JP2018507198A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018507198A5 JP2018507198A5 JP2017541086A JP2017541086A JP2018507198A5 JP 2018507198 A5 JP2018507198 A5 JP 2018507198A5 JP 2017541086 A JP2017541086 A JP 2017541086A JP 2017541086 A JP2017541086 A JP 2017541086A JP 2018507198 A5 JP2018507198 A5 JP 2018507198A5
- Authority
- JP
- Japan
- Prior art keywords
- mof
- compound
- porous
- complex
- biguanide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 26
- 239000013354 porous framework Substances 0.000 claims 11
- 229940123208 Biguanide Drugs 0.000 claims 10
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims 8
- 239000002243 precursor Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- -1 but not limited to Inorganic materials 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 239000011148 porous material Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 4
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229960003260 chlorhexidine Drugs 0.000 claims 3
- 229960003405 ciprofloxacin Drugs 0.000 claims 3
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- 239000012867 bioactive agent Substances 0.000 claims 2
- 239000013626 chemical specie Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000536 complexating effect Effects 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 229960003883 furosemide Drugs 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 150000002466 imines Chemical class 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000003899 bactericide agent Substances 0.000 claims 1
- 230000000975 bioactive effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 229910052796 boron Inorganic materials 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000003581 cosmetic carrier Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 230000000855 fungicidal effect Effects 0.000 claims 1
- 239000000417 fungicide Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 125000005328 phosphinyl group Chemical group [PH2](=O)* 0.000 claims 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 1
- 150000003335 secondary amines Chemical class 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 230000003330 sporicidal effect Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 0 *N(*)N(N=O)O Chemical compound *N(*)N(N=O)O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1501779.1A GB201501779D0 (en) | 2015-02-03 | 2015-02-03 | NONOate compositions |
| GB1501779.1 | 2015-02-03 | ||
| GB1517841.1 | 2015-10-08 | ||
| GBGB1517841.1A GB201517841D0 (en) | 2015-10-08 | 2015-10-08 | NO containing compositions |
| PCT/GB2016/050183 WO2016124889A1 (en) | 2015-02-03 | 2016-01-28 | No containing compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018507198A JP2018507198A (ja) | 2018-03-15 |
| JP2018507198A5 true JP2018507198A5 (enExample) | 2019-03-07 |
| JP6983070B2 JP6983070B2 (ja) | 2021-12-17 |
Family
ID=55299666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017541086A Active JP6983070B2 (ja) | 2015-02-03 | 2016-01-28 | Ｎｏ含有組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10449215B2 (enExample) |
| EP (1) | EP3253485B1 (enExample) |
| JP (1) | JP6983070B2 (enExample) |
| KR (1) | KR102561737B1 (enExample) |
| CN (1) | CN107206351B (enExample) |
| CA (1) | CA2975573C (enExample) |
| DK (1) | DK3253485T3 (enExample) |
| GB (1) | GB2540643B (enExample) |
| WO (1) | WO2016124889A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3253485B1 (en) | 2015-02-03 | 2021-12-15 | University Court of The University of St Andrews | No containing compositions |
| CN110719783A (zh) * | 2017-06-06 | 2020-01-21 | 阿特密斯株式会社 | 药物组合物 |
