JP2018512395A5 - - Google Patents

Info

Publication number

JP2018512395A5

JP2018512395A5 JP2017546904A JP2017546904A JP2018512395A5 JP 2018512395 A5 JP2018512395 A5 JP 2018512395A5 JP 2017546904 A JP2017546904 A JP 2017546904A JP 2017546904 A JP2017546904 A JP 2017546904A JP 2018512395 A5 JP2018512395 A5 JP 2018512395A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

liquid pharmaceutical

composition according

taxane

cyclodextrin

Prior art date

2016-03-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000007788 liquid Substances 0.000 claims 30
• 239000008194 pharmaceutical composition Substances 0.000 claims 30
• WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 10
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 9
• 229940123237 Taxane Drugs 0.000 claims 9
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 9
• 239000002202 Polyethylene glycol Substances 0.000 claims 7
• 229920001223 polyethylene glycol Polymers 0.000 claims 7
• WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 6
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 6
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 6
• 229940069328 povidone Drugs 0.000 claims 6
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
• 229920000858 Cyclodextrin Polymers 0.000 claims 4
• 239000001116 FEMA 4028 Substances 0.000 claims 4
• 235000011175 beta-cyclodextrine Nutrition 0.000 claims 4
• 229960004853 betadex Drugs 0.000 claims 4
• 239000006185 dispersion Substances 0.000 claims 4
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 150000007524 organic acids Chemical class 0.000 claims 3
• 238000007911 parenteral administration Methods 0.000 claims 3
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
• 239000003963 antioxidant agent Substances 0.000 claims 2
• 230000003078 antioxidant effect Effects 0.000 claims 2
• 239000002738 chelating agent Substances 0.000 claims 2
• 239000012456 homogeneous solution Substances 0.000 claims 2
• BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 2
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 229920000604 Polyethylene Glycol 200 Polymers 0.000 claims 1
• 229920002556 Polyethylene Glycol 300 Polymers 0.000 claims 1
• 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 1
• 229920002582 Polyethylene Glycol 600 Polymers 0.000 claims 1
• DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 1
• 229960003668 docetaxel Drugs 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 235000005985 organic acids Nutrition 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims 1
• WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
• HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims 1
• 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 1
• 229940001584 sodium metabisulfite Drugs 0.000 claims 1
• 235000010262 sodium metabisulphite Nutrition 0.000 claims 1
• 230000001954 sterilising effect Effects 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1