JP2018502278A5 - - Google Patents
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- Publication number
- JP2018502278A5 JP2018502278A5 JP2017523530A JP2017523530A JP2018502278A5 JP 2018502278 A5 JP2018502278 A5 JP 2018502278A5 JP 2017523530 A JP2017523530 A JP 2017523530A JP 2017523530 A JP2017523530 A JP 2017523530A JP 2018502278 A5 JP2018502278 A5 JP 2018502278A5
- Authority
- JP
- Japan
- Prior art keywords
- tocopherol
- radical scavenger
- concentrations
- compositions
- antioxidant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960001295 Tocopherol Drugs 0.000 description 6
- 235000010384 tocopherol Nutrition 0.000 description 6
- 239000011732 tocopherol Substances 0.000 description 6
- 229930003799 tocopherols Natural products 0.000 description 6
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 239000002516 radical scavenger Substances 0.000 description 5
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000001954 sterilising Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 230000003078 antioxidant Effects 0.000 description 3
- 235000004418 Durio kutejensis Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000000111 anti-oxidant Effects 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000003211 photoinitiator Substances 0.000 description 1
Description
なお、ラジカルスカベンジャー又は抗酸化剤は、考えられる全ての重合性組成物において必須ではない。しかしながら、（例えばガンマビーム又は電子ビームによる照射滅菌による流動性の維持を促進するために）ラジカルスカベンジャー又は抗酸化剤が含まれる場合、上記ラジカルスカベンジャー及び抗酸化剤のうちの少なくとも一方（例えばトコフェロール）は、いずれの好適なモル濃度で上記重合性組成物中に存在できると考えられる。出願人は驚くべきことに、トコフェロール等のラジカルスカベンジャーが含まれている場合、本発明の主題のいくつかの組成物（例えばＬＡＩＥ）は、３ｋＧｙ超の放射線量、での照射滅菌中に流動性を維持するが、いくつかの他の組成物（例えばＬＡＩ）は、同一の放射線量下で流動性を維持しないことを発見した。別の視点から見ると、ＬＡＩは、最大およそ３ｋＧｙの放射線量までの照射滅菌中にしか、流動性を維持しないことが分かった。いくつかの好ましい実施形態では、上記ラジカルスカベンジャー及び上記抗酸化剤のうちの少なくとも一方はトコフェロールを含み、上記組成物中に、少なくとも７５ｍＭ、より好ましくは少なくとも１００ｍＭ、更に好ましくは少なくとも１３５ｍＭのモル濃度で存在する。様々な理由から、より低いトコフェロール濃度（例えば約７５ｍＭ未満）は好ましくない。例えば、トコフェロール濃度がより低いセパレータ物質は、より低い放射線量においてしか流動性を維持できず、これでは、ＩＳＯプロトコル下でのコスト効率の高い滅菌は不可能である。更に、トコフェロール濃度がより低いセパレータ物質は典型的には、より低い光開始剤濃度（例えば１重量％未満）を必要とし、これは一般に、より長い硬化時間を必要とする。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14190681.8A EP3015169B1 (en) | 2014-10-28 | 2014-10-28 | Sample collection tube with curable polymer separator |
| EP14190681.8 | 2014-10-28 | ||
| PCT/US2015/057359 WO2016069469A2 (en) | 2014-10-28 | 2015-10-26 | Separators for blood collection tubes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502278A JP2018502278A (ja) | 2018-01-25 |
| JP2018502278A5 true JP2018502278A5 (ja) | 2018-11-22 |
| JP6683699B2 JP6683699B2 (ja) | 2020-04-22 |
Family
ID=51795565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017523530A Active JP6683699B2 (ja) | 2014-10-28 | 2015-10-26 | 採血チューブ用のセパレータ |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11344881B2 (ja) |
| EP (1) | EP3015169B1 (ja) |
| JP (1) | JP6683699B2 (ja) |
| KR (1) | KR102583766B1 (ja) |
| CN (1) | CN107405548B (ja) |
| AU (1) | AU2015339570B2 (ja) |
| BR (1) | BR112017009065B1 (ja) |
| CA (1) | CA2966335C (ja) |
| ES (1) | ES2981622T3 (ja) |
| HK (1) | HK1221932A1 (ja) |
| WO (1) | WO2016069469A2 (ja) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3015168B1 (en) | 2014-10-28 | 2017-07-19 | The Regents Of The University Of California | Composite sealants and plasma separators for blood collection tubes |
| ES2981622T3 (es) | 2014-10-28 | 2024-10-10 | The Regents Of The Univ Of California | Tubo de recogida de muestras con separador de polímero curable |
| JP6989609B2 (ja) * | 2017-01-25 | 2022-01-05 | ヤンタイ・アウスビオ・ラボラトリーズ・カンパニー・リミテッド | 診断目的の自動サンプル処理のための装置および方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4848418A (en) | 1987-11-25 | 1989-07-18 | The Coca-Cola Company | Microgravity dispenser |
