JP2018505223A - 腫瘍免疫寛容を破綻させるためのｙａｐの阻害方法 - Google Patents

腫瘍免疫寛容を破綻させるためのｙａｐの阻害方法 Download PDF

Info

Publication number
JP2018505223A
JP2018505223A JP2017560891A JP2017560891A JP2018505223A JP 2018505223 A JP2018505223 A JP 2018505223A JP 2017560891 A JP2017560891 A JP 2017560891A JP 2017560891 A JP2017560891 A JP 2017560891A JP 2018505223 A JP2018505223 A JP 2018505223A
Authority
JP
Japan
Prior art keywords
yap
cells
cancer
cell
gvax
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017560891A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018505223A5 (https=
Inventor
ファン パン
ファン パン
デュオジア パン
デュオジア パン
ドリュー エム． パルドール
ドリュー エム． パルドール
ジョセフ バービ
ジョセフ バービ
ベンジャミン パーク
ベンジャミン パーク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of JP2018505223A publication Critical patent/JP2018505223A/ja
Publication of JP2018505223A5 publication Critical patent/JP2018505223A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2017560891A 2015-02-12 2016-02-12 腫瘍免疫寛容を破綻させるためのｙａｐの阻害方法 Pending JP2018505223A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562115414P 2015-02-12 2015-02-12
US62/115,414 2015-02-12
PCT/US2016/017697 WO2016130889A1 (en) 2015-02-12 2016-02-12 Inhibition of yap for breaking tumor immune tolerance

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020107702A Division JP7186196B2 (ja) 2015-02-12 2020-06-23 腫瘍免疫寛容を破綻させるためのｙａｐの阻害方法

Publications (2)

Publication Number Publication Date
JP2018505223A true JP2018505223A (ja) 2018-02-22
JP2018505223A5 JP2018505223A5 (https=) 2019-03-28

Family

ID=56615092

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017560891A Pending JP2018505223A (ja) 2015-02-12 2016-02-12 腫瘍免疫寛容を破綻させるためのｙａｐの阻害方法
JP2020107702A Active JP7186196B2 (ja) 2015-02-12 2020-06-23 腫瘍免疫寛容を破綻させるためのｙａｐの阻害方法
JP2022117957A Active JP7509830B2 (ja) 2015-02-12 2022-07-25 腫瘍免疫寛容を破綻させるためのｙａｐの阻害方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020107702A Active JP7186196B2 (ja) 2015-02-12 2020-06-23 腫瘍免疫寛容を破綻させるためのｙａｐの阻害方法
JP2022117957A Active JP7509830B2 (ja) 2015-02-12 2022-07-25 腫瘍免疫寛容を破綻させるためのｙａｐの阻害方法

Country Status (7)

Country Link
US (1) US11491139B2 (https=)
EP (1) EP3256123B1 (https=)
JP (3) JP2018505223A (https=)
CN (1) CN107635582B (https=)
AU (2) AU2016219161A1 (https=)
CA (1) CA2976377A1 (https=)
WO (1) WO2016130889A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021181415A (ja) * 2020-05-19 2021-11-25 国立大学法人鳥取大学 胆道がん治療薬
JP2023549674A (ja) * 2020-10-28 2023-11-29 ベイラー カレッジ オブ メディスン 癌の処置用の免疫調節治療薬としての免疫細胞におけるｓｒｃ－３の標的化

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170085619A (ko) * 2016-01-14 2017-07-25 연세대학교 산학협력단 Alk 저해제에 대한 내성을 획득한 eml4-alk 양성 비소세포폐암의 치료를 위한 스타틴계 약물의 용도
US10925869B2 (en) 2016-05-26 2021-02-23 University of Pittsburgh—of the Commonwealth System of Higher Education Compositions and methods for treating pulmonary vascular disease
WO2018085275A1 (en) * 2016-11-02 2018-05-11 The Regents Of The University Of California Targeting lats1/2 and the hippo intracellular signaling pathway for cancer immunotherapy
JP6886278B2 (ja) * 2016-12-01 2021-06-16 学校法人慶應義塾 抗癌剤
WO2018119418A1 (en) * 2016-12-24 2018-06-28 Nivien Therapeutics Company Methods relating to the treatment of chemoresistant and immuno-resistant cancer
WO2018132516A1 (en) * 2017-01-10 2018-07-19 Nodus Therapeutics Combination tumor treatment with an integrin-binding-fc fusion protein and immune modulator
US20200276125A1 (en) * 2017-11-22 2020-09-03 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Compositions and methods for administering a yap1/wwrt1 inhibiting composition and a gls1 inhibiting composition
US11360080B2 (en) * 2018-08-17 2022-06-14 National Health Research Institutes AhR-ROR-γt complex as a biomarker and therapeutic target for autoimmune disease and IL-17A-associated disease
SG11202107399WA (en) * 2019-01-31 2021-08-30 Ionis Pharmaceuticals Inc Modulators of yap1 expression
US20200323905A1 (en) * 2019-04-15 2020-10-15 Trustees Of Boston University Methods and compositions for modulating the immune system
US20210338265A1 (en) * 2020-04-30 2021-11-04 Ethicon, Inc. Methods and devices for delivering cancer therapy to a target tissue site via a cored tissue cavity
CN113456633A (zh) * 2021-06-11 2021-10-01 广西医科大学 红海海绵素a在制备抗肺癌侵袭转移药物中的应用
CN118105483B (zh) * 2024-02-02 2025-03-11 济宁医学院附属医院 Ox40激活抗体和抗血管生成剂在制备抗肿瘤药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011017809A1 (en) * 2009-08-11 2011-02-17 The University Of British Columbia Autophagy inhibitor compounds, compositions and methods for the use thereof in the treatment of cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0605685D0 (en) * 2006-03-21 2006-05-03 Lytix Biopharma As Inhibition of tumour growth
ES2350687T3 (es) 2002-07-03 2011-01-26 Ono Pharmaceutical Co., Ltd. Composiciones de inmunopotenciación.
US20040110731A1 (en) * 2002-12-04 2004-06-10 Chan Agnes H. Photodynamic therapy for the treatment of non-melanoma skin cancer
US20090304711A1 (en) * 2006-09-20 2009-12-10 Drew Pardoll Combinatorial Therapy of Cancer and Infectious Diseases with Anti-B7-H1 Antibodies
KR101050829B1 (ko) * 2008-10-02 2011-07-20 서울대학교산학협력단 항 ｐｄ-1 항체 또는 항 ｐｄ-ｌ1 항체를 포함하는 항암제
EP2858635A1 (en) * 2012-06-11 2015-04-15 The Regents of The University of California Inhibitors of hippo-yap signaling pathway

