JP2018512428A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018512428A5 JP2018512428A5 JP2017552911A JP2017552911A JP2018512428A5 JP 2018512428 A5 JP2018512428 A5 JP 2018512428A5 JP 2017552911 A JP2017552911 A JP 2017552911A JP 2017552911 A JP2017552911 A JP 2017552911A JP 2018512428 A5 JP2018512428 A5 JP 2018512428A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- item
- composition
- compound
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims description 110
- 239000000203 mixture Substances 0.000 claims description 81
- 150000003839 salts Chemical class 0.000 claims description 55
- 241000700721 Hepatitis B virus Species 0.000 claims description 47
- 229960000980 entecavir Drugs 0.000 claims description 40
- YXPVEXCTPGULBZ-WQYNNSOESA-N entecavir hydrate Chemical group O.C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)C1=C YXPVEXCTPGULBZ-WQYNNSOESA-N 0.000 claims description 40
- 239000003795 chemical substances by application Substances 0.000 claims description 36
- 229940002612 prodrug Drugs 0.000 claims description 28
- 239000000651 prodrug Substances 0.000 claims description 28
- 239000003443 antiviral agent Substances 0.000 claims description 19
- 239000008297 liquid dosage form Substances 0.000 claims description 12
- 239000007909 solid dosage form Substances 0.000 claims description 12
- 239000002246 antineoplastic agent Substances 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 208000002672 hepatitis B Diseases 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 229940000425 combination drug Drugs 0.000 claims description 2
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 208000029570 hepatitis D virus infection Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 188
- 102000014150 Interferons Human genes 0.000 description 36
- 108010050904 Interferons Proteins 0.000 description 36
- 229940079322 interferon Drugs 0.000 description 36
- 239000003814 drug Substances 0.000 description 24
- 229940079593 drug Drugs 0.000 description 22
- 230000035772 mutation Effects 0.000 description 14
- 125000003275 alpha amino acid group Chemical group 0.000 description 13
- 150000001413 amino acids Chemical class 0.000 description 12
- 229960004556 tenofovir Drugs 0.000 description 12
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 description 12
- -1 terbivudine Chemical compound 0.000 description 11
- 238000012317 liver biopsy Methods 0.000 description 10
- 229940127073 nucleoside analogue Drugs 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 108010047761 Interferon-alpha Proteins 0.000 description 8
- 102000006992 Interferon-alpha Human genes 0.000 description 8
- 108010078233 Thymalfasin Proteins 0.000 description 8
- YQNQNVDNTFHQSW-UHFFFAOYSA-N acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester Chemical compound CC(=O)OC1=CC=CC=C1C(=O)NC1=NC=C([N+]([O-])=O)S1 YQNQNVDNTFHQSW-UHFFFAOYSA-N 0.000 description 8
- 238000007792 addition Methods 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 230000037430 deletion Effects 0.000 description 8
- 238000012217 deletion Methods 0.000 description 8
- 238000006467 substitution reaction Methods 0.000 description 8
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 description 8
- 229960004231 thymalfasin Drugs 0.000 description 8
- 239000003623 enhancer Substances 0.000 description 7
- 230000003612 virological effect Effects 0.000 description 7
- 108091036055 CccDNA Proteins 0.000 description 6
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 6
- 101710142246 External core antigen Proteins 0.000 description 6
- 239000003112 inhibitor Substances 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- LDEKQSIMHVQZJK-CAQYMETFSA-N tenofovir alafenamide Chemical compound O([P@@](=O)(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)N[C@@H](C)C(=O)OC(C)C)C1=CC=CC=C1 LDEKQSIMHVQZJK-CAQYMETFSA-N 0.000 description 6
- 229960004946 tenofovir alafenamide Drugs 0.000 description 6
- 101710132601 Capsid protein Proteins 0.000 description 5
- 208000037262 Hepatitis delta Diseases 0.000 description 5
- 241000724709 Hepatitis delta virus Species 0.000 description 5
