JP2018504420A - 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 - Google Patents
静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 Download PDFInfo
- Publication number
- JP2018504420A JP2018504420A JP2017540743A JP2017540743A JP2018504420A JP 2018504420 A JP2018504420 A JP 2018504420A JP 2017540743 A JP2017540743 A JP 2017540743A JP 2017540743 A JP2017540743 A JP 2017540743A JP 2018504420 A JP2018504420 A JP 2018504420A
- Authority
- JP
- Japan
- Prior art keywords
- ganaxolone
- formulation
- cyclodextrin
- patient
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021110619A JP7273897B2 (ja) | 2015-02-06 | 2021-07-02 | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
| JP2023042531A JP7566961B2 (ja) | 2015-02-06 | 2023-03-17 | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
| JP2024173821A JP2024178469A (ja) | 2015-02-06 | 2024-10-02 | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562112943P | 2015-02-06 | 2015-02-06 | |
| US62/112,943 | 2015-02-06 | ||
| PCT/US2016/016977 WO2016127170A1 (en) | 2015-02-06 | 2016-02-08 | Intravenous ganaxolone formulations and their use in treating status epilepticus and other seizure disorders |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021110619A Division JP7273897B2 (ja) | 2015-02-06 | 2021-07-02 | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
| JP2023042531A Division JP7566961B2 (ja) | 2015-02-06 | 2023-03-17 | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018504420A true JP2018504420A (ja) | 2018-02-15 |
| JP2018504420A5 JP2018504420A5 (enExample) | 2019-03-14 |
Family
ID=56564813
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540743A Pending JP2018504420A (ja) | 2015-02-06 | 2016-02-08 | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
| JP2021110619A Active JP7273897B2 (ja) | 2015-02-06 | 2021-07-02 | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
| JP2023042531A Active JP7566961B2 (ja) | 2015-02-06 | 2023-03-17 | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
| JP2024173821A Withdrawn JP2024178469A (ja) | 2015-02-06 | 2024-10-02 | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021110619A Active JP7273897B2 (ja) | 2015-02-06 | 2021-07-02 | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
| JP2023042531A Active JP7566961B2 (ja) | 2015-02-06 | 2023-03-17 | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
| JP2024173821A Withdrawn JP2024178469A (ja) | 2015-02-06 | 2024-10-02 | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20160228454A1 (enExample) |
| EP (2) | EP3253418A1 (enExample) |
| JP (4) | JP2018504420A (enExample) |
| CN (3) | CN115487313A (enExample) |
| AU (1) | AU2016214996B2 (enExample) |
| CA (2) | CA3254865A1 (enExample) |
| IL (2) | IL302203A (enExample) |
| WO (1) | WO2016127170A1 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021155457A (ja) * | 2015-02-06 | 2021-10-07 | マリナス ファーマシューティカルズ インコーポレイテッド | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
| JP2022510947A (ja) * | 2018-12-14 | 2022-01-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | １，２－ジヒドロピリジン化合物の水性医薬製剤 |
| JP2022521446A (ja) * | 2019-02-25 | 2022-04-07 | ゾゲニクス インターナショナル リミテッド | 発作制御を改善するための製剤 |
| JP2022530793A (ja) * | 2019-04-29 | 2022-07-01 | マーシュ・アンド・ワン・メディカル・システムズ，エルエルシー | 発作制御組成物およびその使用方法 |
| JP2022543837A (ja) * | 2019-08-05 | 2022-10-14 | マリナス ファーマシューティカルズ， インコーポレイテッド | てんかん重積状態の治療に使用するためのガナキソロン |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT202000008T1 (it) | 2012-01-23 | 2020-03-13 | Sage Therapeutics Inc | Formulazione di steroide neuroattivo comprendente un complesso di allopregnanolone e solfobutil eter beta-ciclodestrina |
| PL2887944T3 (pl) | 2012-08-21 | 2022-02-21 | Sage Therapeutics, Inc. | Allopregnanolon do leczenia lekoopornego stanu padaczkowego |
