JP2018501195A5 - - Google Patents
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- JP2018501195A5 JP2018501195A5 JP2017524040A JP2017524040A JP2018501195A5 JP 2018501195 A5 JP2018501195 A5 JP 2018501195A5 JP 2017524040 A JP2017524040 A JP 2017524040A JP 2017524040 A JP2017524040 A JP 2017524040A JP 2018501195 A5 JP2018501195 A5 JP 2018501195A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- myh
- mes
- group
- functional variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 102100031162 Collagen alpha-1(XVIII) chain Human genes 0.000 claims description 7
- 108010079505 Endostatins Proteins 0.000 claims description 7
- 208000002705 Glucose Intolerance Diseases 0.000 claims description 4
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims description 4
- 206010022489 Insulin Resistance Diseases 0.000 claims description 4
- 208000008589 Obesity Diseases 0.000 claims description 4
- 235000005911 diet Nutrition 0.000 claims description 4
- 230000000378 dietary effect Effects 0.000 claims description 4
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 4
- 235000020824 obesity Nutrition 0.000 claims description 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 210000001789 adipocyte Anatomy 0.000 claims description 3
- 230000004069 differentiation Effects 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410610777 | 2014-11-03 | ||
| CN201410610777.X | 2014-11-03 | ||
| CN201510021469.8 | 2015-01-15 | ||
| CN201510021469 | 2015-01-15 | ||
| PCT/CN2015/093726 WO2016070798A1 (zh) | 2014-11-03 | 2015-11-03 | 一种抑制脂肪细胞分化和胰岛素耐受的药物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020126891A Division JP7227197B2 (ja) | 2014-11-03 | 2020-07-27 | 脂肪細胞分化およびインスリン抵抗性を阻害するための薬物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018501195A JP2018501195A (ja) | 2018-01-18 |
| JP2018501195A5 true JP2018501195A5 (cg-RX-API-DMAC7.html) | 2018-12-13 |
Family
ID=55908589
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017524040A Pending JP2018501195A (ja) | 2014-11-03 | 2015-11-03 | 脂肪細胞分化およびインスリン抵抗性を阻害するための薬物 |
| JP2020126891A Active JP7227197B2 (ja) | 2014-11-03 | 2020-07-27 | 脂肪細胞分化およびインスリン抵抗性を阻害するための薬物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020126891A Active JP7227197B2 (ja) | 2014-11-03 | 2020-07-27 | 脂肪細胞分化およびインスリン抵抗性を阻害するための薬物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20180015148A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3246043A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2018501195A (cg-RX-API-DMAC7.html) |
| CN (2) | CN114558111A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015342324B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3003760A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016070798A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016127948A1 (zh) * | 2015-02-13 | 2016-08-18 | 清华大学 | 一种重组蛋白质药物的分子设计 |
| CN115721730B (zh) | 2016-11-10 | 2025-03-14 | 北京普罗吉生物科技发展有限公司 | 聚乙二醇化血管内皮抑制素类似物及其应用 |
| US10276161B2 (en) | 2016-12-27 | 2019-04-30 | Google Llc | Contextual hotwords |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2307792C (en) * | 1997-10-31 | 2007-06-26 | Children's Medical Center Corporation | Method for regulating size and growth of vascularized normal tissue |
| AU2002323543A1 (en) * | 2001-09-07 | 2003-03-24 | Board Of Regents, The University Of Texas System | Compositions and methods of use of targeting peptides against placenta and adipose tissues |
| US7524811B2 (en) * | 2003-08-29 | 2009-04-28 | Children's Medical Center Corporation | Anti-angiogenic peptides from the N-terminus of endostatin |
| CN101596320B (zh) * | 2006-01-20 | 2013-01-09 | 清华大学 | 一种治疗肿瘤的药物及其应用 |
| CN103083681A (zh) * | 2006-01-20 | 2013-05-08 | 清华大学 | 一种治疗肿瘤的药物及其应用 |
| BRPI0819434A2 (pt) * | 2007-11-08 | 2019-09-24 | Univ Utah Res Found | método de tratamento ou prevenção de doenças hepáticas e uso de antagonistas á angiogênese em condições de proliferação venosa anormal |
| CN101219206A (zh) * | 2008-02-01 | 2008-07-16 | 山东先声麦得津生物制药有限公司 | 重组人血管内皮抑制素在制药中的应用 |
| CN102698270B (zh) * | 2011-03-28 | 2016-02-03 | 清华大学 | 一种增强靶细胞摄取治疗剂的方法和药物组合物 |
| AU2012236199A1 (en) * | 2011-03-30 | 2013-09-26 | Board Of Regents Of The University Of Texas System | Methods and compositions for targeting adipose cells in mammals |
| RU2014113924A (ru) * | 2011-09-09 | 2015-10-20 | Тсинхуа Юниверсити | Мутанты эндостатина с мутациями в сайтах связывания атф |
-
2015
- 2015-11-03 AU AU2015342324A patent/AU2015342324B2/en active Active
- 2015-11-03 JP JP2017524040A patent/JP2018501195A/ja active Pending
- 2015-11-03 EP EP15857606.6A patent/EP3246043A4/en active Pending
- 2015-11-03 CN CN202210191378.9A patent/CN114558111A/zh active Pending
- 2015-11-03 WO PCT/CN2015/093726 patent/WO2016070798A1/zh not_active Ceased
- 2015-11-03 CA CA3003760A patent/CA3003760A1/en active Pending
- 2015-11-03 CN CN201580059881.7A patent/CN107148277B/zh active Active
- 2015-11-03 US US15/524,094 patent/US20180015148A1/en not_active Abandoned
-
2020
- 2020-07-27 JP JP2020126891A patent/JP7227197B2/ja active Active
-
2022
- 2022-07-20 US US17/869,348 patent/US20220409703A1/en not_active Abandoned
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