| CN107349111B (zh) * | 2017-07-24 | 2020-09-08 | 南开大学 | 多孔框架材料在面膜中的应用 |
| JP7349156B2 (ja) * | 2017-12-21 | 2023-09-22 | エイチ アンド エー ファーマケム カンパニー，リミテッド | 金属有機構造体及びナノセルロースを用いた経皮送達用複合体 |
| US10717685B1 (en) * | 2018-04-20 | 2020-07-21 | The United States Of America As Represented By The Secretary Of The Army | Pyrotechnic smoke obscurants containing metal-organic frameworks and composites thereof |
| CN110433333B (zh) * | 2019-08-16 | 2022-07-01 | 上海师范大学 | 一种具有no和铜离子缓释协同作用的金属有机框架/电纺纤维复合材料及制备方法和应用 |
| WO2021118292A2 (ko) * | 2019-12-13 | 2021-06-17 | 서울대학교병원 | 금속-유기 골격체를 포함하는 상처 치유용 조성물 |
| CN113036138B (zh) * | 2021-03-09 | 2022-10-14 | 电子科技大学 | 一种三维多孔亲锂复合材料的制备方法及应用 |
| CN114225910B (zh) * | 2021-12-06 | 2023-08-11 | 桂林理工大学 | 一种具有NO吸附分离性能的胺基化改性Co-MOFs材料 |
| CN114470235B (zh) * | 2022-01-18 | 2023-05-30 | 山东大学 | 铋基金属有机框架材料在作为光控药物载体中的应用 |
| CN115504910B (zh) * | 2022-09-14 | 2024-06-18 | 国科温州研究院(温州生物材料与工程研究所) | 一种酸响应性释放的小分子醛类抗菌纳米颗粒及其制备方法和应用 |
| CN115945206B (zh) * | 2022-12-13 | 2024-05-31 | 华南理工大学 | 一种CrN-TiN NSs及其制备与应用 |
| WO2024186788A2 (en) * | 2023-03-07 | 2024-09-12 | Know Bio, Llc | High purity nitric oxide releasing compounds and methods of preparing same |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA967725A (en) | 1969-08-25 | 1975-05-20 | Thomas L. Mcdonald | Method of purifying gases containing oxides of nitrogen |
| DE2426683A1 (de) | 1974-06-01 | 1975-12-18 | Boehringer Mannheim Gmbh | Biguanide und verfahren zu deren herstellung |
| US4954526A (en) * | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
| US5650447A (en) | 1992-08-24 | 1997-07-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitric oxide-releasing polymers to treat restenosis and related disorders |
| US5453257A (en) * | 1992-10-14 | 1995-09-26 | Nalco Fuel Tech | Process for adjusting the optimum effluent temperature of a nitrogen oxides reducing treatment agent |
| US6706274B2 (en) | 2001-01-18 | 2004-03-16 | Scimed Life Systems, Inc. | Differential delivery of nitric oxide |
| WO2002088148A1 (en) | 2001-04-30 | 2002-11-07 | The Regents Of The University Of Michigan | Isoreticular metal-organic frameworks, process for forming the same, and systematic design of pore size and functionality therein,with application for gas storage |
| DK1648826T3 (en) | 2003-07-03 | 2017-12-04 | The Univ Court Of The Univ Of St Andrews | ZEOLITS FOR NITROGEN OXIDE ADMINISTRATION |
| CA2566873C (en) * | 2004-05-20 | 2013-02-12 | Diamedica Inc. | Use of drug combinations for treating insulin resistance |
| GB0616350D0 (en) * | 2006-08-17 | 2006-09-27 | Univ St Andrews | Adsorption and release of nitric oxide in metal organic frameworks |
| WO2008038302A2 (en) * | 2006-09-26 | 2008-04-03 | Jegannathan Srinivas | Therapeutic formulation comprising a sulfonylurea, metformin and a nitric oxide scavenger. |
| JP2010525005A (ja) * | 2007-04-25 | 2010-07-22 | ニコックス エス エイ | 疼痛および炎症を治療するための４−（ニトロオキシ）−ブチル−（ｓ）−２−（６−メトキシ−２−ナフチル）−プロパノエートの使用 |
| US8399005B2 (en) * | 2007-10-12 | 2013-03-19 | University Of North Carolina At Chapel Hill | Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents |
| WO2010044875A2 (en) * | 2008-10-16 | 2010-04-22 | Novan, Inc. | Nitric oxide releasing particles for oral care applications |
| ES2511049T3 (es) | 2009-03-20 | 2014-10-22 | Basf Se | Procedimiento para la separación de gases ácidos con ayuda de materiales de estructura organometálicos impregnados con aminas |
| US20110086234A1 (en) * | 2009-10-13 | 2011-04-14 | Nathan Stasko | Nitric oxide-releasing coatings |
| GB201013307D0 (en) | 2010-08-09 | 2010-09-22 | Univ St Andrews | Anti-microbial metal organic framework |