- 108020000999 Viral RNA Proteins 0.000 description 5
- 239000008298 dragée Substances 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 239000002777 nucleoside Substances 0.000 description 5
- 150000003833 nucleoside derivatives Chemical class 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 239000006188 syrup Substances 0.000 description 5
- 235000020357 syrup Nutrition 0.000 description 5
- KKMFSVNFPUPGCA-UHFFFAOYSA-N 4-fluoro-3-(4-hydroxypiperidin-1-yl)sulfonyl-n-(3,4,5-trifluorophenyl)benzamide Chemical compound C1CC(O)CCN1S(=O)(=O)C1=CC(C(=O)NC=2C=C(F)C(F)=C(F)C=2)=CC=C1F KKMFSVNFPUPGCA-UHFFFAOYSA-N 0.000 description 4
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 description 4
- 101001057508 Homo sapiens Ubiquitin-like protein ISG15 Proteins 0.000 description 4
- 102100040018 Interferon alpha-2 Human genes 0.000 description 4
- 108010079944 Interferon-alpha2b Proteins 0.000 description 4
- 102000003996 Interferon-beta Human genes 0.000 description 4
- 108090000467 Interferon-beta Proteins 0.000 description 4
- 102000000704 Interleukin-7 Human genes 0.000 description 4
- 108010002586 Interleukin-7 Proteins 0.000 description 4
- 101710085061 Orsellinic acid synthase Proteins 0.000 description 4
- 101710110277 Orsellinic acid synthase armB Proteins 0.000 description 4
- 101710181008 P protein Proteins 0.000 description 4
- 101710177166 Phosphoprotein Proteins 0.000 description 4
- 102400000800 Thymosin alpha-1 Human genes 0.000 description 4
- 102100027266 Ubiquitin-like protein ISG15 Human genes 0.000 description 4
- KDNSSKPZBDNJDF-UHFFFAOYSA-N [1-[(2-aminopurin-9-yl)methyl]cyclopropyl]oxymethylphosphonic acid Chemical compound C12=NC(N)=NC=C2N=CN1CC1(OCP(O)(O)=O)CC1 KDNSSKPZBDNJDF-UHFFFAOYSA-N 0.000 description 4
- WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 description 4
- 229960003205 adefovir dipivoxil Drugs 0.000 description 4
- 229940054685 alinia Drugs 0.000 description 4
- 230000000840 anti-viral effect Effects 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 229950002782 besifovir Drugs 0.000 description 4
- 239000000090 biomarker Substances 0.000 description 4
- 229960005338 clevudine Drugs 0.000 description 4
- GBBJCSTXCAQSSJ-XQXXSGGOSA-N clevudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1[C@H](F)[C@@H](O)[C@H](CO)O1 GBBJCSTXCAQSSJ-XQXXSGGOSA-N 0.000 description 4
- 229960001388 interferon-beta Drugs 0.000 description 4
- 229940100994 interleukin-7 Drugs 0.000 description 4
- 229960001627 lamivudine Drugs 0.000 description 4
- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 description 4
- FVNJBPMQWSIGJK-HNNXBMFYSA-N methyl (4r)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate Chemical compound C1([C@@H]2N=C(NC(C)=C2C(=O)OC)C=2C(=CC(F)=CN=2)F)=CC=C(F)C=C1Cl FVNJBPMQWSIGJK-HNNXBMFYSA-N 0.000 description 4
- 229960002480 nitazoxanide Drugs 0.000 description 4
- 230000004936 stimulating effect Effects 0.000 description 4
- 229960005486 vaccine Drugs 0.000 description 4
- 230000003442 weekly effect Effects 0.000 description 4
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 3
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 3
- 108020005544 Antisense RNA Proteins 0.000 description 3
- 108010006654 Bleomycin Proteins 0.000 description 3
- 208000003322 Coinfection Diseases 0.000 description 3
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 description 3
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 3
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 3
- 108700011259 MicroRNAs Proteins 0.000 description 3
- 102100034574 P protein Human genes 0.000 description 3
- 108091030071 RNAI Proteins 0.000 description 3
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 3
- 229960001561 bleomycin Drugs 0.000 description 3
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 3
- 229940124765 capsid inhibitor Drugs 0.000 description 3
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 3
- 229960004316 cisplatin Drugs 0.000 description 3
- 239000003184 complementary RNA Substances 0.000 description 3
- 229960003901 dacarbazine Drugs 0.000 description 3
