JP2018508525A5 - - Google Patents
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- JP2018508525A5 JP2018508525A5 JP2017546176A JP2017546176A JP2018508525A5 JP 2018508525 A5 JP2018508525 A5 JP 2018508525A5 JP 2017546176 A JP2017546176 A JP 2017546176A JP 2017546176 A JP2017546176 A JP 2017546176A JP 2018508525 A5 JP2018508525 A5 JP 2018508525A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562127684P | 2015-03-03 | 2015-03-03 | |
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| WO2013138753A1 (en) * | 2012-03-16 | 2013-09-19 | Fox Chase Chemical Diversity Center, Inc. | Prodrugs of riluzole and their method of use |
| SG11201703896QA (en) * | 2014-11-21 | 2017-06-29 | Biohaven Pharm Holding Co Ltd | Sublingual formulation of riluzole |
| LT3265448T (lt) | 2015-03-03 | 2022-04-11 | Biohaven Pharmaceutical Holding Company Ltd. | Riluzolo provaistai ir jų naudojimas |
| US11911369B2 (en) * | 2015-03-03 | 2024-02-27 | Biohaven Therapeutics Ltd. | Prodrugs of riluzole and their method of use |
| US12295942B2 (en) | 2015-03-03 | 2025-05-13 | Biohaven Therapeutics Ltd. | Riluzole prodrugs and their use |
| JP2017061430A (ja) * | 2015-09-25 | 2017-03-30 | 芳男 ▲浜▼田 | 新規なプロドラッグ |
| JP7169195B2 (ja) * | 2016-05-20 | 2022-11-10 | バイオヘイブン・ファーマシューティカル・ホールディング・カンパニー・リミテッド | 癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用 |
| US12029731B2 (en) | 2016-08-10 | 2024-07-09 | Biohaven Therapeutics Ltd. | Acyl benzo[d]thiazol-2-amine and their methods of use |
| HUE052854T2 (hu) * | 2016-11-25 | 2021-05-28 | Genuv Inc | Készítmény a neurális õssejtek differenciálódásának elõsegítésére és védelmére, továbbá módszer a neurális regeneráció indukálására ugyanennek a segítségével |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| US12201618B2 (en) * | 2017-01-18 | 2025-01-21 | Biohaven Therapeutics Ltd. | Use of riluzole prodrugs to treat Alzheimer's disease |
| WO2020023324A1 (en) * | 2018-07-22 | 2020-01-30 | Biohaven Therapeutics Ltd. | Use of riluzole prodrugs to treat alzheimer's disease |
| US20180207138A1 (en) | 2017-01-23 | 2018-07-26 | Cadent Therapeutics, Inc. | Methods for the treatment of tremors by positive modulation of sk channels |
| KR102547709B1 (ko) * | 2017-02-28 | 2023-06-23 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 아제티딘 유도체 |
| CN107021959A (zh) * | 2017-05-02 | 2017-08-08 | 青岛科技大学 | 一类新型吲哚衍生物及其体外抗肿瘤活性 |
| PT3706739T (pt) * | 2017-11-12 | 2024-12-04 | Biohaven Therapeutics Ltd | Utilização de profármacos de riluzol para tratar ataxias |
| AU2019322889A1 (en) * | 2018-08-16 | 2021-03-04 | Biohaven Therapeutics Ltd. | Use of riluzole oral disintigrating tablets for treating diseases |
| GB201818651D0 (en) * | 2018-11-15 | 2019-01-02 | Univ Sheffield | Compounds |
| EP4041735A4 (en) * | 2019-10-10 | 2023-11-22 | Biohaven Therapeutics Ltd. | MYELOPEROXIDASE INHIBITOR PRODRUGS |
| WO2021118924A2 (en) | 2019-12-12 | 2021-06-17 | Ting Therapeutics Llc | Compositions and methods for the prevention and treatment of hearing loss |
| CA3187323A1 (en) * | 2020-06-24 | 2021-12-30 | Biohaven Therapeutics Ltd. | Compositions and methods for treating obsessive-compulsive disorder |
