JP2018508569A - 老化関連状態の治療における化合物および使用 - Google Patents

老化関連状態の治療における化合物および使用 Download PDF

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JP2018508569A
JP2018508569A JP2017559779A JP2017559779A JP2018508569A JP 2018508569 A JP2018508569 A JP 2018508569A JP 2017559779 A JP2017559779 A JP 2017559779A JP 2017559779 A JP2017559779 A JP 2017559779A JP 2018508569 A JP2018508569 A JP 2018508569A
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compound
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salt
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JP2018508569A5 (enExample
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ナサニエル デビッド
ナサニエル デビッド
レミ‐マーティン ラバージ
レミ‐マーティン ラバージ
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ユニティ バイオテクノロジー インコーポレイテッド
ユニティ バイオテクノロジー インコーポレイテッド
バック インスティテュート フォー リサーチ オン エイジング
バック インスティテュート フォー リサーチ オン エイジング
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  • Rheumatology (AREA)
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JP2017559779A 2015-02-06 2016-02-05 老化関連状態の治療における化合物および使用 Pending JP2018508569A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562113227P 2015-02-06 2015-02-06
US62/113,227 2015-02-06
PCT/US2016/016894 WO2016127135A1 (en) 2015-02-06 2016-02-05 Compounds and uses in treatment of senescence-associated conditons

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JP2018508569A true JP2018508569A (ja) 2018-03-29
JP2018508569A5 JP2018508569A5 (enExample) 2019-03-14

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US (2) US20170266211A1 (enExample)
EP (1) EP3253387A4 (enExample)
JP (1) JP2018508569A (enExample)
CN (1) CN108025006A (enExample)
AU (1) AU2016215035A1 (enExample)
CA (1) CA2981753A1 (enExample)
HK (1) HK1249030A1 (enExample)
WO (1) WO2016127135A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2021132628A1 (enExample) * 2019-12-26 2021-07-01
JP2021522270A (ja) * 2018-04-30 2021-08-30 ユニティ バイオテクノロジー インコーポレイテッド 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるホスホノアミダート
JP2021528392A (ja) * 2018-06-13 2021-10-21 ユニティ バイオテクノロジー インコーポレイテッド 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるアシルスルホンアミド
JP2023547959A (ja) * 2020-11-10 2023-11-14 ユニティ バイオテクノロジー インコーポレイテッド Ｂｃｌの結晶性固体メグルミン塩阻害物質、並びに前記阻害物質を作製及び使用する方法

