JP2018509413A - ＦｃＲｎアンタゴニストを用いてＦｃ含有剤の血清レベルを低下させる方法 - Google Patents

ＦｃＲｎアンタゴニストを用いてＦｃ含有剤の血清レベルを低下させる方法 Download PDF

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JP2018509413A
JP2018509413A JP2017547456A JP2017547456A JP2018509413A JP 2018509413 A JP2018509413 A JP 2018509413A JP 2017547456 A JP2017547456 A JP 2017547456A JP 2017547456 A JP2017547456 A JP 2017547456A JP 2018509413 A JP2018509413 A JP 2018509413A
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fcrn antagonist
fcrn
disease
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JP2018509413A5 (enExample
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ジー．エイチ．オンゲナエ ニコラス
ジー．エイチ．オンゲナエ ニコラス
ドレイエル トルステン
ドレイエル トルステン
ウルリクフトス ペテル
ウルリクフトス ペテル
デ ハアルド ジョハンネス
デ ハアルド ジョハンネス
ブランチェトト クリストプヘ
ブランチェトト クリストプヘ
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アルゲン−エックス ビーブイビーエー
アルゲン−エックス ビーブイビーエー
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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JP2017547456A 2015-03-09 2016-03-08 ＦｃＲｎアンタゴニストを用いてＦｃ含有剤の血清レベルを低下させる方法 Pending JP2018509413A (ja)

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US201562130076P 2015-03-09 2015-03-09
US62/130,076 2015-03-09
PCT/IB2016/000398 WO2016142782A1 (en) 2015-03-09 2016-03-08 Methods of reducing serum levels of fc-containing agents using fcrn antagonsits

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JP2021016293A Active JP7050191B2 (ja) 2015-03-09 2021-02-04 ＦｃＲｎアンタゴニストを用いてＦｃ含有剤の血清レベルを低下させる方法
JP2022051047A Active JP7391132B2 (ja) 2015-03-09 2022-03-28 ＦｃＲｎアンタゴニストを用いてＦｃ含有剤の血清レベルを低下させる方法
JP2022072043A Active JP7403575B2 (ja) 2015-03-09 2022-04-26 ＦｃＲｎアンタゴニストを用いてＦｃ含有剤の血清レベルを低下させる方法
JP2023209102A Active JP7823011B2 (ja) 2015-03-09 2023-12-12 ＦｃＲｎアンタゴニストを用いてＦｃ含有剤の血清レベルを低下させる方法
JP2025174910A Pending JP2026012786A (ja) 2015-03-09 2025-10-16 ＦｃＲｎアンタゴニストを用いてＦｃ含有剤の血清レベルを低下させる方法

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JP2022051047A Active JP7391132B2 (ja) 2015-03-09 2022-03-28 ＦｃＲｎアンタゴニストを用いてＦｃ含有剤の血清レベルを低下させる方法
JP2022072043A Active JP7403575B2 (ja) 2015-03-09 2022-04-26 ＦｃＲｎアンタゴニストを用いてＦｃ含有剤の血清レベルを低下させる方法
JP2023209102A Active JP7823011B2 (ja) 2015-03-09 2023-12-12 ＦｃＲｎアンタゴニストを用いてＦｃ含有剤の血清レベルを低下させる方法
JP2025174910A Pending JP2026012786A (ja) 2015-03-09 2025-10-16 ＦｃＲｎアンタゴニストを用いてＦｃ含有剤の血清レベルを低下させる方法

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EP (2) EP4006051A1 (enExample)
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KR (1) KR102720769B1 (enExample)
AU (2) AU2016230827B2 (enExample)
CA (1) CA2978253A1 (enExample)
DK (1) DK3268391T3 (enExample)
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JP2022528927A (ja) * 2019-04-11 2022-06-16 アルジェニクス アイアイピー ビーブイ 抗ＩｇＥ抗体
JP2022542884A (ja) * 2019-07-25 2022-10-07 ジェンザイム・コーポレーション Ｆｃｒｎアンタゴニストで抗体媒介性障害を処置する方法
JP2023531451A (ja) * 2020-06-17 2023-07-24 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 遺伝子療法患者の治療のための組成物及び方法

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CN106103476B (zh) 2013-12-24 2020-11-27 阿尔金克斯有限公司 FcRn拮抗剂及使用方法
JP6853178B2 (ja) * 2015-01-30 2021-03-31 モメンタ ファーマシューティカルズ インコーポレイテッド ＦｃＲｎ抗体およびその使用方法
MX386491B (es) * 2015-03-09 2025-03-18 argenx BV Metodos para reducir los niveles de suero de agentes que contienen fc que usan antagonistas de fcrn.
WO2018007999A1 (en) 2016-07-08 2018-01-11 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
GB201618424D0 (en) * 2016-11-01 2016-12-14 Argenix Bvba Treatment of antibody mediated disease
WO2018193427A1 (en) 2017-04-21 2018-10-25 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
CN111315772A (zh) 2017-10-31 2020-06-19 斯塔顿生物技术有限公司 抗apoc3抗体及其使用方法
MA51032A (fr) * 2017-12-08 2021-03-17 Argenx Bvba Utilisation d'antagonistes de fcrn pour le traitement de la myasthénie grave généralisée
JP7486437B2 (ja) 2018-06-08 2024-05-17 アルジェニクス ビーブイ 免疫性血小板減少症を治療する組成物及び方法
WO2020148336A1 (en) * 2019-01-16 2020-07-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of agents capable of inducing lc3-associated phagocytosis for treating sustained inflammation in patients suffering from chronic liver disease
JP7137696B2 (ja) 2019-05-14 2022-09-14 プロヴェンション・バイオ・インコーポレイテッド １型糖尿病を予防するための方法および組成物
BR112021024632A2 (pt) * 2019-06-07 2022-01-18 Argenx Bvba Formulações farmacêuticas de inibidores de fcrn adequados para administração subcutânea
ES2992247T3 (es) 2020-01-08 2024-12-11 argenx BV Antagonistas del receptor de Fc neonatal humano (FcRn) para el tratamiento de trastornos del pénfigo
WO2021160116A1 (zh) * 2020-02-10 2021-08-19 北京拓界生物医药科技有限公司 抗FcRn抗体、其抗原结合片段及其医药用途
KR20230092863A (ko) 2020-06-11 2023-06-26 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
MX2023013851A (es) 2021-05-24 2023-12-08 Provention Bio Inc Metodos para el tratamiento de diabetes tipo 1.
CN117693523A (zh) * 2021-08-13 2024-03-12 舒泰神（北京）生物制药股份有限公司 特异性识别fcrn的抗体及其用途
KR20250037789A (ko) 2022-06-15 2025-03-18 아르젠엑스 비브이 Fcrn/항원-결합 분자 및 사용 방법
IL320846A (en) * 2022-11-14 2025-07-01 argenx BV Fcrn antagonist molecules and methods of use thereof

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