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011017809A1 (en) * 2009-08-11 2011-02-17 The University Of British Columbia Autophagy inhibitor compounds, compositions and methods for the use thereof in the treatment of cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
日本内科学会雑誌, (2014), 103, [6], P.1330-1336, JPN6019050356, ISSN: 0004324137 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021181415A (ja) * 2020-05-19 2021-11-25 国立大学法人鳥取大学 胆道がん治療薬
JP7514508B2 (ja) 2020-05-19 2024-07-11 国立大学法人鳥取大学 胆道がん治療薬
JP2023549674A (ja) * 2020-10-28 2023-11-29 ベイラー カレッジ オブ メディスン 癌の処置用の免疫調節治療薬としての免疫細胞におけるｓｒｃ－３の標的化

Also Published As

Publication number Publication date
AU2021203851A1 (en) 2021-07-22
WO2016130889A1 (en) 2016-08-18
JP7186196B2 (ja) 2022-12-08
JP2022136162A (ja) 2022-09-15
CA2976377A1 (en) 2016-08-18
CN107635582A (zh) 2018-01-26
CN107635582B (zh) 2022-08-02
EP3256123A1 (en) 2017-12-20
AU2016219161A1 (en) 2017-08-31
US20180021306A1 (en) 2018-01-25
US11491139B2 (en) 2022-11-08
JP2020164539A (ja) 2020-10-08
JP7509830B2 (ja) 2024-07-02
AU2021203851B2 (en) 2023-08-31
EP3256123A4 (en) 2019-02-13
EP3256123B1 (en) 2023-06-07

Similar Documents

Publication Publication Date Title
JP7509830B2 (ja) 腫瘍免疫寛容を破綻させるためのｙａｐの阻害方法
US11219645B2 (en) Tumor infiltrating lymphocytes for treatment of cancer
US12312398B2 (en) Compositions and methods for targeting activin signaling to treat cancer
ES2777227T3 (es) CD33 soluble para tratar síndromes mielodisplásicos (MDS)
JP2021520208A (ja) Ｈｈｌａ２受容体としてのｋｉｒ３ｄｌ３、抗ｈｈｌａ２抗体、およびその使用
KR102646708B1 (ko) T 세포 반응을 촉진하는 방법
US20180044422A1 (en) Treating solid tumor by targeting dectin-1 signaling
WO2020146345A1 (en) Methods of treating cancer using lsd1 inhibitors and/or tgf-beta inhibitors in combination with immunotherapy
KR20190028664A (ko) 암의 치료를 위한 면역 체크포인트 억제제와 세포독성 t 세포
WO2014038682A2 (en) Cancer diagnostic and therapeutic method targeting molecules expressed in cancer stem cells
EP3402508A1 (en) Methods and compositions for modulating thymic function
US10722523B2 (en) Chemoimmunotherapy for epithelial cancer
JP2021523098A (ja) Ｔ細胞による認識を強化するよう抗原性を調節する方法
US20250144107A1 (en) Use of a pikfyve inhibitor in combination with immunotherapy
Schlichtner Fundamental immunosuppressive pathway determining ability of cancer and embryonic cells to escape cytotoxic immune attack
EP4531891A2 (en) Activin signaling activity
CN120265755A (zh) 用于疾病治疗的t细胞-nk细胞相互作用抑制剂
EA041126B1 (ru) Антитела и полипептиды, направленные против cd127

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170929

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190212

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190212

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20191223

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200319

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20200813