CA3009983A1 - Lyposomal wnt3a for use in treating tooth sensitivity - Google Patents
Lyposomal wnt3a for use in treating tooth sensitivity Download PDFInfo
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- CA3009983A1 CA3009983A1 CA3009983A CA3009983A CA3009983A1 CA 3009983 A1 CA3009983 A1 CA 3009983A1 CA 3009983 A CA3009983 A CA 3009983A CA 3009983 A CA3009983 A CA 3009983A CA 3009983 A1 CA3009983 A1 CA 3009983A1
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- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 229940099456 transforming growth factor beta 1 Drugs 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/58—Preparations specially adapted for dental root treatment specially adapted for dental implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/69—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462097502P | 2014-12-29 | 2014-12-29 | |
| US62/097,502 | 2014-12-29 | ||
| PCT/US2015/067683 WO2016109433A1 (en) | 2014-12-29 | 2015-12-28 | Compositions and methods for delivering lypophilic agents to dental pulp and for enhancing dentin production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3009983A1 true CA3009983A1 (en) | 2016-07-07 |
Family
ID=56284970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3009983A Pending CA3009983A1 (en) | 2014-12-29 | 2015-12-28 | Lyposomal wnt3a for use in treating tooth sensitivity |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10512668B2 (enExample) |
| EP (1) | EP3240562B1 (enExample) |
| JP (1) | JP6887948B2 (enExample) |
| AU (1) | AU2015374240B2 (enExample) |
| CA (1) | CA3009983A1 (enExample) |
| WO (1) | WO2016109433A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201617820D0 (en) * | 2016-10-21 | 2016-12-07 | King S College London | Dental treatment |
| CN114469863B (zh) * | 2021-11-26 | 2023-09-26 | 南方医科大学南方医院 | 甾醇脂质体作为牙髓和牙本质药物传递系统的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9554975B2 (en) | 2005-03-21 | 2017-01-31 | Glaxo Group Limited | Alkyl sulfate free and orthophosphate free dentifrice composition comprising fluoride source and a silica dental abrasive |
| JP2010520286A (ja) | 2007-03-05 | 2010-06-10 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | Ｗｎｔ組成物およびその使用方法 |
| US20110171607A1 (en) | 2007-10-25 | 2011-07-14 | The Trustees Of Columbia University In The City Of New York | Biopulp |
| TWI457141B (zh) * | 2008-02-08 | 2014-10-21 | Colgate Palmolive Co | 雙組分口腔保健產品 |
| US10391038B2 (en) * | 2008-02-08 | 2019-08-27 | Colgate-Palmolive Company | Tooth sealant |
| EP2502985B1 (en) * | 2009-11-17 | 2015-04-29 | National University Corporation Okayama University | Method for inducing differentiation of dental pulp cells into odontoblasts |
| WO2011063371A1 (en) | 2009-11-23 | 2011-05-26 | University Of Medicine And Dentistry Of New Jersey | Dentinal drug delivery composition |
| EP2533764A4 (en) * | 2010-02-08 | 2016-08-31 | Univ Nebraska | BIOMINERAL AND METAL BINDING LIPOSOME, THEIR SYNTHESIS AND METHOD FOR THE PRODUCTION THEREOF |
| WO2012034070A1 (en) | 2010-09-09 | 2012-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | Use of liposomal wnt compositions to enhance osseointegration |
| WO2012122081A2 (en) | 2011-03-04 | 2012-09-13 | President And Fellows Of Harvard College | Dental treatment systems and uses thereof |
| CN105228557A (zh) | 2013-03-21 | 2016-01-06 | 纽约市哥伦比亚大学理事会 | 用于牙组织再生的组合物和方法 |
-
2015
- 2015-12-28 JP JP2017534221A patent/JP6887948B2/ja not_active Expired - Fee Related
- 2015-12-28 AU AU2015374240A patent/AU2015374240B2/en not_active Ceased
- 2015-12-28 WO PCT/US2015/067683 patent/WO2016109433A1/en not_active Ceased
- 2015-12-28 EP EP15876103.1A patent/EP3240562B1/en active Active
- 2015-12-28 US US15/539,489 patent/US10512668B2/en active Active
- 2015-12-28 CA CA3009983A patent/CA3009983A1/en active Pending
-
2019
- 2019-10-30 US US16/669,340 patent/US11260103B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11260103B2 (en) | 2022-03-01 |
| US10512668B2 (en) | 2019-12-24 |
| AU2015374240A1 (en) | 2017-08-10 |
| JP2018502094A (ja) | 2018-01-25 |
| EP3240562A1 (en) | 2017-11-08 |
| JP6887948B2 (ja) | 2021-06-16 |
| AU2015374240B2 (en) | 2021-11-11 |
| US20200046801A1 (en) | 2020-02-13 |
| WO2016109433A1 (en) | 2016-07-07 |
| US20180000893A1 (en) | 2018-01-04 |
| EP3240562B1 (en) | 2023-03-22 |
| EP3240562A4 (en) | 2018-08-15 |
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