JP2018508793A - クロマトグラフィー適用におけるスウェプトボリュームおよびデッドボリュームを最小限にするための手段および方法 - Google Patents

クロマトグラフィー適用におけるスウェプトボリュームおよびデッドボリュームを最小限にするための手段および方法 Download PDF

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Publication number
JP2018508793A
JP2018508793A JP2017559909A JP2017559909A JP2018508793A JP 2018508793 A JP2018508793 A JP 2018508793A JP 2017559909 A JP2017559909 A JP 2017559909A JP 2017559909 A JP2017559909 A JP 2017559909A JP 2018508793 A JP2018508793 A JP 2018508793A
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Japan
Prior art keywords
column
less
chromatography
fractions
chromatography step
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JP2017559909A
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Japanese (ja)
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JP2018508793A5 (enExample
Inventor
クラーク，ニルス
マン，マティアス
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Max Planck Gesellschaft zur Foerderung der Wissenschaften
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Max Planck Gesellschaft zur Foerderung der Wissenschaften
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Publication of JP2018508793A publication Critical patent/JP2018508793A/ja
Publication of JP2018508793A5 publication Critical patent/JP2018508793A5/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/24—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the treatment of the fractions to be distributed
    • B01D15/247—Fraction collectors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/80—Fraction collectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N2030/6013—Construction of the column end pieces interfaces to detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2017559909A 2015-02-09 2016-02-05 クロマトグラフィー適用におけるスウェプトボリュームおよびデッドボリュームを最小限にするための手段および方法 Pending JP2018508793A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15154374.1 2015-02-09
EP15154374 2015-02-09
PCT/EP2016/052490 WO2016128316A1 (en) 2015-02-09 2016-02-05 Means and methods for minimizing swept and dead volumes in chromatographic applications

Publications (2)

Publication Number Publication Date
JP2018508793A true JP2018508793A (ja) 2018-03-29
JP2018508793A5 JP2018508793A5 (enExample) 2019-02-14

Family

ID=52686078

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017559909A Pending JP2018508793A (ja) 2015-02-09 2016-02-05 クロマトグラフィー適用におけるスウェプトボリュームおよびデッドボリュームを最小限にするための手段および方法

Country Status (8)

Country Link
US (1) US20180031528A1 (enExample)
EP (1) EP3256846A1 (enExample)
JP (1) JP2018508793A (enExample)
KR (1) KR20170110716A (enExample)
CN (1) CN107209155A (enExample)
AU (1) AU2016218072A1 (enExample)
CA (1) CA2975027A1 (enExample)
WO (1) WO2016128316A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3389630B1 (en) 2015-12-16 2023-11-08 Gritstone bio, Inc. Neoantigen identification, manufacture, and use
JP7227237B2 (ja) 2017-10-10 2023-02-21 グリットストーン バイオ インコーポレイテッド ホットスポットを利用した新生抗原の特定
CN111630602A (zh) 2017-11-22 2020-09-04 磨石肿瘤生物技术公司 减少新抗原的接合表位呈递
US20190227040A1 (en) * 2018-01-22 2019-07-25 Thermo Finnigan Llc Method and Apparatus for Chromatograph Nano-Flow Fractionator
CN112034083B (zh) * 2020-07-30 2023-03-31 北京卫星制造厂有限公司 一种液相色谱泵流路超低死体积的标定方法及系统

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6167560U (enExample) * 1984-10-05 1986-05-09
WO2005114168A1 (en) * 2004-05-22 2005-12-01 Agilent Technologies, Inc. Combi column
WO2012172382A1 (en) * 2011-06-14 2012-12-20 MOROVJÁN, Gyõrgy Method and apparatus for improving the performance of column chromatographic separation processes
GB2504622A (en) * 2011-05-26 2014-02-05 Thermo Electron Mfg Ltd Method and apparatus for improved resolution chromatography
JP2014515480A (ja) * 2011-05-26 2014-06-30 サーモ エレクトロン マニュファクチュアリング リミテッド 分解能を向上させたクロマトグラフィの方法および装置

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US5305788A (en) * 1992-08-13 1994-04-26 Whitey Co. Stream selector for process analyzer
FR2809490B1 (fr) * 2000-05-23 2002-11-29 Hocer Installation et procede pour la preparation automatique d'echantillons
US6748975B2 (en) * 2001-12-26 2004-06-15 Micralyne Inc. Microfluidic valve and method of manufacturing same
WO2006078859A2 (en) * 2005-01-20 2006-07-27 Waters Investments Limited Methods for separating compounds
CN2859526Y (zh) * 2005-07-28 2007-01-17 上海烟草（集团）公司 一种大孔径柱到毛细柱的多维气相色谱系统
CN101299986A (zh) * 2005-11-01 2008-11-05 宝洁公司 包含沉积香料的多相个人护理组合物
EP2370193B1 (en) * 2008-12-04 2012-11-14 Vrije Universiteit Brussel A chromatographic separation device with variable length and a method for its use
US8656955B2 (en) * 2010-05-20 2014-02-25 Bio-Rad Laboratories, Inc. Rotary column selector valve
US20120040846A1 (en) * 2010-07-23 2012-02-16 President And Fellows Of Harvard College Methods of Detecting Diseases or Conditions Using Phagocytic Cells
EP2618913B1 (en) * 2010-09-22 2019-07-03 PerkinElmer Health Sciences, Inc. Backflush methods and devices for chromatography
EP2718709B1 (en) * 2011-06-09 2016-08-10 Waters Technologies Corporation Reducing dispersion due to vias in planar microfluidic separation devices
CN203060889U (zh) * 2012-12-19 2013-07-17 大连依利特分析仪器有限公司 液相色谱用全自动制备级馏分收集阀站

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6167560U (enExample) * 1984-10-05 1986-05-09
WO2005114168A1 (en) * 2004-05-22 2005-12-01 Agilent Technologies, Inc. Combi column
GB2504622A (en) * 2011-05-26 2014-02-05 Thermo Electron Mfg Ltd Method and apparatus for improved resolution chromatography
JP2014515480A (ja) * 2011-05-26 2014-06-30 サーモ エレクトロン マニュファクチュアリング リミテッド 分解能を向上させたクロマトグラフィの方法および装置
WO2012172382A1 (en) * 2011-06-14 2012-12-20 MOROVJÁN, Gyõrgy Method and apparatus for improving the performance of column chromatographic separation processes

Also Published As

Publication number Publication date
EP3256846A1 (en) 2017-12-20
WO2016128316A1 (en) 2016-08-18
CA2975027A1 (en) 2016-08-18
AU2016218072A1 (en) 2017-08-24
CN107209155A (zh) 2017-09-26
KR20170110716A (ko) 2017-10-11
US20180031528A1 (en) 2018-02-01

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