JP2018512161A5 - - Google Patents
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- JP2018512161A5 JP2018512161A5 JP2017554035A JP2017554035A JP2018512161A5 JP 2018512161 A5 JP2018512161 A5 JP 2018512161A5 JP 2017554035 A JP2017554035 A JP 2017554035A JP 2017554035 A JP2017554035 A JP 2017554035A JP 2018512161 A5 JP2018512161 A5 JP 2018512161A5
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- JP
- Japan
- Prior art keywords
- cells
- cell
- modified
- receptor
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021203173A JP2022046549A (ja) | 2015-04-15 | 2021-12-15 | 修正ガンマデルタｔ細胞およびその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1506423.1 | 2015-04-15 | ||
| GBGB1506423.1A GB201506423D0 (en) | 2015-04-15 | 2015-04-15 | Gamma delta T cells and uses thereof |
| GBPCT/GB2015/051985 | 2015-07-08 | ||
| PCT/GB2015/051985 WO2016005752A1 (en) | 2014-07-09 | 2015-07-08 | Gamma delta t cells and uses thereof |
| PCT/GB2016/051050 WO2016166544A1 (en) | 2015-04-15 | 2016-04-14 | Modified gamma delta cells and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021203173A Division JP2022046549A (ja) | 2015-04-15 | 2021-12-15 | 修正ガンマデルタｔ細胞およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512161A JP2018512161A (ja) | 2018-05-17 |
| JP2018512161A5 true JP2018512161A5 (enExample) | 2019-05-23 |
| JP6995624B2 JP6995624B2 (ja) | 2022-02-21 |
Family
ID=53333850
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554035A Active JP6995624B2 (ja) | 2015-04-15 | 2016-04-14 | 修正ガンマデルタｔ細胞およびその使用 |
| JP2021203173A Ceased JP2022046549A (ja) | 2015-04-15 | 2021-12-15 | 修正ガンマデルタｔ細胞およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021203173A Ceased JP2022046549A (ja) | 2015-04-15 | 2021-12-15 | 修正ガンマデルタｔ細胞およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10881688B2 (enExample) |
| EP (1) | EP3283620B1 (enExample) |
| JP (2) | JP6995624B2 (enExample) |
| KR (1) | KR20180012754A (enExample) |
| CN (2) | CN114717194A (enExample) |
| AU (2) | AU2016250211B2 (enExample) |
| BR (1) | BR112017022249A2 (enExample) |
| CA (1) | CA2982523A1 (enExample) |
| EA (1) | EA201792041A1 (enExample) |
| ES (1) | ES2993441T3 (enExample) |
| GB (1) | GB201506423D0 (enExample) |
| IL (1) | IL255011B (enExample) |
| SG (1) | SG11201708401WA (enExample) |
| WO (1) | WO2016166544A1 (enExample) |
| ZA (1) | ZA201706922B (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201506423D0 (en) | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| GB201507368D0 (en) | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| EP4295914A3 (en) | 2015-09-03 | 2024-04-10 | The UAB Research Foundation | Genetically-engineered drug resistant t cells and methods of using the same |
| WO2018055191A1 (en) * | 2016-09-26 | 2018-03-29 | Tessa Therapeutics Pte. Ltd. | T cell expansion method |
| WO2018107134A1 (en) | 2016-12-09 | 2018-06-14 | The Uab Research Foundation | Chimeric chlorotoxin receptors |
| GB201701332D0 (en) * | 2017-01-26 | 2017-03-15 | Tc Biopharm Ltd | Immune cells with modified metabolism and their use thereof |
| WO2018147805A1 (en) * | 2017-02-08 | 2018-08-16 | Agency For Science, Technology And Research | Gamma delta t cells and a method of augmenting the tumoricidal activity of the same |
| GB201707048D0 (en) | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
| CA3063807A1 (en) * | 2017-05-18 | 2018-11-22 | Umc Utrecht Holding B.V. | Compositions and methods for cell targeting therapies |
