|
US4603203A
(en)
|
1983-12-14 |
1986-07-29 |
Takeda Chemical Industries, Ltd. |
3-aminopyrazolo[3,4-d]pyrimidine derivatives and production thereof
|
|
CA1251448A
(en)
|
1985-03-27 |
1989-03-21 |
William J. Coates |
Pyridazinone derivatives
|
|
US4666908A
(en)
|
1985-04-05 |
1987-05-19 |
Warner-Lambert Company |
5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
|
|
DE59009485D1
(de)
|
1989-01-26 |
1995-09-14 |
Bayer Ag |
Optisch aktive (Meth)Acrylsäure-Derivate, ihre Herstellung, ihre Polymerisation zu optisch aktiven Polymeren und deren Verwendung.
|
|
NZ238609A
(en)
|
1990-06-21 |
1993-12-23 |
Schering Corp |
Polycyclic guanine derivatives; preparation, pharmaceutical compositions,
|
|
US5294612A
(en)
|
1992-03-30 |
1994-03-15 |
Sterling Winthrop Inc. |
6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
|
|
US5939419A
(en)
|
1993-02-26 |
1999-08-17 |
Schering-Plough Corporation |
2-benzyl-polycyclic guanine derivatives and process for preparing them
|
|
DE19541264A1
(de)
|
1995-11-06 |
1997-05-07 |
Bayer Ag |
Purin-6-on-derivate
|
|
US5824683A
(en)
|
1995-11-28 |
1998-10-20 |
Schering Corporation |
2'- 4'-halo- 1,1'-biphenyl!-4-yl!methyl!-5'-methyl-spiro cyclopentane-1,7' (8'H)- 3H! imidazo 2,1-b!purin!-4' (5'H)-ones
|
|
DE19702785A1
(de)
|
1997-01-27 |
1998-07-30 |
Bayer Ag |
Neue cyclische Harnstoffderivate
|
|
SE9701398D0
(sv)
|
1997-04-15 |
1997-04-15 |
Astra Pharma Prod |
Novel compounds
|
|
IT1291372B1
(it)
|
1997-05-21 |
1999-01-07 |
Schering Plough S P A |
Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
|
|
US6013621A
(en)
|
1997-10-17 |
2000-01-11 |
The Rockfeller University |
Method of treating psychosis and/or hyperactivity
|
|
GB9722520D0
(en)
|
1997-10-24 |
1997-12-24 |
Pfizer Ltd |
Compounds
|
|
DE19931206A1
(de)
|
1999-07-07 |
2001-01-11 |
Stief Christian |
Arzneimittel zur Erhöhung des cAMP-Spiegels und deren Verwendung
|
|
HK1049834A1
(zh)
|
1999-10-11 |
2003-05-30 |
辉瑞大药厂 |
用作磷酸二酯酶抑制剂的5-(2-取代的-5-杂环基磺酰基吡啶-3-基)-二氢吡唑并[4,3-d]嘧啶-7-酮类化合物
|
|
IL139073A0
(en)
|
1999-10-21 |
2001-11-25 |
Pfizer |
Treatment of neuropathy
|
|
US20020006926A1
(en)
|
2000-04-19 |
2002-01-17 |
Roylance H. H. |
Use of cyclic GMP-specific phosphodiesterase inhibitors for treatment of parkinson's disease
|
|
EP1307201B1
(de)
|
2000-08-01 |
2004-11-24 |
Bayer HealthCare AG |
Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
|
|
DE10064105A1
(de)
|
2000-12-21 |
2002-06-27 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
DE10108752A1
(de)
|
2001-02-23 |
2002-09-05 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
SE0102315D0
(sv)
|
2001-06-28 |
2001-06-28 |
Astrazeneca Ab |
Compounds
|
|
ATE395349T1
(de)
|
2001-08-28 |
2008-05-15 |
Schering Corp |
Polycyclische guanin phosphodiesterase inhibitoren
|
|
IL160307A0
(en)
|
2001-08-31 |
2004-07-25 |
Univ Rockefeller |
Phosphodiesterase activity and regulation of phosphodiesterase 1-b-mediated signaling in brain
|
|
CA2465893A1
(en)
|
2001-11-09 |
2003-05-22 |
Schering Corporation |
Polycyclic guanine derivative phosphodiesterase v inhibitors
|
|
IL163575A0
(en)
|
2002-02-21 |
2005-12-18 |
Univ Rockefeller |
Compositions and method for regulation of calcium-dependent signalling in brain
|
|
JP2006509832A
(ja)
|
2002-10-30 |
2006-03-23 |
ニューロ3デー |
