AU2015357496B2 - Organic compounds - Google Patents

Organic compounds Download PDF

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Publication number
AU2015357496B2
AU2015357496B2 AU2015357496A AU2015357496A AU2015357496B2 AU 2015357496 B2 AU2015357496 B2 AU 2015357496B2 AU 2015357496 A AU2015357496 A AU 2015357496A AU 2015357496 A AU2015357496 A AU 2015357496A AU 2015357496 B2 AU2015357496 B2 AU 2015357496B2
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AU
Australia
Prior art keywords
disorder
disorders
methyl
pain
depression
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2015357496A
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English (en)
Other versions
AU2015357496A1 (en
Inventor
Joseph Hendrick
Peng Li
Gretchen Snyder
Lawrence P. Wennogle
Hailin Zheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intra Cellular Therapies Inc
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Intra Cellular Therapies Inc
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Publication of AU2015357496A1 publication Critical patent/AU2015357496A1/en
Application granted granted Critical
Publication of AU2015357496B2 publication Critical patent/AU2015357496B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2015357496A 2014-12-06 2015-12-07 Organic compounds Ceased AU2015357496B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462088541P 2014-12-06 2014-12-06
US62/088,541 2014-12-06
PCT/US2015/064324 WO2016090380A1 (en) 2014-12-06 2015-12-07 Organic compounds

Publications (2)

Publication Number Publication Date
AU2015357496A1 AU2015357496A1 (en) 2017-07-27
AU2015357496B2 true AU2015357496B2 (en) 2019-09-19

Family

ID=56092607

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015357496A Ceased AU2015357496B2 (en) 2014-12-06 2015-12-07 Organic compounds

Country Status (13)

Country Link
US (1) US10300064B2 (https=)
EP (1) EP3226870B1 (https=)
JP (1) JP6608934B2 (https=)
KR (1) KR102557603B1 (https=)
CN (1) CN107205999B (https=)
AU (1) AU2015357496B2 (https=)
BR (1) BR112017012007B1 (https=)
CA (1) CA2969594A1 (https=)
HK (1) HK1243936A1 (https=)
IL (1) IL252579B (https=)
MX (1) MX371158B (https=)
RU (1) RU2709786C2 (https=)
WO (1) WO2016090380A1 (https=)

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WO2018049417A1 (en) * 2016-09-12 2018-03-15 Intra-Cellular Therapies, Inc. Novel uses
MX2020011275A (es) 2018-04-25 2020-11-13 Bayer Ag Novedosos compuestos de heteroaril-triazol y hetroaril[-]tetrazol como plaguicidas.
EP3870300B1 (en) * 2018-10-23 2024-07-10 Intra-Cellular Therapies, Inc. Imidazo[1,5-a]pyrazine compounds as pde2 inhibitors
US12364695B2 (en) 2020-06-02 2025-07-22 Intra-Cellular Therapies, Inc. Methods of treating inflammatory disease

Citations (2)

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US20140080806A1 (en) * 2011-06-07 2014-03-20 Christopher John Helal Pyrazolo[3,4-d]pyrimidine compounds and their use as pde2 inhibitors and/or cyp3a4 inhibitors

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Also Published As

Publication number Publication date
MX2017007380A (es) 2017-10-20
KR102557603B1 (ko) 2023-07-19
EP3226870B1 (en) 2019-09-25
JP6608934B2 (ja) 2019-11-20
AU2015357496A1 (en) 2017-07-27
IL252579B (en) 2021-05-31
BR112017012007A2 (pt) 2017-12-26
EP3226870A1 (en) 2017-10-11
BR112017012007B1 (pt) 2022-11-01
US10300064B2 (en) 2019-05-28
CN107205999B (zh) 2021-08-03
HK1243936A1 (zh) 2018-07-27
EP3226870A4 (en) 2018-05-30
MX371158B (es) 2020-01-20
RU2017123686A3 (https=) 2019-07-17
CN107205999A (zh) 2017-09-26
JP2017536410A (ja) 2017-12-07
HK1243933A1 (zh) 2018-07-27
CA2969594A1 (en) 2016-06-09
WO2016090380A1 (en) 2016-06-09
IL252579A0 (en) 2017-07-31
KR20170089000A (ko) 2017-08-02
US20170360792A1 (en) 2017-12-21
RU2017123686A (ru) 2019-01-09
RU2709786C2 (ru) 2019-12-20

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