| US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| AR105044A1 (es) * | 2015-06-18 | 2017-08-30 | Sage Therapeutics Inc | Soluciones de esteroides neuroactivos y sus métodos de uso, recipiente |
| AU2016338672A1 (en) | 2015-10-16 | 2018-04-12 | Marinus Pharmaceuticals, Inc. | Injectable neurosteroid formulations containing nanoparticles |
| JP2019507111A (ja) | 2015-12-22 | 2019-03-14 | ゾゲニクス インターナショナル リミテッド | 代謝抵抗性フェンフルラミン類縁体およびその使用法 |
| EP3800177B1 (en) | 2015-12-22 | 2025-01-29 | Zogenix International Limited | Fenfluramine compositions and methods of preparing the same |
| RU2766155C2 (ru) | 2016-03-08 | 2022-02-08 | Сейдж Терапьютикс, Инк. | Нейроактивные стероиды, их композиции и применения |
| EP4233861A3 (en) | 2016-08-11 | 2023-10-11 | Ovid Therapeutics, Inc. | Compositions for treatment of essential tremor |
| RU2021106383A (ru) | 2016-08-24 | 2021-04-05 | Зодженикс Интернэшнл Лимитед | Состав для ингибирования образования агонистов 5-ht2b и способы его применения |
| US10391105B2 (en) | 2016-09-09 | 2019-08-27 | Marinus Pharmaceuticals Inc. | Methods of treating certain depressive disorders and delirium tremens |
| BR112019007448A2 (pt) * | 2016-10-14 | 2019-07-16 | Marinus Pharmaceuticals Inc | método de administrar um neuroesteróide para provocar surto- supressão eletroencefalográfica (eeg) |
| JP2019535760A (ja) * | 2016-11-22 | 2019-12-12 | オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | フルピルチンを用いた発達障害および／または発作性障害の処置方法 |
| US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
| US20190160078A1 (en) * | 2017-11-10 | 2019-05-30 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in treating genetic epileptic disorders |
| CN108535398B (zh) * | 2018-04-04 | 2020-03-27 | 福州海王福药制药有限公司 | 一种采用反相高效液相色谱法分离盐酸噻加宾手性对映体的方法 |
| WO2019216919A1 (en) | 2018-05-11 | 2019-11-14 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
| EP3806835A1 (en) | 2018-06-14 | 2021-04-21 | Zogenix International Limited | Compositions and methods for treating respiratory depression with fenfluramine |
| WO2020097045A1 (en) * | 2018-11-05 | 2020-05-14 | Ovid Therapeutics Inc. | Use of gaboxadol, ganaxolone and allopregnanolone to treat movement disorders |
| EA202191079A1 (ru) | 2018-11-19 | 2021-09-20 | Зодженикс Интернэшнл Лимитед | Способы лечения синдрома ретта с применением фенфлурамина |
| US11266662B2 (en) | 2018-12-07 | 2022-03-08 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in prophylaxis and treatment of postpartum depression |
| WO2020157257A1 (en) * | 2019-02-01 | 2020-08-06 | H. Lundbeck A/S | Injectable carbamazepine composition essentially free of 10-br-carbamazepine |
| US10959962B2 (en) * | 2019-02-15 | 2021-03-30 | Saol International Development Ltd. | Injectable phenol formulations and methods of their use |
| US20210260074A1 (en) * | 2019-04-29 | 2021-08-26 | Marsh and Wang Medical Systems, LLC | Seizure control compositions and methods of using same |
| CA3138901A1 (en) | 2019-05-10 | 2020-11-19 | Brii Biosciences, Inc. | Pharmaceutical composition containing brexanolone, ganaxolone, or zuranolone, and use thereof |
| CN114828889B (zh) | 2019-12-06 | 2025-02-14 | 马瑞纳斯制药公司 | 用于治疗结节性硬化症的加奈索酮 |
| US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| WO2022109440A1 (en) * | 2020-11-23 | 2022-05-27 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in treatment of super refractory status epilepticus |
| WO2022125408A1 (en) * | 2020-12-07 | 2022-06-16 | Marinus Pharmaceuticals, Inc | Use of ganaxolone in treating an epilepsy disorder |
| WO2023060020A1 (en) * | 2021-10-04 | 2023-04-13 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in treatment of established status epilepticus |
