JP2018502900A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018502900A5 JP2018502900A5 JP2017540966A JP2017540966A JP2018502900A5 JP 2018502900 A5 JP2018502900 A5 JP 2018502900A5 JP 2017540966 A JP2017540966 A JP 2017540966A JP 2017540966 A JP2017540966 A JP 2017540966A JP 2018502900 A5 JP2018502900 A5 JP 2018502900A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pyrimidin
- phenyl
- carboxamide
- tetrahydroisoquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCC(C)CCC(N(*)C(C)(CC(C)(C)CNC(C)C)O)=*C Chemical compound CCC(C)CCC(N(*)C(C)(CC(C)(C)CNC(C)C)O)=*C 0.000 description 6
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462067070P | 2014-10-22 | 2014-10-22 | |
| US62/067,070 | 2014-10-22 | ||
| US201562204176P | 2015-08-12 | 2015-08-12 | |
| US62/204,176 | 2015-08-12 | ||
| PCT/US2015/056611 WO2016064970A1 (en) | 2014-10-22 | 2015-10-21 | Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018502900A JP2018502900A (ja) | 2018-02-01 |
| JP2018502900A5 true JP2018502900A5 (https=) | 2018-11-22 |
Family
ID=55761466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540966A Pending JP2018502900A (ja) | 2014-10-22 | 2015-10-21 | ジスコイジンドメイン受容体１を標的化する小分子阻害剤およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10370360B2 (https=) |
| EP (1) | EP3209299A4 (https=) |
| JP (1) | JP2018502900A (https=) |
| CN (1) | CN107206004A (https=) |
| AU (1) | AU2015335980A1 (https=) |
| CA (1) | CA2965336A1 (https=) |
| WO (1) | WO2016064970A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3102576B8 (en) | 2014-02-03 | 2019-06-19 | Vitae Pharmaceuticals, LLC | Dihydropyrrolopyridine inhibitors of ror-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| WO2017024018A1 (en) | 2015-08-05 | 2017-02-09 | Vitae Pharmaceuticals, Inc. | Modulators of ror-gamma |
| US11008340B2 (en) * | 2015-11-20 | 2021-05-18 | Vitae Pharmaceuticals, Llc | Modulators of ROR-gamma |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| CN108276388B (zh) * | 2017-03-10 | 2020-01-14 | 成都医学院 | 1h-吲哚类衍生物及其用途 |
| US12133896B2 (en) | 2017-03-23 | 2024-11-05 | Kaohsiung Medical University | Methods for treating or alleviating a bone-loss related disease or condition by administering a nucleic acid encoding a discoidin domain receptor 1 (DDR1) protein |
| TWI676482B (zh) * | 2017-03-23 | 2019-11-11 | 高雄醫學大學 | 盤基蛋白結構域受體１的抑制劑及活化劑及其用途 |
| WO2018214862A1 (zh) * | 2017-05-23 | 2018-11-29 | 江苏恒瑞医药股份有限公司 | 螺环甲酰胺类衍生物、其制备方法及其在医药上的应用 |
| JP2020528904A (ja) | 2017-07-24 | 2020-10-01 | ヴァイティー ファーマシューティカルズ，エルエルシー | ＲＯＲγの阻害剤 |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| KR102066402B1 (ko) * | 2017-12-22 | 2020-01-15 | 대화제약 주식회사 | 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물 |
| CN108624590A (zh) * | 2018-04-19 | 2018-10-09 | 西安医学院 | 一种抑制DDR2表达的siRNA及其应用 |
| WO2019243431A1 (en) * | 2018-06-20 | 2019-12-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions for treating melanoma |
| CN111217748B (zh) * | 2018-11-23 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 一种螺环二氢异喹啉甲酰胺类衍生物的晶型及其制备方法 |
| CN115697485B (zh) | 2020-05-25 | 2025-03-14 | 奇斯药制品公司 | 作为ddr抑制剂的苄胺衍生物 |
| GB202010464D0 (en) * | 2020-07-08 | 2020-08-19 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of diseases |
| CN112321591B (zh) * | 2020-11-03 | 2022-11-08 | 中国药科大学 | 盘状结构域受体1蛋白抑制剂、制备方法及应用 |
| WO2022128850A1 (en) * | 2020-12-16 | 2022-06-23 | Galapagos Nv | Novel isoquinoline derivatives and pharmaceutical copositions thereof for the treatment of diseases |
