JP2018035142A5 - - Google Patents
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- Publication number
- JP2018035142A5 JP2018035142A5 JP2017154022A JP2017154022A JP2018035142A5 JP 2018035142 A5 JP2018035142 A5 JP 2018035142A5 JP 2017154022 A JP2017154022 A JP 2017154022A JP 2017154022 A JP2017154022 A JP 2017154022A JP 2018035142 A5 JP2018035142 A5 JP 2018035142A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- cycloalkyl
- heteroatom group
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000005842 heteroatom Chemical group 0.000 claims 26
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000004432 carbon atom Chemical group C* 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 108091033409 CRISPR Proteins 0.000 claims 4
- 125000004450 alkenylene group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000004419 alkynylene group Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 150000003536 tetrazoles Chemical class 0.000 claims 4
- 150000003852 triazoles Chemical class 0.000 claims 4
- 125000006743 (C1-C60) alkyl group Chemical group 0.000 claims 2
- 125000006651 (C3-C20) cycloalkyl group Chemical group 0.000 claims 2
- 108010081734 Ribonucleoproteins Proteins 0.000 claims 2
- 102000004389 Ribonucleoproteins Human genes 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 210000003494 hepatocyte Anatomy 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 102000005427 Asialoglycoprotein Receptor Human genes 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 108010006523 asialoglycoprotein receptor Proteins 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462000211P | 2014-05-19 | 2014-05-19 | |
| US62/000,211 | 2014-05-19 | ||
| US201462001540P | 2014-05-21 | 2014-05-21 | |
| US62/001,540 | 2014-05-21 | ||
| US201562139254P | 2015-03-27 | 2015-03-27 | |
| US62/139,254 | 2015-03-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016567971A Division JP6193513B2 (ja) | 2014-05-19 | 2015-05-05 | Ａｓｇｐｒ標的化剤としての置換６，８−ジオキサビシクロ［３．２．１］オクタン−２，３−ジオール化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018035142A JP2018035142A (ja) | 2018-03-08 |
| JP2018035142A5 true JP2018035142A5 (https=) | 2018-10-04 |
| JP6663889B2 JP6663889B2 (ja) | 2020-03-13 |
Family
ID=53200246
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016567971A Active JP6193513B2 (ja) | 2014-05-19 | 2015-05-05 | Ａｓｇｐｒ標的化剤としての置換６，８−ジオキサビシクロ［３．２．１］オクタン−２，３−ジオール化合物 |
| JP2017154022A Active JP6663889B2 (ja) | 2014-05-19 | 2017-08-09 | Ａｓｇｐｒ標的化剤としての置換６，８−ジオキサビシクロ［３．２．１］オクタン−２，３−ジオール化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016567971A Active JP6193513B2 (ja) | 2014-05-19 | 2015-05-05 | Ａｓｇｐｒ標的化剤としての置換６，８−ジオキサビシクロ［３．２．１］オクタン−２，３−ジオール化合物 |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US9340553B2 (https=) |
| EP (1) | EP3145934B1 (https=) |
| JP (2) | JP6193513B2 (https=) |
| KR (1) | KR102149572B1 (https=) |
| CN (1) | CN106459120A (https=) |
| AU (1) | AU2015262993B2 (https=) |
| BR (1) | BR112016026809A2 (https=) |
| CA (1) | CA2891717C (https=) |
| DK (1) | DK3145934T5 (https=) |
| ES (1) | ES2841400T3 (https=) |
| HU (1) | HUE052146T2 (https=) |
| IL (1) | IL248667B (https=) |
| MX (1) | MX381383B (https=) |
| MY (1) | MY181586A (https=) |
| NZ (1) | NZ725600A (https=) |
| PE (1) | PE20170024A1 (https=) |
| PH (1) | PH12016502304A1 (https=) |
| PL (1) | PL3145934T3 (https=) |
| PT (1) | PT3145934T (https=) |
| RU (1) | RU2696490C2 (https=) |
| SA (1) | SA516380328B1 (https=) |
| SG (1) | SG11201608936UA (https=) |
| SI (1) | SI3145934T1 (https=) |
| TW (1) | TWI579286B (https=) |
| UY (1) | UY36126A (https=) |
| WO (1) | WO2015177668A1 (https=) |
Families Citing this family (55)
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| US12279989B2 (en) | 2011-02-04 | 2025-04-22 | Seed Health, Inc. | Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity |
| US10245288B2 (en) | 2011-02-04 | 2019-04-02 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing NASH in an individual diagnosed with non-alcoholic fatty liver disease |
