JP2018143239A5 - - Google Patents
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- JP2018143239A5 JP2018143239A5 JP2018034004A JP2018034004A JP2018143239A5 JP 2018143239 A5 JP2018143239 A5 JP 2018143239A5 JP 2018034004 A JP2018034004 A JP 2018034004A JP 2018034004 A JP2018034004 A JP 2018034004A JP 2018143239 A5 JP2018143239 A5 JP 2018143239A5
- Authority
- JP
- Japan
- Prior art keywords
- pluripotent stem
- cell type
- desired cell
- transcription factor
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 9
- 108091023040 Transcription factor Proteins 0.000 claims 6
- 102000040945 Transcription factor Human genes 0.000 claims 6
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 6
- 230000004069 differentiation Effects 0.000 claims 5
- 101001094700 Homo sapiens POU domain, class 5, transcription factor 1 Proteins 0.000 claims 4
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 claims 4
- 239000006143 cell culture medium Substances 0.000 claims 3
- 210000002161 motor neuron Anatomy 0.000 claims 3
- 210000002363 skeletal muscle cell Anatomy 0.000 claims 3
- 102100029283 Hepatocyte nuclear factor 3-alpha Human genes 0.000 claims 2
- 101001062353 Homo sapiens Hepatocyte nuclear factor 3-alpha Proteins 0.000 claims 2
- 241000711408 Murine respirovirus Species 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 101000823089 Equus caballus Alpha-1-antiproteinase 1 Proteins 0.000 claims 1
- 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 claims 1
- 101001045751 Homo sapiens Hepatocyte nuclear factor 1-alpha Proteins 0.000 claims 1
- 101001023043 Homo sapiens Myoblast determination protein 1 Proteins 0.000 claims 1
- 101000603702 Homo sapiens Neurogenin-3 Proteins 0.000 claims 1
- 101000651211 Homo sapiens Transcription factor PU.1 Proteins 0.000 claims 1
- 102100035077 Myoblast determination protein 1 Human genes 0.000 claims 1
- 102100038553 Neurogenin-3 Human genes 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 102100027654 Transcription factor PU.1 Human genes 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000005064 dopaminergic neuron Anatomy 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023212588A JP2024037929A (ja) | 2017-03-01 | 2023-12-16 | 多能性幹細胞を所望の細胞型へ効率的に分化する方法 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762465188P | 2017-03-01 | 2017-03-01 | |
| US62/465,188 | 2017-03-01 | ||
| US201762523324P | 2017-06-22 | 2017-06-22 | |
| US62/523,324 | 2017-06-22 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023212588A Division JP2024037929A (ja) | 2017-03-01 | 2023-12-16 | 多能性幹細胞を所望の細胞型へ効率的に分化する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018143239A JP2018143239A (ja) | 2018-09-20 |
| JP2018143239A5 true JP2018143239A5 (Direct) | 2021-04-08 |
Family
ID=63357266
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018034004A Pending JP2018143239A (ja) | 2017-03-01 | 2018-02-27 | 多能性幹細胞を所望の細胞型へ効率的に分化する方法 |
| JP2023212588A Pending JP2024037929A (ja) | 2017-03-01 | 2023-12-16 | 多能性幹細胞を所望の細胞型へ効率的に分化する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023212588A Pending JP2024037929A (ja) | 2017-03-01 | 2023-12-16 | 多能性幹細胞を所望の細胞型へ効率的に分化する方法 |
Country Status (2)
| Country | Link |
|---|---|
| US (3) | US11136555B2 (Direct) |
