JP2018505163A5 - - Google Patents

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JP2018505163A5
JP2018505163A5 JP2017538332A JP2017538332A JP2018505163A5 JP 2018505163 A5 JP2018505163 A5 JP 2018505163A5 JP 2017538332 A JP2017538332 A JP 2017538332A JP 2017538332 A JP2017538332 A JP 2017538332A JP 2018505163 A5 JP2018505163 A5 JP 2018505163A5
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JP
Japan
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acid
lower alkyl
treat
chor
compound
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JP2017538332A
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Japanese (ja)
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JP6826038B2 (ja
JP2018505163A (ja
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Priority claimed from PCT/US2016/015353 external-priority patent/WO2016123335A1/en
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Publication of JP2018505163A5 publication Critical patent/JP2018505163A5/ja
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Expired - Fee Related legal-status Critical Current
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JP2017538332A 2015-01-30 2016-01-28 新規モノチオール粘液溶解剤 Expired - Fee Related JP6826038B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562109999P 2015-01-30 2015-01-30
US62/109,999 2015-01-30
PCT/US2016/015353 WO2016123335A1 (en) 2015-01-30 2016-01-28 Novel monothiol mucolytic agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020168248A Division JP7112464B2 (ja) 2015-01-30 2020-10-05 新規モノチオール粘液溶解剤

Publications (3)

Publication Number Publication Date
JP2018505163A JP2018505163A (ja) 2018-02-22
JP2018505163A5 true JP2018505163A5 (cg-RX-API-DMAC7.html) 2019-02-28
JP6826038B2 JP6826038B2 (ja) 2021-02-03

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ID=56544326

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JP2017538332A Expired - Fee Related JP6826038B2 (ja) 2015-01-30 2016-01-28 新規モノチオール粘液溶解剤
JP2020168248A Active JP7112464B2 (ja) 2015-01-30 2020-10-05 新規モノチオール粘液溶解剤

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JP2020168248A Active JP7112464B2 (ja) 2015-01-30 2020-10-05 新規モノチオール粘液溶解剤

Country Status (13)

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US (2) US10106551B2 (cg-RX-API-DMAC7.html)
EP (1) EP3250548A4 (cg-RX-API-DMAC7.html)
JP (2) JP6826038B2 (cg-RX-API-DMAC7.html)
KR (1) KR20170108088A (cg-RX-API-DMAC7.html)
CN (2) CN112321472A (cg-RX-API-DMAC7.html)
AU (1) AU2016211440B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017016067A2 (cg-RX-API-DMAC7.html)
CA (1) CA2974210A1 (cg-RX-API-DMAC7.html)
IL (1) IL253501B (cg-RX-API-DMAC7.html)
MX (1) MX387071B (cg-RX-API-DMAC7.html)
SG (1) SG11201705790SA (cg-RX-API-DMAC7.html)
WO (1) WO2016123335A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201705122B (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105228605B (zh) 2013-03-14 2022-08-12 加利福尼亚大学董事会 硫代糖粘液溶解剂
HK1223561A1 (zh) 2013-08-23 2017-08-04 帕里昂科学公司 二巯基化物类粘液溶解剂
MX387071B (es) 2015-01-30 2025-03-19 Parion Sciences Inc Agentes mucolíticos de monotiol novedosos
AU2016255851A1 (en) 2015-04-30 2017-12-14 Parion Sciences, Inc. Novel prodrugs of dithiol mucolytic agents
CN118271374A (zh) 2018-09-10 2024-07-02 加利福尼亚大学董事会 二硫醇糖粘液溶解剂和其用途
EP3797783A1 (en) 2019-09-27 2021-03-31 Freie Universität Berlin Novel medical uses of thiol-functionalized polyglycerol derivatives
CN112758902B (zh) * 2021-01-06 2022-01-28 西南科技大学 用于高效析氧反应的优化电子构型Co4N纳米片的制备方法

