CA2981753A1 - Compounds and uses in treatment of senescence-associated conditions - Google Patents

Compounds and uses in treatment of senescence-associated conditions Download PDF

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Publication number
CA2981753A1
CA2981753A1 CA2981753A CA2981753A CA2981753A1 CA 2981753 A1 CA2981753 A1 CA 2981753A1 CA 2981753 A CA2981753 A CA 2981753A CA 2981753 A CA2981753 A CA 2981753A CA 2981753 A1 CA2981753 A1 CA 2981753A1
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CA
Canada
Prior art keywords
compound
salt
alkyl
disease
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2981753A
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English (en)
French (fr)
Inventor
Nathaniel David
Remi-Martin LABERGE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Buck Institute for Research on Aging
Unity Biotechnology Inc
Original Assignee
Buck Institute for Research on Aging
Unity Biotechnology Inc
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Filing date
Publication date
Application filed by Buck Institute for Research on Aging, Unity Biotechnology Inc filed Critical Buck Institute for Research on Aging
Publication of CA2981753A1 publication Critical patent/CA2981753A1/en
Abandoned legal-status Critical Current

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
CA2981753A 2015-02-06 2016-02-05 Compounds and uses in treatment of senescence-associated conditions Abandoned CA2981753A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562113227P 2015-02-06 2015-02-06
US62/113,227 2015-02-06
PCT/US2016/016894 WO2016127135A1 (en) 2015-02-06 2016-02-05 Compounds and uses in treatment of senescence-associated conditons

Publications (1)

Publication Number Publication Date
CA2981753A1 true CA2981753A1 (en) 2016-08-11

Family

ID=56564790

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2981753A Abandoned CA2981753A1 (en) 2015-02-06 2016-02-05 Compounds and uses in treatment of senescence-associated conditions

Country Status (8)

Country Link
US (2) US20170266211A1 (enExample)
EP (1) EP3253387A4 (enExample)
JP (1) JP2018508569A (enExample)
CN (1) CN108025006A (enExample)
AU (1) AU2016215035A1 (enExample)
CA (1) CA2981753A1 (enExample)
HK (1) HK1249030A1 (enExample)
WO (1) WO2016127135A1 (enExample)

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US9993472B2 (en) 2014-01-28 2018-06-12 Unity Biotechnology, Inc. Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2
TW201613576A (en) 2014-06-26 2016-04-16 Novartis Ag Intermittent dosing of MDM2 inhibitor
PL3541387T3 (pl) 2016-11-15 2021-10-25 Novartis Ag Dawka i schemat dla inhibitorów interakcji hdm2-p53
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
US11419883B2 (en) 2017-05-05 2022-08-23 The Regents Of The University Of California Inhibiting senescent processes in beta cells for the prevention of type 1 diabetes
WO2019033122A1 (en) * 2017-08-11 2019-02-14 Unity Biotechnology, Inc. TREATMENT OF PULMONARY DISEASES USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS
US20200354336A9 (en) * 2017-08-11 2020-11-12 Unity Biotechnology, Inc. Treatment of Lung Diseases Using Pharmaceutical Agents that Eliminate Senescent Cells
CN111372598A (zh) * 2017-08-11 2020-07-03 联合生物科技公司 使用消除衰老细胞的药剂治疗诸如黄斑变性,青光眼,和糖尿病性视网膜病变等眼科状况
US10588916B2 (en) 2017-10-31 2020-03-17 Unity Biotechnology, Inc. Technology to inhibit vascular changes that lead to vision loss in the eye
AU2018357829B2 (en) 2017-12-30 2019-09-26 Unity Biotechnology, Inc. Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer
IL316472A (en) 2018-01-10 2024-12-01 Recurium Ip Holdings Llc Benzamide compounds
WO2019160882A1 (en) 2018-02-13 2019-08-22 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
KR102591947B1 (ko) 2018-04-19 2023-10-25 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
WO2019213151A1 (en) * 2018-04-30 2019-11-07 Unity Biotechnology Phosphonamidates that are bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
US11925640B2 (en) 2018-06-22 2024-03-12 Mayo Foundation For Medical Education And Research Methods and materials for improving arteriovenous fistula maturation and maintaining arteriovenous fistula functionality
MX2021000395A (es) * 2018-07-11 2021-05-12 Rubedo Life Sciences Inc Composiciones senolíticas y usos de las mismas.
PE20210642A1 (es) 2018-07-13 2021-03-23 Gilead Sciences Inc Inhibidores de pd-1/pd-l1
US11236085B2 (en) 2018-10-24 2022-02-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
WO2020092117A2 (en) * 2018-10-30 2020-05-07 Unity Biotechnology, Inc. Killing senescent cells and treating senescence-associated diseases or disorders using a combination of a bcl inhibitor and an mcl-1 inhibitor
US11872237B2 (en) 2018-12-28 2024-01-16 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical composition and preparation method thereof
EP4014040A4 (en) * 2019-08-15 2023-12-27 Mayo Foundation for Medical Education and Research METHODS AND MATERIALS FOR ASSESSMENT AND TREATMENT OF HYPERTENSIVE DISEASES
WO2021092061A1 (en) * 2019-11-08 2021-05-14 Unity Biotechnology, Inc. Combination treatment for senescence-associated diseases
US12291461B2 (en) * 2019-12-26 2025-05-06 Toray Industries, Inc. Cerium oxide nanoparticle, dispersion body, oxidant, antioxidant, and method of producing cerium oxide nanoparticle
WO2021204060A1 (en) * 2020-04-10 2021-10-14 Ascentage Pharma (Suzhou) Co., Ltd. Combinations of bcl-2/bcl-xl inhibitors and related uses
WO2022012481A1 (en) 2020-07-13 2022-01-20 Ascentage Pharma (Suzhou) Co., Ltd. Crystalline or Amorphous form of Bcl-2/Bcl-xL inhibitor compound or its salts
CN114053288B (zh) * 2020-07-31 2024-11-19 苏州亚盛药业有限公司 肺部疾病治疗的组合物和方法
CN114073703B (zh) * 2020-08-21 2022-12-30 苏州亚盛药业有限公司 用于治疗非酒精性脂肪肝炎的组合物和方法
MX2023005447A (es) * 2020-11-10 2023-09-25 Unity Biotechnology Inc Inhibidor de sales sólidas cristalinas de meglumina de bcl y métodos de elaboración y uso de estos.
EP4649499A1 (en) * 2023-01-12 2025-11-19 Koninklijke Philips N.V. Model-guided imaging for mechanical ventilation
CN115837022B (zh) * 2023-02-20 2023-04-25 中山大学附属第八医院（深圳福田） 1,2,4三唑并4,3-b哒嗪衍生物在制备抗衰老药物中的应用
WO2024164543A1 (zh) * 2023-02-09 2024-08-15 中山大学附属第八医院（深圳福田） [1,2,4]三唑并[4,3-b]哒嗪衍生物在衰老及衰老相关性疾病防治中的应用
WO2024245312A1 (en) * 2023-05-30 2024-12-05 Ascentage Pharma (Suzhou) Co., Ltd. Bcl-2/bcl-xl protein degrader and use thereof

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HK1249030A1 (zh) 2018-10-26
CN108025006A (zh) 2018-05-11
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