JP2018502094A5 - - Google Patents
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- Publication number
- JP2018502094A5 JP2018502094A5 JP2017534221A JP2017534221A JP2018502094A5 JP 2018502094 A5 JP2018502094 A5 JP 2018502094A5 JP 2017534221 A JP2017534221 A JP 2017534221A JP 2017534221 A JP2017534221 A JP 2017534221A JP 2018502094 A5 JP2018502094 A5 JP 2018502094A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- dentin
- tooth
- composition according
- dental pulp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 36
- 210000004268 dentin Anatomy 0.000 claims description 26
- 102000013814 Wnt Human genes 0.000 claims description 17
- 108050003627 Wnt Proteins 0.000 claims description 17
- 210000003074 dental pulp Anatomy 0.000 claims description 15
- 102000044880 Wnt3A Human genes 0.000 claims description 7
- 108700013515 Wnt3A Proteins 0.000 claims description 7
- 206010020751 Hypersensitivity Diseases 0.000 claims description 4
- 208000026935 allergic disease Diseases 0.000 claims description 4
- 230000009610 hypersensitivity Effects 0.000 claims description 4
- 239000008346 aqueous phase Substances 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 230000035755 proliferation Effects 0.000 claims description 2
- 210000005239 tubule Anatomy 0.000 claims description 2
- 125000003473 lipid group Chemical group 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 210000004416 odontoblast Anatomy 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 18
- 239000002269 analeptic agent Substances 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 230000004936 stimulating effect Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 210000004262 dental pulp cavity Anatomy 0.000 description 2
- 210000001968 dental pulp cell Anatomy 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000018380 Chemical injury Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462097502P | 2014-12-29 | 2014-12-29 | |
| US62/097,502 | 2014-12-29 | ||
| PCT/US2015/067683 WO2016109433A1 (en) | 2014-12-29 | 2015-12-28 | Compositions and methods for delivering lypophilic agents to dental pulp and for enhancing dentin production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502094A JP2018502094A (ja) | 2018-01-25 |
| JP2018502094A5 true JP2018502094A5 (enExample) | 2019-05-30 |
| JP6887948B2 JP6887948B2 (ja) | 2021-06-16 |
Family
ID=56284970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017534221A Expired - Fee Related JP6887948B2 (ja) | 2014-12-29 | 2015-12-28 | 親油性薬剤を歯髄に送達するため、および象牙質生成を増強するための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10512668B2 (enExample) |
| EP (1) | EP3240562B1 (enExample) |
| JP (1) | JP6887948B2 (enExample) |
| AU (1) | AU2015374240B2 (enExample) |
| CA (1) | CA3009983A1 (enExample) |
| WO (1) | WO2016109433A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201617820D0 (en) * | 2016-10-21 | 2016-12-07 | King S College London | Dental treatment |
| CN114469863B (zh) * | 2021-11-26 | 2023-09-26 | 南方医科大学南方医院 | 甾醇脂质体作为牙髓和牙本质药物传递系统的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9554975B2 (en) | 2005-03-21 | 2017-01-31 | Glaxo Group Limited | Alkyl sulfate free and orthophosphate free dentifrice composition comprising fluoride source and a silica dental abrasive |
| JP2010520286A (ja) | 2007-03-05 | 2010-06-10 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | Ｗｎｔ組成物およびその使用方法 |
| US20110171607A1 (en) | 2007-10-25 | 2011-07-14 | The Trustees Of Columbia University In The City Of New York | Biopulp |
| TWI457141B (zh) * | 2008-02-08 | 2014-10-21 | Colgate Palmolive Co | 雙組分口腔保健產品 |
| US10391038B2 (en) * | 2008-02-08 | 2019-08-27 | Colgate-Palmolive Company | Tooth sealant |
| EP2502985B1 (en) * | 2009-11-17 | 2015-04-29 | National University Corporation Okayama University | Method for inducing differentiation of dental pulp cells into odontoblasts |
| WO2011063371A1 (en) | 2009-11-23 | 2011-05-26 | University Of Medicine And Dentistry Of New Jersey | Dentinal drug delivery composition |
| EP2533764A4 (en) * | 2010-02-08 | 2016-08-31 | Univ Nebraska | BIOMINERAL AND METAL BINDING LIPOSOME, THEIR SYNTHESIS AND METHOD FOR THE PRODUCTION THEREOF |
| WO2012034070A1 (en) | 2010-09-09 | 2012-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | Use of liposomal wnt compositions to enhance osseointegration |
| WO2012122081A2 (en) | 2011-03-04 | 2012-09-13 | President And Fellows Of Harvard College | Dental treatment systems and uses thereof |
| CN105228557A (zh) | 2013-03-21 | 2016-01-06 | 纽约市哥伦比亚大学理事会 | 用于牙组织再生的组合物和方法 |
-
2015
- 2015-12-28 JP JP2017534221A patent/JP6887948B2/ja not_active Expired - Fee Related
- 2015-12-28 AU AU2015374240A patent/AU2015374240B2/en not_active Ceased
- 2015-12-28 WO PCT/US2015/067683 patent/WO2016109433A1/en not_active Ceased
- 2015-12-28 EP EP15876103.1A patent/EP3240562B1/en active Active
- 2015-12-28 US US15/539,489 patent/US10512668B2/en active Active
- 2015-12-28 CA CA3009983A patent/CA3009983A1/en active Pending
-
2019
- 2019-10-30 US US16/669,340 patent/US11260103B2/en active Active
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