| WO2013040415A1 (en) * | 2011-09-16 | 2013-03-21 | The Trustees Of The University Of Pennsylvania | Rapid surface disinfection method and apparatus |
| WO2013186542A1 (en) * | 2012-06-11 | 2013-12-19 | University Court Of The University Of St Andrews | Synthesis of mofs |
| US8859781B2 (en) | 2012-07-12 | 2014-10-14 | Euclises Pharmaceuticals, Inc. | No-releasing nonoate(nitrogen-bound)sulfonamide-linked-coxib anti-cancer agents |
| CN104056599B (zh) | 2014-06-20 | 2016-04-13 | 浙江大学 | 一种复合二氧化碳吸附材料及其制备方法和应用 |
| CN104056598A (zh) | 2014-06-20 | 2014-09-24 | 浙江大学 | 一种MOFs基二氧化碳吸附剂及其制备方法和应用 |
| EP3253485B1 (en) | 2015-02-03 | 2021-12-15 | University Court of The University of St Andrews | No containing compositions |
-
2016
- 2016-01-28 EP EP16702772.1A patent/EP3253485B1/en active Active
- 2016-01-28 US US15/547,670 patent/US10449215B2/en active Active
- 2016-01-28 GB GB1601572.9A patent/GB2540643B/en active Active
- 2016-01-28 CA CA2975573A patent/CA2975573C/en active Active
- 2016-01-28 DK DK16702772.1T patent/DK3253485T3/da active
- 2016-01-28 JP JP2017541086A patent/JP6983070B2/ja active Active
- 2016-01-28 KR KR1020177024628A patent/KR102561737B1/ko active Active
- 2016-01-28 CN CN201680008392.3A patent/CN107206351B/zh active Active
- 2016-01-28 WO PCT/GB2016/050183 patent/WO2016124889A1/en not_active Ceased
-
2019
- 2019-09-12 US US16/568,560 patent/US11344571B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018507198A5 (enExample) | ||
| US11344571B2 (en) | NO containing compositions | |
| Lin et al. | A biocompatible metal–organic framework as a pH and temperature dual-responsive drug carrier | |
| ATE421322T1 (de) | Chinolin-2-on-derivate zur behandlung von erkankungen der atemwege | |
| Neufeld et al. | Water-stable metal–organic framework/polymer composites compatible with human hepatocytes | |
| JP2019014758A5 (enExample) | ||
| US20180155378A1 (en) | Antibacterial bismuth complexes | |
| CY1113890T1 (el) | Φαρμακευτικοι συνδυασμοι που περιεχουν βενζοξαζινες για τη θεραπεια νοσων των αναπνευστικων οδων | |
| JP2009504763A5 (enExample) | ||
| DE602004021363D1 (de) | Imidazotriazin verbindungen zur behandlung von krebserkrankungen | |
| PL424708A1 (pl) | Chiralne iminy bicykliczne oparte na trans-1,2-diaminocykloheksanie i sposób ich wytwarzania | |
| US11866455B2 (en) | Gold(III) complex, a conjugate of the gold(III) complex, a pharmaceutical composition comprising the gold(III) complex and uses and a process for preparing the gold(III) complex | |
| WO2020029591A1 (zh) | L-焦谷氨酸金属配合物及其制备方法和应用 | |
| AR127964A1 (es) | Sal novedosa de un derivado de 1-sulfonilpirrol, método de preparación de la misma y composición farmacéutica que comprende la misma | |
| CN104086597A (zh) | 以3-氧代-环丁烷-1,1-二羧酸根为配体的铂(ii)抗肿瘤化合物 | |
| JP2013521316A5 (enExample) | ||
| Melaiye | Synthesis and Antimicrobial Properties of Silver (I) N-Heterocyclic Carbene Complexes | |
| RU2605603C1 (ru) | N,n'-бис(3-бромпропионил)-n,n'-диметил-1,2-этилендиамин, способ его получения и применение его в качестве водорастворимого реагента, проявляющего противоопухолевые свойства | |
| Kung | Cyclometallated gold (III) complexes for organic synthesis and bioconjugation | |
| TH102896A (th) | สารเลียนแบบกลูโคคอร์ทิคอยด์, วิธีผลิตสารเหล่านั้น, สารผสมทางเภสัชกรรม, และการใช้สารเหล่านั้น | |
| TH92168B (th) | เฮทเทอโรเพนตะไซเคิล (heteropentacycles) ที่ว่องไวในฐานะสารยับยั้งไคเนส (kinase inhibitors) | |
| TH137882A (th) | อนุพันธ์พิแรโซโลพิริมิดีน | |
| TH79822A (th) | เกลืออะมิเนียมของ 1,2,3-ไทรอะโซล เป็นสารตั้งต้นของยาที่รวมถึงสารต้านไวรัส | |
| TH155337A (th) | เกลือฟีโนไธอะซีนไดอะมิเนียมและการใช้เกลือดังกล่าว phenothiazine diaminium salts and their use | |
| TH76787A (th) | สารประกอบเคมี |