| US10086018B2 (en) | 2011-02-04 | 2018-10-02 | Joseph E. Kovarik | Method and system for reducing the likelihood of colorectal cancer in a human being |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| US10842834B2 (en) | 2016-01-06 | 2020-11-24 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease |
| US11273187B2 (en) | 2015-11-30 | 2022-03-15 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing depression in an individual |
| US10687975B2 (en) | 2011-02-04 | 2020-06-23 | Joseph E. Kovarik | Method and system to facilitate the growth of desired bacteria in a human's mouth |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US10548761B2 (en) | 2011-02-04 | 2020-02-04 | Joseph E. Kovarik | Method and system for reducing the likelihood of colorectal cancer in a human being |
| US12533312B2 (en) | 2011-02-04 | 2026-01-27 | Seed Health, Inc. | Method and system for preventing sore throat in humans |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US11419903B2 (en) | 2015-11-30 | 2022-08-23 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US9987224B2 (en) | 2011-02-04 | 2018-06-05 | Joseph E. Kovarik | Method and system for preventing migraine headaches, cluster headaches and dizziness |
| US11523934B2 (en) | 2011-02-04 | 2022-12-13 | Seed Health, Inc. | Method and system to facilitate the growth of desired bacteria in a human's mouth |
| US12257272B2 (en) | 2015-12-24 | 2025-03-25 | Seed Health, Inc. | Method and system for reducing the likelihood of developing depression in an individual |
| US10512661B2 (en) | 2011-02-04 | 2019-12-24 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease |
| US12329783B2 (en) | 2013-12-20 | 2025-06-17 | Seed Health, Inc. | Method and system to improve the health of a person's skin microbiome |
| US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
| US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
| US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
| US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
| US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
| US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
| US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
| US12246043B2 (en) | 2013-12-20 | 2025-03-11 | Seed Health, Inc. | Topical application to treat acne vulgaris |
| KR102149572B1 (ko) | 2014-05-19 | 2020-08-28 | 화이자 인코포레이티드 | 아시알로당단백질 수용체의 표적화제로서 치환된-6,8-다이옥사바이사이클로[3.2.1]옥탄-2,3-다이올 화합물 |
| CA2947904A1 (en) * | 2015-11-12 | 2017-05-12 | Pfizer Inc. | Tissue-specific genome engineering using crispr-cas9 |
| US12239706B2 (en) | 2015-11-30 | 2025-03-04 | Seed Health, Inc. | Method and system for protecting monarch butterflies from pesticides |
| US20230097887A1 (en) | 2018-04-09 | 2023-03-30 | Yale University | Bi-functional Molecules to Degrade Circulating Proteins |
| US12364766B2 (en) | 2018-04-09 | 2025-07-22 | Yale University | Bifunctional small molecules to target the selective degradation of circulating proteins |
| US12485178B2 (en) | 2018-04-09 | 2025-12-02 | Yale University | Bifunctional small molecules to target the selective degradation of circulating proteins |
| WO2019199621A1 (en) * | 2018-04-09 | 2019-10-17 | Yale University | Bi-functional molecules to degrade circulating proteins |
| US12150967B2 (en) | 2018-08-18 | 2024-11-26 | Seed Health, Inc. | Methods and compositions for honey bee health |
| CN109232690A (zh) * | 2018-09-10 | 2019-01-18 | 南方医科大学南方医院 | 一种正电子显像剂标准品前体及其制备方法 |
| RU2712497C1 (ru) * | 2018-11-26 | 2020-01-29 | Автономная некоммерческая образовательная организация высшего образования Сколковский институт науки и технологий | Средство разрезания ДНК на основе Cas9 белка из биотехнологически значимой бактерии Clostridium cellulolyticum |
| CN113301925A (zh) | 2018-12-19 | 2021-08-24 | 小利兰·斯坦福大学理事会 | 用于溶酶体靶向的双官能分子以及相关的组合物和方法 |
| IL294515A (en) | 2020-01-31 | 2022-09-01 | Avilar Therapeutics Inc | Compounds bind asgpr to degrade extracellular proteins |
| EP4100064A1 (en) | 2020-02-07 | 2022-12-14 | Novartis AG | Targeted plasma protein degradation |
| JP2023526533A (ja) | 2020-05-22 | 2023-06-21 | ウェイブ ライフ サイエンシズ リミテッド | 二本鎖オリゴヌクレオチド組成物及びそれに関連する方法 |
