youth activity and/or wound healing activity over skin cells |
| US11466052B2 (en) | 2016-04-11 | 2022-10-11 | Vytrus Biotech, S.L. | Peptides and pharmaceutical, nutraceutical or veterinary compositions for hair loss prevention and/or treatment |
| TWI698247B (zh) * | 2017-03-13 | 2020-07-11 | 大江生醫股份有限公司 | 茶樹癒傷組織萃取物於護膚之用途 |
| CN107522771A (zh) * | 2017-10-19 | 2017-12-29 | 宁夏大学 | 绒毡层细胞总蛋白提取方法 |
| GB2568032B (en) | 2017-10-25 | 2023-03-15 | Cell Science Holdings Ltd | A method of production of phytocannabinoids for use in medical treatments |
| FR3075641B1 (fr) * | 2017-12-21 | 2020-05-22 | L'oreal | Utilisation cosmetique d’un milieu de culture acellulaire a titre d’agent actif pour le soin des matieres keratiniques |
| EP3790568A1 (en) | 2018-05-08 | 2021-03-17 | Gat Biosciences, S.L. | Imac-enriched microalgal culture supernatant and uses thereof |
| US12569537B2 (en) | 2018-07-24 | 2026-03-10 | Rinati Skin, Llc | System and method for the production, formulation and use of conditioned media, cultured cells and the factors included therein |
| US11473117B2 (en) * | 2018-07-24 | 2022-10-18 | Rinati Skin, Llc | System and method for the production, formulation and use of conditioned media, cultured cells and the factors included therein |
| KR101971837B1 (ko) * | 2018-09-19 | 2019-04-23 | 동국제약 주식회사 | 병풀 부정근 추출물을 유효성분으로 함유하는 피부 미백 및 주름개선용 화장료 조성물 |
| IT201900004107A1 (it) * | 2019-03-21 | 2020-09-21 | Demethra Biotech S R L | Fitocomplesso ed estratto di linea cellulare meristematica selezionata da Daucus carota sativa |
| EP3808335B1 (en) * | 2019-10-15 | 2024-05-22 | Faes Farma, S.A. | Compositions for topical administration |
| JP2023130972A (ja) * | 2022-03-08 | 2023-09-21 | 株式会社 資生堂 | 黄ぐすみ抑制方法、黄ぐすみ抑制剤のスクリーニング方法、及び黄ぐすみ感受性の評価方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5119035B1 (https=) * | 1970-08-17 | 1976-06-14 | ||
| US4139619A (en) | 1976-05-24 | 1979-02-13 | The Upjohn Company | 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth |
| US4596812A (en) | 1976-05-24 | 1986-06-24 | The Upjohn Company | Methods and solutions for treating male pattern alopecia |
| DE19817177A1 (de) * | 1998-04-17 | 1999-10-21 | Lohmann Rudolf Lomapharm | Pflanzliche Polysaccharide mit immunstimulierender Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| DE19957710A1 (de) | 1999-11-30 | 2001-05-31 | Asat Ag Applied Science & Tech | Verwendung von Melatonin zur Behandlung der androgenetischen Alopezie |
| JP2002253241A (ja) | 2001-02-27 | 2002-09-10 | Univ Nagoya | シロイヌナズナのファイトスルフォカイン前駆体ポリペプチド、当該ポリペプチドをコードする遺伝子 |
| FR2837385B1 (fr) | 2002-03-20 | 2004-05-28 | Rachid Ennamany | Procede d'obtention de phytoalexines |
| FR2854328B1 (fr) | 2003-04-29 | 2006-08-04 | Rocher Yves Biolog Vegetale | Composition cosmetique ou dermatologique ou pharmaceutique contenant un facteur de croissance du type vegetal de nature peptidique |
| EP1498475A1 (en) | 2003-07-18 | 2005-01-19 | Meristem Therapeutics S.A. | Continuous plant cell bioreactor and method for continuous plant cell culture |
| ITFI20050031A1 (it) | 2005-02-21 | 2006-08-22 | Stefan Coccoloni | Una composizione farmaceutica atta a prevenire l'invecchiamento e l'insorgere di malattie vascolari,neoplastiche,cutanee e dell'apparato pilifero |
| KR20090010178A (ko) | 2006-03-31 | 2009-01-29 | 파나세아 바이오테크 리미티드 | 모발장애에 대한 새로운 조성물 및 이의 조제방법 |
| CH715456B1 (de) | 2007-04-27 | 2020-04-30 | Mibelle Ag | Kosmetisches Produkt zur topischen Anwendung für den Schutz und die Erneuerung von Hautstammzellen, welches sich von dedifferenzierten Pflanzenzellen ableitet. |
| CN102459573A (zh) | 2009-05-28 | 2012-05-16 | 云火公司 | 茄科的形成层来源的植物干细胞及其分离培养方法 |
| CN103237893B (zh) | 2010-08-06 | 2015-11-25 | 加诺普兰特-维勒公司 | 抗病原体的植物及其生产方法 |
| ES2638888T3 (es) | 2011-03-27 | 2017-10-24 | Arch Chemicals, Inc. | Modulación de la metilación epigenética del AND para provocar que las células adopten patrones de metilación del ADN asociados con células jóvenes |
| EP2687592A1 (de) | 2012-07-20 | 2014-01-22 | greenovation Biotech GmbH | Filtration von Zellkulturüberständen |
| ES2613981T3 (es) * | 2012-09-14 | 2017-05-29 | Casen Recordati, S.L. | Cultivos de células vegetales del género Centella, procedimiento de producción y usos de los mismos |
| WO2014120793A1 (en) | 2013-01-30 | 2014-08-07 | The Beauty Cartel, Llc. | Hair loss treatment compositions and methods of making and using same |
| CN103976908B (zh) | 2014-05-29 | 2016-04-27 | 暨南大学 | 一种富含植物多肽的植物提取物组合物及其在化妆品中的应用 |
| US12285513B2 (en) | 2015-04-14 | 2025-04-29 | Vytrus Biotech, S.L. | Cell-free plant cell culture suspension supernatant with re-youth activity and/or wound healing activity over skin cells |
-
2016
- 2016-04-11 US US15/566,601 patent/US12285513B2/en active Active
- 2016-04-11 EP EP16718276.5A patent/EP3283092B1/en active Active
- 2016-04-11 JP JP2017554388A patent/JP2018512440A/ja active Pending
- 2016-04-11 WO PCT/EP2016/057885 patent/WO2016166047A1/en not_active Ceased
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