JP2018502550A5 - - Google Patents

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Publication number
JP2018502550A5
JP2018502550A5 JP2016569603A JP2016569603A JP2018502550A5 JP 2018502550 A5 JP2018502550 A5 JP 2018502550A5 JP 2016569603 A JP2016569603 A JP 2016569603A JP 2016569603 A JP2016569603 A JP 2016569603A JP 2018502550 A5 JP2018502550 A5 JP 2018502550A5
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JP
Japan
Prior art keywords
amino acid
conservative substitutions
acid modifications
acid modification
modifications
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JP2016569603A
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English (en)
Japanese (ja)
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JP7103751B2 (ja
JP7103751B6 (ja
JP2018502550A (ja
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Priority claimed from PCT/IB2015/054107 external-priority patent/WO2015181805A1/en
Publication of JP2018502550A publication Critical patent/JP2018502550A/ja
Publication of JP2018502550A5 publication Critical patent/JP2018502550A5/ja
Publication of JP7103751B2 publication Critical patent/JP7103751B2/ja
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Publication of JP7103751B6 publication Critical patent/JP7103751B6/ja
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JP2016569603A 2015-04-28 2015-05-29 修飾された抗原結合ポリペプチド構築物及びその使用 Active JP7103751B6 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562154055P 2015-04-28 2015-04-28
US62/154,055 2015-04-28
PCT/IB2015/054107 WO2015181805A1 (en) 2014-05-28 2015-05-29 Modified antigen binding polypeptide constructs and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020137041A Division JP7183221B2 (ja) 2015-04-28 2020-08-14 修飾された抗原結合ポリペプチド構築物及びその使用

Publications (4)

Publication Number Publication Date
JP2018502550A JP2018502550A (ja) 2018-02-01
JP2018502550A5 true JP2018502550A5 (https=) 2018-07-05
JP7103751B2 JP7103751B2 (ja) 2022-07-20
JP7103751B6 JP7103751B6 (ja) 2022-08-15

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ID=58848603

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016569603A Active JP7103751B6 (ja) 2015-04-28 2015-05-29 修飾された抗原結合ポリペプチド構築物及びその使用
JP2020137041A Active JP7183221B2 (ja) 2015-04-28 2020-08-14 修飾された抗原結合ポリペプチド構築物及びその使用
JP2022186638A Pending JP2023027107A (ja) 2015-04-28 2022-11-22 修飾された抗原結合ポリペプチド構築物及びその使用
JP2024104675A Pending JP2024125389A (ja) 2015-04-28 2024-06-28 修飾された抗原結合ポリペプチド構築物及びその使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2020137041A Active JP7183221B2 (ja) 2015-04-28 2020-08-14 修飾された抗原結合ポリペプチド構築物及びその使用
JP2022186638A Pending JP2023027107A (ja) 2015-04-28 2022-11-22 修飾された抗原結合ポリペプチド構築物及びその使用
JP2024104675A Pending JP2024125389A (ja) 2015-04-28 2024-06-28 修飾された抗原結合ポリペプチド構築物及びその使用

Country Status (3)

Country Link
JP (4) JP7103751B6 (https=)
KR (2) KR102669686B1 (https=)
CN (1) CN106661121A (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9914785B2 (en) 2012-11-28 2018-03-13 Zymeworks Inc. Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
JP7654539B2 (ja) * 2018-09-07 2025-04-01 ファイザー・インク 抗αｖβ８抗体、組成物及びその使用
AU2019412561A1 (en) * 2018-12-24 2021-08-12 Sanofi Multispecific binding proteins with mutant Fab domains
JP7535273B2 (ja) * 2019-04-26 2024-08-16 スアンズ バイオファーマシューティカル カンパニー，リミテッド Ｃｄ８０バリアントタンパク質とその使用
US20250223379A1 (en) * 2021-01-11 2025-07-10 Adimab, Llc Variant ch3 domains engineered for preferential ch3 heterodimerization, multi-specific antibodies comprising the same, and methods of making thereof
CA3217487A1 (en) * 2021-04-23 2022-10-27 Chimagen Biosciences, Ltd Heterodimeric antibodies and antigen-binding fragment thereof
JP2024544607A (ja) * 2021-11-25 2024-12-03 エフ． ホフマン－ラ ロシュ アーゲー 少量の抗体副産物の定量
CN114106192B (zh) * 2021-12-20 2024-06-14 广州爱思迈生物医药科技有限公司 双特异性抗体及其应用
WO2025167974A1 (zh) * 2024-02-07 2025-08-14 上海齐鲁制药研究中心有限公司 多特异性抗体或抗原结合片段

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0514779D0 (en) * 2005-07-19 2005-08-24 Celltech R&D Ltd Biological products
JP2009541275A (ja) * 2006-06-22 2009-11-26 ノボ・ノルデイスク・エー／エス 二重特異性抗体の生産
CN107501407B (zh) * 2007-03-30 2022-03-18 Ambrx公司 经修饰fgf-21多肽和其用途
DK2786762T3 (da) * 2008-12-19 2019-05-06 Macrogenics Inc Kovalente diabodies og anvendelser deraf
WO2010129304A2 (en) * 2009-04-27 2010-11-11 Oncomed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
BR112013023918A2 (pt) * 2011-03-25 2016-12-13 Glenmark Pharmaceuticals Sa imunoglobulina hetero-dimérica ou fragmento hetero-dimérico da mesma, método para produzir uma imunoglobulina hetero-dimérica ou fragmento hetero-dimérico da mesma, método para construir uma interface proteína-proteína de um domínio de uma proteína de múltiplos domínios e uso de um domínio doador de um primeiro e de um segundo membro de uma super-família de imunoglobulina de ocorrência natural
SG11201401422VA (en) * 2011-10-27 2014-09-26 Genmab As Production of heterodimeric proteins
IN2015DN01299A (https=) * 2012-07-23 2015-07-03 Zymeworks Inc
CN105026430B (zh) 2012-11-28 2025-03-25 酵活英属哥伦比亚有限公司 工程化免疫球蛋白重链-轻链对及其用途
CA3244731A1 (en) * 2014-05-28 2025-11-29 Zymeworks Bc Inc. Modified antigen binding polypeptide constructs and uses thereof

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