| EP4281115A1 (en) | 2021-01-19 | 2023-11-29 | Novartis AG | Degradation of extracellular targets |
| EP4288086A4 (en) * | 2021-02-08 | 2025-04-16 | Emendobio Inc. | OMNI 90-99,101,104-110,11,16,18-123, 125,16,28 129 UND138 CRISPR NUCLEASES |
| JP2024509282A (ja) * | 2021-03-10 | 2024-02-29 | バイオヘイブン・セラピューティクス・リミテッド | ガラクトース欠損免疫グロブリンの二官能性分解剤 |
| WO2022235699A2 (en) | 2021-05-03 | 2022-11-10 | Avilar Therapeutics, Inc. | Potent asgpr-binding compounds for the degradation of immunoglobulins and other proteins |
| WO2022248607A2 (en) * | 2021-05-25 | 2022-12-01 | ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN NANOCIENCIAS "CIC nanoGUNE" | Synthetic cas proteins |
| AU2022310356A1 (en) | 2021-07-14 | 2024-01-25 | Lycia Therapeutics, Inc. | Asgpr cell surface receptor binding compounds and conjugates |
| WO2023009554A1 (en) * | 2021-07-26 | 2023-02-02 | Avilar Therapeutics, Inc. | Methods to reduce adverse effects of gene or biologics therapy |
| EP4392430A4 (en) | 2021-08-27 | 2026-04-29 | Univ Yale | Molecular degraders of extracellular proteins |
| WO2024167900A2 (en) * | 2023-02-06 | 2024-08-15 | Biohaven Therapeutics Ltd. | Bifunctional molecules to target degradation of tumor necrosis factor |
| WO2024229005A2 (en) * | 2023-04-30 | 2024-11-07 | Biohaven Therapeutics Ltd. | Asgpr binders and compositions and methods thereof |
| GB202311334D0 (en) | 2023-07-24 | 2023-09-06 | Astrazeneca Ab | Multivalent cargo-carrying complexes and uses thereof |
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| CN121909203A (zh) | 2023-10-31 | 2026-04-21 | 科罗生物公司 | 包含氨基磷酸酯核苷酸间键的寡核苷酸 |
| WO2025157263A1 (zh) * | 2024-01-26 | 2025-07-31 | 浙江养生堂天然药物研究所有限公司 | 偶联物及其制备方法和用途 |
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2015
- 2015-05-05 KR KR1020167035265A patent/KR102149572B1/ko active Active
- 2015-05-05 HU HUE15724064A patent/HUE052146T2/hu unknown
- 2015-05-05 SG SG11201608936UA patent/SG11201608936UA/en unknown
- 2015-05-05 BR BR112016026809A patent/BR112016026809A2/pt not_active Application Discontinuation
- 2015-05-05 NZ NZ725600A patent/NZ725600A/en unknown
- 2015-05-05 EP EP15724064.9A patent/EP3145934B1/en active Active
- 2015-05-05 JP JP2016567971A patent/JP6193513B2/ja active Active
- 2015-05-05 RU RU2016142704A patent/RU2696490C2/ru active
- 2015-05-05 PL PL15724064T patent/PL3145934T3/pl unknown
- 2015-05-05 PE PE2016002255A patent/PE20170024A1/es unknown
- 2015-05-05 SI SI201531464T patent/SI3145934T1/sl unknown
- 2015-05-05 ES ES15724064T patent/ES2841400T3/es active Active
- 2015-05-05 MX MX2016015199A patent/MX381383B/es unknown
- 2015-05-05 AU AU2015262993A patent/AU2015262993B2/en active Active
- 2015-05-05 CN CN201580028359.2A patent/CN106459120A/zh active Pending
- 2015-05-05 WO PCT/IB2015/053282 patent/WO2015177668A1/en not_active Ceased
- 2015-05-05 DK DK15724064.9T patent/DK3145934T5/da active
- 2015-05-05 MY MYPI2016704172A patent/MY181586A/en unknown
- 2015-05-05 PT PT157240649T patent/PT3145934T/pt unknown
- 2015-05-15 UY UY0001036126A patent/UY36126A/es not_active Application Discontinuation
- 2015-05-15 CA CA2891717A patent/CA2891717C/en active Active
- 2015-05-15 TW TW104115586A patent/TWI579286B/zh active
- 2015-05-18 US US14/714,484 patent/US9340553B2/en active Active
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2016
- 2016-04-07 US US15/093,178 patent/US9617293B2/en active Active
- 2016-11-01 IL IL248667A patent/IL248667B/en active IP Right Grant
- 2016-11-17 SA SA516380328A patent/SA516380328B1/ar unknown
- 2016-11-18 PH PH12016502304A patent/PH12016502304A1/en unknown
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2017
- 2017-02-16 US US15/434,508 patent/US10039778B2/en active Active
- 2017-08-09 JP JP2017154022A patent/JP6663889B2/ja active Active
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2018
- 2018-06-29 US US16/023,232 patent/US10376531B2/en active Active
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2019
- 2019-06-24 US US16/450,649 patent/US10813942B2/en active Active