JP2018168191A5 - - Google Patents
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- Publication number
- JP2018168191A5 JP2018168191A5 JP2018129624A JP2018129624A JP2018168191A5 JP 2018168191 A5 JP2018168191 A5 JP 2018168191A5 JP 2018129624 A JP2018129624 A JP 2018129624A JP 2018129624 A JP2018129624 A JP 2018129624A JP 2018168191 A5 JP2018168191 A5 JP 2018168191A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline form
- excipient
- powder
- ray diffraction
- diffraction pattern
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 238000000634 powder X-ray diffraction Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000004214 philadelphia chromosome Anatomy 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- SNIABFMMCKVXSY-UHFFFAOYSA-N benzoylazanium;chloride Chemical compound Cl.NC(=O)C1=CC=CC=C1 SNIABFMMCKVXSY-UHFFFAOYSA-N 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- -1 imidazo [1,2-b] pyridazin-3-ylethynyl Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021203538A JP7352841B2 (ja) | 2012-12-12 | 2021-12-15 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2023150905A JP2023179498A (ja) | 2012-12-12 | 2023-09-19 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2025171607A JP2026010061A (ja) | 2012-12-12 | 2025-10-10 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261736543P | 2012-12-12 | 2012-12-12 | |
| US61/736,543 | 2012-12-12 | ||
| US201261737007P | 2012-12-13 | 2012-12-13 | |
| US61/737,007 | 2012-12-13 | ||
| US201361788208P | 2013-03-15 | 2013-03-15 | |
| US61/788,208 | 2013-03-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015547524A Division JP6447508B2 (ja) | 2012-12-12 | 2013-12-12 | ３−（イミダゾ［１，２−ｂ］ピリダジン−３−イルエチニル）−４−メチル−Ｎ−｛４−［（４−メチルピペラジン−１−イル）メチル］−３−（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021203538A Division JP7352841B2 (ja) | 2012-12-12 | 2021-12-15 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018168191A JP2018168191A (ja) | 2018-11-01 |
| JP2018168191A5 true JP2018168191A5 (cg-RX-API-DMAC10.html) | 2019-02-14 |
| JP7042175B2 JP7042175B2 (ja) | 2022-03-25 |
Family
ID=50929140
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015547524A Active JP6447508B2 (ja) | 2012-12-12 | 2013-12-12 | ３−（イミダゾ［１，２−ｂ］ピリダジン−３−イルエチニル）−４−メチル−Ｎ−｛４−［（４−メチルピペラジン−１−イル）メチル］−３−（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2018129624A Active JP7042175B2 (ja) | 2012-12-12 | 2018-07-09 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2021203538A Active JP7352841B2 (ja) | 2012-12-12 | 2021-12-15 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2023150905A Pending JP2023179498A (ja) | 2012-12-12 | 2023-09-19 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2025171607A Pending JP2026010061A (ja) | 2012-12-12 | 2025-10-10 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015547524A Active JP6447508B2 (ja) | 2012-12-12 | 2013-12-12 | ３−（イミダゾ［１，２−ｂ］ピリダジン−３−イルエチニル）−４−メチル−Ｎ−｛４−［（４−メチルピペラジン−１−イル）メチル］−３−（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021203538A Active JP7352841B2 (ja) | 2012-12-12 | 2021-12-15 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2023150905A Pending JP2023179498A (ja) | 2012-12-12 | 2023-09-19 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
| JP2025171607A Pending JP2026010061A (ja) | 2012-12-12 | 2025-10-10 | ３－（イミダゾ［１，２－ｂ］ピリダジン－３－イルエチニル）－４－メチル－Ｎ－｛４－［（４－メチルピペラジン－１－イル）メチル］－３－（トリフルオロメチル）フェニル｝ベンズアミドおよびその一塩酸塩の結晶形 |
Country Status (9)
| Country | Link |
|---|---|
| US (9) | US9493470B2 (cg-RX-API-DMAC10.html) |
| JP (5) | JP6447508B2 (cg-RX-API-DMAC10.html) |
| CN (2) | CN115043843A (cg-RX-API-DMAC10.html) |
| CA (3) | CA2815506C (cg-RX-API-DMAC10.html) |
| CL (1) | CL2015001643A1 (cg-RX-API-DMAC10.html) |
| HK (1) | HK1218878A1 (cg-RX-API-DMAC10.html) |
| MX (11) | MX391445B (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ709648A (cg-RX-API-DMAC10.html) |
