JP2018510212A5 - - Google Patents

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Publication number
JP2018510212A5
JP2018510212A5 JP2017564946A JP2017564946A JP2018510212A5 JP 2018510212 A5 JP2018510212 A5 JP 2018510212A5 JP 2017564946 A JP2017564946 A JP 2017564946A JP 2017564946 A JP2017564946 A JP 2017564946A JP 2018510212 A5 JP2018510212 A5 JP 2018510212A5
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JP
Japan
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clec10a
antibody
bind
another embodiment
uniprot identifier
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Ceased
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JP2017564946A
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JP2018510212A (ja
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Priority claimed from PCT/EP2016/054647 external-priority patent/WO2016142288A1/en
Publication of JP2018510212A publication Critical patent/JP2018510212A/ja
Publication of JP2018510212A5 publication Critical patent/JP2018510212A5/ja
Ceased legal-status Critical Current

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又、抗体がＣＬＥＣ１０Ａに特異的に結合することも好ましい。一実施形態では、抗体はＣＬＥＣ１０Ａに結合し得るが、以下の受容体、ＡＳＧＰＲ１、ＣＯＬＥＣ１２、ＣＬＥＣ４Ｆ、ＣＬＥＣ４Ｍ、ＳＣＡＲＡ５及びＭＭＲの全てに結合し得ない。別の実施形態では、抗体はＣＬＥＣ１０Ａに結合し得るが、ＡＳＧＰＲ１（ＵｎｉＰｒｏｔ識別子：Ｐ０７３０６）には結合し得ない。別の実施形態では、抗体はＣＬＥＣ１０Ａに結合し得るが、ＣＯＬＥＣ１２（ＵｎｉＰｒｏｔ識別子、Ｑ５ＫＵ２６）には結合し得ない。別の実施形態では、抗体はＣＬＥＣ１０Ａに結合し得るが、ＣＬＥＣ４Ｆ（ＵｎｉＰｒｏｔ識別子、Ｑ８Ｎ１Ｎ０）には結合し得ない。別の実施形態では、抗体はＣＬＥＣ１０Ａに結合し得るが、ＣＬＥＣ４Ｍ（ＵｎｉＰｒｏｔ識別子、Ｑ９Ｈ２Ｘ３）には結合し得ない。別の実施形態では、抗体はＣＬＥＣ１０Ａに結合し得るが、ＳＣＡＲＡ５（ＵｎｉＰｒｏｔ識別子、Ｑ６ＺＭＪ２）には結合し得ない。別の実施形態では、抗体はＣＬＥＣ１０Ａに結合し得るが、ＭＭＲ（ＵｎｉＰｒｏｔ識別子、Ｐ２２８９７）には結合し得ない。更に別の実施形態では、抗体はＣＬＥＣ１０Ａに結合し得るが、以下の受容体、ＡＳＧＰＲ１、ＣＯＬＥＣ１２、ＣＬＥＣ４Ｆ、ＣＬＥＣ４Ｍ、ＳＣＡＲＡ５及びＭＭＲ、の何れの１種にも結合し得ない。
JP2017564946A 2015-03-06 2016-03-04 向上した半減期を有する改変したフォンヴィレブランド因子 Ceased JP2018510212A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15158065.1 2015-03-06
EP15158065 2015-03-06
PCT/EP2016/054647 WO2016142288A1 (en) 2015-03-06 2016-03-04 Modified von willebrand factor having improved half-life

Publications (2)

Publication Number Publication Date
JP2018510212A JP2018510212A (ja) 2018-04-12
JP2018510212A5 true JP2018510212A5 (ja) 2019-04-04

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ID=52629450

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JP2017564946A Ceased JP2018510212A (ja) 2015-03-06 2016-03-04 向上した半減期を有する改変したフォンヴィレブランド因子

Country Status (13)

Country Link
US (1) US11155601B2 (ja)
EP (1) EP3265483B1 (ja)
JP (1) JP2018510212A (ja)
KR (1) KR20170125941A (ja)
CN (1) CN107406493B (ja)
AU (1) AU2016231327B2 (ja)
BR (1) BR112017018468A2 (ja)
CA (1) CA2978374A1 (ja)
DK (1) DK3265483T3 (ja)
ES (1) ES2772933T3 (ja)
HK (1) HK1244292A1 (ja)
SG (1) SG11201706659WA (ja)
WO (1) WO2016142288A1 (ja)

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JP7307047B2 (ja) 2017-07-07 2023-07-11 武田薬品工業株式会社 組換えｖｗｆの投与による重度のフォンヴィレブランド病を患う患者における消化管出血の治療
EP3793588A1 (en) 2018-05-18 2021-03-24 Bioverativ Therapeutics Inc. Methods of treating hemophilia a
BR112021015068A2 (pt) * 2019-02-01 2021-10-05 Takeda Pharmaceutical Company Limited Métodos de tratamento profilático usando vwf recombinante (rvwf)
JP2022538357A (ja) * 2019-07-04 2022-09-01 ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト 第ＶＩＩＩ凝固因子のｉｎ ｖｉｔｒｏでの安定性を向上させるための切断型フォン・ヴィレブランド因子（ＶＷＦ）

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