- 229960004679 doxorubicin Drugs 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 229960001904 epirubicin Drugs 0.000 description 3
- 229960005420 etoposide Drugs 0.000 description 3
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 3
- 229960002949 fluorouracil Drugs 0.000 description 3
- 230000009368 gene silencing by RNA Effects 0.000 description 3
- 229960000485 methotrexate Drugs 0.000 description 3
- 239000002679 microRNA Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- IVDHYUQIDRJSTI-UHFFFAOYSA-N sorafenib tosylate Chemical compound [H+].CC1=CC=C(S([O-])(=O)=O)C=C1.C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 IVDHYUQIDRJSTI-UHFFFAOYSA-N 0.000 description 3
- 229960000487 sorafenib tosylate Drugs 0.000 description 3
- 229960003048 vinblastine Drugs 0.000 description 3
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 3
- 229960004528 vincristine Drugs 0.000 description 3
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 3
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 3
- 206010016654 Fibrosis Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 108020005202 Viral DNA Proteins 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000004761 fibrosis Effects 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 239000006186 oral dosage form Substances 0.000 description 2
- 230000007863 steatosis Effects 0.000 description 2
- 231100000240 steatosis hepatitis Toxicity 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 description 1
- 241000285387 HBV genotype A Species 0.000 description 1
- 241000285452 HBV genotype B Species 0.000 description 1
- 241000285424 HBV genotype C Species 0.000 description 1
- 241000285366 HBV genotype D Species 0.000 description 1
- 241000285370 HBV genotype E Species 0.000 description 1
- 241000285563 HBV genotype F Species 0.000 description 1
- 241000285576 HBV genotype G Species 0.000 description 1
- 241000285579 HBV genotype H Species 0.000 description 1
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 description 1
- 101710085938 Matrix protein Proteins 0.000 description 1
- 101710127721 Membrane protein Proteins 0.000 description 1
- 101710086987 X protein Proteins 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562144300P | 2015-04-07 | 2015-04-07 | |
| US62/144,300 | 2015-04-07 | ||
| US201562220406P | 2015-09-18 | 2015-09-18 | |
| US62/220,406 | 2015-09-18 | ||
| US201662279382P | 2016-01-15 | 2016-01-15 | |
| US62/279,382 | 2016-01-15 | ||
| PCT/US2016/026498 WO2016164619A2 (en) | 2015-04-07 | 2016-04-07 | Compositions and methods for the treatment of hbv infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018512428A JP2018512428A (ja) | 2018-05-17 |
| JP2018512428A5 true JP2018512428A5 (enExample) | 2019-05-16 |
Family
ID=57072854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017552911A Withdrawn JP2018512428A (ja) | 2015-04-07 | 2016-04-07 | Ｈｂｖ感染の処置のための組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20180110796A1 (enExample) |
| EP (1) | EP3280422A4 (enExample) |
| JP (1) | JP2018512428A (enExample) |
| KR (1) | KR20170132327A (enExample) |
| CN (1) | CN107635566A (enExample) |
| AU (1) | AU2016244828A1 (enExample) |
| CA (1) | CA2982125A1 (enExample) |
| HK (1) | HK1250480A1 (enExample) |
| TW (1) | TW201709912A (enExample) |
| WO (1) | WO2016164619A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190290673A1 (en) * | 2016-10-24 | 2019-09-26 | Spring Bank Pharmaceuticals, Inc. | Compositions and methods for the treatment of hbv infection |
| KR101899773B1 (ko) * | 2017-03-07 | 2018-09-18 | 일동제약(주) | 베시포비르 디피복실 또는 이의 약제학적 허용되는 염 함유 과립, 상기 과립을 포함하는 약제학적 조성물 및 이의 제조 방법 |
| WO2020040327A1 (ko) * | 2018-08-23 | 2020-02-27 | 광주과학기술원 | 시클로피록스의 hbv 코어조립 저해 용도 |
| US11166976B2 (en) | 2018-11-08 | 2021-11-09 | Aligos Therapeutics, Inc. | S-antigen transport inhibiting oligonucleotide polymers and methods |
| WO2021016543A1 (en) * | 2019-07-25 | 2021-01-28 | Romark Laboratories L.C. | Antiviral combinations of thiazolide compounds |
| CA3155068A1 (en) * | 2019-09-29 | 2021-04-01 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Drug combination containing tlr7 agonist |
