JP2018507254A - 抗代替軽鎖抗体 - Google Patents

抗代替軽鎖抗体 Download PDF

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Publication number
JP2018507254A
JP2018507254A JP2017558627A JP2017558627A JP2018507254A JP 2018507254 A JP2018507254 A JP 2018507254A JP 2017558627 A JP2017558627 A JP 2017558627A JP 2017558627 A JP2017558627 A JP 2017558627A JP 2018507254 A JP2018507254 A JP 2018507254A
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Japan
Prior art keywords
antibody
sequence
seq
human
antigen
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Pending
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JP2017558627A
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English (en)
Japanese (ja)
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JP2018507254A5 (OSRAM
Inventor
ローレンス ホロヴィッツ，
ローレンス ホロヴィッツ，
Original Assignee
アイツー ファーマシューティカルズ， インコーポレーテッド
アイツー ファーマシューティカルズ， インコーポレーテッド
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Application filed by アイツー ファーマシューティカルズ， インコーポレーテッド, アイツー ファーマシューティカルズ， インコーポレーテッド filed Critical アイツー ファーマシューティカルズ， インコーポレーテッド
Publication of JP2018507254A publication Critical patent/JP2018507254A/ja
Publication of JP2018507254A5 publication Critical patent/JP2018507254A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2017558627A 2015-02-02 2016-01-27 抗代替軽鎖抗体 Pending JP2018507254A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562111018P 2015-02-02 2015-02-02
US62/111,018 2015-02-02
PCT/US2016/015166 WO2016126488A1 (en) 2015-02-02 2016-01-27 Anti-surrogate light chain antibodies

Publications (2)

Publication Number Publication Date
JP2018507254A true JP2018507254A (ja) 2018-03-15
JP2018507254A5 JP2018507254A5 (OSRAM) 2019-02-28

Family

ID=56564528

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017558627A Pending JP2018507254A (ja) 2015-02-02 2016-01-27 抗代替軽鎖抗体

Country Status (10)

Country Link
US (1) US10858448B2 (OSRAM)
EP (2) EP3253793A4 (OSRAM)
JP (1) JP2018507254A (OSRAM)
KR (1) KR102590740B1 (OSRAM)
CN (1) CN107849123A (OSRAM)
AU (1) AU2016215676B2 (OSRAM)
CA (2) CA2975346A1 (OSRAM)
HK (1) HK1247941A1 (OSRAM)
IL (1) IL253579A0 (OSRAM)
WO (1) WO2016126488A1 (OSRAM)

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EP3253793A4 (en) 2015-02-02 2018-11-14 i2 Pharmaceuticals, Inc. Anti-surrogate light chain antibodies
AU2016215110A1 (en) 2015-02-05 2017-09-21 Stc.Unm Anti-pre-BCR antagonists and methods
BR112019011277A2 (pt) 2016-12-02 2019-10-22 University Of Southern California polinucleotídeo, sistema de expressão recombinante, vetor, polipeptídeo, célula recombinante, polipeptídeo de receptor imune sintético isolado ou heterodímero de polipeptídeo, célula efetora imune ou célula-tronco, população de células imunes ou efetoras, métodos de fabricação de uma célula efetora imune que expressa sir, de geração de uma população de células modificadas por rna, de fornecimento de imunidade antidoença e de tratamento ou prevenção de uma doença, composição, uso ou método, kit, e, sequência de aminoácidos.
EP3917564A4 (en) * 2019-02-01 2022-12-21 NovaRock Biotherapeutics, Ltd. ANTI-CLAUDINE 18 ANTIBODIES AND THEIR METHODS OF USE
US12134655B2 (en) * 2019-04-30 2024-11-05 Absci Corporation Cancer associated antibody compositions and methods of use
CN112300282A (zh) * 2020-11-03 2021-02-02 南京北恒生物科技有限公司 靶向cd7的人源化抗体及其用途
IL305188A (en) * 2021-02-16 2023-10-01 Childrens Health Care D/B/A Childrens Minnesota Methods for treating B-ALL by administering a pre-BCR complex antagonist
WO2024077104A2 (en) * 2022-10-04 2024-04-11 Mink Therapeutics, Inc. Fibroblast activation protein (fap) car-invariant natural killer t cells and uses thereof
WO2025212740A1 (en) * 2024-04-03 2025-10-09 Mink Therapeutics, Inc. Composition and methods for treating colorectal cancer liver metastasis (crc liver mets)

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Also Published As

Publication number Publication date
CN107849123A (zh) 2018-03-27
AU2016215676A1 (en) 2017-08-10
HK1247941A1 (zh) 2018-10-05
US20180265594A1 (en) 2018-09-20
EP3253793A4 (en) 2018-11-14
CA2975346A1 (en) 2016-08-11
KR102590740B1 (ko) 2023-10-18
EP4177267A1 (en) 2023-05-10
IL253579A0 (en) 2017-09-28
CA3185253A1 (en) 2016-08-11
AU2016215676B2 (en) 2021-12-02
WO2016126488A1 (en) 2016-08-11
KR20170120120A (ko) 2017-10-30
US10858448B2 (en) 2020-12-08
EP3253793A1 (en) 2017-12-13

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