| JP (2) | JP2018143239A (Direct) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013163628A2 (en) | 2012-04-27 | 2013-10-31 | Duke University | Genetic correction of mutated genes |
| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| US10676726B2 (en) | 2015-02-09 | 2020-06-09 | Duke University | Compositions and methods for epigenome editing |
| WO2017066497A2 (en) | 2015-10-13 | 2017-04-20 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
| KR20250044471A (ko) | 2015-11-30 | 2025-03-31 | 듀크 유니버시티 | 유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법 |
| WO2017180915A2 (en) | 2016-04-13 | 2017-10-19 | Duke University | Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use |
| JP7490211B2 (ja) | 2016-07-19 | 2024-05-27 | デューク ユニバーシティ | Ｃｐｆ１に基づくゲノム編集の治療適用 |
| JP2018143239A (ja) | 2017-03-01 | 2018-09-20 | エリクサジェン，エルエルシー． | 多能性幹細胞を所望の細胞型へ効率的に分化する方法 |
| WO2019107354A1 (ja) * | 2017-11-30 | 2019-06-06 | アイ ピース， インコーポレイテッド | 神経系細胞の作製方法 |
| WO2019144061A1 (en) | 2018-01-19 | 2019-07-25 | Duke University | Genome engineering with crispr-cas systems in eukaryotes |
| JP7548494B2 (ja) * | 2018-10-30 | 2024-09-10 | 国立大学法人京都大学 | 細胞の製造方法 |
| JP2022545461A (ja) * | 2019-08-19 | 2022-10-27 | デューク ユニバーシティ | 細胞型運命指定の調節因子を同定するための組成物および方法 |
| CN115551994A (zh) | 2020-03-11 | 2022-12-30 | 倍特博有限公司 | 产生肝细胞的方法 |
| JP7654238B2 (ja) * | 2020-05-15 | 2025-04-02 | 学校法人 愛知医科大学 | 共培養システム |
| AU2023289696A1 (en) | 2022-06-24 | 2025-01-16 | Tune Therapeutics, Inc. | Compositions, systems, and methods for reducing low-density lipoprotein through targeted gene repression |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4478788B2 (ja) * | 2005-05-27 | 2010-06-09 | 独立行政法人産業技術総合研究所 | センダイウイルス温度感受性株由来のウイルスベクター |
| JP2009045004A (ja) | 2007-08-20 | 2009-03-05 | Japan Science & Technology Agency | クロマチン制御因子による幹細胞未分化制御方法 |
| CN102417894B (zh) | 2011-10-21 | 2013-06-05 | 中国科学院广州生物医药与健康研究院 | 一种提高诱导生成多能性干细胞效率的方法 |
| JP6083877B2 (ja) * | 2011-11-18 | 2017-02-22 | 国立大学法人京都大学 | 多能性幹細胞から骨格筋細胞への分化誘導方法 |
| CN109182376B (zh) | 2012-10-29 | 2022-05-10 | 学校法人埼玉医科大学 | 分化多能性干细胞的制造方法 |
| US10023838B2 (en) * | 2013-03-01 | 2018-07-17 | Kyoto University | Method of inducing differentiation from pluripotent stem cells to germ cells |
| US10744183B2 (en) | 2013-03-15 | 2020-08-18 | Elixirgen Therapeutics, Inc. | Methods of using ZSCAN4 for rejuvenating human cells |
| AU2014324233B2 (en) * | 2013-09-24 | 2020-07-23 | Id Pharma Co., Ltd. | Method for improving efficiency of inducing pluripotent stem cell |
| WO2016143826A1 (ja) * | 2015-03-09 | 2016-09-15 | 学校法人慶應義塾 | 多能性幹細胞を所望の細胞型へ分化する方法 |
| JP2018513686A (ja) * | 2015-04-10 | 2018-05-31 | シンガポール科学技術研究庁Ａｇｅｎｃｙ ｆｏｒ Ｓｃｉｅｎｃｅ， Ｔｅｃｈｎｏｌｏｇｙ ａｎｄ Ｒｅｓｅａｒｃｈ | 幹細胞からの機能性細胞の生成 |
| JP6874994B2 (ja) | 2015-10-28 | 2021-05-19 | 学校法人慶應義塾 | 多能性幹細胞の分化抵抗性を減弱する方法 |
| JP6885598B2 (ja) * | 2016-01-31 | 2021-06-16 | 学校法人慶應義塾 | 未分化性低減による多能性幹細胞の分化促進法 |
| JP2018143239A (ja) | 2017-03-01 | 2018-09-20 | エリクサジェン，エルエルシー． | 多能性幹細胞を所望の細胞型へ効率的に分化する方法 |
-
2018
- 2018-02-27 JP JP2018034004A patent/JP2018143239A/ja active Pending
- 2018-02-27 US US15/905,982 patent/US11136555B2/en active Active
-
2021
- 2021-08-27 US US17/458,609 patent/US12098392B2/en active Active
-
2023
- 2023-12-16 JP JP2023212588A patent/JP2024037929A/ja active Pending
-
2024
- 2024-07-29 US US18/786,913 patent/US20250027054A1/en active Pending
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