JP2018510202A - 新規の複素環化合物及び細菌感染を予防又は治療する際のそれらの使用 - Google Patents

新規の複素環化合物及び細菌感染を予防又は治療する際のそれらの使用 Download PDF

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Publication number
JP2018510202A
JP2018510202A JP2017551710A JP2017551710A JP2018510202A JP 2018510202 A JP2018510202 A JP 2018510202A JP 2017551710 A JP2017551710 A JP 2017551710A JP 2017551710 A JP2017551710 A JP 2017551710A JP 2018510202 A JP2018510202 A JP 2018510202A
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Japan
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nhq
nhc
membered
heterocycle
saturated
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JP2017551710A
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English (en)
Japanese (ja)
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JP2018510202A5 (enExample
Inventor
カラバノ オドレイ
カラバノ オドレイ
シャセ ソフィー
シャセ ソフィー
シュブルイユ フランシス
シュブルイユ フランシス
フェーブル ファビアン
フェーブル ファビアン
ルコワント ニコラ
ルコワント ニコラ
ルドゥサル ブノワ
ルドゥサル ブノワ
ル ストラ フレデリク
ル ストラ フレデリク
リシャール セバスチャン
リシャール セバスチャン
シモン クリストフ
シモン クリストフ
ボムシャイド ソフィー
ボムシャイド ソフィー
ブリア ジュリー
ブリア ジュリー
バルビオン ジュリアン
バルビオン ジュリアン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mutabilis SA
Original Assignee
Mutabilis SA
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Publication date
Priority claimed from EP15305473.9A external-priority patent/EP3075733A1/en
Application filed by Mutabilis SA filed Critical Mutabilis SA
Publication of JP2018510202A publication Critical patent/JP2018510202A/ja
Publication of JP2018510202A5 publication Critical patent/JP2018510202A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2017551710A 2015-03-31 2016-03-30 新規の複素環化合物及び細菌感染を予防又は治療する際のそれらの使用 Pending JP2018510202A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15305473.9 2015-03-31
EP15305473.9A EP3075733A1 (en) 2015-03-31 2015-03-31 Novel heterocyclic compounds and their use in preventing or treating bacterial infections
EP16305073 2016-01-26
EP16305073.5 2016-01-26
PCT/EP2016/056847 WO2016156348A1 (en) 2015-03-31 2016-03-30 Novel heterocyclic compounds and their use in preventing or treating bacterial infections

Publications (2)

Publication Number Publication Date
JP2018510202A true JP2018510202A (ja) 2018-04-12
JP2018510202A5 JP2018510202A5 (enExample) 2019-04-11

Family

ID=55642467

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017551710A Pending JP2018510202A (ja) 2015-03-31 2016-03-30 新規の複素環化合物及び細菌感染を予防又は治療する際のそれらの使用

Country Status (13)

Country Link
US (1) US10072006B2 (enExample)
EP (1) EP3277686B1 (enExample)
JP (1) JP2018510202A (enExample)
KR (1) KR20170132301A (enExample)
CN (1) CN107531708A (enExample)
AU (1) AU2016239209A1 (enExample)
BR (1) BR112017020796A2 (enExample)
CA (1) CA2980085A1 (enExample)
CL (1) CL2017002451A1 (enExample)
MX (1) MX2017012535A (enExample)
RU (1) RU2017133660A (enExample)
TW (1) TW201643164A (enExample)
WO (1) WO2016156348A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018515504A (ja) * 2015-05-07 2018-06-14 ミュタビリスMutabilis 複素環式化合物及び細菌感染の治療又は予防におけるその使用
JP2019532928A (ja) * 2016-09-16 2019-11-14 エンタシス・セラピューティックス・リミテッド ベータラクタマーゼ阻害剤化合物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3300736B1 (en) * 2016-09-30 2021-05-05 Mutabilis Composition comprising antibiotic compound and an heterocyclic compound and their use in preventing or treating bacterial infections
EP3357924A1 (en) * 2017-02-06 2018-08-08 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
EP4272831A3 (en) 2018-08-09 2024-02-21 Antabio SAS Diazabicyclooctanones as inhibitors of serine beta-lactamases
CN109942579B (zh) * 2019-04-18 2021-06-22 成都千禧莱医药科技有限公司 β-内酰胺酶抑制剂含脲双环化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
AR090539A1 (es) 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
WO2014141132A1 (en) * 2013-03-14 2014-09-18 Naeja Pharmaceutical Inc. NEW HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018515504A (ja) * 2015-05-07 2018-06-14 ミュタビリスMutabilis 複素環式化合物及び細菌感染の治療又は予防におけるその使用
JP2019532928A (ja) * 2016-09-16 2019-11-14 エンタシス・セラピューティックス・リミテッド ベータラクタマーゼ阻害剤化合物
JP6997178B2 (ja) 2016-09-16 2022-02-03 エンタシス・セラピューティックス・リミテッド ベータラクタマーゼ阻害剤化合物

Also Published As

Publication number Publication date
EP3277686A1 (en) 2018-02-07
RU2017133660A (ru) 2019-03-28
AU2016239209A1 (en) 2017-10-12
WO2016156348A1 (en) 2016-10-06
CA2980085A1 (en) 2016-10-06
CL2017002451A1 (es) 2018-04-20
RU2017133660A3 (enExample) 2019-08-22
US20180086761A1 (en) 2018-03-29
CN107531708A (zh) 2018-01-02
BR112017020796A2 (pt) 2018-06-26
EP3277686B1 (en) 2020-07-22
TW201643164A (zh) 2016-12-16
US10072006B2 (en) 2018-09-11
MX2017012535A (es) 2018-07-06
KR20170132301A (ko) 2017-12-01

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