| CN114272216B (zh) * | 2021-10-11 | 2023-07-04 | 浙江歌文达生物医药科技有限公司 | 一种2-氧代-1-吡咯烷衍生物的冻干制剂及其制备 |
| CN116769070B (zh) * | 2023-06-07 | 2025-07-01 | 浙江工业大学 | 一种功能化磁性纳米颗粒及作为手性萃取剂在液-液萃取拆分手性化合物中的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009524582A (ja) * | 2005-11-28 | 2009-07-02 | マリナス ファーマシューティカルズ | ガナキソロン製剤、およびその作製方法、およびその使用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| US8697678B2 (en) * | 2010-01-21 | 2014-04-15 | Drawbridge Pharmaceuticals Pty Ltd | Anaesthetic formulation |
| PL2887944T3 (pl) * | 2012-08-21 | 2022-02-21 | Sage Therapeutics, Inc. | Allopregnanolon do leczenia lekoopornego stanu padaczkowego |
| ES2973320T3 (es) * | 2012-11-30 | 2024-06-19 | Univ California | Alopregnanolona para tratar, reducir o mitigar los síntomas de la depresión posparto |
| JOP20200195A1 (ar) * | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| CA3254865A1 (en) * | 2015-02-06 | 2025-05-28 | Marinus Pharmaceuticals, Inc. | Intravenous ganaxolone formulations and their use in treating status epilepticus and other seizure disorders |
| US10391105B2 (en) * | 2016-09-09 | 2019-08-27 | Marinus Pharmaceuticals Inc. | Methods of treating certain depressive disorders and delirium tremens |
-
2016
- 2016-02-08 CA CA3254865A patent/CA3254865A1/en active Pending
- 2016-02-08 EP EP16706109.2A patent/EP3253418A1/en not_active Withdrawn
- 2016-02-08 CN CN202211152228.3A patent/CN115487313A/zh active Pending
- 2016-02-08 IL IL302203A patent/IL302203A/en unknown
- 2016-02-08 CN CN201680008938.5A patent/CN107427458A/zh active Pending
- 2016-02-08 US US15/018,258 patent/US20160228454A1/en not_active Abandoned
- 2016-02-08 CA CA2973140A patent/CA2973140C/en active Active
- 2016-02-08 EP EP22152108.1A patent/EP4059522A1/en active Pending
- 2016-02-08 IL IL252848A patent/IL252848B2/en unknown
- 2016-02-08 CN CN202211150855.3A patent/CN115381772A/zh active Pending
- 2016-02-08 JP JP2017540743A patent/JP2018504420A/ja active Pending
- 2016-02-08 WO PCT/US2016/016977 patent/WO2016127170A1/en not_active Ceased
- 2016-02-08 AU AU2016214996A patent/AU2016214996B2/en active Active
-
2021
- 2021-07-02 JP JP2021110619A patent/JP7273897B2/ja active Active
-
2023
- 2023-03-17 JP JP2023042531A patent/JP7566961B2/ja active Active
- 2023-03-28 US US18/191,445 patent/US20230293549A1/en not_active Abandoned
- 2023-09-21 US US18/472,048 patent/US20240016817A1/en not_active Abandoned
-
2024
- 2024-10-02 JP JP2024173821A patent/JP2024178469A/ja not_active Withdrawn
- 2024-12-20 US US18/989,280 patent/US20250325562A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009524582A (ja) * | 2005-11-28 | 2009-07-02 | マリナス ファーマシューティカルズ | ガナキソロン製剤、およびその作製方法、およびその使用 |
Non-Patent Citations (2)
| Title |
|---|
| "Marinus Pharmaceuticals, Inc. Enters Into Use Agreement With CyDex Pharmaceuticals, Inc. for Use of", [ONLINE], vol. [2019年10月24日検索], JPN6019042058, 12 August 2014 (2014-08-12), pages インターネット, ISSN: 0004600653 * |
| 堀岡正義ほか監修, 注射剤−その基礎と調剤と適用−, JPN6019042059, 1995, pages 20 - 25, ISSN: 0004600654 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021155457A (ja) * | 2015-02-06 | 2021-10-07 | マリナス ファーマシューティカルズ インコーポレイテッド | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 |
| JP2022510947A (ja) * | 2018-12-14 | 2022-01-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | １，２－ジヒドロピリジン化合物の水性医薬製剤 |
| JP7177937B2 (ja) | 2018-12-14 | 2022-11-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | １，２－ジヒドロピリジン化合物の水性医薬製剤 |
| JP2022521446A (ja) * | 2019-02-25 | 2022-04-07 | ゾゲニクス インターナショナル リミテッド | 発作制御を改善するための製剤 |
| JP2022530793A (ja) * | 2019-04-29 | 2022-07-01 | マーシュ・アンド・ワン・メディカル・システムズ，エルエルシー | 発作制御組成物およびその使用方法 |