サイクリックヌクレオチドホスホジエステラーゼ阻害剤、その調製及び使用
|
|
CA2504820C
(en)
|
2002-11-06 |
2011-08-23 |
Grelan Pharmaceutical Co., Ltd. |
Pyrazolonaphthyridine derivatives
|
|
HRP20050848A2
(en)
|
2003-03-04 |
2006-06-30 |
Altana Pharma Ag |
Purin-6-one-derivatives
|
|
EP1613747A1
(en)
|
2003-03-31 |
2006-01-11 |
Pfizer Products Inc. |
Crystal structure of 3 ,5 -cyclic nucleotide phosphodiesterase 1b (pde1b) and uses thereof
|
|
US7153824B2
(en)
|
2003-04-01 |
2006-12-26 |
Applied Research Systems Ars Holding N.V. |
Inhibitors of phosphodiesterases in infertility
|
|
US7268133B2
(en)
*
|
2003-04-23 |
2007-09-11 |
Pfizer, Inc. Patent Department |
Cannabinoid receptor ligands and uses thereof
|
|
WO2005041957A1
(en)
|
2003-10-29 |
2005-05-12 |
Pfizer Products Inc. |
Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
|
|
AP2006003632A0
(en)
|
2003-12-16 |
2006-06-30 |
Pfizer Prod Inc |
Pyridol[2,3-D] pyrimidine-2,4-Diamines as PDE 2 inhibitors
|
|
EP1548011A1
(en)
|
2003-12-23 |
2005-06-29 |
Neuro3D |
Benzo[1,4]diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors, preparation and therapeutic use thereof
|
|
WO2005083069A1
(en)
*
|
2004-01-30 |
2005-09-09 |
Pfizer Products Inc. |
Pde2 crystal structures for structure based drug design
|
|
KR101368093B1
(ko)
|
2004-09-02 |
2014-03-14 |
다케다 게엠베하 |
트리아졸로프탈라진
|
|
CA2591991C
(en)
|
2005-01-05 |
2013-11-19 |
Altana Pharma Ag |
Triazolophthalazines
|
|
CN101103033B
(zh)
|
2005-01-05 |
2010-08-04 |
尼科梅德有限责任公司 |
作为pde2抑制剂的三唑并酞嗪
|
|
DOP2006000009A
(es)
*
|
2005-01-13 |
2006-08-15 |
Arena Pharm Inc |
Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina
|
|
AU2006255028B2
(en)
|
2005-06-06 |
2012-04-19 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
EP1749824A1
(en)
|
2005-08-03 |
2007-02-07 |
Neuro3D |
Benzodiazepine derivatives, their preparation and the therapeutic use thereof
|
|
US20080194592A1
(en)
|
2005-08-23 |
2008-08-14 |
Intra-Cellular Therapies, Inc. |
Organic Compounds
|
|
KR20080046728A
(ko)
|
2005-09-15 |
2008-05-27 |
아스카 세이야쿠 가부시키가이샤 |
복소환 화합물, 그의 제조 방법 및 용도
|
|
EP1940389A2
(en)
|
2005-10-21 |
2008-07-09 |
Braincells, Inc. |
Modulation of neurogenesis by pde inhibition
|
|
KR20090042227A
(ko)
|
2006-06-06 |
2009-04-29 |
인트라-셀룰라 써래피스, 인코퍼레이티드. |
유기 화합물
|
|
WO2008063505A1
(en)
|
2006-11-13 |
2008-05-29 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
WO2008070095A1
(en)
|
2006-12-05 |
2008-06-12 |
Intra-Cellular Therapies, Inc. |
Novel uses
|
|
RS52166B
(sr)
|
2007-05-11 |
2012-08-31 |
Pfizer Inc. |
Amino-heterociklična jedinjenja
|
|
US7807629B1
(en)
|
2007-06-05 |
2010-10-05 |
Alcon Research, Ltd. |
Use of bradykinin and related B2R agonists to treat ocular hypertension and glaucoma
|
|
EP2240028B1
(en)
|
2007-12-06 |
2016-07-20 |
Intra-Cellular Therapies, Inc. |
Pyrazolopyrimidine-4,6-dione derivatives and their use as pharmaceutical
|
|
KR20120012831A
(ko)
|
2007-12-06 |
2012-02-10 |
인트라-셀룰라 써래피스, 인코퍼레이티드. |
유기 화합물
|
|
US20120065165A1
(en)
|
2008-10-31 |
2012-03-15 |
Arginetix, Inc |
Compositions and methods of treating endothelial disorders
|
|
WO2010054253A1
(en)
|
2008-11-07 |
2010-05-14 |
Biotie Therapies Gmbh |
Triazine derivatives as inhibitors of phosphodiesterases
|
|
WO2010054260A1
(en)
|
2008-11-07 |
2010-05-14 |
Biotie Therapies Gmbh |
Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases
|
|
MA32942B1
(fr)
|
2008-12-06 |
2012-01-02 |
Intra Cellular Therapies Inc |
Composes organiques
|
|
EP2367431B1
(en)
|
2008-12-06 |
2015-08-05 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
KR20110103949A
(ko)
|
2008-12-06 |
2011-09-21 |
인트라-셀룰라 써래피스, 인코퍼레이티드. |
유기 화합물
|
|
BRPI0922809A2
(pt)
|
2008-12-06 |
2018-05-29 |
Intracellular Therapies Inc |
compostos orgânicos
|
|
EP2367430B1
(en)
|
2008-12-06 |
2014-08-13 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
JP5778582B2
(ja)
|
2008-12-06 |
2015-09-16 |
イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. |
有機化合物
|
|
WO2010098839A1
(en)
|
2009-02-25 |
2010-09-02 |
Intra-Cellular Therapies, Inc. |
Pde 1 inhibitors for ophthalmic disorders
|
|
JP2012526810A
(ja)
|
2009-05-13 |
2012-11-01 |
イントラ−セルラー・セラピーズ・インコーポレイテッド |
有機化合物
|
|
US8680116B2
(en)
|
2009-07-22 |
2014-03-25 |
Merck Sharp & Dohme Corp. |
Quinolinone PDE2 inhibitors
|
|
WO2011043816A1
(en)
|
2009-10-08 |
2011-04-14 |
Intra-Cellular Therapies, Inc. |
Phosphodiesterase 1-targeting tracers and methods
|
|
WO2011049722A1
(en)
|
2009-10-19 |
2011-04-28 |
Merck Sharp & Dohme Corp. |
PYRAZOLO [3,4-b] PYRIDIN-4-ONE KINASE INHIBITORS
|
|
WO2011153136A1
(en)
|
2010-05-31 |
2011-12-08 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
WO2011153135A1
(en)
|
2010-05-31 |
2011-12-08 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
EP2576551A4
(en)
|
2010-05-31 |
2014-04-16 |
Intra Cellular Therapies Inc |
ORGANIC CONNECTIONS
|
|
TW201206937A
(en)
|
2010-05-31 |
2012-02-16 |
Intra Cellular Therapies Inc |
Organic compounds
|
|
US9540379B2
(en)
|
2011-01-31 |
2017-01-10 |
Boehringer Ingelheim International Gmbh |
(1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
|
|
KR101548443B1
(ko)
|
2011-02-23 |
2015-08-28 |
화이자 인코포레이티드 |
신경 장애의 치료를 위한 이미다조[5,1-f][1,2,4]트라이아진
|
|
CA2836851C
(en)
|
2011-06-07 |
2016-06-21 |
Christopher J. Helal |
Pyrazolo[3,4-d]pyrimidine compounds and their use as pde2 inhibitors and/or cyp3a4 inhibitors
|
|
JP6051210B2
(ja)
|
2011-06-10 |
2016-12-27 |
イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. |
有機化合物
|
|
WO2013000924A1
(en)
|
2011-06-27 |
2013-01-03 |
Janssen Pharmaceutica Nv |
1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES
|
|
EP2763989A1
(en)
|
2011-09-09 |
2014-08-13 |
H. Lundbeck A/S |
Pyridine compounds and uses thereof
|
|
WO2013034758A1
(en)
|
2011-09-09 |
2013-03-14 |
H. Lundbeck A/S |
Substituted triazolopyrazines and uses thereof
|
|
WO2013034755A1
(en)
|
2011-09-09 |
2013-03-14 |
H. Lundbeck A/S |
Triazolopyrazine derivatives and their use for treating neurological and psychiatric disorders
|
|
AR091507A1
(es)
|
2012-06-21 |
2015-02-11 |
Intra Cellular Therapies Inc |
SALES DE (6aR,9aS)-5,6a,7,8,9,9a-HEXAHIDRO-5-METIL-3-(FENILAMINO)-2-((4-(6-FLUOROPIRIDIN-2-IL)FENIL)METIL)-CICLOPENT[4,5]IMIDAZO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(2H)-ONA
|
|
KR102240326B1
(ko)
|
2013-03-15 |
2021-04-13 |
인트라-셀룰라 써래피스, 인코퍼레이티드. |
유기 화합물
|
|
AU2014243257A1
(en)
|
2013-03-25 |
2015-10-15 |
Sanofi |
Pyrazolonaphthyridinone derivatives as METAP2 inhibitors (methionine aminopeptidase type-2)
|
|
US9546175B2
(en)
|
2014-08-07 |
2017-01-17 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|