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639635A (en) 1969-02-11 1972-02-01 Riker Laboratories Inc Process for the liquefaction of mucus
US3663690A (en) 1969-08-12 1972-05-16 Hoechst Co American Mucolytic composition and method of treatment of broncho-pulmonary disorders therewith
FR2155776B1 (cg-RX-API-DMAC7.html) 1971-10-04 1974-11-15 Rech Pharmaceut Scient
BE789811A (fr) * 1971-10-07 1973-04-06 Bristol Myers Co 1,4-bis-acylpiperazines
FR2434149A1 (fr) * 1978-06-22 1980-03-21 Parcor Nouveaux derives de la l-cysteine
JPH01226866A (ja) * 1988-03-08 1989-09-11 Wako Pure Chem Ind Ltd メルカプトメチル化方法
FR2685323B1 (fr) * 1991-12-19 1994-04-08 Rhone Poulenc Chimie Mercaptomethylbenzylamines et leur utilisation dans la synthese de bisphenols.
US20010037037A1 (en) 1995-10-31 2001-11-01 Kurt Dietliker Oximesulfonic acid esters and the use thereof as latent sulfonic acids
JP2002012583A (ja) * 2000-04-28 2002-01-15 Sumitomo Chem Co Ltd アミン誘導体の製造方法
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
WO2003075832A2 (en) 2002-03-06 2003-09-18 Duke University Methods and composition based on discovery of metabolism of nitroclycerin
DE60302454T2 (de) 2002-04-19 2006-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Beta-agonisten-verbindungen mit stickoxid-donatoren-gruppen und reaktionsfähige sauerstoffspezies-fängergruppen und ihre verwendung bei der behandlung von atemwegsstörungen
MY141521A (en) * 2002-12-12 2010-05-14 Hoffmann La Roche 5-substituted-six-membered heteroaromatic glucokinase activators
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
CA2534568A1 (en) 2003-08-18 2005-03-24 Parion Sciences, Inc. Aliphatic pyrazinoylguanidine sodium channel blockers
JP4805824B2 (ja) 2003-08-18 2011-11-02 パリオン・サイエンシィズ・インコーポレーテッド キャップ化ピラジノイルグアニジンナトリウムチャネルブロッカー
US20050090505A1 (en) 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
JP2007502829A (ja) 2003-08-18 2007-02-15 パリオン・サイエンシィズ・インコーポレーテッド 環状ピラジノイルグアニジンナトリウムチャネルブロッカー
US20090253714A1 (en) 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20050059639A1 (en) 2003-09-11 2005-03-17 Wei Edward T. Ophthalmic compositions and method for treating eye discomfort and pain
WO2005094269A2 (en) 2004-03-24 2005-10-13 National Jewish Medical And Research Center Mucolytic and anti-elastase compounds and methods of use thereof
WO2006023573A2 (en) 2004-08-18 2006-03-02 Johnson Michael R Aliphatic amide & ester pyrazinoylguanidine sodium channel blockers
US20090324724A1 (en) 2004-08-18 2009-12-31 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
JP2008510708A (ja) 2004-08-18 2008-04-10 マイケル・アール・ジョンソン 環式アミド及びエステルピラジノイルグアニジンナトリウムチャネル遮断薬
US7399766B2 (en) 2004-08-18 2008-07-15 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
US7807834B2 (en) 2005-08-03 2010-10-05 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US20090192227A1 (en) 2005-08-24 2009-07-30 Rabindra Tirouvanziam N-Acetylcysteine Compositions and Methods for Treating Acute Exacerbations of Inflammatory Lung Disease
EP2007358A4 (en) 2006-04-04 2012-01-25 Stc Unm INFLATING PARTICLES FOR THE ADMINISTRATION OF A MEDICINAL PRODUCT
CA2650035C (en) 2006-04-27 2015-02-03 Intezyne Technologies, Inc. Poly (ethylene glycol) containing chemically disparate endgroups
SI2035004T1 (sl) 2006-06-09 2012-12-31 Parion Sciences, Inc. S fenilom substituirani pirazinoilgvanidinski blokatorji natrijevih kanalov, ki imajo beta-agonistiäśno aktivnost
CA2653757A1 (en) 2006-06-09 2007-12-21 Parion Sciences, Inc. Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity
WO2007146870A1 (en) 2006-06-09 2007-12-21 Parion Sciences, Inc. Cyclic substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity
AU2007294547A1 (en) 2006-09-07 2008-03-13 Parion Sciences, Inc. Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
US7981898B2 (en) 2006-09-07 2011-07-19 Parion Sciences, Inc. Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
CN101534813A (zh) * 2006-09-07 2009-09-16 帕里昂科学公司 通过使用钠通道阻断剂和渗透调节剂的治疗来增加粘膜水化和粘液清除的方法
US20080131500A1 (en) 2006-12-04 2008-06-05 The Board Of Regents Of The University Of Texas System Methods and compositions for rapid inactivation of proteins
WO2008124496A1 (en) 2007-04-03 2008-10-16 Parion Sciences, Inc. Method of treating acid-sensing ion channel mediated pain, cough, and central nervous system disorders
WO2008124491A1 (en) 2007-04-03 2008-10-16 Parion Sciences, Inc. Pyrazinoylguanidine compounds for use taste modulators
WO2009049159A1 (en) 2007-10-10 2009-04-16 Parion Sciences, Inc. Delivering osmolytes by nasal cannula
WO2009078782A1 (en) 2007-12-19 2009-06-25 Pharmalundensis Ab Method and means for producing bronchorelaxation
WO2009076792A1 (en) 2007-12-19 2009-06-25 Givaudan Sa Cooling compounds
ES2485642T3 (es) 2008-02-26 2014-08-14 Parion Sciences, Inc. Bloqueantes poli-aromáticos de los canales de sodio
US20100074881A1 (en) 2008-07-11 2010-03-25 Parion Sciences, Inc. Multiple nebulizer systems
US10117906B2 (en) 2009-01-09 2018-11-06 The Schepens Eye Research Institute, Inc. Methods for reducing corneal nerves damage, corneal lymphangiogenesis or immunity to corneal antigens in dry-eye associated ocular surface diseases by IL-1Ra
EP2210936A1 (en) 2009-01-27 2010-07-28 Curetis AG Processing and analysis of viscous liquid biological samples
EP2428582B1 (en) 2010-09-14 2013-09-04 miacom Diagnostics GmbH Clearance buffer
BR112013007160A2 (pt) 2010-09-29 2016-06-14 Philogen Spa ligante tiazolidina para a conjugação de fármacos a anticorpos
CA2839709C (en) 2011-06-27 2020-01-14 Parion Sciences, Inc. A chemically and metabolically stable dipeptide possessing potent sodium channel blocker activity
AR086745A1 (es) * 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
PT2855435T (pt) 2012-05-29 2018-07-03 Parion Sciences Inc Aminoamidas do tipo dendrímeros possuindo atividade bloqueadora de canais de sódio para o tratamento do olho seco e outras doenças das mucosas
US20150307530A1 (en) 2012-08-31 2015-10-29 Parion Sciences, Inc. Novel mucolytic agents
EP2925719A4 (en) 2012-11-28 2016-07-13 Yansong Lu Novel Synthetic Antioxidants And Their Uses
UA120343C2 (uk) 2012-12-17 2019-11-25 Періон Сайєнсіз, Інк. Похідні хлорпіразинкарбоксаміду, які мають активність блокування епітеліальних натрієвих каналів
CN108658876A (zh) 2012-12-17 2018-10-16 帕里昂科学公司 3,5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物
HK1223561A1 (zh) 2013-08-23 2017-08-04 帕里昂科学公司 二巯基化物类粘液溶解剂
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
CN104078680B (zh) 2014-05-23 2015-09-09 南京中储新能源有限公司 一种碳硫复合正极及二次铝硫电池
US20150376145A1 (en) 2014-06-30 2015-12-31 Parion Sciences, Inc. Stable sodium channel blockers
FR3024801A1 (fr) 2014-08-08 2016-02-12 Commissariat Energie Atomique Materiau d'electrode positive a base d'un materiau carbone specifique fonctionnalise par des composes organiques specifiques
MX387071B (es) 2015-01-30 2025-03-19 Parion Sciences Inc Agentes mucolíticos de monotiol novedosos
AU2016255851A1 (en) 2015-04-30 2017-12-14 Parion Sciences, Inc. Novel prodrugs of dithiol mucolytic agents

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