| MX2020000900A (es) * | 2017-07-29 | 2021-01-08 | Juno Therapeutics Inc | Reactivos para expandir celulas que expresan receptores recombinantes. |
| GB201715918D0 (en) | 2017-09-29 | 2017-11-15 | Tc Biopharm Ltd | Modified CAR-T |
| TWI687227B (zh) * | 2017-10-03 | 2020-03-11 | 生倍科技股份有限公司 | 用於t細胞免疫療法之組合及其用途 |
| CN109777778B (zh) * | 2017-11-14 | 2023-07-18 | 中国科学院广州生物医药与健康研究院 | 一种基因改造的γδT细胞 |
| DE102017127984B4 (de) | 2017-11-27 | 2019-12-05 | Immatics US, Inc. | Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen |
| CN108085341A (zh) * | 2017-12-28 | 2018-05-29 | 河南省华隆生物技术有限公司 | 一种msgv重组载体及其制备方法和应用 |
| GB201804701D0 (en) * | 2018-03-23 | 2018-05-09 | Gammadelta Therapeutics Ltd | Lymphocytes expressing heterologous targeting constructs |
| CN108588023B (zh) * | 2018-05-09 | 2020-02-14 | 河北森朗生物科技有限公司 | 一种生产嵌合抗原受体修饰的γδT细胞的方法 |
| CN110577932A (zh) * | 2018-06-07 | 2019-12-17 | 亘喜生物科技（上海）有限公司 | 一种脐带血来源的嵌合抗原受体t细胞 |
| CN109234236A (zh) * | 2018-09-29 | 2019-01-18 | 吉林大学第医院 | 一种嵌合抗原受体γδT细胞的制备方法 |
| EA202190926A1 (ru) * | 2018-10-01 | 2021-06-25 | Эдисет Био, Инк. | Композиции и способы в отношении сконструированных и несконструированных t-клеток для лечения гематологических опухолей |
| KR20210087458A (ko) | 2018-10-01 | 2021-07-12 | 아디셋 바이오, 인크. | 고형 종양 치료를 위한 조작된 및 비-조작된 γδ-T 세포에 관한 조성물 및 방법 |
| MY208861A (en) * | 2018-11-05 | 2025-06-04 | Xyphos Biosciences Inc | Non-natural nkg2d receptors that do not directly signal the cells to which they are attached |
| CN109517793B (zh) * | 2018-11-30 | 2022-05-10 | 广州长峰生物技术有限公司 | 一种NK细胞和γδT细胞共培养的建立方法 |
| EP4219688A1 (en) * | 2018-12-19 | 2023-08-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Mucosal-associated invariant t (mait) cells expressing chimeric antigen receptors |
| CN109762843A (zh) * | 2018-12-29 | 2019-05-17 | 武汉波睿达生物科技有限公司 | 一种利用脐血来源的cd3阳性t细胞制备通用car-t细胞的方法 |
| CN109609465A (zh) * | 2018-12-29 | 2019-04-12 | 武汉波睿达生物科技有限公司 | 一种利用脐血来源的γδT细胞制备CAR-T细胞的方法及该CAR-T细胞和应用 |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | ANTI-CD19 CHEMERIC ANTIGEN RECEPTORS AND THEIR USE IN IMMUNOTHERAPY |
| AU2020261886A1 (en) * | 2019-04-22 | 2021-11-18 | Nanjing Legend Biotech Co., Ltd. | Engineered cells and uses thereof |
| US12480958B2 (en) | 2019-08-13 | 2025-11-25 | Immatics Biotechnologies Gmbh | Method for the characterization of peptide:MHC binding polypeptides |
| BR112022002837A2 (pt) * | 2019-08-16 | 2022-05-10 | Gammadelta Therapeutics Ltd | Anticorpo anti-vd1 ou fragmento do mesmo, anticorpo multiespecífico isolado ou fragmento do mesmo, anticorpo humano e anticorpo multiespecífico isolado humano ou fragmento do mesmo |
| US20220290101A1 (en) * | 2019-08-16 | 2022-09-15 | GammaDelta Therapeutics Limited | Ex vivo gamma delta t cell populations |
| CN110964698B (zh) * | 2019-12-25 | 2022-05-10 | 杭州中赢生物医疗科技有限公司 | 一种人工抗原递呈细胞及其制备方法和应用 |
| EP4090432A4 (en) * | 2020-01-15 | 2024-04-17 | The Regents Of The University Of California | Compositions and methods for altering gamma delta t cell activity |
| MX2022010461A (es) * | 2020-02-24 | 2022-12-13 | Immatics Us Inc | Metodos para expandir linfocitos t para el tratamiento de cancer y neoplasias malignas asociadas. |
| WO2021176373A1 (en) * | 2020-03-03 | 2021-09-10 | Janssen Biotech, Inc. | ꝩδ T CELLS AND USES THEREOF |
| JP2023527502A (ja) * | 2020-03-20 | 2023-06-29 | ガンマデルタ セラピューティクス リミティッド | 骨髄性悪性病変の治療のためのｖデルタ１＋ｔ細胞 |