| WO (2) | WO2014093579A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX343042B (es) | 2005-12-23 | 2016-10-21 | Ariad Pharma Inc | Compuestos heteroarilicos biciclicos. |
| TWI568722B (zh) | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物 |
| CA2815506C (en) | 2012-12-12 | 2018-12-11 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
| EP3016954B1 (en) * | 2013-07-04 | 2018-10-31 | Sandoz AG | Crystalline forms of ponatinib hydrochloride |
| CN104496994B (zh) * | 2014-01-06 | 2016-12-07 | 广东东阳光药业有限公司 | 一种炔类杂芳基化合物的新晶型 |
| JP7158383B2 (ja) * | 2016-12-15 | 2022-10-21 | アリアド ファーマシューティカルズ， インコーポレイテッド | Ｃ－ｋｉｔ阻害剤としてのベンズイミダゾール化合物 |
| US10221184B2 (en) | 2017-01-20 | 2019-03-05 | Apicore Us Llc | Polymorphs of ponatinib hydrochloride |
| WO2018232501A1 (en) * | 2017-06-20 | 2018-12-27 | Apotex Inc. | Crystalline forms of ponatinib hydrochloride |
| CN118206614A (zh) * | 2018-04-02 | 2024-06-18 | 隐形生物治疗公司 | 用于合成elamipretide的结晶二肽 |
| WO2019246479A1 (en) | 2018-06-22 | 2019-12-26 | Johnson Matthey Public Limited Company | Form of ponatinib |
| KR20210118812A (ko) | 2018-11-01 | 2021-10-01 | 사이로스 파마수티컬스, 인크. | 시클린-의존성 키나제 7 (cdk7)의 억제제 |
| WO2020223235A1 (en) | 2019-04-29 | 2020-11-05 | Incyte Corporation | Mini-tablet dosage forms of ponatinib |
| CN111004240B (zh) * | 2019-12-13 | 2020-12-01 | 山东铂源药业有限公司 | 一种泊那替尼中间体3-乙炔基咪唑并[1,2-b]哒嗪的合成方法 |
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| US5099067A (en) | 1988-08-05 | 1992-03-24 | Northwestern University | Use of ammonium formate as a hydrogen transfer reagent for reduction of chiral nitro compounds with retention of configuration |
| ATE298325T1 (de) | 1999-11-08 | 2005-07-15 | Schering Corp | Verfahren zur herstellung von n-(4-hydroxyphenyl)-n'-(4'-aminophenyl)-piperaz ne |
| HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| DE10021246A1 (de) | 2000-04-25 | 2001-10-31 | Schering Ag | Substituierte Benzoesäureamide und deren Verwendung als Arzneimittel |
| IL159811A0 (en) | 2001-07-13 | 2004-06-20 | Neurogen Corp | Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands |
| TW200418466A (en) | 2002-11-06 | 2004-10-01 | Smithkline Beecham Corp | Chemical compounds |
| GB0230089D0 (en) | 2002-12-24 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| EP1689376A2 (en) | 2003-11-28 | 2006-08-16 | Novartis AG | Diaryl urea derivatives in the treatment of protein kinase dependent diseases |
| EP1694691A1 (en) | 2003-12-05 | 2006-08-30 | Biovitrum Ab | Improved synthesis of 2-substituted adenosines |
| DE602004018193D1 (de) | 2003-12-24 | 2009-01-15 | Astrazeneca Ab | Pyrimidine mit tie2 (tek) aktivität |
| EP1737462B1 (en) | 2003-12-24 | 2008-07-30 | AstraZeneca AB | Pyrimidines with tie2 (tek) activity |
| MXPA06011678A (es) | 2004-04-07 | 2007-01-23 | Applied Research Systems | Derivados de 1,1??(1,2-etinediil)bis-benceno como inhibidores de proteina-tirosina fosfatasa 1-b. |
| KR20070083484A (ko) | 2004-07-14 | 2007-08-24 | 피티씨 테라퓨틱스, 인크. | Ｃ형 간염 치료 방법 |
| US7776869B2 (en) | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
| GB0502418D0 (en) | 2005-02-05 | 2005-03-16 | Astrazeneca Ab | Compounds |
| WO2006103449A2 (en) | 2005-03-31 | 2006-10-05 | Astrazeneca Ab | Saminopyrimidine derivates with tie2 inhibiting activity |
| JP2009502734A (ja) | 2005-07-29 | 2009-01-29 | アステラス製薬株式会社 | Ｌｃｋ阻害剤としての縮合複素環 |
| EP1940843A4 (en) | 2005-08-11 | 2010-09-15 | Ariad Pharma Inc | UNSATURATED HETEROCYCLIC DERIVATIVES |
| MX343042B (es) | 2005-12-23 | 2016-10-21 | Ariad Pharma Inc | Compuestos heteroarilicos biciclicos. |
| SI1973545T1 (sl) * | 2005-12-23 | 2013-04-30 | Ariad Pharmaceuticals, Inc. | Spojine bicikličnega heteroarila |
| JP5273037B2 (ja) | 2006-05-08 | 2013-08-28 | アリアド・ファーマシューティカルズ・インコーポレイテッド | アセチレン性ヘテロアリール化合物 |