| PL4313293T3 (pl) | 2021-03-26 | 2025-09-01 | Chiesi Farmaceutici S.P.A. | Pochodne tetrahydrotienopirydyny jako inhibitory DDR |
| WO2022200576A1 (en) | 2021-03-26 | 2022-09-29 | Chiesi Farmaceutici S.P.A. | Indoline derivatives as ddr1 and ddr2 inhibitors |
| EP4313972B1 (en) | 2021-03-26 | 2025-01-29 | Chiesi Farmaceutici S.p.A. | Indoline derivatives as ddrs inhibitors |
| KR20230163465A (ko) * | 2021-03-26 | 2023-11-30 | 키에시 파르마슈티시 엣스. 피. 에이. | Ddr 억제제로서 테트라하이드로싸이에노 피리딘 유도체 |
| PT4313293T (pt) * | 2021-11-22 | 2025-07-25 | Chiesi Farm Spa | Derivados de tetraidrotieno piridina como inibidores de ddrs |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ335162A (en) * | 1996-11-27 | 2000-01-28 | Pfizer | Apo b-secretion/mtp inhibitory amides |
| IN188411B (https=) | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
| JP2007523152A (ja) * | 2004-02-18 | 2007-08-16 | ファイザー・プロダクツ・インク | キナゾリンおよびイソキノリンのテトラヒドロイソキノリニル誘導体 |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| NZ595087A (en) | 2009-02-11 | 2013-03-28 | Merck Patent Gmbh | Novel amino azaheterocyclic carboxamides |
| WO2011143155A1 (en) * | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| CN103965195B (zh) * | 2013-02-01 | 2016-09-28 | 中国科学院广州生物医药与健康研究院 | 用于盘状结构域受体小分子抑制剂的化合物及其应用 |
| WO2014167444A1 (en) * | 2013-04-08 | 2014-10-16 | Glenmark Pharmaceuticals S.A. | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS |
-
2015
- 2015-10-21 EP EP15852998.2A patent/EP3209299A4/en not_active Withdrawn
- 2015-10-21 US US15/521,107 patent/US10370360B2/en active Active
- 2015-10-21 CA CA2965336A patent/CA2965336A1/en not_active Abandoned
- 2015-10-21 WO PCT/US2015/056611 patent/WO2016064970A1/en not_active Ceased
- 2015-10-21 CN CN201580067710.9A patent/CN107206004A/zh active Pending
- 2015-10-21 JP JP2017540966A patent/JP2018502900A/ja active Pending
- 2015-10-21 AU AU2015335980A patent/AU2015335980A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018502900A5 (https=) | ||
| ES2391382T3 (es) | Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos | |
| JP5825535B2 (ja) | Ｈｅｃ１活性の調節因子およびそのための方法 | |
| JPWO2021085653A5 (https=) | ||
| JP2013056930A5 (https=) | ||
| JP2019517487A5 (https=) | ||
| JP2009513703A5 (https=) | ||
| US12187720B2 (en) | Compounds for treatment of cancer | |
| HRP20141094T1 (hr) | 1,2,5-oksadiazoli kao inhibitori indolamin 2,3-dioksigenaze | |
| JP2014518544A5 (https=) | ||
| US20080207572A1 (en) | Use of Dual C-Kit/Fgfr3 Inhibitors for Treating Multiple Myeloma | |
| JP2015521166A5 (https=) | ||
| JP2016528197A5 (https=) | ||
| JP2012502927A5 (https=) | ||
| AU2012273133A1 (en) | Heterocyclic compounds for treating helminth infections | |
| US11485711B2 (en) | Compounds for inhibiting TNIK and medical uses thereof | |
| RU2758259C2 (ru) | Соединение формулы (I), фармацевтическая композиция, применение соединения формулы (I) для лечения гематологических и/или пролиферативных нарушений | |
| US20110301188A1 (en) | Synergistic Effects Between Sphingosine-1-Phosphate Receptor Antagonists and Antimicrotubule Agents | |
| ES2440799T3 (es) | Métodos para tratar cáncer resistente a los fármacos | |
| JP2018501261A5 (https=) | ||
| AU2014280354A1 (en) | Combinations for the treatment of cancer comprising a Mps-1 kinase inhibitor and a mitotic inhibitor | |
| JP2016502540A5 (https=) | ||
| RU2015155438A (ru) | Ингибиторы вирусной репликации, способ их получения и их терапевтические применения | |
| KR101879992B1 (ko) | c-Myc/Max/DNA 복합체 형성을 억제하는 화합물 | |
| KR101920163B1 (ko) | 항암용 약학 조성물 |