| BR112022023371A2 (pt) | 2020-05-22 | 2022-12-20 | Chongqing Prec Biotech Co Ltd | Proteína de fusão para reversão do microambiente tumoral, vetor de expressão, célula imune, receptor de antígeno quimérico resistente à imunossupressão tumoral, sequência de ácido nucleico, método para preparar uma célula imune, composição farmacêutica, e, uso da composição farmacêutica |
| EP4189074A4 (en) * | 2020-06-22 | 2025-01-15 | Nanjing Legend Biotech Co., Ltd. | GENETICALLY MODIFIED GAMMA DELTA T CELLS FOR IMMUNOTHERAPY |
| IL299886A (en) | 2020-07-17 | 2023-03-01 | Instil Bio Uk Ltd | Receptors that provide targeted costimulation for host cell therapy |
| ES2943063T3 (es) * | 2020-08-14 | 2023-06-08 | Gammadelta Therapeutics Ltd | Anticuerpos multiespecíficos anti-TCR delta variable 1 |
| CN114591907A (zh) * | 2020-12-03 | 2022-06-07 | 复旦大学 | 一种γδT细胞的制备和扩增方法以及应用 |
| CN112481284B (zh) * | 2020-12-07 | 2023-07-25 | 深圳瑞吉生物科技有限公司 | 一种编码CAR基因的mRNA、组合mRNA、构建方法、CAR-T细胞和应用 |
| CN114685684A (zh) * | 2020-12-31 | 2022-07-01 | 博生吉医药科技(苏州)有限公司 | MUC1-Tn嵌合抗原受体修饰的Vγ9Vδ2T细胞及其应用 |
| EP4294527A1 (en) * | 2021-02-17 | 2023-12-27 | GammaDelta Therapeutics Limited | Anti-tcr delta variable 1 antibodies |
| IL305266A (en) | 2021-02-17 | 2023-10-01 | Gammadelta Therapeutics Ltd | Multispecific antibodies against variable TCR delta 1 |
| JP2024516118A (ja) * | 2021-04-06 | 2024-04-12 | ユニセット バイオテック カンパニー リミテッド ライアビリティ カンパニー | γδ Ｔ細胞のウイルス形質導入の安定性を改善する方法及びその応用 |
| CN113156142B (zh) * | 2021-04-16 | 2024-09-27 | 苏州才博医学科技有限公司 | 一种针对异体cart细胞特异性抗体的检测方法 |
| EP4322972A4 (en) * | 2021-04-16 | 2025-03-12 | Acepodia Biotechnologies Ltd. | Novel compositions enriched in gamma delta t cells, methods of preparation, and uses thereof |
| CA3218215A1 (en) * | 2021-05-19 | 2022-11-24 | Biliang HU | Bi-specific chimeric antigen receptors and genetically engineered immune cells expressing such |
| EP4355340A4 (en) | 2021-06-16 | 2025-05-21 | Instil Bio, Inc. | RECEPTORS FOR TARGETED COSTIMULATION FOR ADOPTIVE CELL THERAPY |
| WO2023288278A1 (en) | 2021-07-16 | 2023-01-19 | Instil Bio (Uk) Limited | Chimeric molecules providing targeted costimulation for adoptive cell therapy |
| CN113667640B (zh) * | 2021-08-27 | 2022-09-02 | 广州百暨基因科技有限公司 | CAR-γδT细胞的制备方法 |
| WO2023069322A1 (en) * | 2021-10-20 | 2023-04-27 | University Of Pittsburgh – Of The Commonwealth System Of Higher Education | Methods and materials for expanding tumor infiltrating gamma-delta t cells |
| JP2025506506A (ja) | 2022-02-16 | 2025-03-11 | プリオセラ エスエーエス | Ｓ１ｐ受容体モジュレーターと組み合わせたｃａｒ細胞を用いた処置方法 |
| CN114645022B (zh) * | 2022-05-13 | 2022-09-02 | 首都医科大学宣武医院 | 靶向CD5的CAR-γ δ T细胞及其制备方法与应用 |
| WO2023235511A1 (en) * | 2022-06-01 | 2023-12-07 | Sens Research Foundation | Targeted elimination of senescent cells by gamma-delta t cells |
| CN116813794B (zh) * | 2023-02-27 | 2024-07-12 | 武汉波睿达生物科技有限公司 | 共表达spi1的嵌合抗原受体及其应用 |
| EP4458412A1 (en) | 2023-05-05 | 2024-11-06 | University College Cardiff Consultants, Ltd. | Novel phosphoantigen prodrug compound and use thereof |
| CN120554516B (zh) * | 2025-07-30 | 2025-10-24 | 杭州华大生命科学研究院 | 抗cd45抗体及其应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2360046A1 (en) | 1999-01-28 | 2000-08-03 | Lawrence S. Lamb, Jr. | In vitro activated gamma delta lymphocytes |
| AU4816201A (en) | 2000-04-03 | 2001-10-15 | Hemosol Inc | Production of tcr gamma delta t cells |
| ES2302106T3 (es) | 2000-09-11 | 2008-07-01 | Novartis Vaccines And Diagnostics, Inc. | Procedimiento de preparacion de derivados de bencimidazol-2-il quinolina. |
