JP2018502048A5 - - Google Patents
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- JP2018502048A5 JP2018502048A5 JP2017518064A JP2017518064A JP2018502048A5 JP 2018502048 A5 JP2018502048 A5 JP 2018502048A5 JP 2017518064 A JP2017518064 A JP 2017518064A JP 2017518064 A JP2017518064 A JP 2017518064A JP 2018502048 A5 JP2018502048 A5 JP 2018502048A5
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- JP
- Japan
- Prior art keywords
- hal
- cor
- nhr
- unsubstituted
- conhr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14003391 | 2014-10-01 | ||
| EP14003391.1 | 2014-10-01 | ||
| PCT/EP2015/001931 WO2016050356A1 (en) | 2014-10-01 | 2015-10-01 | Boronic acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502048A JP2018502048A (ja) | 2018-01-25 |
| JP2018502048A5 true JP2018502048A5 (cg-RX-API-DMAC7.html) | 2019-10-17 |
| JP6896618B2 JP6896618B2 (ja) | 2021-06-30 |
Family
ID=51690788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518064A Expired - Fee Related JP6896618B2 (ja) | 2014-10-01 | 2015-10-01 | ボロン酸誘導体 |
Country Status (14)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6835711B2 (ja) | 2014-10-01 | 2021-02-24 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ボロン酸誘導体 |
| RU2717558C2 (ru) | 2014-10-01 | 2020-03-24 | Мерк Патент Гмбх | Производные бороновой кислоты |
| RU2017115193A (ru) | 2014-10-01 | 2018-11-06 | Мерк Патент Гмбх | Производные бороновой кислоты |
| PT3571208T (pt) * | 2017-01-18 | 2021-04-13 | Principia Biopharma Inc | Inibidores do imunoproteassoma |
| DK3672977T3 (da) | 2017-08-24 | 2022-09-26 | Merck Patent Gmbh | Boronsyrederivater |
| WO2019060651A1 (en) | 2017-09-21 | 2019-03-28 | Kezar Life Sciences | POLY THERAPY FOR IMMUNOLOGICAL DISEASES |
| BR112021001359A2 (pt) | 2018-07-26 | 2021-04-20 | Merck Patent Gmbh | derivados de ácido borônico |
| CN113135944A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| CN113135943A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| JP2024529468A (ja) | 2021-07-29 | 2024-08-06 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の［（１ｒ）－２－（１－ベンゾフラン－３－イル）－１－｛［（１ｓ，２ｒ，４ｒ）－７－オキサビシクロ［２．２．１］ヘプタン－２－イル］ホルムアミド｝エチル］ボロン酸の結晶性形態、その付加物、および得るためのプロセス |
| JP7734276B2 (ja) * | 2021-10-14 | 2025-09-04 | ショウヤオ ホールディングス（ベイジン） カンパニー， リミテッド | ボロン酸誘導体 |
| CN117003776A (zh) * | 2022-04-29 | 2023-11-07 | 科辉智药生物科技(深圳)有限公司 | 一种硼酸类蛋白酶体抑制剂及其用途 |
| WO2023232830A1 (en) | 2022-06-02 | 2023-12-07 | Merck Patent Gmbh | Boronic acid adducts |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111175A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| CA2376965A1 (en) * | 1999-07-07 | 2001-01-11 | Timothy Patrick Forsyth | Peptide boronic acid inhibitors of hepatitis c virus protease |
| US7589066B2 (en) * | 2005-03-11 | 2009-09-15 | The University Of North Carolina At Chapel Hill | Potent and specific immunoproteasome inhibitors |
| MX2010005252A (es) * | 2007-11-13 | 2011-04-11 | Novartis Int Pharm Ltd | Inhibidores de beta-lactamasa. |
| AR075090A1 (es) * | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| CA2791651C (en) * | 2010-03-01 | 2019-08-20 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
| JP6129203B2 (ja) * | 2011-12-22 | 2017-05-17 | アレス トレーディング ソシエテ アノニム | α−アミノボロン酸誘導体、選択性免疫プロテアソーム阻害剤 |
| BR112015012909A2 (pt) * | 2012-12-03 | 2017-07-11 | Hoffmann La Roche | compostos de ácido borônico de triazol substituído |
| JP6835711B2 (ja) | 2014-10-01 | 2021-02-24 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ボロン酸誘導体 |
| RU2717558C2 (ru) | 2014-10-01 | 2020-03-24 | Мерк Патент Гмбх | Производные бороновой кислоты |
| RU2017115193A (ru) | 2014-10-01 | 2018-11-06 | Мерк Патент Гмбх | Производные бороновой кислоты |
-
2015
- 2015-10-01 KR KR1020177011646A patent/KR20170062518A/ko not_active Withdrawn
- 2015-10-01 AU AU2015327412A patent/AU2015327412B2/en not_active Ceased
- 2015-10-01 EP EP15800714.6A patent/EP3201208B1/en active Active
- 2015-10-01 CA CA2963198A patent/CA2963198A1/en active Pending
- 2015-10-01 WO PCT/EP2015/001931 patent/WO2016050356A1/en not_active Ceased
- 2015-10-01 RU RU2017115191A patent/RU2017115191A/ru not_active Application Discontinuation
- 2015-10-01 BR BR112017006349A patent/BR112017006349A2/pt not_active IP Right Cessation
- 2015-10-01 MX MX2017004043A patent/MX2017004043A/es unknown
- 2015-10-01 CN CN201580053454.8A patent/CN107074885B/zh not_active Expired - Fee Related
- 2015-10-01 SG SG11201702620SA patent/SG11201702620SA/en unknown
- 2015-10-01 US US15/516,422 patent/US10253049B2/en active Active
- 2015-10-01 JP JP2017518064A patent/JP6896618B2/ja not_active Expired - Fee Related
- 2015-10-01 ES ES15800714T patent/ES2876287T3/es active Active
-
2017
- 2017-03-21 IL IL251299A patent/IL251299A0/en unknown
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