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170216286A1 (en) 2014-01-28 2017-08-03 Mayo Foundation For Medical Education And Research Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid
US9993472B2 (en) 2014-01-28 2018-06-12 Unity Biotechnology, Inc. Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2
TW201613576A (en) 2014-06-26 2016-04-16 Novartis Ag Intermittent dosing of MDM2 inhibitor
PL3541387T3 (pl) 2016-11-15 2021-10-25 Novartis Ag Dawka i schemat dla inhibitorów interakcji hdm2-p53
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
US11419883B2 (en) 2017-05-05 2022-08-23 The Regents Of The University Of California Inhibiting senescent processes in beta cells for the prevention of type 1 diabetes
WO2019033122A1 (en) * 2017-08-11 2019-02-14 Unity Biotechnology, Inc. TREATMENT OF PULMONARY DISEASES USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS
CN111372598A (zh) * 2017-08-11 2020-07-03 联合生物科技公司 使用消除衰老细胞的药剂治疗诸如黄斑变性,青光眼,和糖尿病性视网膜病变等眼科状况
US10588916B2 (en) 2017-10-31 2020-03-17 Unity Biotechnology, Inc. Technology to inhibit vascular changes that lead to vision loss in the eye
AU2018357829B2 (en) 2017-12-30 2019-09-26 Unity Biotechnology, Inc. Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer
IL316472A (en) 2018-01-10 2024-12-01 Recurium Ip Holdings Llc Benzamide compounds
WO2019160882A1 (en) 2018-02-13 2019-08-22 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
KR102591947B1 (ko) 2018-04-19 2023-10-25 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
US11925640B2 (en) 2018-06-22 2024-03-12 Mayo Foundation For Medical Education And Research Methods and materials for improving arteriovenous fistula maturation and maintaining arteriovenous fistula functionality
MX2021000395A (es) * 2018-07-11 2021-05-12 Rubedo Life Sciences Inc Composiciones senolíticas y usos de las mismas.
PE20210642A1 (es) 2018-07-13 2021-03-23 Gilead Sciences Inc Inhibidores de pd-1/pd-l1
US11236085B2 (en) 2018-10-24 2022-02-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
WO2020092117A2 (en) * 2018-10-30 2020-05-07 Unity Biotechnology, Inc. Killing senescent cells and treating senescence-associated diseases or disorders using a combination of a bcl inhibitor and an mcl-1 inhibitor
US11872237B2 (en) 2018-12-28 2024-01-16 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical composition and preparation method thereof
EP4014040A4 (en) * 2019-08-15 2023-12-27 Mayo Foundation for Medical Education and Research METHODS AND MATERIALS FOR ASSESSMENT AND TREATMENT OF HYPERTENSIVE DISEASES
WO2021092061A1 (en) * 2019-11-08 2021-05-14 Unity Biotechnology, Inc. Combination treatment for senescence-associated diseases
WO2021204060A1 (en) * 2020-04-10 2021-10-14 Ascentage Pharma (Suzhou) Co., Ltd. Combinations of bcl-2/bcl-xl inhibitors and related uses
WO2022012481A1 (en) 2020-07-13 2022-01-20 Ascentage Pharma (Suzhou) Co., Ltd. Crystalline or Amorphous form of Bcl-2/Bcl-xL inhibitor compound or its salts
CN114053288B (zh) * 2020-07-31 2024-11-19 苏州亚盛药业有限公司 肺部疾病治疗的组合物和方法
CN114073703B (zh) * 2020-08-21 2022-12-30 苏州亚盛药业有限公司 用于治疗非酒精性脂肪肝炎的组合物和方法
EP4649499A1 (en) * 2023-01-12 2025-11-19 Koninklijke Philips N.V. Model-guided imaging for mechanical ventilation
CN115837022B (zh) * 2023-02-20 2023-04-25 中山大学附属第八医院（深圳福田） 1,2,4三唑并4,3-b哒嗪衍生物在制备抗衰老药物中的应用
WO2024164543A1 (zh) * 2023-02-09 2024-08-15 中山大学附属第八医院（深圳福田） [1,2,4]三唑并[4,3-b]哒嗪衍生物在衰老及衰老相关性疾病防治中的应用
WO2024245312A1 (en) * 2023-05-30 2024-12-05 Ascentage Pharma (Suzhou) Co., Ltd. Bcl-2/bcl-xl protein degrader and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012103059A2 (en) * 2011-01-25 2012-08-02 The Regents Of The University Of Michigan Bcl-2/bcl-xl inhibitors and therapeutic methods using the same
WO2014113413A1 (en) * 2013-01-16 2014-07-24 The Regents Of The University Of Michigan Bcl-2bcl-xl inhibitors and therapeutic methods using the same
WO2014174511A1 (en) * 2013-04-21 2014-10-30 Yeda Research And Development Co. Ltd. Agents for downregulation of the activity and/or amount of bcl-xl and/or bcl-w

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228873B1 (en) * 1994-12-09 2001-05-08 The Regents Of The University Of California Method for enhancing outflow of aqueous humor in treatment of glaucoma
MX2009002422A (es) * 2006-09-05 2009-03-20 Abbott Lab Inhibidores bcl para tratar exceso de plaquetas.
US9993472B2 (en) * 2014-01-28 2018-06-12 Unity Biotechnology, Inc. Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012103059A2 (en) * 2011-01-25 2012-08-02 The Regents Of The University Of Michigan Bcl-2/bcl-xl inhibitors and therapeutic methods using the same
WO2014113413A1 (en) * 2013-01-16 2014-07-24 The Regents Of The University Of Michigan Bcl-2bcl-xl inhibitors and therapeutic methods using the same
WO2014174511A1 (en) * 2013-04-21 2014-10-30 Yeda Research And Development Co. Ltd. Agents for downregulation of the activity and/or amount of bcl-xl and/or bcl-w

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ＰＡＬＯＭＡ Ｂ． ＬＩＴＯＮ ＥＴ ＡＬ．: "Ｃｅｌｌｕｌａｒ ｓｅｓｅｎｅｓｃｅｎｃｅ ｉｎ ｔｈｅ ｇｌａｕｃｏｍａｔｏｕｓ ｏｕｔｆｌｏｗ ", ＥＸＰＥＲＩＭＥＮＴＡＬ ＧＥＲＯＮＴＯＬＯＧＹ, JPN6019045648, 2005, pages 745 - 748, ISSN: 0004371520 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021522270A (ja) * 2018-04-30 2021-08-30 ユニティ バイオテクノロジー インコーポレイテッド 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるホスホノアミダート
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JP7089062B2 (ja) 2018-04-30 2022-06-21 ユニティ バイオテクノロジー インコーポレイテッド 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるホスホリジン
JP2021528392A (ja) * 2018-06-13 2021-10-21 ユニティ バイオテクノロジー インコーポレイテッド 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Ｂｃｌファミリーアンタゴニストであるアシルスルホンアミド
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JPWO2021132628A1 (enExample) * 2019-12-26 2021-07-01
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