| WO2006006720A1 (ja) | 2004-07-13 | 2006-01-19 | Medinet., Co.Ltd | γδＴ細胞の培養方法、γδＴ細胞及び治療・予防剤 |
| DK1778836T3 (da) | 2004-08-19 | 2010-11-22 | Univ Cardiff | Fremstilling af antigenpræsenterende humane gammadelta-T-celler og anvendelse ved immunterapi |
| KR101419711B1 (ko) | 2005-09-08 | 2014-07-17 | 가부시키가이샤 메디넷 | 항원제시세포의 활성화 처리방법 |
| WO2008152822A1 (ja) | 2007-06-15 | 2008-12-18 | Medinet Co., Ltd. | 医薬 |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| JP6850528B2 (ja) | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| WO2014124143A1 (en) | 2013-02-06 | 2014-08-14 | Anthrogenesis Corporation | Modified t lymphocytes having improved specificity |
| KR102238226B1 (ko) | 2013-05-14 | 2021-04-09 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 가공된 키메라 항원 수용체 (ｃａｒ) ｔ-세포의 인간 적용 |
| EP3925618A1 (en) | 2013-07-29 | 2021-12-22 | 2seventy bio, Inc. | Multipartite signaling proteins and uses thereof |
| CA2926859A1 (en) | 2013-10-25 | 2015-04-30 | Board Of Regents, The University Of Texas System | Polyclonal gamma delta t cells for immunotherapy |
| WO2015066262A1 (en) | 2013-11-04 | 2015-05-07 | Trustees Of Dartmouth College | Methods for preventing toxicity of adoptive cell therapy |
| WO2015075468A1 (en) | 2013-11-21 | 2015-05-28 | Ucl Business Plc | Cell |
| KR102375998B1 (ko) | 2014-02-14 | 2022-03-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 항원 수용체 및 제조방법 |
| WO2015142675A2 (en) * | 2014-03-15 | 2015-09-24 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| KR20160145802A (ko) | 2014-04-23 | 2016-12-20 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법 |
| GB201506423D0 (en) | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| JP2017524031A (ja) | 2014-07-09 | 2017-08-24 | ティーシー バイオファーム リミテッド | ガンマデルタｔ細胞およびその使用 |
| US11135245B2 (en) | 2014-11-17 | 2021-10-05 | Adicet Bio, Inc. | Engineered γδ T-cells |
| GB201507368D0 (en) | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| CN105158466B (zh) * | 2015-05-05 | 2017-12-22 | 中国科学院广州生物医药与健康研究院 | 一种检测抗cd19的嵌合抗原受体t细胞对白血病细胞抑制作用的方法 |
-
2015
- 2015-04-15 GB GBGB1506423.1A patent/GB201506423D0/en not_active Ceased
-
2016
- 2016-04-14 ES ES16721208T patent/ES2993441T3/es active Active
- 2016-04-14 KR KR1020177032986A patent/KR20180012754A/ko not_active Ceased
- 2016-04-14 CA CA2982523A patent/CA2982523A1/en active Pending
- 2016-04-14 US US15/566,324 patent/US10881688B2/en active Active
- 2016-04-14 CN CN202210369545.4A patent/CN114717194A/zh active Pending
- 2016-04-14 WO PCT/GB2016/051050 patent/WO2016166544A1/en not_active Ceased
- 2016-04-14 EA EA201792041A patent/EA201792041A1/ru unknown
- 2016-04-14 CN CN201680034862.3A patent/CN107810267B/zh active Active
- 2016-04-14 JP JP2017554035A patent/JP6995624B2/ja active Active
- 2016-04-14 BR BR112017022249A patent/BR112017022249A2/pt not_active Application Discontinuation
- 2016-04-14 AU AU2016250211A patent/AU2016250211B2/en active Active
- 2016-04-14 EP EP16721208.3A patent/EP3283620B1/en active Active
- 2016-04-14 SG SG11201708401WA patent/SG11201708401WA/en unknown
-
2017
- 2017-10-12 ZA ZA2017/06922A patent/ZA201706922B/en unknown
- 2017-10-15 IL IL255011A patent/IL255011B/en unknown
-
2020
- 2020-11-19 US US16/953,068 patent/US20210252055A1/en not_active Abandoned
-
2021
- 2021-12-15 JP JP2021203173A patent/JP2022046549A/ja not_active Ceased
-
2022
- 2022-05-30 AU AU2022203664A patent/AU2022203664A1/en not_active Abandoned
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