| EP4037706A4 (en) * | 2019-10-02 | 2023-09-13 | University of Washington | Compositions and methods for treatment of hepatitis b virus infection |
| TW202200136A (zh) | 2020-04-10 | 2022-01-01 | 日商小野藥品工業股份有限公司 | 癌治療方法 |
| KR102292147B1 (ko) * | 2020-11-18 | 2021-08-23 | 주식회사 차백신연구소 | 경구용 항바이러스제 및 리포펩타이드와 폴리(i:c) 아쥬반트를 포함한 치료백신을 유효성분으로 포함하는 만성 b형 간염의 예방 또는 치료용 약제학적 조성물, 약제학적 병용제제, 병용제 키트 |
| WO2022115765A1 (en) * | 2020-11-30 | 2022-06-02 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis e virus infection with interferon lambda |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2913889A (en) * | 1987-11-16 | 1989-06-14 | Fox Chase Cancer Center | Determination of anti-pol as an early marker of viral hepatitis infection |
| US6432966B2 (en) * | 1999-10-29 | 2002-08-13 | Smithkline Beecham Corporation | Antiviral combinations |
| CN1268345C (zh) * | 2000-03-29 | 2006-08-09 | 乔治敦大学 | 治疗丁型肝炎病毒感染的核苷化合物 |
| US7202354B2 (en) * | 2001-03-30 | 2007-04-10 | Abbott Laboratories | Hepatitis B virus surface antigen mutant and methods of detection thereof |
| CA2529997A1 (en) * | 2003-06-20 | 2004-12-29 | Dade Behring Marburg Gmbh | Novel surface protein (hbsag) variant of hepatitis b virus |
| CN101278938A (zh) * | 2008-03-20 | 2008-10-08 | 黑龙江加州国际投资咨询有限公司 | 泰诺福韦酯和恩替卡韦的复方制剂及其抗乙肝病毒的应用 |
| EP2271351A4 (en) * | 2008-04-03 | 2016-08-31 | Spring Bank Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS |
| CN103298475A (zh) * | 2010-08-30 | 2013-09-11 | 斯普林银行医药公司 | 作为治疗剂的寡核苷酸类似物的设计 |
-
2016
- 2016-04-07 WO PCT/US2016/026498 patent/WO2016164619A2/en not_active Ceased
- 2016-04-07 TW TW105111010A patent/TW201709912A/zh unknown
- 2016-04-07 JP JP2017552911A patent/JP2018512428A/ja not_active Withdrawn
- 2016-04-07 EP EP16777303.5A patent/EP3280422A4/en not_active Withdrawn
- 2016-04-07 HK HK18109890.2A patent/HK1250480A1/zh unknown
- 2016-04-07 CA CA2982125A patent/CA2982125A1/en not_active Abandoned
- 2016-04-07 KR KR1020177031848A patent/KR20170132327A/ko not_active Withdrawn
- 2016-04-07 US US15/565,046 patent/US20180110796A1/en not_active Abandoned
- 2016-04-07 CN CN201680033034.8A patent/CN107635566A/zh active Pending
- 2016-04-07 AU AU2016244828A patent/AU2016244828A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018512428A5 (enExample) | ||
| Liang et al. | Present and future therapies of hepatitis B: from discovery to cure | |
| US20250215031A1 (en) | Crystalline forms of tenofovir alafenamide | |
| US20170313707A1 (en) | Solid forms of a toll-like receptor modulator | |
| WO2018087345A1 (en) | COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON | |
| CA3072733C (en) | Bisdiazabicyclo compound for treatment and/or prevention of hepatitis virus-related diseases or disorders | |
| KR20180058828A (ko) | Hbv 캡시드 조립 억제제와 인터페론의 조합 치료 | |
| JP2018531272A6 (ja) | Ｈｂｖキャプシドアセンブリ阻害剤とインターフェロンの併用療法 | |
| EP4098273A1 (en) | Combination therapy of hbv and hdv infection | |
| US20180110796A1 (en) | Compositions and methods for the treatment of hbv infection | |
| US20230044958A1 (en) | Method of treating virus infection using a tlr7 agonist | |
| CN112245570A (zh) | 一种基于干扰素的疾病治疗方法 | |
| US20190290673A1 (en) | Compositions and methods for the treatment of hbv infection | |
| Aguilar-Rubido et al. | Chronic Hepatitis B therapies: challenges and opportunities | |
| KR20120125253A (ko) | Ｂ형 간염 바이러스 감염 치료용 조성물 및 치료방법 | |
| Korkmaz et al. | Comparison of adefovir dipivoxil and pegylated interferon alpha-2a treatment in chronic hepatitis B patients | |
| Chen et al. | Patents and development of HBV and HCV clinical treatment: From 2001 to April 2005 | |
| Aguilar-Rubido et al. | Terapias contra la hepatitis B crónica: desafíos y oportunidades | |
| WO2008104133A1 (es) | Terapia combinada para el tratamiento de la hepatitis b crónica | |
| Yim et al. | A perspective on future clinical practice: ongoing clinical trials | |
| Lieveld et al. | New Viral and Immunological Targets for Hepatitis B Treatment and Cure: A Review | |
| JP2015512900A (ja) | 特別な患者の遺伝子亜型分集団のｈｃｖ感染症を治療するための併用療法 |