| US4867887A (en) | 1988-07-12 | 1989-09-19 | Becton Dickinson And Company | Method and apparatus for separating mononuclear cells from blood |
| JP3090778B2 (ja) | 1992-04-20 | 2000-09-25 | 積水化学工業株式会社 | 血清又は血漿分離用組成物及び血液検査用容器 |
| US5461124A (en) * | 1992-07-24 | 1995-10-24 | Henkel Kommanditgesellschaft Auf Aktien | Reactive systems and/or polymer composition for tissue contact with the living body |
| US5695689A (en) | 1994-10-04 | 1997-12-09 | Bayer Aktiengesellschaft | Polyether polyols stabilized with tocopherol |
| US5859280A (en) | 1997-07-01 | 1999-01-12 | Betzdearborn Inc. | Methods for inhibiting the polymerization of vinyl monomers |
| US6497325B1 (en) | 1998-12-05 | 2002-12-24 | Becton Dickinson And Company | Device for separating components of a fluid sample |
| JP2001122909A (ja) | 1999-10-27 | 2001-05-08 | Mitsubishi Chemicals Corp | 重合防止用組成物及びこれを用いる重合防止方法 |
| US6790371B2 (en) * | 2001-04-09 | 2004-09-14 | Medtronic, Inc. | System and method for automated separation of blood components |
| US20050056954A1 (en) * | 2003-09-12 | 2005-03-17 | Devlin Brian Gerrard | Method for making contact lenses |
| US7971730B2 (en) * | 2005-08-10 | 2011-07-05 | The Regents Of The University Of California | Collection tubes apparatus, systems and methods |
| US7775962B2 (en) | 2005-08-10 | 2010-08-17 | The Regents Of The University Of California | Centrifuge with polymerizing energy source |
| US9248447B2 (en) * | 2005-08-10 | 2016-02-02 | The Regents Of The University Of California | Polymers for use in centrifugal separation of liquids |
| US7674388B2 (en) | 2005-08-10 | 2010-03-09 | The Regents Of The University Of California | Photopolymer serum separator |
| US7673758B2 (en) * | 2005-08-10 | 2010-03-09 | The Regents Of The University Of California | Collection tubes apparatus, systems, and methods |
| TW201026307A (en) | 2008-11-07 | 2010-07-16 | Hitachi Chemical Co Ltd | Serum or plasma separation material and blood collection tube the same |
| AT508099B1 (de) | 2009-03-17 | 2015-07-15 | Semperit Ag Holding | Verfahren zur herstellung eines vernetzten elastomers |
| CN102770762B (zh) | 2010-02-26 | 2015-02-18 | 积水医疗株式会社 | 血液分离剂及血液采集容器 |
| WO2013011947A1 (ja) * | 2011-07-19 | 2013-01-24 | 日東電工株式会社 | 透明粘接着剤層付飛散防止部材 |
| JP5812935B2 (ja) * | 2012-05-16 | 2015-11-17 | 住友ゴム工業株式会社 | 表面改質方法及び表面改質弾性体 |
| CA2881028C (en) | 2012-09-06 | 2021-11-02 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample collection |
| US9669405B2 (en) * | 2012-10-22 | 2017-06-06 | The Regents Of The University Of California | Sterilizable photopolymer serum separator |
| EP3015168B1 (en) | 2014-10-28 | 2017-07-19 | The Regents Of The University Of California | Composite sealants and plasma separators for blood collection tubes |
| ES2981622T3 (es) | 2014-10-28 | 2024-10-10 | The Regents Of The Univ Of California | Tubo de recogida de muestras con separador de polímero curable |
-
2014
- 2014-10-28 ES ES14190681T patent/ES2981622T3/es active Active
- 2014-10-28 EP EP14190681.8A patent/EP3015169B1/en active Active
-
2015
- 2015-10-26 CN CN201580068901.7A patent/CN107405548B/zh not_active Expired - Fee Related
- 2015-10-26 JP JP2017523530A patent/JP6683699B2/ja active Active
- 2015-10-26 CA CA2966335A patent/CA2966335C/en active Active
- 2015-10-26 BR BR112017009065-1A patent/BR112017009065B1/pt not_active IP Right Cessation
- 2015-10-26 AU AU2015339570A patent/AU2015339570B2/en active Active
- 2015-10-26 WO PCT/US2015/057359 patent/WO2016069469A2/en active Application Filing
- 2015-10-26 US US15/522,770 patent/US11344881B2/en active Active
- 2015-10-26 KR KR1020177014514A patent/KR102583766B1/ko active IP Right Grant
-
2016
- 2016-08-23 HK HK16110031.2A patent/HK1221932A1/zh unknown
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