JP2018504123A - 自閉症スペクトル障害を有する児童の唾液中のエピジェネティックバイオマーカーの同定 - Google Patents

自閉症スペクトル障害を有する児童の唾液中のエピジェネティックバイオマーカーの同定 Download PDF

Info

Publication number
JP2018504123A
JP2018504123A JP2017539370A JP2017539370A JP2018504123A JP 2018504123 A JP2018504123 A JP 2018504123A JP 2017539370 A JP2017539370 A JP 2017539370A JP 2017539370 A JP2017539370 A JP 2017539370A JP 2018504123 A JP2018504123 A JP 2018504123A
Authority
JP
Japan
Prior art keywords
mirna
subject
biological sample
collection
asd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017539370A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018504123A5 (enExample
Inventor
スティーブン、ディー．ヒックス
フランク、エイ．ミドルトン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of the State University of New York
Original Assignee
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York
Publication of JP2018504123A publication Critical patent/JP2018504123A/ja
Publication of JP2018504123A5 publication Critical patent/JP2018504123A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2017539370A 2015-01-21 2016-01-20 自閉症スペクトル障害を有する児童の唾液中のエピジェネティックバイオマーカーの同定 Pending JP2018504123A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562106107P 2015-01-21 2015-01-21
US62/106,107 2015-01-21
US201562263467P 2015-12-04 2015-12-04
US62/263,467 2015-12-04
PCT/US2016/014182 WO2016118662A1 (en) 2015-01-21 2016-01-20 Identification of epigenetic biomarkers in the saliva of children with autism spectrum disorder

Publications (2)

Publication Number Publication Date
JP2018504123A true JP2018504123A (ja) 2018-02-15
JP2018504123A5 JP2018504123A5 (enExample) 2019-02-28

Family

ID=56417707

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017539370A Pending JP2018504123A (ja) 2015-01-21 2016-01-20 自閉症スペクトル障害を有する児童の唾液中のエピジェネティックバイオマーカーの同定

Country Status (5)

Country Link
US (1) US20180171406A1 (enExample)
EP (1) EP3247798A4 (enExample)
JP (1) JP2018504123A (enExample)
CA (1) CA2974191A1 (enExample)
WO (1) WO2016118662A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3601563A4 (en) * 2017-03-21 2021-04-14 Quadrant Biosciences Inc. AUTISTIC SPECTRUM DISORDER ANALYSIS
WO2018175422A1 (en) * 2017-03-23 2018-09-27 Quadrant Biosciences Inc. Method for diagnosing or monitoring conditions characterized by abnormal temporal variations method of normalizing epigenetic data to compensate for temporal variations
WO2018175941A1 (en) * 2017-03-23 2018-09-27 Quadrant Biosciences Inc. Analysis and prediction of traumatic brain injury and concusion symptoms
US20230295728A1 (en) * 2020-06-04 2023-09-21 Centre National De La Recherche Scientifique (Cnrs) Methods for diagnosing and treating autism

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090099034A1 (en) * 2007-06-07 2009-04-16 Wisconsin Alumni Research Foundation Reagents and Methods for miRNA Expression Analysis and Identification of Cancer Biomarkers
US20100202973A1 (en) * 2007-05-18 2010-08-12 Karolinska Institutet Innovations Ab Microrna molecules associated with inflammatory skin disorders
US20130012403A1 (en) * 2009-12-23 2013-01-10 George Washington University Compositions and Methods for Identifying Autism Spectrum Disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100202973A1 (en) * 2007-05-18 2010-08-12 Karolinska Institutet Innovations Ab Microrna molecules associated with inflammatory skin disorders
US20090099034A1 (en) * 2007-06-07 2009-04-16 Wisconsin Alumni Research Foundation Reagents and Methods for miRNA Expression Analysis and Identification of Cancer Biomarkers
US20130012403A1 (en) * 2009-12-23 2013-01-10 George Washington University Compositions and Methods for Identifying Autism Spectrum Disorders

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ABU-ELNEEL, K. ET AL.: "Heterogeneous dysregulation of microRNAs across the autism spectrum", NEUROGENETICS, vol. 9, JPN6019048865, 19 June 2008 (2008-06-19), pages 153 - 161, ISSN: 0004314593 *
SARACHANA, T. ET AL.: "Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disor", GENOME MEDICINE, vol. 2, no. 23, JPN6019048864, 7 April 2010 (2010-04-07), pages 1 - 18, ISSN: 0004314592 *
VASU, M. M. ET AL.: "Serum microRNA profiles in children with autism", MOLECULAR AUTISM, vol. 5, no. 40, JPN6019048867, 30 July 2014 (2014-07-30), pages 1 - 9, ISSN: 0004173613 *

Also Published As

Publication number Publication date
CA2974191A1 (en) 2016-07-28
WO2016118662A1 (en) 2016-07-28
EP3247798A4 (en) 2019-01-02
EP3247798A1 (en) 2017-11-29
US20180171406A1 (en) 2018-06-21

Similar Documents

Publication Publication Date Title
Hicks et al. Salivary miRNA profiles identify children with autism spectrum disorder, correlate with adaptive behavior, and implicate ASD candidate genes involved in neurodevelopment
Chang et al. The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders
Kong et al. Characteristics and predictive value of blood transcriptome signature in males with autism spectrum disorders
JP2021176328A (ja) エピジェネティックな染色体相互作用
KR102621064B1 (ko) 외상성 뇌 손상 및 뇌진탕 증상의 분석 및 예측
US20130123124A1 (en) Methods and compositions for characterizing autism spectrum disorder based on gene expression patterns
AU2019391602B2 (en) Methods of diagnosing a disease state
JP2012501181A (ja) バイオマーカー・プロファイルを測定するためのシステムおよび方法
Clelland et al. Utilization of never-medicated bipolar disorder patients towards development and validation of a peripheral biomarker profile
JP2020502999A (ja) 抗うつ治療に対する対象の反応を予測するための方法およびシステム
CN115701286A (zh) 使用无循环mRNA谱分析检测阿尔茨海默病风险的系统和方法
WO2021230379A1 (ja) パーキンソン病の検出方法
CN114514329A (zh) 治疗或预防方法
JP2024111161A (ja) 気分障害検査用バイオマーカーとしてのｒｎａ編集
JP2018504123A (ja) 自閉症スペクトル障害を有する児童の唾液中のエピジェネティックバイオマーカーの同定
EP3294933A1 (en) Systems and methods to predict autism before onset of behavioral symptoms and/or to diagnose autism
EP3149208B1 (en) Genetic markers for memory loss
EP3599286A1 (en) Biomarkers for diagnosis and/or prognosis of frailty
US20250154594A1 (en) Blood biomarker for diagnosis, prognosis prediction, or treatment of parkinson’s disease, method for diagnosing parkinson’s disease, or predicting prognosis using the same, and method for screening substances for treating parkinson’s disease
Sun et al. Plasma exosomal miRNA analysis of Alzheimer’s disease reveals the dysfunction of a neural network
Francis et al. Deconvolution-based transcriptomic analysis in the hippocampus reveals cell type-specific risk genes and pathways associated with depression and suicide
WO2025039033A1 (en) Methods and reagents for diagnosis and/or prognosis of traumatic brain injury
CN121075626A (zh) 肺结核患病风险评估的方法
CN117210549A (zh) 检测人atp5d、cd69和cxcr4基因的物质及其应用
Lee et al. Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190118

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190118

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190118

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20191213

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20200731