| EA200870515A1 (ru) | 2006-05-08 | 2009-06-30 | Ариад Фармасьютикалз, Инк. | Моноциклические гетероарильные соединения |
| EP2107054A1 (en) | 2008-04-01 | 2009-10-07 | Università Degli Studi Di Milano - Bicocca | Antiproliferative compounds and therapeutic uses thereof |
| US20100273772A1 (en) * | 2009-04-23 | 2010-10-28 | Wyeth Llc | Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5) |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| PH12012500809A1 (en) | 2009-10-30 | 2012-11-26 | Ariad Pharma Inc | Methods and compositions for treating cancer |
| MX2013011589A (es) | 2011-04-07 | 2013-12-16 | Ariad Pharma Inc | Metodos y composiciones para tratar enfermedad de parkinson. |
| BR112013024171A2 (pt) * | 2011-04-07 | 2016-12-13 | Ariad Pharma Inc | método para o tratamento e prevenção de uma condição neurodegenerativa |
| EP2841062A4 (en) | 2012-04-25 | 2015-11-25 | Ariad Pharma Inc | METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISEASES MEDIATED BY RAF KINASE |
| CA2815506C (en) * | 2012-12-12 | 2018-12-11 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
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2013
- 2013-05-09 CA CA2815506A patent/CA2815506C/en active Active
- 2013-05-09 CA CA3167093A patent/CA3167093A1/en active Pending
- 2013-05-09 CA CA3022250A patent/CA3022250A1/en not_active Abandoned
- 2013-12-12 CN CN202210369530.8A patent/CN115043843A/zh active Pending
- 2013-12-12 MX MX2018010998A patent/MX391445B/es unknown
- 2013-12-12 HK HK16106954.3A patent/HK1218878A1/zh unknown
- 2013-12-12 JP JP2015547524A patent/JP6447508B2/ja active Active
- 2013-12-12 NZ NZ709648A patent/NZ709648A/en unknown
- 2013-12-12 CN CN201380072027.5A patent/CN105188701A/zh active Pending
- 2013-12-12 WO PCT/US2013/074571 patent/WO2014093579A2/en not_active Ceased
- 2013-12-12 MX MX2015007578A patent/MX359147B/es active IP Right Grant
- 2013-12-12 US US14/651,577 patent/US9493470B2/en active Active
- 2013-12-12 WO PCT/US2013/074585 patent/WO2014093583A2/en not_active Ceased
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2015
- 2015-06-12 MX MX2021002253A patent/MX2021002253A/es unknown
- 2015-06-12 MX MX2021002257A patent/MX2021002257A/es unknown
- 2015-06-12 MX MX2021002256A patent/MX2021002256A/es unknown
- 2015-06-12 MX MX2021002264A patent/MX2021002264A/es unknown
- 2015-06-12 MX MX2021002259A patent/MX2021002259A/es unknown
- 2015-06-12 MX MX2021002261A patent/MX2021002261A/es unknown
- 2015-06-12 CL CL2015001643A patent/CL2015001643A1/es unknown
- 2015-06-12 MX MX2021002254A patent/MX2021002254A/es unknown
- 2015-06-12 MX MX2021002258A patent/MX2021002258A/es unknown
- 2015-06-12 MX MX2021002255A patent/MX2021002255A/es unknown
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2016
- 2016-11-02 US US15/341,898 patent/US10125136B2/en active Active
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2018
- 2018-07-09 JP JP2018129624A patent/JP7042175B2/ja active Active
- 2018-09-28 US US16/146,143 patent/US10662197B2/en active Active
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2020
- 2020-05-22 US US16/881,790 patent/US11279705B2/en active Active
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2021
- 2021-05-12 US US17/318,677 patent/US11192895B2/en active Active
- 2021-05-12 US US17/318,832 patent/US11192897B2/en active Active
- 2021-05-12 US US17/318,772 patent/US11192896B2/en active Active
- 2021-05-12 US US17/318,876 patent/US11384086B2/en active Active
- 2021-12-15 JP JP2021203538A patent/JP7352841B2/ja active Active
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2023
- 2023-02-27 US US18/175,272 patent/US20240083902A1/en not_active Abandoned
- 2023-09-19 JP JP2023150905A patent/JP2023179498A/ja active Pending
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2025
- 2025-10-10 JP JP2025171607A patent/JP2026010061A/ja active Pending