JP2018502900A5 - - Google Patents
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- Publication number
- JP2018502900A5 JP2018502900A5 JP2017540966A JP2017540966A JP2018502900A5 JP 2018502900 A5 JP2018502900 A5 JP 2018502900A5 JP 2017540966 A JP2017540966 A JP 2017540966A JP 2017540966 A JP2017540966 A JP 2017540966A JP 2018502900 A5 JP2018502900 A5 JP 2018502900A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pyrimidin
- phenyl
- carboxamide
- tetrahydroisoquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCC(C)CCC(N(*)C(C)(CC(C)(C)CNC(C)C)O)=*C Chemical compound CCC(C)CCC(N(*)C(C)(CC(C)(C)CNC(C)C)O)=*C 0.000 description 6
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462067070P | 2014-10-22 | 2014-10-22 | |
| US62/067,070 | 2014-10-22 | ||
| US201562204176P | 2015-08-12 | 2015-08-12 | |
| US62/204,176 | 2015-08-12 | ||
| PCT/US2015/056611 WO2016064970A1 (en) | 2014-10-22 | 2015-10-21 | Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018502900A JP2018502900A (ja) | 2018-02-01 |
| JP2018502900A5 true JP2018502900A5 (https=) | 2018-11-22 |
Family
ID=55761466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540966A Pending JP2018502900A (ja) | 2014-10-22 | 2015-10-21 | ジスコイジンドメイン受容体１を標的化する小分子阻害剤およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10370360B2 (https=) |
| EP (1) | EP3209299A4 (https=) |
| JP (1) | JP2018502900A (https=) |
| CN (1) | CN107206004A (https=) |
| AU (1) | AU2015335980A1 (https=) |
| CA (1) | CA2965336A1 (https=) |
| WO (1) | WO2016064970A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015210833B2 (en) | 2014-02-03 | 2019-01-03 | Vitae Pharmaceuticals, Llc | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| DK3331876T3 (da) | 2015-08-05 | 2021-01-11 | Vitae Pharmaceuticals Llc | Modulators of ror-gamma |
| MA53943A (fr) * | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals Llc | Modulateurs de ror-gamma |
| TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| CN108276388B (zh) * | 2017-03-10 | 2020-01-14 | 成都医学院 | 1h-吲哚类衍生物及其用途 |
| US12133896B2 (en) | 2017-03-23 | 2024-11-05 | Kaohsiung Medical University | Methods for treating or alleviating a bone-loss related disease or condition by administering a nucleic acid encoding a discoidin domain receptor 1 (DDR1) protein |
| TWI676482B (zh) | 2017-03-23 | 2019-11-11 | 高雄醫學大學 | 盤基蛋白結構域受體１的抑制劑及活化劑及其用途 |
| WO2018214862A1 (zh) * | 2017-05-23 | 2018-11-29 | 江苏恒瑞医药股份有限公司 | 螺环甲酰胺类衍生物、其制备方法及其在医药上的应用 |
| CN115650976A (zh) | 2017-07-24 | 2023-01-31 | 生命医药有限责任公司 | RORγ的抑制剂 |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| KR102066402B1 (ko) * | 2017-12-22 | 2020-01-15 | 대화제약 주식회사 | 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물 |
| CN108624590A (zh) * | 2018-04-19 | 2018-10-09 | 西安医学院 | 一种抑制DDR2表达的siRNA及其应用 |
| WO2019243431A1 (en) * | 2018-06-20 | 2019-12-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions for treating melanoma |
| CN111217748B (zh) * | 2018-11-23 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 一种螺环二氢异喹啉甲酰胺类衍生物的晶型及其制备方法 |
| EP4157447A1 (en) | 2020-05-25 | 2023-04-05 | Chiesi Farmaceutici S.p.A. | Benzylamine derivatives as ddrs inhibitors |
| GB202010464D0 (en) * | 2020-07-08 | 2020-08-19 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of diseases |
| CN112321591B (zh) * | 2020-11-03 | 2022-11-08 | 中国药科大学 | 盘状结构域受体1蛋白抑制剂、制备方法及应用 |
| WO2022128850A1 (en) * | 2020-12-16 | 2022-06-23 | Galapagos Nv | Novel isoquinoline derivatives and pharmaceutical copositions thereof for the treatment of diseases |
| CN117157300A (zh) * | 2021-03-26 | 2023-12-01 | 奇斯药制品公司 | 作为ddr抑制剂的四氢噻吩并吡啶衍生物 |
| US20240217967A1 (en) * | 2021-03-26 | 2024-07-04 | Chiesi Farmaceutici S.P.A. | Indoline derivatives as ddrs inhibitors |
| CA3212769A1 (en) * | 2021-03-26 | 2022-09-29 | Laura Carzaniga | Tetrahydrothieno pyridine derivatives as ddrs inhibitors |
| US20240190847A1 (en) * | 2021-03-26 | 2024-06-13 | Chiesi Farmaceutici S.P.A. | Indoline derivatives as ddr1 and ddr2 inhibitors |
| MD4313293T2 (ro) | 2021-03-26 | 2025-08-31 | Chiesi Farm Spa | Derivati de tetrahidrotienopiridine ca inhibitori DDR |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA001539B1 (ru) * | 1996-11-27 | 2001-04-23 | Пфайзер Инк. | Амиды, ингибирующие секрецию аполипопротеина в (аро в) и/или микросомного протеина переноса триглицеридов (мтр) |
| IN188411B (https=) * | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
| EP1723134A2 (en) * | 2004-02-18 | 2006-11-22 | Pfizer Products Incorporated | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| SI2396307T1 (sl) * | 2009-02-11 | 2015-02-27 | Merck Patent Gmbh | Novi amino azaheterockliäśni karboksamidi |
| TW201206444A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| CN103965195B (zh) * | 2013-02-01 | 2016-09-28 | 中国科学院广州生物医药与健康研究院 | 用于盘状结构域受体小分子抑制剂的化合物及其应用 |
| WO2014167444A1 (en) * | 2013-04-08 | 2014-10-16 | Glenmark Pharmaceuticals S.A. | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS |
-
2015
- 2015-10-21 AU AU2015335980A patent/AU2015335980A1/en not_active Abandoned
- 2015-10-21 WO PCT/US2015/056611 patent/WO2016064970A1/en not_active Ceased
- 2015-10-21 CA CA2965336A patent/CA2965336A1/en not_active Abandoned
- 2015-10-21 EP EP15852998.2A patent/EP3209299A4/en not_active Withdrawn
- 2015-10-21 CN CN201580067710.9A patent/CN107206004A/zh active Pending
- 2015-10-21 JP JP2017540966A patent/JP2018502900A/ja active Pending
- 2015-10-21 US US15/521,107 patent/US10370360B2/en active Active
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