| US20240009133A1 (en) | 2020-11-16 | 2024-01-11 | Orcosa Inc. | Methods of treating autoimmune or inflammatory conditions with cannabidiol or its derivatives/analogs |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| WO2022155564A1 (en) * | 2021-01-18 | 2022-07-21 | Biohaven Therapeutics Ltd. | Use of riluzole prodrugs to treat alzheimer's disease |
| WO2022178425A1 (en) * | 2021-02-22 | 2022-08-25 | Yale University | Targeted bifunctional degraders |
| KR102785404B1 (ko) | 2022-08-19 | 2025-03-21 | 부산대학교 산학협력단 | 리루졸 유도체 및 이를 유효성분으로 포함하는 대장 표적성 염증성 장질환 예방 또는 치료용 조성물 |
| CN114344297B (zh) * | 2022-03-01 | 2024-05-14 | 暨南大学 | 利鲁唑在治疗少精症中的应用 |
| IL317334A (en) * | 2022-06-26 | 2025-01-01 | Biohaven Therapeutics Ltd | Methods for treating glioblastoma using riluzole prodrugs |
| CN118085016B (zh) * | 2024-04-24 | 2024-07-30 | 天津卡普希科技有限公司 | 一种d-苯甘氨酰-甘氨酸的制备方法 |
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| DE69829409D1 (de) * | 1997-11-05 | 2005-04-21 | Mitsubishi Chem Corp | Alkylaminoderivate |
| FR2774592B1 (fr) * | 1998-02-06 | 2000-03-17 | Rhone Poulenc Rorer Sa | Application du 2-amino-6-trifluoromethoxybenzothiazole pour la prevention ou le traitement des dysfonctionnements du cervelet |
| WO2002100399A1 (en) * | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| WO2005037845A1 (en) * | 2003-10-17 | 2005-04-28 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole[5,5-b] pyridine compositions and their use as ubiquitin ligase inhibitors |
| AR050258A1 (es) * | 2004-07-21 | 2006-10-11 | Mitsui Chemicals Inc | Derivado de diamina, proceso de la preparacion de este, y fungicida que contiene el derivado de diamina como ingrediente activo |
| EP3753561A1 (en) | 2005-04-05 | 2020-12-23 | Yale University | Glutamate modulating agents in the treatment of mental disorders |
| FR2885129B1 (fr) * | 2005-04-29 | 2007-06-15 | Proskelia Sas | Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation. |
| WO2013138753A1 (en) * | 2012-03-16 | 2013-09-19 | Fox Chase Chemical Diversity Center, Inc. | Prodrugs of riluzole and their method of use |
| WO2013192610A2 (en) * | 2012-06-23 | 2013-12-27 | Fox Chase Chemical Diversity Center, Inc. | Pro-drugs of riluzole and their method of use for the treatment of amyotrophic lateral sclerosis |
| LT3265448T (lt) * | 2015-03-03 | 2022-04-11 | Biohaven Pharmaceutical Holding Company Ltd. | Riluzolo provaistai ir jų naudojimas |
| US11911369B2 (en) * | 2015-03-03 | 2024-02-27 | Biohaven Therapeutics Ltd. | Prodrugs of riluzole and their method of use |
| US12295942B2 (en) * | 2015-03-03 | 2025-05-13 | Biohaven Therapeutics Ltd. | Riluzole prodrugs and their use |
| WO2017087594A1 (en) | 2015-11-19 | 2017-05-26 | Biohaven Pharmaceutical Holding Company Ltd. | Amine prodrugs of pharmaceutical compounds |
| JP7169195B2 (ja) * | 2016-05-20 | 2022-11-10 | バイオヘイブン・ファーマシューティカル・ホールディング・カンパニー・リミテッド | 癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用 |
| US12029731B2 (en) | 2016-08-10 | 2024-07-09 | Biohaven Therapeutics Ltd. | Acyl benzo[d]thiazol-2-amine and their methods of use |
| PT3706739T (pt) | 2017-11-12 | 2024-12-04 | Biohaven Therapeutics Ltd | Utilização de profármacos de riluzol para tratar ataxias |
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