| JP7661238B2 (ja) | 2019-04-29 | 2025-04-14 | マーシュ・アンド・ワン・メディカル・システムズ，エルエルシー | 発作制御組成物およびその使用方法 |
| JP2022543837A (ja) * | 2019-08-05 | 2022-10-14 | マリナス ファーマシューティカルズ， インコーポレイテッド | てんかん重積状態の治療に使用するためのガナキソロン |
| JP7754799B2 (ja) | 2019-08-05 | 2025-10-15 | マリナス ファーマシューティカルズ， インコーポレイテッド | てんかん重積状態の治療に使用するためのガナキソロン |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107427458A (zh) | 2017-12-01 |
| JP7566961B2 (ja) | 2024-10-15 |
| US20160228454A1 (en) | 2016-08-11 |
| CN115487313A (zh) | 2022-12-20 |
| US20230293549A1 (en) | 2023-09-21 |
| JP2023078301A (ja) | 2023-06-06 |
| US20240016817A1 (en) | 2024-01-18 |
| CA2973140A1 (en) | 2016-08-11 |
| CN115381772A (zh) | 2022-11-25 |
| US20250325562A1 (en) | 2025-10-23 |
| IL252848B2 (en) | 2024-07-01 |
| JP7273897B2 (ja) | 2023-05-15 |
| IL252848B1 (en) | 2024-03-01 |
| AU2016214996A1 (en) | 2017-06-29 |
| CA3254865A1 (en) | 2025-05-28 |
| EP4059522A1 (en) | 2022-09-21 |
| WO2016127170A1 (en) | 2016-08-11 |
| EP3253418A1 (en) | 2017-12-13 |
| JP2024178469A (ja) | 2024-12-24 |
| JP2021155457A (ja) | 2021-10-07 |
| CA2973140C (en) | 2025-09-16 |
| IL252848A0 (en) | 2017-08-31 |
| IL302203A (en) | 2023-06-01 |
| AU2016214996B2 (en) | 2021-03-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7566961B2 (ja) | 静注用ガナキソロン製剤ならびにてんかん重積状態および他の発作性障害の治療におけるその使用 | |
| US20210128583A1 (en) | Injectable neurosteroid formulations containing nanoparticles | |
| KR101747476B1 (ko) | 마취 제제 | |
| JP3274687B2 (ja) | ９−ヒドロキシリスペリドン脂肪酸エステルの水性懸濁物 | |
| KR100882378B1 (ko) | 허용가능한 혈청 테스토스테론 수준의 신뢰성 있는 달성을위한 방법 및 제약 조성물 | |
| JP2008044951A (ja) | 鼻内投与用フェンタニル組成物 | |
| JP2004506698A (ja) | ヒトに用いるためのテストステロンエステル製剤 | |
| WO2014066442A2 (en) | Methods of managing childhood cerebral injury | |
| JP2006509758A (ja) | 心血管疾患の重症度を予防あるいは軽減するエストロゲンベータ受容体アゴニスト | |
| JP2019537565A (ja) | 脳波（ｅｅｇ）バーストサプレッションをもたらすために神経ステロイドを投与する方法 | |
| JP2934023B2 (ja) | コルチコステロイド治療組成物 | |
| JP7634476B2 (ja) | 関節への送達に適した医薬組成物及びその関節痛の治療における使用 | |
| AU2007280440A1 (en) | Treatment and prevention of excessive scarring | |
| JP2007224030A (ja) | 黄斑変性および関連する眼の症状の治療方法 | |
| KR20120089444A (ko) | 정맥내 이부프로펜에 의한 위독한 환자의 치료방법 | |
| RU2355406C2 (ru) | Средство для стимуляции роста мотонейронов спинного мозга растущего организма млекопитающих и способ его применения |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190131 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190131 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20191007 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191105 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200120 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200616 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20200910 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20201112 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201215 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20210302 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210702 |
|
| C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20210702 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20210713 |
|
| C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20210727 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20211001 |
|
| C211 | Notice of termination of reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C211 Effective date: 20211005 |
|
| C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20221101 |
|
| C13 | Notice of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: C13 Effective date: 20221220 |
|
| C28A | Non-patent document cited |
Free format text: JAPANESE INTERMEDIATE CODE: C2838 Effective date: 20221220 |
|
| C23 | Notice of termination of proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C23 Effective date: 20230425 |